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*  Signal peptide peptidase
Another family of signal aspartic endopeptidases was found in bacteria. Bacteria produce a number of protein precursors that ... A nine amino acid-long cleavage fragment is then presented on HLA-E receptors and modulates the activity of natural killer ... Martoglio B, Golde TE (October 2003). "Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide ... which differ from mature pilin by virtue of containing a 6-8 residue leader peptide consisting of charged amino acids. Mature ...
*  Nodavirus endopeptidase
Capsid assembly in a family of animal viruses primes an autoproteolytic maturation that depends on a single aspartic acid ... Nodavirus endopeptidase (EC 3.4.23.44, Black Beetle virus endopeptidase, Flock House virus endopeptidase) is an enzyme. This ... Nodavirus endopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ... Johnson, J.E.; Schneemann, A. (1998). "Nodavirus endopeptidase". In Barrett, A.J.; Rawlings, N.D.; Woessner, J.F. Handbook of ...
*  Glutamyl endopeptidase GluV8
... especially glutamic acid, and to some extent aspartic acid. Glutamyl endopeptidase has been shown to cleave certain target ... Glutamyl endopeptidase is in S. aureus expressed from the gene sspA within the operon ssp. Downstream of sspA, the operon also ... Glutamyl endopeptidase is expressed as a zymogen that, in order to become fully active, has been modified both through ... Glutamyl endopeptidase can inhibit the activation of targets within the complement system. It is indicated to cause inhibition ...
*  LGMN
1998). "Autocatalytic activation of human legumain at aspartic acid residues". FEBS Lett. 438 (1-2): 114-8. doi:10.1016/S0014- ... 1999). "An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation". Nature. 396 (6712): 695-9. ... 1998). "Cloning and expression of mouse legumain, a lysosomal endopeptidase". Biochem. J. 335 (Pt 1): 111-7. PMC 1219758 . PMID ... 2003). "Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo". J. Biol. Chem. 278 (40): 38980-90. doi: ...
*  Rhizopuspepsin
... (EC 3.4.23.21, Rhizopus aspartic proteinase, neurase, Rhizopus acid protease, Rhizopus acid proteinase) is an ... A similar endopeptidase is found in R. niveus [2]. In peptidase family A1 (pepsin A family). Tsuru, D.; Hattori, A.; Tsuji, H ... Substrate specificity of acid protease of Rhizopus chinensis". Agric. Biol. Chem. 33: 1419-1426. doi:10.1080/00021369.1969. ... "Binding of a reduced peptide inhibitor to the aspartic proteinase from Rhizopus chinensis: implications for a mechanism of ...
*  Nepenthesin
Alternative names for this enzyme include Nepenthes acid proteinase and Nepenthes aspartic proteinase. Two isozymes have been ... The names cephalotusin, dionaeasin and droserasin have been proposed for similar aspartic endopeptidases originating from the ... 3. Acid proteases in the genus Nepenthes and Drosera peltata". J. Biochem. 72 (1): 73-81. PMID 5069751. Amagase S, Mori M, ... Aspartic proteinases: retroviral and cellular enzymes. New York: Plenum. pp. 453-458. ISBN 0-306-45809-8. Takahashi K, Tanji M ...
*  Candidapepsin
Candida albicans secretory acid proteinase, Candida olea acid proteinase, Candida aspartic proteinase, Candida olea aspartic ... Activates trypsinogen, and degrades keratin This endopeptidase js present in yeast Candida albicans. Remold, H.; Fasold, H.; ... This enzyme catalyses the following chemical reaction Preferential cleavage at the carboxyl of hydrophobic amino acids, but ... Candidapepsin (EC 3.4.23.24, Candida albicans aspartic proteinase, Candida albicans carboxyl proteinase, ...
*  Glutamyl endopeptidase I
Proteases of this group hydrolyzes peptide bonds after the negatively charged glutamic acid or aspartic acid, with a higher ... subtilis glutamyl endopeptidase GluBS Enterococcus E. faecalis glutamyl endopeptidase SprE Glutamyl endopeptidase is in at ... S. epidermidis glutamyl endopeptidase GluSE Also called S. epidermidis serine protease (Esp). S. warneri glutamyl endopeptidase ... Glutamyl endopeptidase I is a family of extracellular bacterial serine proteases. The proteases within this family have been ...
*  Aspartic protease
Aspartic endopeptidases EC 3.4.23. of vertebrate, fungal and retroviral origin have been characterised. More recently, aspartic ... Taylor RK, LaPointe CF (2000). "The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases". J. Biol. ... The MEROPS online database for peptidases and their inhibitors: Aspartic Peptidases Aspartic Endopeptidases at the US National ... GPR endopeptidase family) Clan AF (e.g. Omptin family) Many eukaryotic aspartic endopeptidases (MEROPS peptidase family A1) are ...
