Limb regeneration in the axolotl and newt has been extensively studied and researched. The nineteenth century studies of this ... an organism with exceptional limb regenerative capabilities, likely undergoes epigenetic alterations in its blastema cells that ... In some cases a shed limb can itself regenerate a new individual. Limited regeneration of limbs occurs in most fishes and ... Limb blastema formation: How much do we know at a genetic and epigenetic level? J Biol Chem. 2023 Feb;299(2):102858. doi: ...

... including newts and axolotls, are species with the most known regenerative abilities. Adult newts can regenerate limbs, tail, ... some animal models dedifferentiate their cells to form blastema, which are analogous to plant calluses, after limb amputation. ... Dedifferentiation in the newt occurs 4-5 days after limb amputation and is characterized by cell cycle re-entry and down- ... A strong example of this is lens regeneration [10] in the newt. Across various vertebrate models that have been used to study ...

It seems that after the loss of a limb, cells draw together to form a clump known as a blastema. This superficially appears ... When the front limbs have been worked clear, a series of body ripples pushes the skin towards the rear. The hind limbs are ... Handling the newts does no harm, but ingestion of even a minute fragment of skin is deadly. In feeding trials, fish, frogs, ... However, the axolotl has the benefit of being raised in farms for the purpose of research facilities. So there is still a ...

Despite the costs, axolotls have unique regenerative abilities and ultimately provide useful information in understanding ... In addition, transgenic lines have been produced in other salamanders including the Japanese newt Pyrrhogaster and Pleurodeles ... This technique allows spinal cord cells to be labeled and is very important in studying limb regeneration in many other cells; ... "In Vivo Imaging Indicates Muscle Fiber Dedifferentiation Is a Major Contributor to the Regenerating Tail Blastema". ...