βTrCP2 (beta-transducin repeat containing protein 2; also known as Fbxw11 or HOS) is a protein that in humans is encoded by the ... Fong A, Sun SC (Jun 2002). "Genetic evidence for the essential role of beta-transducin repeat-containing protein in the ... Fbxws containing WD40 repeats, Fbxls containing leucine-rich repeats, and Fbxos containing either "other" protein-protein ... The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (Skp1-Cul1-F-box protein ...
Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with ... Takagaki Y, Manley JL (November 1992). "A human polyadenylation factor is a G protein beta-subunit homologue". The Journal of ... Cleavage stimulation factor 50 kDa subunit is a protein that in humans is encoded by the CSTF1 gene. This gene encodes one of ... Takagaki Y, Manley JL (March 2000). "Complex protein interactions within the human polyadenylation machinery identify a novel ...
Transducin beta-like protein 3 is a protein that in humans is encoded by the TBL3 gene. The protein encoded by this gene has ... It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal ... beta)-like 3". Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein ... sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, ...
Fong A, Sun SC (Jun 2002). "Genetic evidence for the essential role of beta-transducin repeat-containing protein in the ... Nuclear factor NF-kappa-B p100 subunit is a protein that in humans is encoded by the NFKB2 gene. NF-κB has been detected in ... The protein NFKB2 can become mutated and lead to hereditary endocrine and immuneodeficiences. The mutation occurs at the C- ... NFKB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Overview of all the structural ...
Transducin (beta)-like 1X-linked, also known as TBL1X, is a protein which in humans is encoded by the TBL1X gene. The protein ... It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal ... "Entrez Gene: TBL1X transducin (beta)-like 1X-linked". Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 ... a WD40-repeat protein linked to deafness". Genes Dev. 14 (9): 1048-57. doi:10.1101/gad.14.9.1048 (inactive 2021-01-11). PMC ...
Beta-transducin repeat-containing protein (βTRCP) is an FBP that targets emi1-an APC/C-Cdh1 inhibitor-and wee1 for degradation ... Skp1 - Skp1 is an adaptor protein that is essential for the recognition and binding of F-box proteins. Cullin (CUL1) - Cullin ... The SCF complex also marks various other cellular proteins for destruction. SCF contains a variable F-box protein and three ... Instead, FBP affinity for protein substrates is regulated through cyclin-CDK-mediated phosphorylation of target proteins. ...
Fong A, Sun SC (June 2002). "Genetic evidence for the essential role of beta-transducin repeat-containing protein in the ... beta-transducin repeat containing) gene. This gene encodes a member of the F-box protein family which is characterized by an ... "Entrez Gene: BTRC beta-transducin repeat containing". Margottin F, Bour SP, Durand H, Selig L, Benichou S, Richard V, Thomas D ... Fbxws containing WD40 repeats, Fbxls containing leucine-rich repeats, and Fbxos containing either "other" protein-protein ...
... receptor kinase and beta-spectrin to WD40/beta-transducin repeat containing regions of the beta-subunit of trimeric G-proteins ... ARAP proteins contain five PH domains. Serine/threonine-specific protein kinases such as the Akt/Rac family, protein kinase D1 ... spectrin beta-chain, syntrophin (2 PH domains), and S. cerevisiae nuclear migration protein NUM1. Oxysterol-binding proteins ... and proteins such as the βγ-subunits of heterotrimeric G proteins, and protein kinase C. Through these interactions, PH domains ...
The WD40 repeat (also known as the WD or beta-transducin repeat) is a short structural motif of approximately 40 amino acids, ... ZFP106 Beta-propeller Tomosyn, a protein two WD40 domains Protein tandem repeats PDB: 1erj​; Sprague ER, Redd MJ, Johnson AD, ... WD40 domain-containing proteins have 4 to 16 repeating units, all of which are thought to form a circularised beta-propeller ... The blades interlock so that the last beta strand of one repeat forms with the first three of the next repeat to form the 3D ...
WD40 repeats, also known as beta-transducin repeats, are short fragments found primarily in eukaryotes. They usually form beta- ... Rather than having the typical four beta-strands in a sheet, beta-lactamase inhibitor protein-II only has three beta-strands ... SCOP 4-bladed beta propellers SCOP 5-bladed beta propellers SCOP 6-bladed beta propellers SCOP 7-bladed beta propellers SCOP 8- ... The influenza virus protein viral neuraminidase is a six-bladed beta-propeller protein whose active form is a tetramer. It is ...
Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, consist of three subunits, called alpha, beta, ... The amino acid sequence contains 7 WD repeat motifs of about 40 amino acids, each highly conserved and possessing the Trp-Asp ... Nevertheless, recent in vivo findings demonstrate the necessity of the transducin Gβγ complex in the functioning of rod ... "Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors". ...
This protein is conserved all the way back to invertebrates. Proteins containing WD transducin repeating domains have been ... beta turns, and random coils. The human protein WDR90 adopts a 7-bladed beta propeller that is indicative of the WD40 repeat ... WD repeat-containing protein 90 is a protein that in humans is encoded by the WDR90 gene (16p13.3). This human protein is 1750 ... its ties to the protein superfamily WD40 domain-containing proteins, and the known protein interactions, it could play a role ...
F-box-like/WD repeat-containing protein TBL1XR1 is a protein that in humans is encoded by the TBL1XR1 gene. The protein encoded ... "Entrez Gene: TBL1XR1 transducin (beta)-like 1X-linked receptor 1". "OMIM Entry - # 602342 - PIERPONT SYNDROME; PRPTS". www.omim ... It is believed that the WD40 repeats mediate protein-protein interactions, and members of the family are involved in signal ... by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large ...
They form a G-protein regulator family that also contains TPR repeats. Human proteins containing this domain include: GPSM1, ... The inactive form contains the alpha subunit bound to GDP and complexes with the beta and gamma subunit. When the ligand is ... "AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin". J. Biol ... Two classes of intracellular proteins act as inhibitors of G protein activation: GTPase activating proteins (GAPs), which ...
... bcr-abl fusion protein - benzene - benzene ring - beta-2 microglobulin - beta adrenergic receptor - beta sheet - beta-1 ... talin protein - tandem repeat sequence - taste bud - TATA box - tax gene product - taxonomy - telophase - Tertiary structure - ... transducin - transformation - transforming growth factor - transforming growth factor alpha - transforming growth factor beta ... protein - protein biosynthesis - Protein Data Bank - protein design - protein expression - protein folding - protein isoform - ...
"The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or ... "Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin ... "Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1". ... "Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of ...
1jah: H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MAGNESIUM ... "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes & Development ... GO:0001948 protein binding. • GTPase activity. • identical protein binding. Cellular component. • cytoplasm. • cytosol. • ... The K-Ras protein is turned off (inactivated) when it converts the GTP to GDP. When the protein is bound to GDP, it does not ...
... is a family of cytoskeletal motor proteins that move along microtubules in cells. They convert the chemical energy ... One projection, the coiled-coil stalk, binds to and "walks" along the surface of the microtubule via a repeated cycle of ... Dynactin is a protein that aids in intracellular transport throughout the cell by linking to cytoplasmic dynein. Dynactin can ... The protein responsible for movement of cilia and flagella was first discovered and named dynein in 1963 (Karp, 2005). 20 years ...
... s (/ˈmaɪəsɪn, -oʊ-/[1][2]) are a superfamily of motor proteins best known for their roles in muscle contraction and in a ... ATP hydrolysis within the myosin will cause it to bind to actin again to repeat the cycle. The combined effect of the myriad ... The neck domain can also serve as a binding site for myosin light chains which are distinct proteins that form part of a ... Myosin IX is a group of single-headed motor proteins. It was first shown to be minus-end directed,[33] but a later study showed ...
Anchoring of transducin to the membrane has been drawn in black.. RPE65 isomerohydrolases are homologous with beta-carotene ... Opsins are proteins and the retinal-binding visual pigments found in the photoreceptor cells in the retinas of eyes. An opsin ... beta-carotene + O2 → 2 retinal. catalyzed by a beta-carotene 15,15'-monooxygenase[7] or a beta-carotene 15,15'-dioxygenase.[8] ... Type 2 rhodopsin (rainbow colored) embedded in a lipid bilayer (heads red and tails blue) with transducin below it. Gtα is ...
... regulate G proteins in several different ways. Small GTPases act as molecular switches in ... and thus requires another class of regulatory proteins to accelerate this activity, the GTPase activating proteins (GAPs). ... GTP-Binding+Protein+Regulators at the US National Library of Medicine Medical Subject Headings (MeSH) ... The inactive form of GTPases (GDP-form) are activated by a class of proteins called Guanosine nucleotide exchange factors (GEFs ...