RIP1/RIP3 Necrosome: A signalling complex involved in necrotic cell death. Inflammasomes: The AIM2 and NLRP3 inflammasomes are ... proteins to recruit the Axin complex for inactivation. B-cell receptor (BCR) signalosome: The B-cell receptor (BCR) binds ... Prabakaran, Sudhakaran (2015). "B cell receptor signaling dynamics". Science Signaling. 8 (384): ec186-ec186. doi:10.1126/ ... "A Role of Dishevelled in Relocating Axin to the Plasma Membrane during Wingless Signaling". Current Biology. 13 (11): 960-966. ...

The combination of LRP-axin induces Dvl phosphorylation (P) which blocks the APC-axin-GSK3 complex from phosphorylating β-Cat. ... β-Cat is an intracellular signal that is held in check by axin. In this pathway, the activation of Wnt receptors can be ... The signals are initiated at the 7 transmembrane domain and transmitted through receptor coupling to G-proteins. This protein ... A signal transduction cascade results in the secretion of first and second group antagonists. First group antagonists are ...

... through the Wnt signals that destroy the conformation of the complex.[citation needed] In the nucleus it complexes with legless ... and Axin via interactions with the 20 AA and SAMP repeats. This complex is then able to bind β-catenins in the cytoplasm, that ... "Testing models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signaling ... "Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly". Science. 272 (5264): 1023-1026. ...

β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling ... The scaffold protein axin (two closely related paralogs, axin 1 and axin 2) contains a similar interaction motif on its long, ... Cell-cell adhesion complexes are essential for the formation of complex animal tissues. β-catenin is part of a protein complex ... the β-catenin destruction complex - by Dsh. Once bound to the receptor complex, axin will be rendered incompetent for β-catenin ...

Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A (1998). "Axin, a negative regulator of the Wnt signaling pathway, ... "The tuberin-hamartin complex negatively regulates beta-catenin signaling activity". J. Biol. Chem. 278 (8): 5947-51. doi: ... Nakamura T, Hamada F, Ishidate T, Anai K, Kawahara K, Toyoshima K, Akiyama T (1998). "Axin, an inhibitor of the Wnt signalling ... "Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network". Nat Struct Mol Biol. 23 (4): 324-32. doi:10.1038/ ...

However, upon Wnt signaling, MACF1 is involved in a translation and binding of the axin complex to LTP6 at the cell membrane. ... When Wnt signalling is not present, MACF1 associates with a complex containing axin, β-catenin, GSK3β, and APC. ... Extracellular Wnt signalling acts on the Frizzled receptor on the cellular membrane, which then, through a signalling cascade ... In vivo, GSK3β activity is inhibited by Wnt signalling, but in vitro it is typically inhibited by cdc42. ...

Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A (1998). "Axin, a negative regulator of the Wnt signaling pathway, ... forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin". EMBO J. 17 ( ... Li L, Yuan H, Weaver CD, Mao J, Farr GH, Sussman DJ, Jonkers J, Kimelman D, Wu D (1999). "Axin and Frat1 interact with dvl and ... Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A (Jun 1999). "DIX domains of Dvl and axin are necessary for protein ...

... leads to stabilization of β-catenin through inactivation of a protein complex containing the tumor suppressors APC and Axin. ... This can be contrasted with paracrine signaling, intracrine signaling, or classical endocrine signaling. An example of an ... De-regulation of the autocrine Wnt signaling pathway via mutations in APC and Axin have been linked to activation of various ... Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ...

... the Axin complex) to Wnt receptors at the plasma membrane. The formation of these Dishevelled and Axin containing droplets is ... The Dsh protein functions both in planar polarity and Wnt signalling, where it recruits another supramolecular complex ( ... Gammons M, Bienz M (April 2018). "Multiprotein complexes governing Wnt signal transduction". Current Opinion in Cell Biology. ... "A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling". Current Biology. 13 (11): 960-6. ...

Phosphorylation of LRP6 by CK1gamma promotes binding of axin to LRP and activation of the Wnt signaling pathway. CK1ε and CK1δ ... However, this CK1ε-mediated constraint to the cytoplasm can be overcome when the PER protein complex is bound to CRY. CK1ε has ... CK1gamma was found to be needed for Wnt signaling through LRP, and is both necessary and sufficient to transduce LRP6 signaling ... Amit S, Hatzubai A, Birman Y, Andersen JS, Ben-Shushan E, Mann M, Ben-Neriah Y, Alkalay I (May 2002). "Axin-mediated CKI ...

