Benzomorphans Dezocine. No data available.. Mixed opioid agonist-antagonist.. IM, IV.. Volume of distribution = 9-12 L/kg; half ...
This family of opioid drugs is called the benzomorphans or benzazocines. It is a KOR agonist and MOR partial agonist, and also ... Benzomorphan Archer, S.; Glick, S. D.; Bidlack, J. M. (1996). "Cyclazocine Revisited". Neurochemical Research. 21 (11): 1369- ... novel benzomorphan". J. Pharmacol. Exp. Ther. 302 (1): 374-80. doi:10.1124/jpet.302.1.374. PMID 12065740. S2CID 15864569. ...
Benzomorphan. References[edit]. *^ Index nominum 2000: international drug directory. Taylor & Francis US. 2000. p. 396. ISBN ...
... (INN) is an opioid analgesic of the benzomorphan family which was never marketed. Benzomorphan Macdonald F (1997 ...
Benzomorphan F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 146. ISBN 978-0-412-46630-4. Retrieved ... Anazocine (INN; also known as azabicyclane or CS-307) is an opioid analgesic of the morphan/benzomorphan family developed in ...
"Antagonist-Agonist Activity of Some N-Substituted Benzomorphans". Advances in Endogenous and Exogenous Opioids. Elsevier: 411- ...
... is an opioid analgesic of the benzomorphan family which was never marketed. Benzomorphan World Health Organization ...
A related compound is benzomorphan. Azocine Benzomorphan v t e. ...
... (INN) is an opioid analgesic of the benzomorphan family which was never marketed. Benzomorphan World Health ...
... is a much more potent analgesic than pentazocine and other drugs in the benzomorphan series, most probably due to ... It was one of a number of benzomorphan opioids (including pentazocine, dezocine, and cyclazocine) developed in the search for ... Eckenhoff JE (May-June 1959). "Phenazocine, a new benzomorphan narcotic analgesic". Anesthesiology. 20 (3): 355-8. doi:10.1097/ ... "Some Narcotic Antagonists in the Benzomorphan Series". Journal of Pharmacology and Experimental Therapeutics. 143: 141-8. PMID ...
Benzomorphan Ethylketazocine Leander JD (September 1982). "Effects of ketazocine, ethylketazocine and phenazocine on schedule- ... Ketazocine (INN), also known as ketocyclazocine, is a benzomorphan derivative used in opioid receptor research. Ketocyclazocine ... 1S, 5R, 9R)-2-Cyclopropylmethyl-2'-hydroxy-5, 9-dimethyl-8-oxo-6, 7-benzomorphan hydrochloride monohydrate (ketazocine), ...
It is the base of the benzomorphan family of drugs. Benzomorphan Azocine Morphinan Ginsburg, David (1950). "The synthesis of ...
... is an opioid analgesic of the benzomorphan class which was never marketed. Benzomorphan ketazocine cyclazocine World ...
Benzomorphan Dictionary of Pharmacological Agents Volume 2. CRC Press. 21 November 1996. p. 1108. ISBN 978-0-412-46630-4. ...
... novel benzomorphan". The Journal of Pharmacology and Experimental Therapeutics. 302 (1): 374-80. doi:10.1124/jpet.302.1.374. ...
... (BL-4566) is an opioid analgesic of the benzomorphan family which was never marketed. It acts as a partial agonist ... Reduction of the carbonyl group in oxygenated benzomorphan 1 affords the corresponding alcohol (2). This intermediate is then N ... Cleavage of the phenolic ether by one of the standard schemes affords moxazocine (6). Benzomorphan Dictionary of ...
... (R-15,497), also known as cyclogemine, is a non-selective opioid antagonist of the benzomorphan class. It may have ... Gelders, Y. G.; de Ranter, C. J.; Schenk, H. (1979). "Structural Studies of Substituted 6,7-Benzomorphan Compounds. I. The ... 7-benzomorphans in the rabbit vas deferens". Eur. J. Pharmacol. 153 (1): 83-7. doi:10.1016/0014-2999(88)90590-0. PMID 2850928. ... Absolute Configuration of (−)-2-Cyclopropylmethyl-2'-hydroxy-5-ethyl-9,9-dimethyl-6,7-benzomorphan (Gemazocine) Hydrobromide". ...
The prototype benzomorphan, metazocine (6), can be obtained from a variation of the morphinan synthesis. Thus, reaction of the ... XI.1Analogs and a Diastereoisomer of 2'-Hydroxy-2,5,9-trimethyl-6,7-benzomorphan". The Journal of Organic Chemistry. 24 (10): ... Further Syntheses in the Benzomorphan Series*1,2". The Journal of Organic Chemistry. 22 (11): 1366-1369. doi:10.1021/ ... Cyclization by means of acid leads directly to the benzomorphan ring system (5). Demethylation of the aromatic ring system ...
Benzomorphan Ketazocine Foye WO, Lemke TL (24 September 2007). Foye's Principles of Medicinal Chemistry. Lippincott Williams & ... Ethylketazocine (WIN-35,197-2), is an opioid drug of the benzomorphan family which has been used extensively in scientific ...
7-benzomorphans". J. Heterocycl. Chem. 8 (3): 465. doi:10.1002/jhet.5570080317. Angle, S. R.; Henry, R. M. (1998). "Studies ...
Benzomorphan Azocines at the US National Library of Medicine Medical Subject Headings (MeSH). ...
Unlike many other benzomorphans however, it is a silent antagonist of the κ-opioid receptor, and in accordance, does not ... It is related to other benzomorphans such as pentazocine, with a similar profile of effects that include analgesia and euphoria ... Dezocine (INN, USAN) (brand name Dalgan) is a marketed opioid analgesic of the benzomorphan group. First synthesized in 1970, ...
... (NIH-7856) is an opioid analgesic of the benzomorphan family which was never marketed. It acts as a partial agonist ... Benzomorphan National Research Council (U.S.). Committee on Problems of Drug Dependence, American Medical Association. ...
... was one of the early members of the benzomorphan family of opioid analgesics to be investigated. It was first ... The psychotomimetic effects of alazocine and the other benzomorphans were initially attributed incorrectly to agonism of the σ1 ... Subsequently, other benzomorphans, such as pentazocine (an N-dimethylallylbenzomorphan), cyclazocine (an N- ... benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain". Brain Research ...
Starting material for this preparation is ketoester 1, available by one of the classical benzomorphan syntheses. Condensation ...
The crystal structure of bremazocine was determined in 1984 Benzomorphan Dortch-Carnes J, Potter DE (2005). "Bremazocine: a ... 7-benzomorphan hydrochloride (bremazocine), C20H29NO2. HCl". Acta Crystallogr. C. 40: 1759-1761. v t e. ...
... (WIN-44,441) is an opioid antagonist of the benzomorphan family which is used in scientific research. It acts as a ...
January 2000). "Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu ...