"Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin ... 117 (1): 47-57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480. Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE ( ... 424 (1-2): 63-8. doi:10.1016/s0014-5793(98)00141-0. PMID 9537516. S2CID 25328791. Mancini A, Koch A, Stefan M, Niemann H, ... 424 (1-2): 63-8. doi:10.1016/S0014-5793(98)00141-0. PMID 9537516. S2CID 25328791. Barritt DS, Pearn MT, Zisch AH, Lee SS, ...
... adenosine triphosphate binding (ATP) cassette (ABC) transporters which found to be indispensable for the regulation of sterol ... In 2001, The STSL locus was found to be comprises two genes, ABCG5 and ABCG8, encoding 2 members of the ABC-transporter family ... ABCG5 and ABCG8 genes encode for two proteins sterolin-1 and -2, respectively. Sterolin-1 and -2 are two 'half' ... named sterolin-1 and sterolin-2, respectively, Sterolin-2, discovered after sterolin-1, is located ...
ATP-binding cassette transporters, Protein families). ... proteins and one or two peripheral membrane ATP-binding ... Bacterial binding protein-dependent transport systems, are multicomponent systems typically composed of a periplasmic substrate ... Higgins CF, Hyde SC, Mimmack MM, Gileadi U, Gill DR, Gallagher MP (August 1990). "Binding protein-dependent transport systems ... Saurin W, Kaster W, Dassa E (June 1994). "Bacterial binding protein-dependent permeases: characterization of distinctive ...
Mfrn1 plays a key role in mitochondrial iron homeostasis as an iron transporter, importing ferrous iron from the intermembrane ... ABC10 binding enhances the stability and functionality of Mfrn1, suggesting that transcriptional and post-translational ... Mitoferrin-1 (Mfrn1) is a 38 kDa protein that is encoded by the SLC25A37 gene in humans. It is a member of the Mitochondrial ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, ...
The ATP-binding cassette (ABC) transporter, ABCA1, was induced during differentiation of human monocytes into macrophages, and ... because several papers reported that some transcriptional factors bound to the exonic coding sequences of some genes and ... Kang, H.J. ( 1,2,3 ), et al. "FESD: A Functional Element Snps Database In Human." Nucleic Acids Research 33. Database ISS. ( ... It was suggested that Ets-1 may be an important transcription factor in the cytokine-mediated inflammatory pathway and ...
ABC transporters ATP-binding cassette transporter genes) in intact cells as it is an excellent substrate of the multidrug ... Glavinas H, Krajcsi P, Cserepes J, Sarkadi B (January 2004). "The role of ABC transporters in drug resistance, metabolism and ... for screening transporter substrates and/or inhibitors; and also to determine in vitro drug resistance of cells, including ... resistance transporter 1 (MDR1) P-glycoprotein and the Multidrug Resistance-Associated Protein (MRP1). The calcein AM assay can ...
... a member of the ATP-binding cassette transporter superfamily. Whether MRP4 is the only transporter releasing prostaglandins ... The release of prostaglandin has now also been shown to be mediated by a specific transporter, namely the multidrug resistance ... The discovery of the prostaglandin transporter (PGT, SLCO2A1), which mediates the cellular uptake of prostaglandin, ... DP1-2 receptors bind to PGD2). The diversity of receptors means that prostaglandins act on an array of cells and have a wide ...
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ... 2002). "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ... "Entrez Gene: ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8". Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The ... ATP-binding cassette sub-family A member 8 is a protein that in humans is encoded by the ABCA8 gene. ...
ATP-binding cassette (ABC) transporters and protein kinase A binding proteins. The 540 interacting proteins include ABCF1, ACTB ... Possible transcription factors for human SOGA2 include: Modulator recognition factor 2 cAMP-responsive element binding protein ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and ... 6 (1&2): 39-43. "GeneCards". Retrieved 9 May 2011. "NCBI Conserved Domains". National Center for Biotechnology Information. ...
ATP-binding cassette transporter GRCh38: Ensembl release 89: ENSG00000198691 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular ... the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease". The Journal of Biological ... "Genotype/Phenotype analysis of a photoreceptor-specific ATP-binding cassette transporter gene, ABCR, in Stargardt disease". ...