Kikuchi A (2000). "Modulation of Wnt signaling by Axin and Axil". Cytokine Growth Factor Rev. 10 (3-4): 255-65. doi:10.1016/ ... Diversin recruits Casein kinase Iε to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling". ... Axin-2, also known as axin-like protein (Axil), axis inhibition protein 2 (AXIN2), or conductin, is a protein that in humans is ... "Axin is a scaffold protein in TGF-β signaling that promotes degradation of Smad7 by Arkadia". EMBO J. 25 (8): 1646-58. doi: ...

Conversely, without Wnt signaling, the destruction complex, made of APC, CKI, GSK3β and Axin, degrades β-catenin buildup, ... inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/beta-catenin complex". Cellular Signalling. 22 (11 ... Wnt signals induce DVL to form a complex with Daam1 (Dishevelled associated activator of morphogenesis 1). This complex then ... A masterful conductor of complex Wnt signals". Cellular Signalling. 47: 52-64. doi:10.1016/j.cellsig.2018.03.004. PMC 6317740. ...

"The tuberin-hamartin complex negatively regulates beta-catenin signaling activity". The Journal of Biological Chemistry. 278 (8 ... Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A (June 1999). "DIX domains of Dvl and axin are necessary for ... Bhat RV, Budd SL (2003). "GSK3beta signalling: casting a wide net in Alzheimer's disease". Neuro-Signals. 11 (5): 251-61. doi: ... Li Y, Kuwahara H, Ren J, Wen G, Kufe D (March 2001). "The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 ...

... forms distinct complexes with cadherins and desmosomal cadherins. Plakoglobin is a major cytoplasmic component of ... Hearts also exhibited increases in β-catenin signaling. Further investigations on the role of β-catenin and plakoglobin in the ... Kodama S, Ikeda S, Asahara T, Kishida M, Kikuchi A (Sep 1999). "Axin directly interacts with plakoglobin and regulates its ... Phosphorylation of N-terminal Serines by a "destruction complex" composed of glycogen synthase kinase 3β (GSK3β) and scaffold ...

... is also involved in nuclear transcriptional activator kappa B (NFκB) signaling pathway, Hedgehog signaling pathway, Notch ... while the phosphorylation of Beta-catenin by GSK-3 is mediated by the binding of both proteins to Axin, a scaffold protein, ... GSK-3 may be further regulated by cellular localization or the formation of protein complexes. The activity of GSK-3 is far ... GSK-3 is therefore a part of the canonical Beta-catenin/Wnt pathway, which signals the cell to divide and proliferate. GSK-3 ...

"Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex". Genes & ... Moreover, the Hpo signaling pathway seems to be related with both, Wnt signaling. and p53 regulation In presence of Wnt ligand ... a nuclear localization signal (NLS) as well as a centrosome localization signal (CLS) can be found. However, the first one is ... lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation". Cellular Signalling. ...

Phosphorylation by other proteins in the destruction complex subsequently binds Axin to the cytoplasmic tail of LRP5/6. Axin ... The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell ... inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/beta-catenin complex". Cellular Signalling. 22 (11 ... This is due to Wnt causing the translocation of the negative Wnt regulator, Axin, and the destruction complex to the plasma ...

Axin is a scaffolding protein which holds the degradation complex together. The activated Dvl associates with Axin and prevents ... SFRPs are also able to downregulate Wnt signaling by the formation of an inhibitory complex with the Frizzled receptors. The ... Hedgehog signaling in the intestinal epithelium represses the canonical Wnt signaling to restrict expression of Wnt target ... and Axin. APC promotes the degradation of β-catenin by increasing the affinity of the degradation complex to β-catenin. ...

... of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin". ... Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A ... "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2-3): 197-201. doi: ... Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A ...

The formation of the primitive streak in the chick, is highly regulated by a complex network of signaling pathways. Activation ... In addition, mutating the intracellular negative regulator of Wnt signaling, Axin, and misexpression of the chick cWnt8C ... All cells in the epiblast can respond to signals from the marginal zone, but once a given region is induced by these signals ... Furthermore, ectopic streak formation induced by Vg1 required FGF signaling. Finally, BMP signaling is also important for ...