*  Metalloproteinase
... aspartic; C, cysteine; G, glutamic acid; M, metallo; S, serine; T, threonine; and U, unknown. The serine, threonine and ... These endopeptidases include CAAX prenyl protease 1, which proteolytically removes the C-terminal three residues of ... The metal ion is held in place by amino acid ligands, usually three in number. The known metal ligands are His, Glu, Asp or Lys ... In the case of aspartic, glutamic and metallopeptidases, the nucleophile is an activated water molecule. In many instances the ...
*  Retroviral aspartyl protease
Aspartic endopeptidases EC 3.4.23. of vertebrate, fungal and retroviral origin have been characterised. More recently, aspartic ... Taylor RK, LaPointe CF (2000). "The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases". J. Biol. ... Structurally, aspartic endopeptidases are bilobal enzymes, each lobe contributing a catalytic Asp residue, with an extended ... Jarrell KF, Bardy SL (2003). "Cleavage of preflagellins by an aspartic acid signal peptidase is essential for flagellation in ...
*  Subtilase
The defining features of these enzymes are a unique catalytic triad, Ser/Glu/Asp, as well as the presence of an aspartic acid ... The proprotein-processing endopeptidases kexin, furin and related enzymes form a distinct subfamily known as the kexin ... Members of the kexin family, along with endopeptidases R, T and K from the yeast Tritirachium and cuticle-degrading peptidase ... Over 200 subtilases are presently known, more than 170 of which with their complete amino acid sequence. Subtilase is ...
*  Osteopontin
The protein is rich in acidic residues: 30-36% are either aspartic or glutamic acid. OPN is a highly negatively charged, ... PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) is one such enzyme, which extensively ... Contiguous stretches of high negative charge in OPN have been identified and named the polyAsp motif (poly-aspartic acid) and ... Kiefer MC, Bauer DM, Barr PJ (April 1989). "The cDNA and derived amino acid sequence for human osteopontin". Nucleic Acids Res ...
*  Protease
... aspartic acid, metallo- and acid proteases) nucleophilic so that it can attack the peptide carboxyl group. One way to make a ... endopeptidases, such as trypsin, chymotrypsin, pepsin, papain, elastase). Catalysis is achieved by one of two mechanisms: ... aspartic, and metallo proteases. The threonine and glutamic-acid proteases were not described until 1995 and 2004 respectively ... using a threonine secondary alcohol Aspartic proteases - using an aspartate carboxylic acid Glutamic proteases - using a ...
*  List of EC numbers (EC 3)
Ste24 endopeptidase EC 3.4.24.85: S2P endopeptidase EC 3.4.24.86: ADAM 17 endopeptidase EC 3.4.24.87: ADAMTS13 endopeptidase EC ... Lotus aspartic proteinase EC 3.4.23.14: Deleted entry: sorghum aspartic proteinase EC 3.4.23.15: renin EC 3.4.23.16: HIV-1 ... Rhizopus acid proteinase. Now EC 3.4.23.21, rhizopuspepsin EC 3.4.23.10: Endothia acid proteinase. Now EC 3.4.23.22, ... ADAM10 endopeptidase EC 3.4.24.82: ADAMTS-4 endopeptidase EC 3.4.24.83: anthrax lethal factor endopeptidase EC 3.4.24.84: ...
*  Scytalidopepsin B
This endopeptidase is isolated from Scytalidium lignicolum. It is an acid protease, and is most active at pH 2.0 when casein is ... Scytalidium lignicolum aspartic proteinase B, SLB) is a proteolytic enzyme. It was previously thought to be an aspartic ... Eqolosins prefer bulky amino acid residues at the P1 site and small amino acid residues at the P1′ site. The substrate ... "Complete amino acid sequence of Scytalidium lignicolum acid protease B". J. Biochem. 95: 465-473. doi:10.1093/oxfordjournals. ...
*  Protease inhibitor (biology)
Green TB, Ganesh O, Perry K, Smith L, Phylip LH, Logan TM, Hagen SJ, Dunn BM, Edison AS (April 2004). "IA3, an aspartic ... This family includes PinA, which inhibits the endopeptidase La. It binds to the La homotetramer but does not interfere with the ... Murai H, Hara S, Ikenaka T, Oda K, Murao S (January 1985). "Amino acid sequence of Streptomyces metallo-proteinase inhibitor ... The saccharopepsin inhibitor I34 is highly specific for the aspartic peptidase saccharopepsin. In the absence of saccharopepsin ...