ABCA7 is a member of the highly conserved family of ATP-binding cassette (ABC) transporters, which use energy from ATP ... Fewer than 1% of AD cases are caused by deterministic genes. Of the genes known to be associated with AD in non-Hispanic White ... Presenilin 1 (PS1) and Presenilin 2 (PS2) are the cleaving enzymes in the γ-secretase complex. There are close to 200 mutations ... FAD accounts for fewer than 1% of all AD cases. APP is cleaved first by β-secretase and then γ-secretase to produce amyloid ...
"Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice ... cholesterol/lipid homeostatis by binding in the 3'UTRs of genes involved in cholesterol transport such as ATP binding cassette ... miR-33a and miR-33b are located on intron 16 of human sterol regulatory element-binding protein 2 (SREBP2) gene on chromosome ... ABC) transporters and enhance or represses its expression. Study have shown that ABCA1 mediates transport of cholesterol from ...
2004). "ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with ... The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... 2002). "Mutations in the human ATP-binding cassette transporters ABCG5 and ABCG8 in sitosterolemia". Hum. Mutat. 20 (2): 151. ... 2002). "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ...
... and subsequently the vast majority are pumped back into the gut lumen by ATP-binding cassette transporter (ABC transporter) ... If dietary treatment alone is insufficient, bile acid-binding resins (e.g., cholestyramine, colestipol) could be considered. In ... located in chromosome 2 in band 2p21 and encode for ABC transporter proteins named sterolin-1 and sterolin-2, respectively. ... "Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters" (PDF). Science. 290 ( ...
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... 2002). "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ... ATP-binding cassette transporters, All stub articles, Membrane protein stubs). ... "Entrez Gene: ABCD4 ATP-binding cassette, sub-family D (ALD), member 4". Gärtner J, Jimenez-Sanchez G, Roerig P, Valle D (1998 ...
... efflux Arsenite-transporting ATPase Solute carrier family Active transport ATP-binding cassette transporter Transporter ... ATP ⇌ Arsenite or Antimonite (out) + ADP + Pi. Arsenic toxicity Arsenite Antimonite Ion transporter Ion transporter superfamily ... In the E. coli ArsAB transporter, both ArsA and ArsB recognize and bind their anionic substrates. A model has been proposed in ... Thus these cells have an influx transporter on one side and an efflux transporter on the other side of the cell to permit the ...
HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits ... The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... ATP-binding cassette transporter GRCh38: Ensembl release 89: ENSG00000124574 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... ATP-binding cassette transporters, All stub articles, Membrane protein stubs). ...
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... ATP-binding cassette transporter GRCh38: Ensembl release 89: ENSG00000114770 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... ATP-binding cassette transporters, All stub articles, Membrane protein stubs). ... "Entrez Gene: ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5". Kool M, de Haas M, Scheffer GL, Scheper RJ, van ...
Another example of a xenobiotic tolerance mechanism is the use of ATP-binding cassette (ABC) transporters, which is largely ... "Functional analysis of the ATP-binding cassette (ABC) transporter gene family of Tribolium castaneum". BMC Genomics. 14: 6. doi ... Such transporters contribute to resistance by enabling the transport of toxins across the cell membrane, thus preventing ... 207 (1): 33-37. doi:10.1051/jbio/2013003. PMID 23694723. Park, B.K.; Laverty, H.; Srivastava, A.; Antoine, D.J.; Naisbitt, D.; ...
D and G all participate in transport of the FeEnt through the inner membrane by means of an ATP-binding cassette transporter. ... Enterobactin is the strongest siderophore known, binding to the ferric ion (Fe3+) with affinity K = 1052 M−1. This value is ... Due to the extreme iron binding affinity of enterobactin, it is necessary to cleave FeEnt with ferrienterobactin esterase to ... "An Iron-Based Molecular Redox Switch as a Model for Iron Release from Enterobactin via the Salicylate Binding Mode". Inorganic ...
ABC transporters belong to the ATP-Binding Cassette superfamily, which uses the hydrolysis of ATP to translocate a variety of ... ABC transporters are minimally constituted of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less ... Articles with short description, Short description matches Wikidata, Protein domains, ATP-binding cassette transporters). ... In molecular biology, ATP-binding domain of ABC transporters is a water-soluble domain of transmembrane ABC transporters. ...
