Adderall
"Amphetamine aspartate". Drug Information Portal. U.S. National Library of Medicine. "Dextroamphetamine saccharate". Drug ... Psychostimulants] increase cAMP levels in striatum, which activates protein kinase A (PKA) and leads to phosphorylation of its ... The review indicated that magnesium L-aspartate and magnesium chloride produce significant changes in addictive behavior; other ... "Amphetamine Aspartate". Mallinckrodt Pharmaceuticals. March 2014. Retrieved 19 August 2015. "Vyvanse Prescribing Information" ( ...
Thioredoxin
... role of aspartate 60, and crystal structure of the aspartate 60 --> asparagine mutant". Biochemistry. 36 (46): 13979-88. doi: ... "Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1". The EMBO Journal. 17 (9): 2596-606 ...
Fibrolamellar hepatocellular carcinoma
"DNAJB1-PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular ... aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase - are often normal or only slightly elevated. FLC ... "Oncogenic Addiction of Fibrolamellar Hepatocellular Carcinoma to the Fusion Kinase DNAJB1-PRKACA". Clinical Cancer Research. 29 ... "Disruption of proteome by an oncogenic fusion kinase alters metabolism in fibrolamellar hepatocellular carcinoma". Science ...
Neuroprotection
Tikka TM, Koistinaho JE (June 2001). "Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by ... it inhibits glycogen synthase kinase-3 (GSK-3), upregulates neurotrophins and growth factors (e.g., brain-derived neurotrophic ...
Neuropathic pain
The N-methyl-D-aspartate (NMDA) receptor seems to play a major role in neuropathic pain and in the development of opioid ... NMDA activation also triggers a change in the post synapse, it activates receptor kinases that increase receptor trafficking ... Davis AM, Inturrisi CE (1999). "d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia". J. ...
Liver function tests
The liver transaminases aspartate transaminase (AST or SGOT) and alanine transaminase (ALT or SGPT) are useful biomarkers of ... Nageh T, Sherwood RA, Harris BM, Byrne JA, Thomas MR (2003). "Cardiac troponin T and I and creatine kinase-MB as markers of ... LDH isotype-1 (or cardiac) is used for estimating damage to cardiac tissue, although troponin and creatine kinase tests are ... aspartate aminotransferase (AST), and alkaline phosphatases (APs). Bilirubin may be used to estimate the excretory function of ...
Protein C
APC protects endothelial barrier function by inducing PAR-1 dependent sphingosine kinase-1 activation and up-regulating ... beta-Hydroxylation of Asp71 in one of the two EGF-like domains to give erythro-L-beta-hydroxy-aspartate (bHA). The modification ... sphingosine-1-phosphate with sphingosine kinase.: 3165 Several studies have indicated that the proteolytic activity of APC ...
Dextroamphetamine
Psychostimulants] increase cAMP levels in striatum, which activates protein kinase A (PKA) and leads to phosphorylation of its ... "Amphetamine Aspartate". Mallinckrodt Pharmaceuticals. March 2014. Retrieved 19 August 2015. Wikimedia Commons has media related ... Adderall contains equal amounts of four amphetamine salts: One-quarter racemic (d,l-)amphetamine aspartate monohydrate One- ... The review indicated that magnesium L-aspartate and magnesium chloride produce significant changes in addictive behavior; other ...
Neurotoxin
It is this intracellular calcium increase that activates protein kinase C (PKC), which manifests as learning deficits in ... Takadera, Tsuneo; Suzuki, Risa; Mohri, Tetsuro (1990). "Protection by Ethanol of Cortical Neurons from N-methyl-d-aspartate- ... Konopacka, Agnieszka; Konopacki, Filip A.; Albrecht, Jan (2009). "Protein Kinase G Is Involved in Ammonia-induced Swelling of ... by Mild and Intense Insults with N-Methyl-D-Aspartate or Nitric Oxide/Superoxide in Cortical Cell Cultures". Proceedings of the ...
Cryptochrome
Cailliez F, Müller P, Gallois M, de la Lande A (September 2014). "ATP binding and aspartate protonation enhance photoinduced ... Unlike phytochromes and phototropins, cryptochromes are not kinases. Their flavin chromophore is reduced by light and ...
Adiponectin
The receptors affect the downstream target AMP kinase, an important cellular metabolic rate control point. Expression of the ... "Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine ...
Synaptotagmin
... and the binding pockets are coordinated by five conserved aspartate residues: three calcium ions bind to C2A via D172, D178, ... "C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the ...
S-Nitrosoglutathione
It was particularly noteworthy that in cultured normal rat cholangiocytes, GSNO activated protein kinase B, protected against ... "Glutathione is an endogenous ligand of rat brain N-methyl-D-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4- ...
Transporter Classification Database
Family 2.A.81 The Aspartate:Alanine Exchanger (AAEx) Family 2.A.82 The Organic Solute Transporter (OST) Family 2.A.83 The Na+- ... Family 1.A.105 The Mixed Lineage Kinase Domain-like (MLKL) Family 1.A.106 The Calcium Load-activated Calcium Channel (CLAC) ...
List of MeSH codes (D12.776.543)
... fms-like tyrosine kinase 3 MeSH D12.776.543.750.060.061 - receptor, fibroblast growth factor, type 1 MeSH D12.776.543.750. ... n-methyl-d-aspartate MeSH D12.776.543.750.720.200.470 - receptors, glycine MeSH D12.776.543.750.720.300 - receptors, biogenic ...
