"Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583-94. doi:10.1016/S0092- ... "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583-94. doi:10.1016/S0092- ...
Gelsolin inhibition of fast axonal transport indicates a requirement for actin microfilaments. Nature, 1984; 310:56-58. 82. ... Calcium transport by macrophage plasma membranes. J Biol Chem. 1980; 255:5841-5846. 54. Amrein PC, Stossel TP. Prevention of ... Transport of Macromolecules in Biological Systems. Berlin: Dahlem Konferenzen, 1978:503-16. 36. Stossel TP, Hartwig JH, Yin HL ... In: Current Topics in Membranes and Transport. 1990; 36:97-107. 66. Stossel TP. How cells crawl. American Scientist. 1990; 78: ...
R2 vaccines retain native replication in epithelial cells but are incapable of retrograde axonal transport and invasion of the ... "The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion". PLOS Pathogens. 13 ( ...
"The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport". Proceedings of the National ... In addition to transport of various organelles in the cytoplasm, dynactin also links kinesin II to organelles. Motor protein ... Schroer TA, Sheetz MP (December 1991). "Two activators of microtubule-based vesicle transport". The Journal of Cell Biology. ... Carter AP, Diamant AG, Urnavicius L (April 2016). "How dynein and dynactin transport cargos: a structural perspective". Current ...
Kratchmarov R, Taylor MP, Enquist LW (2013). "Role of us9 phosphorylation in axonal sorting and anterograde transport of ... In the retrograde direction, SuHV-1-Bartha is transported to a neuronal cell body via its axon, where it is replicated and ... Koyuncu OO, Perlman DH, Enquist LW (Jan 16, 2013). "Efficient retrograde transport of pseudorabies virus within neurons ... the extent to which non-synaptic transneuronal transport may also occur is uncertain. Using temporal studies and/or genetically ...
"Role of us9 phosphorylation in axonal sorting and anterograde transport of pseudorabies virus". PLOS ONE. 8 (3): e58776. ... Viruses can be transported in one of two directions: either anterograde (from soma to synapse), or retrograde (from synapse to ... Retrograde transport uses a protein called dynein to move viruses along the axon in the retrograde direction. It is important ... Anterograde transport uses a protein called kinesin to move viruses along the axon in the anterograde direction. Retrograde ...
"Axonal Transport of Mitochondria to Synapses Depends on Milton, a Novel Drosophila Protein". Neuron. 36 (6): 1063-1077. doi: ...
April 2009). "Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta". Proceedings of the ...
... the complex roles of JIPs in axonal transport". BioEssays. 30 (1): 10-4. doi:10.1002/bies.20695. PMID 18081006. Nihalani D, ... This sophisticated mechanism couples kinesin-dependent transport to local JNK activation, not only in mammals, but also in the ... JIPs on the other hand, are apparently transport proteins, responsible for enrichment of MAPK signaling components in certain ...
... -mediated anterograde axonal transport is of critical importance for the development and maintenance of the nervous system ... It was also found that KIF1A expressed abundantly in neurons, suggesting its role in axons as an axonal transport motor. To ... KIF1A is one of the many motors that helps execute the transport of organelles within the cell through axonal anterograde cargo ... Another primary role of KIF1A is the axonal transport of DCVs to their appropriate subcellular sites, which are synthesized in ...
"Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria". PLOS Genetics. ...
2004). "Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome". J. Virol. 78 (13 ... Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065-8. doi:10.1074/jbc.273.46.30065. PMID ... type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport ...
Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. Nat Commun. 2018;9(1): ... "Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy". Nature Communications ...
Bearer, E. L.; Breakefield, X. O.; Schuback, D.; Reese, T. S.; LaVail, J. H. (2000). "Retrograde axonal transport of herpes ... Bearer, Elaine L. (2012). "HSV, axonal transport and Alzheimer's disease: in vitro and in vivo evidence for causal ... Satpute-Krishnan, Prasanna; DeGiorgis, Joseph A.; Bearer, Elaine L. (2003). "Fast anterograde transport of herpes simplex virus ... Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome". NeuroImage. 37 (1): 230-242. doi: ...
During axonal transport, pre-pro-AVP is proteolytically cleaved into vasopressin, neurophysin II and copeptin. These molecules ... However, when pre-pro-vasopressin is processed during the axonal transport, copeptin may contribute to the 3D folding of ... sequential conformation shaping of neurohypophysial preprohormones during intraneuronal secretory transport". Journal of ...
... has shown to act as a cargo receptor in axonal transport for intact proteins. APLP2 is part of a family of mammalian ...
Cai Q, Pan PY, Sheng ZH (2007). "Syntabulin-kinesin-1 family member 5B-mediated axonal transport contributes to activity- ... Cai Q, Gerwin C, Sheng ZH (2005). "Syntabulin-mediated anterograde transport of mitochondria along neuronal processes". J. Cell ... 2004). "Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons". Nat. Cell Biol. 6 (10): ...
... the rabies virus is enveloped in a vesicle which is transported towards the cell body via axonal dynein. In the wildtype rabies ... Both the anterograde and retrograde tracing techniques are based on the visualization of axonal transport. Retrograde tracing ... "Interconnected Parallel Circuits between Rat Nucleus Accumbens and Thalamus Revealed by Retrograde Transynaptic Transport of ...
"Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production". Human Molecular Genetics ...
MY5A perform an important role in the regulation of axonal vesicle transport on the neurofilaments. The GB of MYO5A can form a ... The C-terminal globular domain (GB) decides the Myosin class and moderate the cargo transport. Also, the GB interacts with ... This defect is due a mutation in which a premature stop codon in the globular tail disrupt melanosome transport producing ... Unconventional myosin-Va is a motor protein in charge of the intracellular transport of vesicles, organelles and protein ...
He discovered the blocking effect of colchicine on axonal and dendritic transport in nerve cells. Using the experimental model ... 2 661-662, Birkhäuser Boston ISBN 3-7643-3335-9. Kreutzberg, G. W. (1995) "Reaction of the neuronal body to axonal damage" In: ... 1, 123.191, Arnold, London ISBN 0-340-76221-7. Kreutzberg, G. W. (1987) "Dendrites, Transport and Secretion" in: Encyclopedia ...
1 May 2002). "Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive ... Holzbaur has used her understanding of axonal transport to better understand neurodegenerative disease, including Parkinson's ... In the axons of neurons, these motor proteins are responsible for the transport of organelles over extraordinarily long ...
The electric organs of Malapterurus have been used in studies of neuronal metabolism, axonal transport. In their natural ...
Damaged axons can also show a sign of inhibition of axonal transport, forming axonal spheroids. These spheroids can occur ... The axonal damage due to the channel deficiency can cause a reactive axonal overgrowth leading to small, tumor-like growths, or ... This occurs by axonal disease paralyzing the skeletal muscles, including the respiratory muscles, as a result of axonal damage ... throughout the cerebral hemispheres, explaining the psychotic symptoms by disconnection of the brain from itself by axonal ...
... dissecting the axonal paths of calsyntenin-1 transport vesicles". Proteomics. 10 (21): 3775-88. doi:10.1002/pmic.201000384. ... Calsyntenin 1-mediated trafficking of axon guidance receptors regulates the switch in axonal responsiveness at a choice point. ... and thus to co-determine transport of distinct cargo. Recent studies identified a role for calsyntenin 1 in the regulation of ...
There is evidence suggesting that it could be due to defects in the axonal transport of mitochondria. Increasing evidence ... Misko A, Jiang S, Wegorzewska I, Milbrandt J, Baloh RH (March 2010). "Mitofusin 2 is necessary for transport of axonal ... February 2006). "Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2". Annals of Neurology. 59 (2): 276- ... Chen Y, Han S, Huang X, Ni J, He X (January 2016). "The Protective Effect of Icariin on Mitochondrial Transport and ...
The results of Vale and colleagues on axonal transport were published in five papers in 1985. Vale did not finish his MD, and ... In 1983, Vale and Sheetz decided to test whether the movement of myosin on actin was the source for organelle transport in ... They found that membrane organelle transport occurred bidirectionally on a microtubule, and not actin filament as Vale had ... Vale became interested in exploring the mechanism of how receptors and other molecules are transported in nerve axons. He then ...
Baloh RH, Schmidt RE, Pestronk A, Milbrandt J (January 2007). "Altered axonal mitochondrial transport in the pathogenesis of ... GARS1-Related Axonal Neuropathy CMT2 types are typically referred to as axonal neuropathies due to the axonal degeneration ... GARS1-associated axonal neuropathy is progressive, meaning that it worsens over time. Unknown mechanisms are thought to cause ... "OMIM Entry - # 601472 - Charcot-Marie-Tooth disease, axonal, type 2D; CMT2D". Online Mendelian Inheritance in Man. Retrieved ...
October 2014). "Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR ... inhibition of deacetylases HDAC6 and Sirt2 through knockdown processes rescued both axonal transport and locomotor behavior. ... It also influences neuronal subtype specification and regulates axonal growth, branching, and targeting in the central nervous ...
Fabian, R. H. (1991). "Retrograde axonal transport and transcytosis of immunoglobulins: Implications for the pathogenesis of ... Transcytosis (also known as cytopempsis) is a type of transcellular transport in which various macromolecules are transported ... This way, the amount of transported antibody is based on the concentration of antibody on either side of the barrier. The other ... Examples of macromolecules transported include IgA, transferrin, and insulin. While transcytosis is most commonly observed in ...