... inhibits the ATP-binding cassette (ABC) transporter family of proteins found in stem cells and has been used to study ... It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such ... bound to plasma proteins and has a volume of distribution of 3-5 L/kg. It takes 1 to 2 hours to reach peak plasma concentration ... 11: 1-7. doi:10.2147/ORR.S154289. PMC 6367723. PMID 30774465. Dutta D, Nagendra L, Raizada N, Bhattacharya S, Sharma M (May- ...
To overcome this difficulty, the ATP-binding cassette (ABC) transporter C1 (ABCC1) serves as the "exit door" for S1P. On the ... It binds rhodopsin, a well-characterized GPCR that binds all-cis retinal in its inactive state. Upon photoisomerization by a ... The binding of IP3 to IP3R releases Ca2+ from the ER into the normally Ca2+-poor cytoplasm, which then triggers various events ... DAG remains bound to the membrane by its fatty acid "tails" where it recruits and activates both conventional and novel members ...
One such disease, Stargardt's disease (OMIM #601691), can involve a mutation in the ATP-binding cassette transporter 4 (ABCA4) ... "OMIM - ATP-BINDING CASSETTE, SUBFAMILY A, MEMBER 4; ABCA4". Ncbi.nlm.nih.gov. Retrieved 2010-03-19. "Ensembl genome browser 57 ... In the cases of some HIV-1-derived lentiviral vectors, both immune responses can occur. In an innate immune response, toll-like ... HIV-1) or equine infectious anemia virus (EIAV). Although both the lentiviral and rAAV vectors provide a high efficiency of ...
The gene ABCG2, located on chromosome 4q22.1, encodes an ATP-binding cassette transporter protein that carries the Jr(a) ... ABCG2 is a uric acid transporter, and the Jr(a) negative phenotype is associated with gout in Japanese populations. An ... The highest rates of the Jr(a) negative blood type have been reported in Japan, where its prevalence ranges from 1 in 60 in the ... Retrieved 1 September 2019. Castilho L, Reid ME (2019). "A review of the JR blood group system". Immunohematology. 29 (2): 63-8 ...
ATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ABCC8 gene. ABCC8 ... The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... ATP-binding cassette transporter Sulfonylurea receptor GRCh38: Ensembl release 89: ENSG00000006071 - Ensembl, May 2017 GRCm38: ... ATP-binding cassette transporters, All stub articles, Membrane protein stubs). ...
... of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes". Pigment Cell Research. 18 (2): 102-12. ... of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes". Pigment Cell Research. 18 (2): 102-12. ... a novel human ATP-binding cassette transporter". The Journal of Biological Chemistry. 278 (47): 47156-65. doi:10.1074/jbc. ... ATP-binding cassette sub-family B member 5 also known as P-glycoprotein ABCB5 is a plasma membrane-spanning protein that in ...
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... ATP-binding cassette transporter GRCm38: Ensembl release 89: ENSMUSG00000020865 - Ensembl, May 2017 "Human PubMed Reference:". ... ATP-binding cassette transporters, All stub articles, Membrane protein stubs). ... "Entrez Gene: ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3". Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, ...
One example is ATP-binding cassette (ABC) transporter families. P-glycoproteins (PGPs) are part of this family and substrates ... MLs bind irreversible to Glutmate gated chloride ion (GluCl) channels, leading to hyperpolarisation. Pharyngeal and somatic ... This includes transporters which are part of the xenobiotic metabolism by absorbing, distributing and eliminating external ... IgA/antigen complex can bind to the Fc receptor of the eosinophil and thereby induce the release of anti-inflammatory mediators ...
Other possible targets include glycerol kinase and substrate binding proteins in ATP-binding cassette transporters (ABC ... This CU-rich region is suggested to be the functional region that binds the ribosome-binding site (RBS) of mRNAs. While the ... it has been suggested that tsRNAs regulate gene expression by binding the ribosome binding sequence of multiple mRNAs. The low ... 7 (1): 15665. doi:10.1038/s41598-017-15818-3. PMC 5688073. PMID 29142288. Kimelman A, Levy A, Sberro H, Kidron S, Leavitt A, ...