Basic helix-loop-helix leucine zipper transcription factors
... are, as their name indicates, transcription factors containing both ... Basic+helix-loop-helix+leucine+zipper+transcription+factors at the U.S. National Library of Medicine Medical Subject Headings ( ... Basic helix-loop-helix and leucine zipper motifs. Examples include Microphthalmia-associated transcription factor and Sterol ... Transcription factors, All stub articles, Genetics stubs). ...
Basic helix-loop-helix
... leucine zipper transcription factors PDB: 1x0o; Card PB, Erbel PJ, Gardner KH (October 2005). " ... PDOC00038 in PROSITE Basic+Helix-Loop-Helix+Transcription+Factors at the U.S. National Library of Medicine Medical Subject ... "Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer". Genes Dev. 8 (8): ... Wang GL, Jiang BH, Rue EA, Semenza GL (June 1995). "Hypoxia-inducible factor 1 is a basic helix-loop-helix-PAS heterodimer ...
Sterol regulatory element-binding protein
SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to ... a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell ... Gasic GP (Apr 1994). "Basic-helix-loop-helix transcription factor and sterol sensor in a single membrane-bound molecule". Cell ... SREBPs have a structure similar to E-box-binding helix-loop-helix (HLH) proteins. However, in contrast to E-box-binding HLH ...
MAX (gene)
"Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac ... The protein product of MAX contains the basic helix-loop-helix and leucine zipper motifs. It is therefore included in the bHLHZ ... "Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac ... Blackwood EM, Eisenman RN (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ...
MLX (gene)
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These ... a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene. 181 (1-2): 7-11. doi: ... Billin AN, Eilers AL, Coulter KL, Logan JS, Ayer DE (December 2000). "MondoA, a novel basic helix-loop-helix-leucine zipper ... Song Z, Yang H, Zhou L, Yang F (2019). "Glucose-Sensing Transcription Factor MondoA/ChREBP as Targets for Type 2 Diabetes: ...
Sterol regulatory element-binding protein 2
... a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of ... a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element ... a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell ... The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain. Various single nucleotide polymorphisms ...
Carbohydrate-responsive element-binding protein
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc / Max / Mad superfamily. This protein ... Song Z, Yang H, Zhou L, Yang F (October 2019). "Glucose-Sensing Transcription Factor MondoA/ChREBP as Targets for Type 2 ... de Luis O, Valero MC, Jurado LA (March 2000). "WBSCR14, a putative transcription factor gene deleted in Williams-Beuren ... is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617-627. doi:10.1093/hmg/10.6.617. ...
Sterol regulatory element-binding protein 1
The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. SREBP-1a regulates ... a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell ... a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element ... Wang X, Sato R, Brown MS, Hua X, Goldstein JL (Apr 1994). "SREBP-1, a membrane-bound transcription factor released by sterol- ...
USF1
... gene encodes a member of the basic helix-loop-helix leucine zipper family and can function as a cellular transcription factor. ... "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds ... "The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo". Oncogene. 14 (5): 589-94. ... "Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF". Nature ...
USF2
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription ... "Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting". Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, ... "The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo". Oncogene. 14 (5): 589-94. ... Blanar MA, Rutter WJ (May 1992). "Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with ...
Microphthalmia-associated transcription factor
MITF is a basic helix-loop-helix leucine zipper transcription factor involved in lineage-specific pathway regulation of many ... MITF, TFE3 and TFEB are part of the basic helix-loop-helix-leucine zipper family of transcription factors. Each protein encoded ... "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate ... Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein ...
Myc
... basic helix-loop-helix) and LZ (leucine zipper) structural motifs. The bHLH motif allows Myc proteins to bind with DNA, while ... the leucine zipper TF-binding motif allows dimerization with Max, another bHLH transcription factor. Myc mRNA contains an IRES ... Blackwood EM, Eisenman RN (March 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ... Blackwood EM, Eisenman RN (March 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ...
BZIP domain
... structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains". Curr. Opin. Struct. ... AP-1 fos/jun heterodimer that forms a transcription factor Jun-B transcription factor CREB cAMP response element transcription ... Proteins containing this domain are transcription factors. bZIP transcription factors are found in all eukaryotes and form one ... Plant Transcription Factor Database Plant bZIP transcription factors Archived 2012-03-20 at the Wayback Machine (Articles with ...
HLF (gene)
"Entrez Gene: HLF hepatic leukemia factor". LeBrun DP (May 2003). "E2A basic helix-loop-helix transcription factors in human ... Hunger SP, Li S, Fall MZ, Naumovski L, Cleary ML (June 1996). "The proto-oncogene HLF and the related basic leucine zipper ... Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (July 1992). "Fusion of the leucine zipper gene HLF ... This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The ...
Microprotein
... discovered was during a research in the early 1990s on genes for basic helix-loop-helix (bHLH) transcription factors from a ... The LITTLE ZIPPER protein contains a leucine zipper domain but does not have the domains required for DNA binding and ... and it negatively regulated the transcription factor complex. The ID protein was 16 kDa and consisted of a helix-loop-helix ( ... The microprotein formed bHLH/HLH heterodimers which disrupted the functional basic helix-loop-helix (bHLH) homodimers. The ...
Chimeric nuclease
DNA-binding domains including the basic helix-loop-helix, zinc finger, helix-turn-helix and leucine zipper motifs have been ... and low-affinity binding sites of transcription factors in vitro, to study recruitment of factors to promoter sites in vivo ...
