*Aspirin-induced asthma

... and rhinitis (AIAR) A sufferer who has not yet experienced asthma or aspirin sensitivity might be ... Aspirin-induced asthma, also termed Samter's triad, Samter's syndrome, aspirin-exacerbated respiratory disease (AERD), and ... are often helpful in treating the symptoms of aspirin-induced asthma. Some patients require oral steroids to alleviate asthma ... Aspirin-induced asthma is also referred to as leukotriene associated hypersensitivity Samter's triad goes by several other ...

*Leukotriene E4

Lee TH, Christie PE (1993). "Leukotrienes and aspirin induced asthma". Thorax. 48 (12): 1189-1190. doi:10.1136/thx.48.12.1189. ... urinary LTE4 levels are increased during severe asthma attacks and are especially high in people with aspirin-induced asthma, ... "Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor". The Journal of Experimental Medicine. 206 (11 ... also known as Samter's Triad or aspirin-exacerbated respiratory disease (AERD). Studies have suggested that LTE4 works through ...

*Andrzej Szczeklik

Szczeklik A, Stevenson DD (2003). "Aspirin-induced asthma: advances in pathogenesis, diagnosis, and management". J. Allergy ... He is perceived as an expert on aspirin-sensitive asthma. For the research on asthma he received "Lancet Investigators Award" ... aspirin-induced asthma, chemical mediators in diseases of circulatory and respiratory systems with special reference to ... In 2001 he was awarded the gold medal and "The Robert A. Cook Memorial Lectureship" by American Academy Allergy Asthma and ...

*TBX21

"Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma". Human Genetics. 117 (1): 16-26. doi ... Asthma is a disease of chronic inflammation, and it is known that transgenic mice born without TBX21 spontaneously develop ... It is thought that TBX21, therefore, may play a role in the development of asthma in humans as well. GRCh38: Ensembl release 89 ... "HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response". Biochemical and Biophysical Research ...

*Eicosanoid

... see Aspirin-induced asthma); exercise- and cold-air induced asthma (see Exercise-induced bronchoconstriction); and childhood ... or aspirin-treated COX2 to form the lipoxins and epi-lipoxins or with P450 oxygenases or aspirin-treated COX2 to form Resolvin ... are used clinically as maintenance treatment for allergen-induced asthma and rhinitis; nonsteroidal anti-inflammatory drug- ... Aspirin and NSAIDS-drugs that block the COX pathways and stop prostanoid synthesis-limit fever or the heat of localized ...

*Filipendula ulmaria

About one in five people with asthma has Samter's triad, in which aspirin induces asthma symptoms. Therefore, asthmatics should ... ISBN 0-85389-446-9 Jenkins, C; Costello, J; Hodge, L (2004). "Systematic review of prevalence of aspirin induced asthma and its ... will also induce symptoms of asthma. Filipendula ulmaria flowers or herb have been used in the traditional Austrian medicine ... The new drug, formally acetylsalicylic acid, was named aspirin by Hoffmann's employer Bayer AG after the old botanical name for ...

*GPR17

... see Aspirin-induced asthma). Subsequent reports, however, have varied in results: studies focusing on the allergen and non- ... In consequence, GPR17 attracted attention as a potential mediator of reactions caused by LTC4 and LTD4 viz., asthma, rhinitis, ... Kanaoka Y, Boyce JA (2014). "Cysteinyl leukotrienes and their receptors; emerging concepts". Allergy, Asthma & Immunology ... GPR17 expression is induced in dying neurons within and on the borders of injury, in infiltrating microglia and macrophages, ...

*Prostaglandin EP3 receptor

A in PTGER3 has been associated with Aspirin-induced asthma in a Korean population; and 6 SNP variants have been associated ... In a mouse model of ovalbumin-induced asthma, a selective EP3 agonist reduced airway cellularity, mucus, and ... "Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity". ... Furthermore, a selective EP3 agonist, ONO-AE-248, induces hyperalgesia pain in wild type but not EP3-deficient mice. While pain ...

*Salicylic acid

Ongoing clinical studies of patients with aspirin-induced asthma have shown some benefits of a diet low in salicylic acid. ... It is poorly soluble in water (2 g/L at 20 °C). Aspirin (acetylsalicylic acid or ASA) can be prepared by the esterification of ... It is involved in the systemic acquired resistance in which a pathogenic attack on one part of the plant induces resistance in ... In addition to serving as an important active metabolite of aspirin (acetylsalicylic acid), which acts in part as a prodrug to ...

