The basement membrane is also essential for angiogenesis (development of new blood vessels). Basement membrane proteins have ... The most notable examples of basement membranes is the glomerular basement membrane of the kidney, by the fusion of the basal ... other roles for basement membrane include blood filtration and muscle homeostasis. Fractones may be a type of basement membrane ... the basement membrane is organized as follows: Epithelial/mesothelial/endothelial tissue (outer layer) Basement membrane Basal ...
... is secreted and maintained by podocyte cells. The glomerular basement membrane contains three ... a protein linked to heparan sulfate basement membrane nephrin Renal corpuscle (glomerulus) showing glomular basement membrane. ... The glomerular basement membrane is a fusion of the endothelial cell and podocyte basal laminas, and is the main site of ... The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus. The glomerular endothelial cells, ...
... (EBMD) is a disorder of the eye that can cause pain and dryness. It is sometimes ... The main pathological feature of the disease is thickened, multilaminar and disfigured basement membrane of corneal epithelium ... Corneal dystrophy Online Mendelian Inheritance in Man, #121820: Corneal dystrophy, epithelial basement membrane; EBMD, archived ... "A subset of patients with epithelial basement membrane corneal dystrophy have mutations in TGFBI/BIGH3". Hum. Mutat. 27 (6): ...
A kidney biopsy is the only way to diagnose thin basement membrane disease. It reveals thinning of the glomerular basement ... Thin basement membrane disease may co-exist with other kidney diseases, which may in part be explained by the high prevalence ... of thin basement membrane disease. Fujinaga S, Kaneko K, Ohtomo Y, et al. (February 2006). "Thin basement membrane nephropathy ... Thin basement membrane disease (previously referred to as "benign familial hematuria") is, along with IgA nephropathy, the most ...
Glomerular basement membrane ped/117 at eMedicine antiglomerular+basement+membrane+antibody at the U.S. National Library of ... Anti-glomerular basement membrane antibody (anti-GBM Ab) is an antibody which is found in Goodpasture's syndrome but not found ...
This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the ... Hahn E, Wick G, Pencev D, Timpl R (1980). "Distribution of basement membrane proteins in normal and fibrotic human liver: ... This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. ... Gunwar S, Saus J, Noelken ME, Hudson BG (1990). "Glomerular basement membrane. Identification of a fourth chain, alpha 4, of ...
"Skin Basement Membrane". The Doctor's Doctor. April 10, 2006. (Articles lacking in-text citations from December 2013, All ... The basal lamina and lamina reticularis together make up the basement membrane. Anchoring fibrils are essential to the ...
The basement membrane is intact. Up to 66% of fibroadenomas harbor mutations in the exon (exon 2) of the mediator complex ...
Pöschl E, Pollner R, Kühn K (1988). "The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen ... This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C- ... Brazel D, Pollner R, Oberbäumer I, Kühn K (1988). "Human basement membrane collagen (type IV). The amino acid sequence of the ... Griffin CA, Emanuel BS, Hansen JR, Cavenee WK, Myers JC (Feb 1987). "Human collagen genes encoding basement membrane alpha 1 ( ...
... epithelial basement membrane; 121820; TGFBI Corneal dystrophy, Fuchs endothelial, 1; 136800; COL8A2 Corneal dystrophy, Fuchs ...
All cells touch the basement membrane.[citation needed] The urothelium is the most impermeable membrane in the mammalian body. ... "Membranes and membrane surfaces: Dynamics of cytoplasmic membranes in pancreatic acinar cells". Philosophical Transactions of ... The tonofilaments play a role in the attachment of the basal layer to the basement membrane via desmosomes. The intermediate ... These tonofibrils converge at hemidesmosomes to attach the cells at the basement membrane. The transitional epithelium cells ...
The basement membrane is frequently thickened. Elongated, fat crypts and little to no serration. Therefore, they may not be ...
... forms a complex network with several other proteins in the basement membrane. It has been shown to ... The stability of the basement membrane and dermal-epidermal junction is thought to be due to these interactions. Collagen ... Gatseva A, Sin YY, Brezzo G, Van Agtmael T (September 2019). "Basement membrane collagens and disease mechanisms". Essays in ... contribute greatly to the overall stability of the basement membrane. Type VII collagen is composed of three main domains in ...
... s secrete and maintain the basement membrane. There are numerous coated vesicles and coated pits along the basolateral ...
Cultrex Basement Membrane Extract (BME) is the trade name for a extracellular protein mixture secreted by Engelbreth-Holm-Swarm ... These components are found in the basement membrane extracellular matrix that forms an interface between stromal tissue and ... The extracellular matrix proteins that compose the basement membrane extract are needed to maintain stem cells in an ... Benton, Gabriel; Kleinman, Hynda K.; George, Jay; Arnaoutova, Irina (2011-04-15). "Multiple uses of basement membrane-like ...
Examples of basement membranes include: Basilar membrane Bruch's membrane Descemet's membrane Glomerular basement membrane The ... The basement membrane is visible under light microscopy. Electron microscopy shows that the basement membrane consists of three ... It is often incorrectly referred to as the basement membrane, though it does constitute a portion of the basement membrane. The ... Alveolar-capillary barrier Basolateral membrane Collagen Glomerular basement membrane Lamina propria Reticular lamina Histology ...
The basement membrane controls the traffic of the cells and molecules between the dermis and epidermis but also serves, through ... The epidermis and dermis are separated by a thin sheet of fibers called the basement membrane, which is made through the action ... The dermis is tightly connected to the epidermis through a basement membrane and is structurally divided into two areas: a ... ISBN 978-1-711494-06-7. Breitkreutz, D; Mirancea, N; Nischt, R (2009). "Basement membranes in skin: Unique matrix structures ...
