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*  Aspartate carbamoyltransferase
... (also known as aspartate transcarbamoylase or ATCase) catalyzes the first step in the pyrimidine ... "2.5 A structure of aspartate carbamoyltransferase complexed with the bisubstrate analog N-(phosphonacetyl)-L-aspartate". ... Aspartate carbamoyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Two catalytic trimers and two regulatory dimers assemble to form an intermediate of aspartate carbamoyltransferase consisting ...
*  Protomer
Aspartate carbamoyltransferase has a α6β6 subunit composition. The six αβ-protomers are arranged in D3 symmetry. Viral capsid ...
*  Biosynthesis
Aspartate carbamoyltransferase condenses carbamoyl phosphate with aspartate to form uridosuccinate. Dihydroorotase performs ... The biosynthesis of aspartate is a one step reaction that is catalyzed by a single enzyme. The enzyme aspartate ... The aspartate family of amino acids includes: threonine, lysine, methionine, isoleucine, and aspartate. Lysine and isoleucine ... Aspartate semialdehyde dehydrogenase catalyzes the NADPH-dependent reduction of aspartyl phosphate to yield aspartate ...
*  Don Craig Wiley
Noteworthy in this effort was that Wiley managed to grow crystals of aspartate carbamoyltransferase suitable for obtaining its ... There, Wiley did early work on the structure of aspartate carbamoyltransferase, the largest molecular structure determined at ... "Complex of aspartate carbamoyltransferase from Escherichia coli with its allosteric inhibitor, cytidine triphosphate: Electron ... "Crystal and molecular structures of native and CTP-liganded aspartate carbamoyltransferase from Escherichia coli". Journal of ...
*  Cooperative binding
"Crystal and molecular structures of native and CTP-liganded aspartate carbamoyltransferase from Escherichia coli". Journal of ... Another enzyme that has been suggested early to bind ligands cooperatively is aspartate trans-carbamylase. Although initial ... Changeux, J. P.; Rubin, M. M. (1968). "Allosteric interactions in aspartate transcarbamylase. 3. Interpretation of experimental ...
*  Cytidine triphosphate
CTP acts as an inhibitor of the enzyme aspartate carbamoyltransferase, which is used in pyrimidine biosynthesis. CTP synthase ...
*  Allosteric enzyme
... coli enzyme aspartate carbamoyltransferase (ATCase) has become another good example of allosteric regulation. The kinetic ...
*  ATCase/OTCase family
Aspartate carbamoyltransferase (ATCase) catalyses the conversion of aspartate and carbamoyl phosphate to carbamoylaspartate, ... aspartate carbamoyltransferase EC 2.1.3.2 and ornithine carbamoyltransferase EC 2.1.3.3. It has been shown that these enzymes ... Ke HM, Honzatko RB, Lipscomb WN (July 1984). "Structure of unligated aspartate carbamoyltransferase of Escherichia coli at 2.6- ... Ornithine carbamoyltransferase (OTCase) catalyses the conversion of ornithine and carbamoyl phosphate to citrulline. In mammals ...
*  Nucleotide
Next, aspartate carbamoyltransferase catalyzes a condensation reaction between aspartate and carbamoyl phosphate to form ... This new carbon is modified by the additional of a third NH2 unit, this time transferred from an aspartate residue. Finally, a ... First, GTP hydrolysis fuels the addition of aspartate to IMP by adenylosuccinate synthase, substituting the carbonyl oxygen for ... Pyrimidines are synthesized first from aspartate and carbamoyl-phosphate in the cytoplasm to the common precursor ring ...
*  Unikont
... aspartate carbamoyltransferase. This must have involved a double fusion, a rare pair of events, supporting the shared ancestry ...
*  Raymond C. Stevens
"Crystal Structures of Aspartate Carbamoyltransferase Li gated with Phosphonoacetamide, Malonate and CTP or ATP at 2.8-A ... "Escherichia coli aspartate carbamoyltransferase: The probing of crystal structure analysis via site-specific mutagenesis," ... "Crystal structure of the Glu-239 to Gln mutant of aspartate carbamoyltransferase at 3.1 A resolution: An intermediate ... "Structural Consequences of Effector Binding to the T State of Aspartate Carbamoyltransferase Crystal Structures of the ...
*  Thomas A. Steitz
Steitz made contributions to determining the atomic structures of carboxypeptidase A and aspartate carbamoyltransferase, each ... The structure of aspartate transcarbamylase, I. A molecular twofold axis in the complex with cytidine triphosphate. Proc Natl ...
*  List of EC numbers (EC 2)
... aspartate carbamoyltransferase EC 2.1.3.3: ornithine carbamoyltransferase EC 2.1.3.4: deleted EC 2.1.3.5: oxamate ... putrescine carbamoyltransferase EC 2.1.3.7: 3-hydroxymethylcephem carbamoyltransferase EC 2.1.3.8: lysine carbamoyltransferase ... aspartate kinase EC 2.7.2.5: now EC 6.3.4.16 EC 2.7.2.6: formate kinase EC 2.7.2.7: butyrate kinase EC 2.7.2.8: acetylglutamate ... aspartate transaminase EC 2.6.1.2: alanine transaminase EC 2.6.1.3: cysteine transaminase EC 2.6.1.4: glycine transaminase EC ...
*  List of MeSH codes (D08)
... aspartate carbamoyltransferase MeSH D08.811.913.555.275.600 --- ornithine carbamoyltransferase MeSH D08.811.913.555.400 --- ... aspartate carbamoyltransferase MeSH D08.811.600.130 --- aspartokinase homoserine dehydrogenase MeSH D08.811.600.200 --- ... aspartate aminotransferases MeSH D08.811.913.477.700.225.249 --- aspartate aminotransferase, cytoplasmic MeSH D08.811.913.477. ... aspartate-tRNA ligase MeSH D08.811.464.263.200.250 --- glutamate-trna ligase MeSH D08.811.464.263.200.350 --- glycine-trna ...
*  Opisthokont
... and aspartate carbamoyltransferase that is not present in plants, and plants have a fusion of thymidylate synthase and ...
*  Transferase
Kirsch JF, Eichele G, Ford GC, Vincent MG, Jansonius JN, Gehring H, Christen P (Apr 1984). "Mechanism of action of aspartate ... "carbamoyltransferase". The Free Dictionary. Farlex, Inc. Retrieved 25 November 2013. "carbamoyl group (CHEBI:23004)". ChEBI: ... In ATCase such a transfer is written as Carbamyl phosphate + L-aspertate → {\displaystyle \rightarrow } L-carbamyl aspartate + ... Reichard P, Hanshoff G (1956). "Aspartate Carbamyl Transferase from Escherichia Coli" (PDF). Acta Chemica Scandinavica: 548-566 ...