*Salicylate sensitivity

Samter's triad refers to aspirin sensitivity in conjunction with nasal polyps and asthma. Aspirin-induced asthma NSAID ... Montelukast is one form of treatment used in aspirin-intolerant asthma. An important salicylate drug is aspirin, which has a ... However, it is possible for aspirin to trigger non-allergic hypersensitivity reactions. About 5-10% of asthmatics have aspirin ... November 2008). "Obesity in aspirin-tolerant and aspirin-intolerant asthmatics". Respirology. 13 (7): 1034-8. doi:10.1111/j. ...

*Prinzmetal's angina

Raynaud's phenomenon or aspirin-induced asthma. In contrast to patient with unstable angina secondary to coronary ... It was first referred to as cardiac syndrome X (CSX) by Kemp in 1973, to describe patients with exercise-induced angina and ... While acetylcholine induces vasoconstriction of vascular smooth muscle cells through a direct mechanism, acetylcholine also ... In healthy arterial walls, the overall indirect relaxation induced by acetylcholine (via nitric oxide) is of greater effect ...

*Prostaglandin EP2 receptor

... allergic diseases such as asthma (particular aspirin and nonsteroidal inflammatory drug-induced asthma syndromes) and rhinitis ... in a Korean population have been associated with an increased incidence of Aspirin-induced asthma. Prostanoid receptors ... "Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity". ... Desai S, April H, Nwaneshiudu C, Ashby B (December 2000). "Comparison of agonist-induced internalization of the human EP2 and ...

*Eoxin

... aspirin-induced asthma attacks, and perhaps other allergic reactions. A subsequent study found that eoxin levels in the exhaled ... "Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity: The ... breath of aspirin-sensitive and aspirin-intolerant asthmatic individuals did not rise after aspirin challenge and did not ... Eoxins have been implicated in inflammation of the airways in asthma patients, and in those with Hodgkin lymphoma, a malignant ...

*15-Hydroxyeicosatetraenoic acid

... aspirin-induced asthma attacks, and perhaps other allergic reactions. The production of eoxins by Reed-Sternburg cells has also ... When pretreated with aspirin, however, COX-1 is inactive while COX-2 attacks arachidonic acid to produce almost exclusively 15( ... Some of the inhibitory effects of 15(S)-HpETE and 15(S)-HETE, particularly when induced by high concentrations (e.g. >1-10 ... Serhan, C. N.; Takano, T; Maddox, J. F. (1999). "Aspirin-triggered 15-epi-lipoxin A4 and stable analogs on lipoxin A4 are ...

*ALOX15

... human allergen-induced asthma, aspirin-induced asthma, and perhaps other allergic diseases. In colorectal, breast, and kidney ... which have pro-inflammatory actions and contribute to severe asthma, aspirin-induced asthma attacks, and other allergy ... Neighbour H (2014). "Mechanisms of aspirin-intolerant asthma: identifying inflammatory pathways in the pathogenesis of asthma ... and other pathogen-induced inflammatory responses; in eczema, arthritis, asthma, cystic fibrosis, atherosclerosis, and adipose ...

*AERD

... may refer to: Aspirin-exacerbated respiratory disease, also known aspirin-induced asthma Atheroembolic renal disease, a ...

*Nonsteroidal anti-inflammatory drug

... see aspirin-induced asthma) symptoms in individuals with a history of asthma or rhinitis and 2) exacerbation or first-time ... aspirin-induced asthma The widespread use of NSAIDs has meant that the adverse effects of these drugs have become increasingly ... excluding aspirin) Past stroke (excluding aspirin) Past myocardial infarction (excluding aspirin) Coronary artery disease ( ... NSAIDs, aside from aspirin, increase the risk of myocardial infarction and stroke. This occurs at least within a week of use. ...

*NSAID hypersensitivity reactions

... see aspirin-induced asthma) in individuals with a history of asthma and/or nasal congestion, rhinorrhea or other symptoms of ... Allergy Asthma Immunol Res. 2015 Jul;7(4):312-20. doi: 10.4168/aair.2015.7.4.312 Buer JK (Oct 2014). "Origins and impact of the ... 5 Single NSAID-induced delayed reactions (SNIDR) are a set of delayed onset (usually more than 24 hour) reactions to NSAIDs. ... 4) Single NSAID-induced urticarial/angioedema or anaphylaxis (SNIUAA) is the acute development of urticarial, angioedema, or ...

