... the gene encodes both of the human proteins Bcl-xL and Bcl-xS. The protein encoded by this gene belongs to the Bcl-2 protein ... encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". The ... "Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins". Biochemical ... Tagami S, Eguchi Y, Kinoshita M, Takeda M, Tsujimoto Y (Nov 2000). "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl ...

... encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". EMBO ... The anti-apoptotic Bcl-2 and Bcl-xL proteins inhibit cytochrome c release through the mitochondrial pore and also inhibit ... Ayllón V, Cayla X, García A, Fleischer A, Rebollo A (July 2002). "The anti-apoptotic molecules Bcl-xL and Bcl-w target protein ... Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins". J. Biol. Chem. 272 (49): ...

... encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". The ... Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins ... These pro-apoptotic proteins are in turn activated by BH3-only proteins, and are inhibited by the function of BCL-2 and its ... ABT-737 is superior to previous BCL-2 inhibitors given its higher affinity for Bcl-2, Bcl-xL and Bcl-w. In vitro studies showed ...

Bcl-2, Bcl-x(L) and Bcl-w), which is also seen in some pro-apoptotic proteins like Bcl-x(S), Diva, Bok-L and Bok-S. On the ... Bcl-x(S)) and the β-isoform (Bcl-xβ) promote cell death. Bcl-x(L), Bcl-x(S) and Bcl-xβ are three isoforms derived by ... The anti-apoptotic Bcl-2 proteins, such as Bcl-2 and Bcl-xL, conserve all four BH domains. The BH domains also serve to ... Proteins that are known to contain these domains include vertebrate Bcl-2 (alpha and beta isoforms) and Bcl-x (isoforms Bcl-x(L ...

Other Bcl-2 proteins include Bcl-2, Bcl-w, Bcl-xs, and Mcl-1. Korsmeyer SJ (March 1995). "Regulators of cell death". Trends in ... Small molecule Bcl-xL inhibitor that directly binds to Bcl-xL and releases their partner such as Bax, a proapoptotic protein, ... It is a member of the Bcl-2 family of proteins, and acts as an anti-apoptotic protein by preventing the release of ... While the exact signaling pathway of Bcl-xL is still not known, it is believed that Bcl-xL differs highly from Bcl-2 in their ...

In molecular biology, the Bcl-x interacting domain is a protein domain found in BAM, Bim and Bcl2-like protein 11. It is a long ... This article incorporates text from the public domain Pfam and InterPro: IPR015040 (Protein domains). ... "The structure of a Bcl-xL/Bim fragment complex: implications for Bim function". Immunity. 19 (3): 341-52. doi:10.1016/S1074- ... alpha helix, which is required for interaction with Bcl-x. Liu X, Dai S, Zhu Y, Marrack P, Kappler JW (September 2003). " ...

... encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". EMBO ... Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene. The protein encoded by this gene is known to ... This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. Bcl-2-interacting killer has been ... a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist". J. Biol. Chem. 273 (14): 7783- ...

The lymphocytes have marker protein profiles (e.g. CD20 and Bcl-2 positive; CD5, cyclin D1 and CD10 negative) that are typical ... CD20 and BCL-6 but not CD10 proteins. Patients with primary thyroid EMZL are at an increased risk of developing a more ... marker proteins but do not express the cyclin D1 marker protein., the T-cell marker, CD10, or BCL6. There are various EMZL ... whose protein product indirectly regulates activation of the NF-κB cell signaling pathway; 4) KLF2 whose product protein is a ...

Such proteins include Bcl-2 and Bax. Bcl-2 is an antiapoptotic protein. The level of Bcl-2 in PD8 male rats is much higher than ... Tsukahara S, Kakeyama M, Toyofuku Y (2006). "Sex Differences in the level of Bcl-2 Family Proteins and Caspase-3 Activation in ... It is proved that Bcl-2 level in AVPV is higher whereas Bax level is lower in females than in males, just as being opposite of ... On the other hand, Bax, a proapoptotic protein, shows lower level in PD8 males than in PD8 females. Also, the number of active ...

Here, BCl-2 inhibits proteins called caspases. Caspases are part of the apoptosis pathway. When BCl-2 decreases, the expression ... Its purified protein is composed of alpha and beta subunits in equal quantities. R-PC II has PCB at beta-84 and the ... Stability of this protein invitro at these temperatures has been shown to be substantially lower. Photo-spectral analysis of ... As of March 21, 2023, there are 310 crystal structures of phycocyanin deposited in the Protein Data Bank. C-phycocyanin has a ...

