*Beta-lactamase

Beta-lactamases are ancient bacterial enzymes. The class B beta-lactamases (the metallo-beta-lactamases) are divided into three ... The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases ... OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze ... although carbapenems are relatively resistant to beta-lactamase. Beta-lactamase provides antibiotic resistance by breaking the ...

*Beta-lactamase inhibitor protein

"Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase". Nat. ... Beta-Lactamase Inhibitor Proteins (BLIPs) are a family of proteins produced by bacterial species including Streptomyces. BLIP ... BLIP is able to inhibit a variety of class A beta-lactamases, possibly through flexibility of its two domains. The two tandemly ... "A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex ...

*Metallo-beta-lactamase protein fold

The metallo-beta-lactamase protein fold is a protein domain contained in class B beta-lactamases and a number of other proteins ... New Delhi metallo-beta-lactamase PDB: 1bmc​ ; Carfi A, Pares S, Duée E, Galleni M, Duez C, Frère JM, Dideberg O (October 1995 ... Metallo-beta-lactamases are important enzymes because they are involved in the breakdown of antibiotics by antibiotic-resistant ... It is unclear whether metallo-beta-lactamase activity evolved once or twice within the superfamily; if twice, this would ...

*New Delhi metallo-beta-lactamase 1

... (NDM-1) is an enzyme that makes bacteria resistant to a broad range of beta-lactam ... The NDM-1 enzyme is one of the class B metallo-beta-lactamase; other types of carbapenemase are class A or class D beta- ... The gene for NDM-1 is one member of a large gene family that encodes beta-lactamase enzymes called carbapenemases. Bacteria ... ISBN 978-953-176-637-1. Muir A, Weinbren MJ (July 2010). "New Delhi metallo-beta-lactamase: a cautionary tale". J. Hosp. Infect ...

*Cefoxitin

... bacteria that make beta-lactamases will increase their production and secretion to cleave the beta lactam ring. As a cephamycin ... Cephamycin C was the first cephem discovered but while it was highly resistant to a lot of beta-lactamases-as is its derivative ... This followed a 2012 French study on the same E. coli strain with CTX-M-15 extended release beta-lactamase. Lepeule et al. ... It is a strong beta-lactamase inducer, as are certain other antibiotics (such as imipenem). However, cefoxitin is a better ...

*Pathogenic Escherichia coli

... as strains of bacteria that produce extended-spectrum beta-lactamases have become more common. These beta-lactamase enzymes ... Extended-spectrum beta-lactamase-producing E. coli (ESBL E. coli) are highly resistant to an array of antibiotics, and ... In 2009, a gene called New Delhi metallo-beta-lactamase (shortened NDM-1) that even gives resistance to intravenous antibiotic ... Paterson DL, Bonomo RA (2005). "Extended-spectrum beta-lactamases: a clinical update". Clin. Microbiol. Rev. 18 (4): 657-86. ...

*Ureidopenicillin

... s are not resistant to beta-lactamases. They are used parenterally, and are particularly indicated in ...

*Discovery and development of cephalosporins

They secrete their beta-lactamases into the periplasmic space between the inner and outer membrane so they can't easily escape ... There are many beta lactamases which vary in substrate specificity and host range. The enzymes active site is easily ... This gave an increased resistance to β-lactamases due to stereochemical blocking of the beta-lactam ring. Cefuroxime was the ... Gram-positive bacteria, such as a staphylococci, have a high release of beta-lactamases into their extracellular space, where ...

*List of veterinary drugs

clavulanic acid - Adjunct to penicillin-derived antibiotics used to overcome resistance in bacteria that secrete beta-lactamase ... Ineffective against species that produce beta-lactamase. apomorphine - emetic (used to induce vomiting) artificial tears - ...

*Cefalexin

However, some bacterial cells have the enzyme β-lactamase, which hydrolyzes the beta-lactam ring, rendering the drug inactive. ... Subscription required (help)). Drawz SM, Bonomo RA (Jan 2010). "Three decades of beta-lactamase inhibitors". Clinical ... Cefalexin is a beta-lactam antibiotic of the cephalosporin family. It is bactericidal and acts by inhibiting synthesis of the ... Cefalexin is a beta-lactam antibiotic within the class of first-generation cephalosporins. It works similarly to other agents ...

*Catalytic triad

Jelsch, C; Lenfant, F; Masson, JM; Samama, JP (Mar 9, 1992). "Beta-lactamase TEM1 of E. coli. Crystal structure determination ... "The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme". Proceedings of ... β-lactamases such as TEM-1 use a lysine residue as the base. Because lysine's pKa is so high (pKa=11), a glutamate and several ... lipases and β-lactamases). An Acid-Base-Nucleophile triad is a common motif for generating a nucleophilic residue for covalent ...

*Ampicillin

Its spectrum of activity is enhanced by co-administration of sulbactam, a drug that inhibits beta lactamase, an enzyme produced ... 25-28 Akova M (January 2008). "Sulbactam-containing beta-lactamase inhibitor combinations". Clin. Microbiol. Infect. 14 Suppl 1 ... Ampicillin is in the penicillin group of beta-lactam antibiotics and is part of the aminopenicillin family. It is roughly ...

