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*  Dopaminergic
Aromatic L-amino acid decarboxylase or DOPA decarboxylase inhibitors including benserazide, carbidopa, and methyldopa, which ... Enzymes that regulate the biosynthesis or metabolism of dopamine such as aromatic L-amino acid decarboxylase or DOPA ... decarboxylase, monoamine oxidase (MAO), and catechol O-methyl transferase (COMT) may be referred to as dopaminergic as well. ...
*  Aromatic L-amino acid decarboxylase
... inhibitor, a class of anti-Parkinson drugs Aromatic amino acids Histidine decarboxylase PDB ... Aromatic L-amino acid decarboxylase (AADC or AAAD), also known as DOPA decarboxylase (DDC), tryptophan decarboxylase, and 5- ... Aromatic-L-Amino-Acid Decarboxylases at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... "Aromatic L-amino acid decarboxylase deficiency: clinical features, treatment, and prognosis". Neurology. 62 (7): 1058-65. doi: ...
*  Aromatic L-amino acid decarboxylase inhibitor
An aromatic L-amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, DDCI and AAADI) is a drug which ... inhibits the synthesis of dopamine by the enzyme aromatic L-amino acid decarboxylase (AADC, AAAD, or DOPA decarboxylase). ... ISBN 3-8047-1763-2. "Editorial: Dopa decarboxylase inhibitors". British Medical Journal. 4 (5939): 250-1. November 1974. doi: ...
*  Aromatic amino acid
Aromatic L-amino acid decarboxylase Expanded genetic code Logan, Carolynn M.; Rice, M. Katherine (1987). Logan's Medical and ... An aromatic amino acid (AAA) is an amino acid that includes an aromatic ring. Examples include: Among 20 standard amino acids: ... Aromatic amino acids are able to absorb light due to their conjugated double bonds. This characteristic of aromatic amino acids ... Animals obtain aromatic amino acids from their diet, but all plants and micro-organisms must synthesize their aromatic amino ...
*  Phenylalanine decarboxylase
Other names in common use include L-phenylalanine decarboxylase, aromatic L-amino acid decarboxylase, and L-phenylalanine ... Schulz AR, Oliner L (1967). "The possible role of thyroid aromatic amino acid decarboxylase in thyroxine biosynthesis". Life ... LOVENBERG W, WEISSBACH H, UDENFRIEND S (1962). "Aromatic L-amino acid decarboxylase". J. Biol. Chem. 237: 89-93. PMID 14466899 ... In enzymology, a phenylalanine decarboxylase (EC 4.1.1.53) is an enzyme that catalyzes the chemical reaction L-phenylalanine ...
*  Meta-Tyramine
"EC 4.1.1.28 - Aromatic-L-amino-acid decarboxylase (Homo sapiens)". BRENDA. Technische Universität Braunschweig. July 2016. ... meta-Tyramine is produced in humans via aromatic amino acid decarboxylase-mediated metabolism of meta-tyrosine. meta-Tyramine ...
*  3-O-Methyldopa
On the other hand, the possibility of blocking peripheral decarboxylation by adding an aromatic amino acid decarboxylase (AADC ... This reaction happen in the process of decarboxylation by aromatic amino acid decarboxylase (AADC) also called dopa- ... Vanilpyruvate is reduced to the final conversion: venillactate which are the same, predominantly by aromatic α-keto acid ... Some studies have proposed that 3-OMD increases homocysteine levels, and this amino acid induces cardiovascular disease and ...
*  Entacapone
... entacapone is given as an adjunct to levodopa and an aromatic amino acid decarboxylase inhibitor, carbidopa. Entacapone ... When administered with a decarboxylase inhibitor, COMT acts as the major metabolizing enzyme for levodopa and metabolizes it to ...
*  N,N-Dimethyltryptamine
No matter the source of L-tryptophan, the biosynthesis begins with its decarboxylation by an aromatic amino acid decarboxylase ... In plants, the parent amino acid L-tryptophan is produced endogenously where in animals L-tryptophan is an essential amino acid ... as other DMT acid salts are extremely hygroscopic and will not readily crystallize. Its freebase form, although less stable ...