If the Ragulator complex receives signals for low amino acid count, it will start the process of catabolizing the cell. If ... serves as an endosomal docking site for LKB1-mediated AMPK activation by forming the v-ATPase-Ragulator-AXIN/LKB1-AMPK complex ... mTOR signaling is sensitive to amino acid concentrations in the cytoplasm of the cell, and the Ragulator complex works to ... The Ragulator-Rag complex is a regulator of lysosomal signalling and trafficking in eukaryotic cells, which plays an important ...

"Wnt/β-catenin Signaling". Cell Signaling Technology. November 2010. Mosimann C, Hausmann G, Basler K (April 2009). "β-catenin ... These complexes, which help regulate cell growth in addition to creating and maintaining epithelial layers, are known as ... APC or Axin, each of which can lead to this de-regulated β-catenin level stabilization in cells. While less attention is ... Guardavaccaro D, Clevers H (2012). "Wnt/β-Catenin and MAPK Signaling: Allies and Enemies in Different Battlefields". Sci Signal ...

Li D, Wang F, Lai M, Chen Y, Zhang JF (February 2005). "A protein phosphatase 2calpha-Ca2+ channel complex for ... Feng found that PPM1A can terminate TGF-beta signaling by inactivating Smad3 via dephosphorylation. Smad3 is an essential ... Strovel ET, Wu D, Sussman DJ (January 2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent ... "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. ...

... ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes". Immunological Reviews. 228 (1): 225-240 ... Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin ... Cytokine signaling through MAP3K1 utilises two-stage cell signaling to recruit the signal transduction mechanism to cytokine ... August 2008). "Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex". Science. 321 (5889): ...

Presenilin 1 has been shown to form a complex with beta-catenin, an important component in Wnt signaling, and stabilize beta- ... "Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in ... These evidences collectively suggest a critical role of presenilin 1 in the Notch signaling pathway. Wnt signaling pathway has ... Presenilin-1 is one of the four core proteins in the gamma secretase complex, which is considered to play an important role in ...

"Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia". The EMBO Journal. 25 (8): 1646 ... "Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex ... Niederländer C, Walsh JJ, Episkopou V, Jones CM (Apr 2001). "Arkadia enhances nodal-related signalling to induce mesendoderm". ... and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic ...

2014) Ras Stabilization via Aberrant Activation of Wnt/b-catenin Signaling Promotes Intestinal Tumorigenesis. Science Signaling ... He served as the Chief of the National Research Laboratory and Molecular Complex Control at Yonsei University. Currently, he is ... 2017) Small molecule binding of the Axin-RGS domain promotes β-catenin and Ras degradation. Nature Chemical Biology. (2016) ... "Ras Stabilization Through Aberrant Activation of Wnt/β-Catenin Signaling Promotes Intestinal Tumorigenesis". Science Signaling ...

Xiong Y, Zhou L, Su Z, Song J, Sun Q, Liu SS, Xia Y, Wang Z, Lu D (2019-02-05). "Longdaysin inhibits Wnt/β-catenin signaling ... Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin ... If CRY binds to PER before it is phosphorylated by CK1ε, these three proteins stabilize into a complex that can enter the ... On the other hand, the protein complex FBXL3 mediates the degradation of CRY proteins in the cytoplasm and nucleus. ...

Zolnierowicz S (Oct 2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochemical ... Hsu W, Zeng L, Costantini F (Feb 1999). "Identification of a domain of Axin that binds to the serine/threonine protein ... "Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A". Cell. 60 (1): ... "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2-3): 197-201. doi: ...

Lee YS, Han JM, Son SH, Choi JW, Jeon EJ, Bae SC, Park YI, Kim S (July 2008). "AIMP1/p43 downregulates TGF-beta signaling via ... Guo X, Ramirez A, Waddell DS, Li Z, Liu X, Wang XF (January 2008). "Axin and GSK3- control Smad3 protein stability and modulate ... "The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex". The EMBO Journal. ... Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, Oren M, Tanaka N (March 2008). "Hedgehog signaling overrides p53- ...