Wang HG, Takayama S, Rapp UR, Reed JC (July 1996). "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1 ... Reed JC, Zha H, Aime-Sempe C, Takayama S, Wang HG (1997). Structure-function analysis of Bcl-2 family proteins. Regulators of ... Wang HG, Rapp UR, Reed JC (November 1996). "Bcl-2 targets the protein kinase Raf-1 to mitochondria". Cell. 87 (4): 629-38. doi: ... 14-3-3 proteins also contribute to the autoinhibition. As 14-3-3 proteins are all known to form constitutive dimers, their ...

BAD is a pro-apoptotic protein of the Bcl-2 family. Akt1 can phosphorylate BAD on Ser136, which makes BAD dissociate from the ... Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases ... Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that ... Akt1 is involved in the PI3K/AKT/mTOR pathway and other signaling pathways.[citation needed] The Akt proteins possess a protein ...

"RecName: Full=Uncharacterized protein C20orf144; AltName: Full=Bcl-2-like protein from testis; Short=Bclt - Gene - NCBI". ... The human c20orf144 protein consists of 153 amino acids, with the first 150 amino acids being characterized as part of the Bcl- ... "Human Protein Atlas C20orf144 entry". The Human Protein Atlas. Retrieved 8 December 2022. "NCBI Entry on Bclt". National Center ... The tertiary protein structure, produced by AlphaFold, predicts the presence of 3 α helices, and the absence of β sheets in ...

... attaches to a protein called Bcl-2. This protein is present in high amounts in CLL cancer cells, where it helps the ... Venetoclax blocks the anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein, leading to programmed cell death of CLL cells. ... By attaching to Bcl-2 and blocking its actions, venetoclax causes the death of cancer cells and thereby slows down progression ... Overexpression of Bcl-2 in some lymphoid malignancies has been linked to increased resistance to chemotherapy. The maximum ...

"Presenilin 1 protein directly interacts with Bcl-2". J. Biol. Chem. 274 (43): 30764-9. doi:10.1074/jbc.274.43.30764. PMID ... Levesque G (1999). "Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta ... They found that there is higher level expression of both proteins and a multidrug resistance-associated protein 1 (ABCC1) was ... "A new splice variant of glial fibrillary acidic protein, GFAP epsilon, interacts with the presenilin proteins". J. Biol. Chem. ...

... resides on the outer mitochondrial membrane where it co-localizes with the apoptotic Bcl-2 family protein BID. MTCH2 ... Gross A (August 2016). "BCL-2 family proteins as regulators of mitochondria metabolism". Biochimica et Biophysica Acta (BBA) - ... Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene. ... Gross A (June 2005). "Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle?". Journal of Bioenergetics ...

"The Bcl-2 protein family: arbiters of cell survival". Science. 281 (5381): 1322-6. doi:10.1126/science.281.5381.1322. PMID ... while studying the bcl-2 gene in follicular lymphoma, the most common human lymphoma. He studied for his B.Sc at Emory ...

... also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. BAX is a member of the Bcl-2 gene ... "Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins". Biochem. ... Bcl-2-associated X protein has been shown to interact with: Bcl-2, BCL2L1, BCL2A1 SH3GLB1, SLC25A4, VDAC1, TCTP, YWHAQ, Bid, ... In addition, it can become activated by binding BCL-2, as well as non-BCL-2 proteins such as p53 and Bif-1. Conversely, BAX can ...

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene. The protein encoded by this gene belongs to ... This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively ... 2001). "In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display ... the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are ...

2004). "FAST is a BCL-X(L)-associated mitochondrial protein". Biochem. Biophys. Res. Commun. 318 (1): 95-102. doi:10.1016/j. ... The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... "FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression". Mol ...

... has been shown to interact with: Bcl-2-associated X protein, and Bcl-2-associated death promoter. ... Bcl-2-related protein A1 is a protein in humans which is encoded by the BCL2A1 gene. This gene encodes a member of the bcl2 ... 1997). "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with ... 2001). "Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis". Apoptosis. 6 ...

... is an inhibitor of the Bcl-2 family of proteins. This inhibition induces apoptosis in cancer cells, preventing tumor ... a Small-Molecule BCL-2 Family Antagonist, for Patients with Myelofibrosis". Clinical Lymphoma, Myeloma & Leukemia. 10 (4): 285- ... a small molecule pan-Bcl-2 family antagonist in patients with relapsed or refractory classical Hodgkin lymphoma". Blood. 119 (9 ... "Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)". Cancer Research. 68 (9 ...