*  Asparagine peptide lyase
Nucleic Acids Res 44, D343-D350". Dautin, N., Barnard, T. J., Anderson, D. E., and Bernstein, H. D. (2007) EMBO J. 26, 1942- ... Family N2: Includes tetraviruses endopeptidases. The known autolytic cleavage is from the C-terminus of the coat protein. The ... Asparagine Lyase Protein precursor Proteolysis Nucleophilic substitution Protease cysteine- serine- threonine- aspartic- ... Reddy, A., Schneemann, A. & Johnson, J.E. Nodavirus endopeptidase. In Handbook of Proteolytic Enzymes, 2 edn (Barrett, A.J., ...
*  Ecadotril
"Substitution of potential metal-coordinating amino acid residues in the zinc-binding site of endopeptidase-24.11". FEBS Lett. ... in the case of the metallopeptidases and aspartic, the nucleophiles clan or family for example MA, is an activated water ... Ecadotril is a neutral endopeptidase inhibitor ((NEP) EC 3.4.24.11) and determined by the presence of peptidase family M13 as a ... Malfroy B, Schofield PR, Kuang WJ, Seeburg PH, Mason AJ, Henzel WJ (April 1987). "Molecular cloning and amino acid sequence of ...
*  Proteases in angiogenesis
... arginine-glycine-aspartic acid) motif. Most disintegrins contain this conserved RGD motif, but ADAM15 is the only member of the ... MMPs are a large multigene family of zinc-dependent endopeptidases. The collective MMP family is capable of degrading all known ... They include serine, aspartic, and cysteine-type proteases. A highly characterized example of the serine protease family is the ... Aminopeptidases function as exopeptidases which remove amino acids from the amino-terminus of proteins. Aminopeptidase N (CD13/ ...
*  Cysteine protease
Protease serine- threonine- aspartic- metallo- Enzyme Proteolysis Catalytic triad Convergent evolution PA clan The Proteolysis ... Mitchel, R. E.; Chaiken, I. M.; Smith, E. L. (1970). "The complete amino acid sequence of papain. Additions and corrections". ... The MEROPS online database for peptidases and their inhibitors: Cysteine Peptidases Cysteine endopeptidases at the US National ... The thioester bond is subsequently hydrolyzed to generate a carboxylic acid moiety on the remaining substrate fragment, while ...
*  Chymosin
It is an aspartic endopeptidase belonging to MEROPS A1 family. It is produced by newborn ruminant animals in the lining of the ... The native substrate of chymosin is K-casein which is specifically cleaved at the peptide bond between amino acid residues 105 ... Nucleic Acids Res. 10 (7): 2177-87. doi:10.1093/nar/10.7.2177. PMC 320601 . PMID 6283469. "Chymosin". GMO Compass. Archived ... "X-ray analyses of aspartic proteinases. IV. Structure and refinement at 2.2 A resolution of bovine chymosin". J. Mol. Biol. 221 ...
*  Osteoclast
Energy-dependent acid transport was verified and the postulated proton pump purified. With the successful culture of ... The matrix metalloproteinases (MMPs) comprise a family of more than 20 zinc-dependent endopeptidases. The role of matrix ... The function of these cysteine and aspartic proteases is generally unknown within bone, and they are expressed at much lower ... Attachment to the bone matrix is facilitated by integrin receptors, such as αvβ3, via the specific amino acid motif Arg-Gly-Asp ...
*  Serine protease
... generally a negatively charged aspartic acid or glutamic acid). The S1 pocket of chymotrypsin-like enzymes is more hydrophobic ... Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the ... The carboxyl group on the aspartic acid in turn hydrogen bonds with the histidine, making the nitrogen atom mentioned above ... These three key amino acids each play an essential role in the cleaving ability of the proteases. While the amino acid members ...
*  Picornain 3C
Both 2A(pro) and 3C(pro) induce caspase-8-mediated by activation of caspase-3. Caspase stands for cysteine-aspartic acid ... Picornain 3C (EC 3.4.22.28, Picornain 3C is a protease and endopeptidase enzyme found in the picornavirus, that cleaves peptide ... Picornain 3C are cysteine proteases related by amino acid sequence to trypsin-like serine proteases. Picornain 3C is encoded by ...
*  List of MeSH codes (D08)
... endopeptidases MeSH D08.811.277.656.300.066 --- aspartic endopeptidases MeSH D08.811.277.656.300.066.180 --- cathepsin d MeSH ... amino acid oxidoreductases MeSH D08.811.682.664.500.062 --- alanine dehydrogenase MeSH D08.811.682.664.500.125 --- d-amino-acid ... endopeptidase clp MeSH D08.811.277.656.300.760.247 --- endopeptidase k MeSH D08.811.277.656.300.760.284 --- enteropeptidase ... oxo-acid-lyases MeSH D08.811.520.224.600.200 --- anthranilate synthase MeSH D08.811.520.224.600.700 --- isocitrate lyase MeSH ...