Basement membrane and muscularis mucosae are intact. Adenomas of the colon, also called adenomatous polyps, are quite prevalent ...
Chan F, Inoue S (1994). "Lamina lucida of basement membrane: an artefact". Microsc Res Tech. 28 (1): 48-59. doi:10.1002/jemt. ... The lamina lucida is a component of the basement membrane which is found between the epithelium and underlying connective ... lamina densa of the basement membrane. Similarly, electron-lucent and electron-dense zones can be seen between enamel of teeth ... It is a roughly 40 nanometre wide electron-lucent zone between the plasma membrane of the basal cells and the (electron-dense) ...
The glomerular basement membrane: not gone, just forgotten. J. Clin. Invest. 116:2090-2093. Zhang YW, Luo WJ, Wang H, Lin P, ... While at Yale, Farquhar's research focused on secretory granule membranes that merge with cell membranes during exocytosis. She ... MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16. Proc. Natl. Acad. Sci. 97:3999-4004. ... Her research focuses on control of intracellular membrane traffic and the molecular pathogenesis of auto immune kidney diseases ...
ISBN 978-0-323-53265-5. DeVrieze BW, Hurley JA (2019). "Goodpasture Syndrome (Anti-glomerular Basement Membrane Antibody ...
... macro-plaques or mini-basement membranes in human term fetal membranes?". Philosophical Transactions of the Royal Society of ... Basement membrane assembly is a cooperative process in which laminins polymerise through their N-terminal domain (LN or domain ... The long arm is capable of binding to cells and helps anchor organized tissue cells to the basement membrane. Laminins are ... The A chain has a unique globular domain and homology with the basement membrane proteoglycan and the laminin B chains". The ...
The mitotic activity that occurs in the neonatal period is necessary for the migration of gonocytes to the basement membrane of ... The differentiation of gonocytes to SSC only occur once the cells have established close contact with the basement membrane in ... These complexes consist of various proteins that bind to integrins found on the basement membrane of the seminiferous cords and ... Gonocytes migrate to the basement membrane to proliferate. Gonocytes that do not migrate undergo apoptosis and are cleared from ...
The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to ... 1996). "97-kDa linear IgA bullous dermatosis (LAD) antigen localizes to the lamina lucida of the epidermal basement membrane". ... "Entrez Gene: LAD1 ladinin 1". Uitto J, Pulkkinen L (1997). "Molecular complexity of the cutaneous basement membrane zone". Mol ... a novel basement membrane zone component". Genomics. 39 (3): 323-30. doi:10.1006/geno.1996.4507. PMID 9119369. " ...
Macro-Plaques or Mini-Basement Membranes in Human Term Fetal Membranes?". Phil. Trans. R. Soc. Lond. B. 342 (1300): 121-136. ... Both nidogen-1 and nidogen-2 are essential components of the basement membrane alongside other components such as type IV ... Nidogen-1 is a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other ... Yurchenco PD, Schittny JC (1990). "Molecular architecture of basement membranes". FASEB J. 4 (6): 1577-90. doi:10.1096/fasebj. ...
1987). "Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of ... Hahn E, Wick G, Pencev D, Timpl R (1980). "Distribution of basement membrane proteins in normal and fibrotic human liver: ... Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits; ... In Goodpasture's syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. ...
"Macromolecular organization of basement membranes. Characterization and comparison of glomerular basement membrane and lens ... The lens capsule is a relatively thick basement membrane forming the outermost layer of the lens. Inside the capsule much ... The lens capsule is a smooth, transparent basement membrane that completely surrounds the lens. The capsule is elastic and its ... Membrane proteins such as aquaporins which allow water to flow into and out of cells are the most abundant membrane protein in ...
Ehrig K, Leivo I, Argraves WS, Ruoslahti E, Engvall E (Jun 1990). "Merosin, a tissue-specific basement membrane protein, is a ... Laminin, an extracellular matrix protein, is a major component of the basement membrane. It is thought to mediate the ... 1999). "Characterization and Expression of the Laminin γ3 Chain: A Novel, Non-Basement Membrane-associated, Laminin Chain". J. ... "Macromolecular organization of basement membranes". Curr. Opin. Cell Biol. 8 (5): 618-24. doi:10.1016/S0955-0674(96)80102-5. ...
Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues ... Timpl R (1997). "Macromolecular organization of basement membranes". Curr. Opin. Cell Biol. 8 (5): 618-24. doi:10.1016/S0955- ...
"Macromolecular organization of basement membranes. Characterization and comparison of glomerular basement membrane and lens ... The capsule is the basement membrane for the epithelial cells at the front of the lens and the rapidly growing more flexible ... It is a clear elastic basement membrane composed of collagen IV laminin etc. a quality that keeps it under constant tension. As ... The lens capsule is the thickest basement membrane in the body. Normally, the lens capsule serves as a diffusion barrier. It is ...
Campbell KP, Stull JT (April 2003). "Skeletal muscle basement membrane-sarcolemma-cytoskeleton interaction minireview series". ... The membrane also contains membrane proteins, including integral proteins that span the membrane and serve as membrane ... plasmatic membrane (Pfeffer, 1900), plasma membrane, cytoplasmic membrane, cell envelope and cell membrane. Some authors who ... The apical membrane or luminal membrane of a polarized cell is the surface of the plasma membrane that faces inward to the ...