Examples of viral Bcl-2 proteins include the Epstein-Barr virus BHRF1 protein and the adenovirus E1B 19K protein. Some viruses ... The adenovirus E1B-55K protein and the hepatitis B virus HBx protein are examples of viral proteins that can perform such a ... Bcl-Xl and Bcl-2) members of the Bcl-2 family are established. This balance is the proportion of proapoptotic homodimers that ... these inhibitory proteins target retinoblastoma tumor-suppressing proteins. These tumor-suppressing proteins regulate the cell ...

Neuroprotection that is associated with 4-PPBP increases Bcl-2 expression; Bcl-2 expression is regulated by CREB. 3-PPP Yang S ... Yang S, Alkayed NJ, Hurn PD, Kirsch JR (March 2009). "Cyclic adenosine monophosphate response element-binding protein ... "Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2". Anesthesia and Analgesia. 104 (5): 1179-84, ... using a mechanism that activates the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB ...

2005). "BMRP is a Bcl-2 binding protein that induces apoptosis". J. Cell. Biochem. 94 (3): 611-26. doi:10.1002/jcb.20292. PMID ... 39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene. Mammalian mitochondrial ... This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. GRCh38: Ensembl release 89: ... 2005). "Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1". Mol. Cell. Biol. 25 ( ...

Zhang Z, Sobel RA, Cheng D, Steinberg GK, Yenari MA (November 2001). "Mild hypothermia increases Bcl-2 protein expression ... and there may be an increase in expression of the anti-apoptotic protein BCl-2. Many physicians over the centuries have tried ... April 1992). "Induction of apoptosis in fibroblasts by c-myc protein". Cell. 69 (1): 119-128. doi:10.1016/0092-8674(92)90123-T ...

Members of the Bcl-2 family of pro-apoptotic proteins can induce the opening of the VDAC (12). This will cause the same release ... Scientists have found that binding depressors to Bcl-2 anti-apoptotic proteins inhibits them and leaves direct activators free ... The term Apoptosome was first introduced in Yoshihide Tsujimoto's 1998 paper "Role of Bcl-2 family proteins in apoptosis: ... Tsujimoto Y (November 1998). "Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?". Genes to Cells. 3 (11 ...

Fernandez-Sarabia MJ, Bischoff JR (November 1993). "Bcl-2 associates with the ras-related protein R-ras p23". Nature. 366 (6452 ... Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene. RRAS has been shown to interact with: ARAF, ... Fernandez-Sarabia MJ, Bischoff JR (1993). "Bcl-2 associates with the ras-related protein R-ras p23". Nature. 366 (6452): 274-5 ... "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112-25. doi: ...

Reed, John C. (April 2008). "Bcl-2-family proteins and hematologic malignancies: history and future prospects". Blood. 111 (7 ... and anti-apoptotic proteins, namely caspases, IAPs, and Bcl-2 family members. The demonstration by Institute scientists that ... The common trend is discovery of proteins that are linked to the development of a disease and identification of chemical ... Findings are translated into new therapies that improve protein folding and preserve cell function in diseases that have global ...

June 2005). "An inhibitor of Bcl-2 family proteins induces regression of solid tumours". Nature. 435 (7042): 677-681. Bibcode: ... There are few protein-protein interaction inhibitors with specific and non-toxic effect in various cancer types. The first and ... AI-10-49 belongs to a select group of protein-protein interaction inhibitors that has been shown to have specific and potent ... ChIP-seq and ATAC-seq analysis revealed that inhibition of the CBFβ-SMHHC-RUNX1 protein-protein interaction by AI-10-49 results ...

... is a protein that in humans is encoded by the BCOR gene. The protein encoded by this gene was identified as ... This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II ... "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273-81. ...

October 1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell. 79 (2): 341-51 ... Protein families, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane ... December 1997). "The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis". The ... December 1997). "The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis". The ...

Bcl-2 is an important family of intracellular proteins that helps regulate apoptosis, or cell suicide. Bcl-2, paired with other ... In particular, the oncoprotein Myc and the Bcl-2 protein family are of interest to her current research lab. ... The caspases, a type of protease, remain inactive until signaled through a cascade to degrade the proteins that make up a cell ... Cory, Suzanne; Huang, David C. S.; Adams, Jerry M. (1 January 2003). "The Bcl-2 family: roles in cell survival and oncogenesis ...