The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. ... This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from ... "Phosphorylation of rat mitochondrial transcription termination factor (mTERF) is required for transcription termination but not ... Mitochondrial transcription termination factor 1, also known as MTERF1, is a protein which in humans is encoded by the MTERF ...

... structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains". Curr. Opin. Struct. ... AP-1 fos/jun heterodimer that forms a transcription factor Jun-B transcription factor CREB cAMP response element transcription ... Proteins containing this domain are transcription factors. bZIP transcription factors are found in all eukaryotes and form one ... Plant Transcription Factor Database Plant bZIP transcription factors Archived 2012-03-20 at the Wayback Machine (Articles with ...

The basic leucine zipper (bZIP) domain is found mainly in eukaryotes and to a limited extent in bacteria. The bZIP domain ... DBD database of predicted transcription factors Kummerfeld SK, Teichmann SA (January 2006). "DBD: a transcription factor ... For example, proteins that regulate transcription by binding DNA are called transcription factors. The final output of most ... the leucines can interact as the teeth in a zipper, allowing dimerization of two proteins. When binding to the DNA, basic amino ...

... a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several ... The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP ... 2006). "CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but ... C/EBPγ along with its regulator, the trauma-induced transcription factor EGR1, plays an important role in the development of ...

Kehat I, Hasin T, Aronheim A (October 2006). "The role of basic leucine zipper protein-mediated transcription in physiological ... "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in ... via basic leucine zipper domains, and increases DNA-binding activity of the Nrf2-MafK complex to the ARE and the transcription ... "Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation". Cardiovascular Research. 70 (3): ...

... is assembled through the dimerization of a characteristic bZIP domain (basic region leucine zipper) ... A typical bZIP domain consists of a "leucine zipper" region, and a "basic region". The leucine zipper is responsible for ... Apart from the "leucine zipper" and the "basic region" which are important for dimerization and DNA-binding, the c-jun protein ... The basic region of the bZIP domain is just upstream to the leucine zipper, and contains positively charged residues. This ...

... leucine zipper transcription factor (RRFIP1), and Y sex-determining transcription factors (SRY). With these transcription ... "Entrez Gene: BZW2 basic leucine zipper and W2 domains 2". "BZW2 basic leucine zipper and W2 domains 2 [Homo sapiens (human)] - ... It is regulated by numerous transcription factors, including an estrogen receptor transcription factor (ESR2, ES3), ... BZW2 is known as Basic Leucine Zipper W2 Domain-Containing Protein 2, MST017, MSTP017, 5MP1, Eukaryotic Translation Factor 5, ...

LITTLE ZIPPER protein contains a leucine zipper domain but does not have the domains required for DNA binding and transcription ... However, the homeodomain transcription factors that belong to the three-amino-acid loop-extension (TALE) family are targets of ... The first microprotein (miP) discovered was during a research in the early 1990s on genes for basic helix-loop-helix (bHLH) ... The protein was found to be an inhibitor of DNA binding (ID protein), and it negatively regulated the transcription factor ...

"Entrez Gene: HLF hepatic leukemia factor". LeBrun DP (May 2003). "E2A basic helix-loop-helix transcription factors in human ... Hunger SP, Li S, Fall MZ, Naumovski L, Cleary ML (June 1996). "The proto-oncogene HLF and the related basic leucine zipper ... Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (July 1992). "Fusion of the leucine zipper gene HLF ... This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The ...

... the microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix leucine zipper transcription factor that ... Microphthalmia-associated transcription factor (MITF) is the master transcription factor that controls the expression of TYR, ... of which CREB is a transcription factor. Alpha-melanocyte stimulating hormone (α-MSH), beta-melanocyte stimulating hormone (β- ... A 2000 study performed in Dakar, Senegal, indicated that chronic usage of skin lighteners was a risk factor for hypertension ...

Lu R, Yang P, Padmakumar S, Misra V (Aug 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper ... Gunther M, Laithier M, Brison O (Jul 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two- ... Lu R, Yang P, Padmakumar S, Misra V (Aug 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper ... a role for YY1 transcription factor in the regulation of its expression". Genomics. 34 (1): 85-91. doi:10.1006/geno.1996.0244. ...

C/EBP proteins are known to have a conserved C-terminal structure, basic leucine zipper domain(bZIP), that is necessary for the ... eukaryotic initiation factor 2α (eIF2α), and induction of a transcription factor, activation transcription factor 4 (ATF4), ... As a transcription factor, CHOP can regulate the expression of many anti-apoptotic and pro-apoptotic genes, including genes ... Yang Y, Liu L, Naik I, Braunstein Z, Zhong J, Ren B (2017). "Transcription Factor C/EBP Homologous Protein in Health and ...

DBD database of predicted transcription factors Uses a curated set of DNA-binding domains to predict transcription factors in ... DNA-binding proteins can incorporate such domains as the zinc finger, the helix-turn-helix, and the leucine zipper (among many ... "The Arabidopsis GAGA-Binding Factor BASIC PENTACYSTEINE6 Recruits the POLYCOMB-REPRESSIVE COMPLEX1 Component LIKE ... Each transcription factor binds to one specific set of DNA sequences and activates or inhibits the transcription of genes that ...

... protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no ... Gupta K, Anand G, Yin X, Grove L, Prochownik EV (March 1998). "Mmip1: a novel leucine zipper protein that reverses the ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ...

... basic helix loop helix) transcription factors act sequentially in myogenic differentiation. Vertebrate MRF family members ... Gupta K, Anand G, Yin X, Grove L, Prochownik EV (March 1998). "Mmip1: a novel leucine zipper protein that reverses the ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785-93 ... MyoD is a transcription factor and can also direct chromatin remodelling through binding to a DNA motif known as the E-box. ...