MXI1
This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that ... "Entrez Gene: MXI1 MAX interactor 1". Gupta K, Anand G, Yin X, Grove L, Prochownik EV (Mar 1998). "Mmip1: a novel leucine zipper ... Wechsler DS, Hawkins AL, Li X, Jabs EW, Griffin CA, Dang CV (Nov 1994). "Localization of the human Mxi1 transcription factor ... Gupta K, Anand G, Yin X, Grove L, Prochownik EV (1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive ...
Transcription factor
Helix-loop-helix / leucine zipper factors (bHLH-ZIP) 1.3.1 Family: Ubiquitous bHLH-ZIP factors; includes USF (USF1, USF2); ... Basic Domains 1.1 Class: Leucine zipper factors (bZIP) 1.1.1 Family: AP-1(-like) components; includes (c-Fos/c-Jun) 1.1.2 ... Helix-loop-helix factors (bHLH) 1.2.1 Family: Ubiquitous (class A) factors 1.2.2 Family: Myogenic transcription factors (MyoD) ... Plant transcription factor database TcoF-DB: Database of transcription co-factors and transcription factor interactions ...
Skin whitening
... the microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix leucine zipper transcription factor that ... Microphthalmia-associated transcription factor (MITF) is the master transcription factor that controls the expression of TYR, ... of which CREB is a transcription factor. Alpha-melanocyte stimulating hormone (α-MSH), beta-melanocyte stimulating hormone (β- ... A 2000 study performed in Dakar, Senegal, indicated that chronic usage of skin lighteners was a risk factor for hypertension ...
MXD4
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that ... is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617-27. doi:10.1093/hmg/10.6.617. ... a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". The Journal of Biological ... Transcription factors, All stub articles, Human chromosome 4 gene stubs). ...
Protein kinase N1
"Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Res. Mol. Brain Res ... Mukai H, Ono Y (1994). "A novel protein kinase with leucine zipper-like sequences: its catalytic domain is highly homologous to ... which is a potential transcription factor". Exp. Cell Res. 241 (2): 363-72. doi:10.1006/excr.1998.4060. PMID 9637778. Takahashi ...
Michael Stuart Brown
Oct 1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein ... Wang X, Sato R, Brown MS, Hua X, Goldstein JL (Apr 1994). "SREBP-1, a membrane-bound transcription factor released by sterol- ... regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor". Cell. 89 (3): 331-40. doi: ... "1985 Basic Medical Research Award". The Lasker Foundation. 2007-09-16. Archived from the original on 2015-09-13. Retrieved 2015 ...
DNA-binding domain
The basic helix-loop-helix (bHLH) domain is found in some transcription factors and is characterized by two alpha helices (α- ... If two such helices find one another, the leucines can interact as the teeth in a zipper, allowing dimerization of two proteins ... DBD database of predicted transcription factors Kummerfeld SK, Teichmann SA (January 2006). "DBD: a transcription factor ... helixes) connected by a loop. One helix is typically smaller and due to the flexibility of the loop, allows dimerization by ...
Basic leucine zipper and W2 domain-containing protein 2
... leucine zipper transcription factor (RRFIP1), and Y sex-determining transcription factors (SRY). With these transcription ... giving rise to the characteristic leucine zipper helix within the 3D structure. An eIF5C domain follows the leucine motif, ... There are four major stem loops in the 5' untranslated and four in the 3' untranslated region that function in transcript-level ... "Entrez Gene: BZW2 basic leucine zipper and W2 domains 2". "BZW2 basic leucine zipper and W2 domains 2 [Homo sapiens (human)] - ...
ID1
"Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ... Gupta K, Anand G, Yin X, Grove L, Prochownik EV (March 1998). "Mmip1: a novel leucine zipper protein that reverses the ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ... Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H (March 2002). "Modulation of basic helix-loop-helix transcription complex ...
Cryptochrome
HY5 is a basic leucine zipper (bZIP) factor that promotes photomorphogenesis by binding to light-responsive genes. CRY ... The structure of CRY1 is almost entirely made up of alpha helices, with several loops and few beta sheets. In plants, ... The interaction inhibits COP1 activity and allows transcription factors such as ELONGATED HYPOCOTYL 5 (HY5) to accumulate. ... The transcription of the Cry gene also cycles with a similar trend. CRY protein levels, however, cycle in a different manner ...
MyoD
... basic helix loop helix) transcription factors act sequentially in myogenic differentiation. Vertebrate MRF family members ... Gupta K, Anand G, Yin X, Grove L, Prochownik EV (March 1998). "Mmip1: a novel leucine zipper protein that reverses the ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785-93 ... now referred to as basic helix loop helix) for dimerization and a basic site upstream of this bHLH region facilitated DNA ...
Lipogenesis
... a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element ... transcription factors that are a part of the Signal Transducer And Activator Of Transcription (STAT) family. There is also ... It is hypothesized that this effect occurs through the transcription factor SREBP-1, where the association of insulin and SREBP ... "Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes ...
DNA-binding protein
Comparison of nucleic acid simulation software DNA-binding domain Helix-loop-helix Helix-turn-helix HMG-box Leucine zipper ... DBD database of predicted transcription factors Uses a curated set of DNA-binding domains to predict transcription factors in ... "The Arabidopsis GAGA-Binding Factor BASIC PENTACYSTEINE6 Recruits the POLYCOMB-REPRESSIVE COMPLEX1 Component LIKE ... DNA-binding proteins can incorporate such domains as the zinc finger, the helix-turn-helix, and the leucine zipper (among many ...