*Carboxypenicillin

The carboxypenicillins are beta-lactamase sensitive. Aminopenicillin "Mayo Clinic Proceedings". Retrieved 2015-12-08. ... The carboxypenicillins feature the beta-lactam backbone of all penicillins but also feature a carboxylic acid or carboxylic ...

*Cefquinome

... is resistant to beta-lactamase. Chemically, its zwitterionic structure can facilitate rapid penetration across ... by selecting bacteria which have acquired beta-lactamases. The use may cause resistance in Salmonella present in the intestinal ... The reactive site is a beta-lactam nucleus, while the main peripheral functional groups are a quaternary quinolinium, an ... they are active against bacteria carrying the AmpC-type β-lactamase resistance mechanism. Since the late 1990s, the US and EU ...

*Doripenem

Beta-lactamases (such as penicillinases) formed by gram-positive and gram-negative bacteria can stabilize doripenem to ... However, carbapenem-hydrolyzing beta-lactamases are an exception. On average, about 8.1% of plasma proteins attached to ... It is stable against beta-lactamases including those with extended spectrum, but it is susceptible to the action of ... It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name ...

*PBR322

The AmpR gene is penicillin beta-lactamase. Promoters P1 and P3 are for the beta-lactamase gene. P3 is the natural promoter, ...

*Drug resistance

Bush, K (Jan 1988). "Beta-lactamase inhibitors from laboratory to clinic". Clin Microbiol Rev. 1 (1): 109-123. PMC 358033 . ... Beta-lactam bacterial resistance can also be dealt with by administering beta-lactam antibiotics with drugs that block beta- ... can be circumvented by using antibiotics such as nafcillin that are not susceptible to destruction by certain beta-lactamases ( ... For example, bacterial resistance against beta-lactam antibiotics (such as penicillins and cephalosporins) ...

*SCHEMA (bioinformatics)

Meyer, M; Hochrein, L.; Arnold, F (2006). "Structure-guided SCHEMA recombination of distantly related beta-lactamases". Protein ... SCHEMA algorithm has been applied in the recombinant libraries of distantly related β-lactamases. Voigt, CA; Martinez, C; Wang ...

*Tazobactam

Ceftolozane Sulbactam Clavulanate Yang Y, Rasmussen BA, Shlaes DM (1999). "Class A beta-lactamases-enzyme-inhibitor ... Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 ... Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express β-lactamase and would ...

*LACTB2

Lactamase, beta 2". Retrieved 2015-07-07. Dominski Z (2007-03-01). "Nucleases of the metallo-beta-lactamase family and their ... The metallo beta-lactamases were first identified in bacteria; they give some strains antibiotic resistance by degrading beta- ... Lactamase, beta 2 is a protein that in humans is encoded by the LACTB2 gene. LACTB2 is located on the 8th chromosome, with its ... The LACTB2 protein has a metallo β-lactamase (MBL) fold, with two zinc ions in the active site. ...

*MCR-1

New Delhi metallo-beta-lactamase 1 Liu, YY; Wang, Y; Walsh, TR; et al. (18 November 2015). "Emergence of plasmid-mediated ...

*Natalie Strynadka

"Structural and kinetic characterization of a beta-lactamase-inhibitor protein". Nature. 368 (6472): 657-60. doi:10.1038/ ... "Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 a resolution". Nature. 359 (6397): 700-5. ... "Aspergillomarasmine a overcomes metallo-β-lactamase antibiotic resistance". Nature. 510 (7506): 503-6. doi:10.1038/nature13445 ...

*Aminopenicillin

This does not, however, confer resistance to bacterial beta-lactamases. Members of this family include ampicillin, amoxicillin ... Like other penicillins they contain a beta-lactam ring that is believed to be crucial to its antibacterial activity. ...

*Nitrocefin

indicates beta-lactamase activity Antibiotic resistance Antimicrobial Beta-lactam β-Lactam antibiotic Beta-lactamase ... Other methods for beta-lactamase detection exist including PCR; however, nitrocefin allows for rapid beta-lactamase detection ... Beta-lactamases hydrolyze the amide bond between the carbonyl carbon and the nitrogen in the beta-lactam ring of susceptible ... Beta-lactamase mediated resistance to beta-lactam antibiotics such as penicillin is a widespread mechanism of resistance for a ...

*Enterobacter cloacae

Metallo-beta-lactamases: a last frontier for beta-lactams? Lancet Infect. Dis.11(5),381-393 (2011). 86.Deshpande LM, Jones RN, ... Extended-spectrum beta-lactamases: a clinical update. Clin. Microbiol. Rev.18,657-686 (2005). 65.Jiang X, Ni Y, Jiang Y et al. ... Metallo-beta-lactamase-producing Enterobacteriaceae isolates in a university hospital in Taiwan: prevalence of IMP-8 in ... Characterization of a new metallo-beta-lactamase gene, bla NDM-1, and a novel erythromycin esterase gene carried on a unique ...

*Antonius Suwanto

Teo, J. W.; Suwanto, A; Poh, C. L. (2000). "Novel beta-lactamase genes from two environmental isolates of Vibrio harveyi". ...