*Hypereosinophilia

... asthma, atopic dermatitis, eosinophilic esophagitis, chronic sinusitis, aspirin-induced asthma, allergic bronchopulmonary ... Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. 118 (4): 411-418. doi: ... Manti S, Leonardi S, Salpietro A, Del Campo G, Salpietro C, Cuppari C (2017). "A systematic review of food protein-induced ... Chronic eosinophilic leukemia, not otherwise specified (i.e. CEL, NOS), is a leukemia-inducing disorder in the eosinophil cell ...

*Eosinophilic myocarditis

Allergic and autoimmune diseases such as severe asthma, rhinitis, or urticarial, chronic sinusitis, aspirin-induced asthma, ... Before cardiac symptoms are detected, some 66% of cases have symptoms of a common cold and 33% have symptoms of asthma, ... These causes are classified as primary (i.e. a defect intrinsic to the eosinophil cell line), secondary (induced by an ... Sentürk T, Özdemir B, Keçebaş M, Beşli F, Yesilbursa D, Serdar OA (2012). "Ascaris-induced eosinophilic myocarditis presenting ...

*Arachidonate 5-lipoxygenase

ALOX5 contributes to non-allergic reactions of the respiratory system and skin such as Aspirin-induced asthma, NSAID ... asthma, rashes, and eczema; d) NSAID-induced acute non-allergic reactions such as asthma, rhinitis, conjunctivitis, angioedema ... NSAID-induced non-allergic conjunctivitis, NSAID-induced Angioedema, NSAID-induced urticarial; it may also contribute to ... and conjunctiva reactions as well as exercise-induced asthma. Zileuton has shown some beneficial effects in clinical trials for ...

*Thromboxane receptor

... a South Korean test group was found to be elevated in patients suffering a type of severe asthma termed Aspirin-induced asthma ... For example, prostacyclin I2 (PGI2)-induced activation of its prostacyclin receptor (IP) and prostaglandin D2-induced ... prevented from developing angiotensin II-induced and N-Nitroarginine methyl ester-induced hypertension along with associated ... These findings suggest that TP contributes to asthma in animal models at least in part by mediating the actions of LTC4. ...

*Metamizole

... history of aspirin-induced asthma and other hypersensitivity reactions to analgesics. Oral anticoagulants (blood thinners), ... Despite this studies in animals have found that the CB1 cannabinoid receptor is not involved in the analgesia induced by ... "The dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2-dependent and -independent fever while 4-AA only blocks ... especially in those with asthma. Serious side effects include agranulocytosis, aplastic anaemia, hypersensitivity reactions ( ...

*Prostacyclin receptor

The rare SNP variant 795C of 794T in the PTGIR gene is associated with an increased incidence of Aspirin-induced asthma and a ... or bradykinin-induced paw edema. IP antagonists likewise reduce experimentally-induced capillary permeability and swelling in ... These IP-induced responses likely contribute to its apparent function in inhibiting certain mouse inflammation responses as ... IP(-/-) mice exhibit little or no writhing responses in an acetic acid-induced pain model. The mouse IP receptor also appears ...

*Diflunisal

... and hands Yellowing of skin Rash Ecchymosis Hypersensitivity to aspirin/NSAID-induced asthma or urticaria Aspirin triad 3rd ... New Metabolic Pathway Reveals Aspirin-Like Compound's Anti-Cancer Properties. June 2016 Jayamani, E. "Characterization of a ... after showing promise in a research project studying more potent chemical analogs of aspirin. It was first sold under the brand ... Impaired liver function Impaired kidney function Dehydration Fluid retention History of gastrointestinal bleeds/PUD Asthma ...

*Eicosanoid receptor

PGF2α-induced activation of FP has pro-inflammatory effects as well as roles in ovulation, luteolysis, contraction of uterine ... Claar D, Hartert TV, Peebles RS (2015). "The role of prostaglandins in allergic lung inflammation and asthma". Expert Review of ... aspirin-triggered lipoxin A4>leukotriene C4=leukotriene D4>>15-deoxy-LXA4>>N-Formylmethionine-leucyl-phenylalanine (http://www. ... and asthma, particularly in the area of airways constriction. EP2-(PGE2) (PTGER2) - PTGER2; EP2 is a receptor for prostaglandin ...