Oct 1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein ... Wang X, Sato R, Brown MS, Hua X, Goldstein JL (Apr 1994). "SREBP-1, a membrane-bound transcription factor released by sterol- ... regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor". Cell. 89 (3): 331-40. doi: ... "1985 Basic Medical Research Award". The Lasker Foundation. 2007-09-16. Archived from the original on 2015-09-13. Retrieved 2015 ...

"Dissecting the Role of Leucine Zippers in the Binding of bZIP Domains of Jun Transcription Factor to DNA". Biochemical and ... Homo sapiens CFAP97D2 Isoform X1 is a basic protein with a predicted PI of 10.4 and Mw 19.3 kaD. There is nuclear leucine ... zipper motif (AA #37-52) and nuclear localization signal (AA #102-116). By definition, the leucine zipper region of Homo ... "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. pp. [XP_016876399.1]. Retrieved 2022-12-14. "CFAP97D1 CFAP97 ...

c-Fos is a 380 amino acid protein with a basic leucine zipper region for dimerisation and DNA-binding and a transactivation ... nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ... c-Fos encodes a 62 kDa protein, which forms heterodimer with c-jun (part of Jun family of transcription factors), resulting in ... Glover JN, Harrison SC (January 1995). "Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to ...

The promoter of TMEM39B transcript variant 1 contains numerous transcription factor binding sites. The transcription factors ... which is not predicted to form a leucine zipper. There is an "F..Y" motif with three repeats from amino acids 183-202 and a ... making it basic overall. It contains two pairs of tandem repeats: "GSSG" from amino acids 21-28 and "PPSH" from amino acids 107 ... and CMYB have binding sites with high affinity near the binding site of transcription factor IIB, so they are potential ...

The molecular mechanisms governing this function are not yet known, but a basic zipper transcription factor called ATF4 is a ... Following leucine-deprivation in mammals, GCN2 decreases the expression of lipogenic genes via SREBP-1c. SREBP-1c actions upon ... It acts as a transcription factor and activates several genes required for amino acid synthesis. Recently GCN2 has also been ... Eukaryotic initiation factors The three subunits of eIF2: α - EIF2S1 β - EIF2S2 γ - EIF2S3 Kinases of eIF2 HRI (Heme-regulated ...

DNA-binding domains including the basic helix-loop-helix, zinc finger, helix-turn-helix and leucine zipper motifs have been ... and low-affinity binding sites of transcription factors in vitro, to study recruitment of factors to promoter sites in vivo ...

... of mutations prevent CCAAT/enhancer-binding protein alpha DNA binding by altering its COOH-terminal basic leucine zipper domain ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters ... It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma, as well as distinct transcription factors ...

"The GCN4 basic-region-leucine zipper binds DNA as a dimer of uninterrupted a-helices: crystal structure of the protein-DNA ... Struhl, Kevin (1988-04-14). "The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast". Nature ... genome-scale analysis of transcription factor binding in mammalian cells, leading to the discovery of far more transcription ... He showed that Gcn4 binds as a dimer via its leucine zipper, described how it recognizes target sites at atomic resolution, and ...

This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein ... Takemori H, Kajimura J, Okamoto M (Jul 2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain ... Don J, Stelzer G (Feb 2002). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis". ... Pandey SC (Oct 2004). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and ...

... a basic amino acid region, and leucine zipper. All these domains, including a proline rich region, are consistent with the fact ... "Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription". J. ... This has been associated with cancer due to the large number of roles that peptide growth factors, of which TGF-beta are a ... SKI also directly interacts with the R-Smad ∙ Smad-4 complex, which directly represses normal transcription of the TGF-β ...

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein ... Lu R, Yang P, Padmakumar S, Misra V (1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper ... 2005). "Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman". J. Biol. Chem ... "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J ...

"Entrez Gene: MXI1 MAX interactor 1". Gupta K, Anand G, Yin X, Grove L, Prochownik EV (Mar 1998). "Mmip1: a novel leucine zipper ... Wechsler DS, Hawkins AL, Li X, Jabs EW, Griffin CA, Dang CV (Nov 1994). "Localization of the human Mxi1 transcription factor ... This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that ... Gupta K, Anand G, Yin X, Grove L, Prochownik EV (1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive ...

"The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate ... Beckmann H, Kadesch T (1991). "The leucine zipper of TFE3 dictates helix-loop-helix dimerization specificity". Genes Dev. 5 (6 ... Zhao GQ, Zhao Q, Zhou X, Mattei MG, de Crombrugghe B (1993). "TFEC, a basic helix-loop-helix protein, forms heterodimers with ... "Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-beta-induced transcription of the Smad7 ...

The DNA binding of CREB is mediated via its basic leucine zipper domain (bZIP domain) as depicted in the image. Evidence ... The phosphorylated CREB recognizes the cAMP Response Element and serves as a transcription factor for Per1 and Per2, two genes ... This chain of leucine residues forms the leucine zipper motif. The protein also has a magnesium ion that facilitates binding to ... CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences ...

Zhao H, Cao Y, Grunz H (May 2003). "Xenopus X-box binding protein 1, a leucine zipper transcription factor, is involved in the ... Song J, Slack JM (December 1994). "Spatial and temporal expression of basic fibroblast growth factor (FGF-2) mRNA and protein ... "Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in ... During fertilization, the sperm provides three essential parts to the oocyte: (1) a signalling or activating factor, which ...