Genome-wide CRISPR-Cas9 knockout screens
Chase D, Serafinas C, Ashcroft N, Kosinski M, Longo D, Ferris DK, Golden A (January 2000). "The polo-like kinase PLK-1 is ... "An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis". Cell. ... August 2000). "Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding ... including targeted sublibraries for distinct subpools such as kinases and ribosomal genes (Addgene #51043-51048). Further, ...
Multiple sclerosis research
Masitinib, a tyrosine kinase inhibitor, is in late-stage testing for the treatment of patients with secondary and primary ... "Periventricular white matter lesion and incomplete MRZ reaction in a male patient with anti-N-methyl-D-aspartate receptor ...
Caspase 3
His-121 stabilizes the carbonyl group of the key aspartate residue, while Cys-163 attacks to ultimately cleave the peptide bond ... Roig J, Traugh JA (2001). Cytostatic p21 G protein-activated protein kinase gamma-PAK. Vitamins & Hormones. Vol. 62. pp. 167-98 ... Ruzzene M, Penzo D, Pinna LA (May 2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis ...
Osteopontin
... and aspartate-rich motif), with the latter sequence having multiple phosphorylation sites. This overall negative charge of OPN ... "Osteopontin localizes to the nucleus of 293 cells and associates with polo-like kinase-1". American Journal of Physiology. Cell ...
Metaplasticity
... a critical role for protein kinase A in synaptic tagging". Eur. J. Neurosci. 23 (7): 1784-94. doi:10.1111/j.1460-9568.2006. ... and N-methyl-D-aspartate (NMDA), respectively, but they both bind glutamate. When a glutamatergic synapse releases glutamate it ...
Dopamine receptor D1
They are Gs/a coupled and can stimulate neurons by indirectly activating cyclic AMP-dependent protein kinase. The DRD1 gene ... August 2017). "Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as ...
TAAR1
Upon entering the presynaptic neuron, these compounds activate TAAR1 which, through protein kinase A (PKA) and protein kinase C ... firing patterns of these neurons in the presence of N-Methyl D-Aspartate. Temporally, it was found that the trace amine ... Phosphorylation by either protein kinase can result in DAT internalization (non-competitive reuptake inhibition), but PKC- ...
Index of oncology articles
... protein kinase C - proteoglycan - proteomic profile - proteomics - proton beam radiation therapy - proton magnetic resonance ... aspartate transaminase - aspergillosis - Aspergillus - asthenia - astrocyte - astrocytoma - asymptomatic - atamestane - ataxia ... tyrosine kinase inhibitor - TZT-1027 ubiquinone - UCN-01 - UGT1A1 - ultrasonogram - ultrasonography - ultrasound-guided biopsy- ...
List of EC numbers (EC 3)
N-acyl-D-aspartate deacylase EC 3.5.1.84: biuret amidohydrolase EC 3.5.1.85: (S)-N-acetyl-1-phenylethylamine hydrolase EC 3.5. ... pyruvate kinase]-phosphatase EC 3.1.3.50: sorbitol-6-phosphatase EC 3.1.3.51: dolichyl-phosphatase EC 3.1.3.52: [3-methyl-2- ... aspartate carboxypeptidase EC 3.4.12.10: Now EC 3.4.19.9, γ-glutamyl hydrolase EC 3.4.12.11: Now EC 3.4.17.6, alanine ... acetyl-L-aspartate hydrolase * EC 3.5.1.135: N 4-acetylcytidine amidohydrolase * EC 3.5.1.136: N,N′-diacetylchitobiose non- ...
Inflammatory demyelinating diseases of the central nervous system
Ma C, Wang C, Zhang Q, Lian Y (2019). "Emerging role of prodromal headache in patients with anti-N-methyl-D-aspartate receptor ... MLKL-MS: Mixed lineage kinase domain like pseudokinase (MLKL) related MS - A preliminary report has pointed out evidence of a ... "Periventricular white matter lesion and incomplete MRZ reaction in a male patient with anti-N-methyl-D-aspartate receptor ...
Protein
Domains usually also have specific functions, such as enzymatic activities (e.g. kinase) or they serve as binding modules (e.g ... and threonine from aspartate. If amino acids are present in the environment, microorganisms can conserve energy by taking up ...
Ketamine
Morris PJ, Moaddel R, Zanos P, Moore CE, Gould TD, Zarate CA, Thomas CJ (September 2017). "Synthesis and N-Methyl-d-aspartate ( ... kinase. In addition to blockade of the NMDA receptor, the active metabolite of ketamine hydroxynorketamine, which does not ... Orser BA, Pennefather PS, MacDonald JF (April 1997). "Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate ... and activation of its signaling receptor tropomyosin receptor kinase B (TrkB), activation of the mammalian target of rapamycin ...
ATP-binding cassette transporter
This Mg2+ ion also coordinates with the terminal aspartate residue in the Walker B motif through the attacking H2O. A general ... Matte A, Tari LW, Delbaere LT (Apr 1998). "How do kinases transfer phosphoryl groups?". Structure. 6 (4): 413-9. doi:10.1016/ ...
Non-alcoholic fatty liver disease
The ratio of the transaminase liver enzyme aspartate aminotransferase (AST) to platelets in the blood, known as the AST/ ... apoptosis signal-regulating kinase 1) inhibitors may improve NAFLD by multiple mechanisms simultaneously. Drugs in phase III ... and c-Jun N-terminal kinase inhibitors aim to directly reduce liver damage, but these drugs have not shown benefit. Anti- ...
Morphine
Winger G, Hursh SR, Casey KL, Woods JH (May 2002). "Relative reinforcing strength of three N-methyl-D-aspartate antagonists ... mitogen-activated protein kinase)-dependent pathway. Usually, the p38 within the dendritic cell expresses TLR 4 (toll-like ...