*  List of OMIM disorder codes
CYP19A1 Aromatic L-amino acid decarboxylase deficiency; 608643; DDC Arrhythmogenic right ventricular dysplasia 1; 107970; TGFB3 ... FREM1 Bile acid malabsorption, primary; 613291; SLC10A2 Bile acid synthesis defect, congenital, 2; 235555; AKR1D1 Bile acid ... SBDS Sialic acid storage disorder, infantile; 269920; SLC17A5 Sialidosis, type I; 256550; NEU1 Sialidosis, type II; 256550; ... SLC7A7 Lysosomal acid phosphatase deficiency; 200950; ACP2 Lysyl hydroxylase 3 deficiency; 612394; PLOD3 Machado-Joseph disease ...
*  Neurotransmitter
... and the biosynthetic enzyme aromatic amino acid decarboxylase (AADC). Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 6: ... Major neurotransmitters: Amino acids: glutamate, aspartate, D-serine, γ-aminobutyric acid (GABA), glycine Gasotransmitters: ... Most neurotransmitters are about the size of a single amino acid, however, some neurotransmitters may be the size of larger ... Dividing them into amino acids, peptides, and monoamines is sufficient for some classification purposes. ...
*  Nucleus accumbens
... and the biosynthetic enzyme aromatic amino acid decarboxylase (AADC). Barrot, Michel; Marinelli, Michela; Abrous, Djoher Nora; ... More recently, Fuller's laboratory also discovered that sleep can be promoted by the activation of a gamma-aminobutyric acid- ...
*  Amphetamine
... and the biosynthetic enzyme aromatic amino acid decarboxylase (AADC). ... AMPH release of DA from synapses requires both an ... phenethylamine is produced directly from L-phenylalanine by the aromatic amino acid decarboxylase (AADC) enzyme, which converts ... SLC1A1 is excitatory amino acid transporter 3 (EAAT3), a glutamate transporter located in neurons, SLC22A3 is an extraneuronal ... Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 5: Excitatory and Inhibitory Amino Acids". In Sydor A, Brown RY. Molecular ...
*  Trace amine
... and the biosynthetic enzyme aromatic amino acid decarboxylase (AADC). Grandy DK, Miller GM, Li JX (February 2016). ""TAARgeting ... decreases in the urine and plasma levels of the PE metabolite phenylacetic acid and the precursors phenylalanine and tyrosine ...
*  Reverse transport
... and the biosynthetic enzyme aromatic amino acid decarboxylase (AADC). ... AMPH release of DA from synapses requires both an ...
*  Vesicular monoamine transporter
... and amino acid aromatic decarboxylase (AADC) are physically and functionally coupled with VMAT2. It was initially thought that ... and the biosynthetic enzyme aromatic amino acid decarboxylase (AADC). Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill ... Studies indicate that the amino acid residue His419, located on the domain between TMD X and XI of rat VMAT1, plays a role in ... Scientists have used these tools to analyze DNA and amino acid sequences, discovering that transporters in bacteria and humans ...
*  Lisdexamfetamine
... and the biosynthetic enzyme aromatic amino acid decarboxylase (AADC). Sulzer D, Cragg SJ, Rice ME (August 2016). "Striatal ... The attachment of the amino acid lysine slows down the relative amount of dextroamphetamine available to the blood stream. ... Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 5: Excitatory and Inhibitory Amino Acids". In Sydor A, Brown RY. Molecular ... Its chemical structure consists of dextroamphetamine coupled with the essential amino acid L-lysine. Lisdexamfetamine itself is ...
*  Adderall
... and the biosynthetic enzyme aromatic amino acid decarboxylase (AADC). Broadley KJ (March 2010). "The vascular effects of trace ... phenethylamine is produced directly from L-phenylalanine by the aromatic amino acid decarboxylase (AADC) enzyme, which converts ... Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 5: Excitatory and Inhibitory Amino Acids". In Sydor A, Brown RY. Molecular ... benzoic acid, hippuric acid, norephedrine, and phenylacetone. Among these metabolites, the active sympathomimetics are 4- ...
*  Dextroamphetamine
... phenethylamine is produced directly from L-phenylalanine by the aromatic amino acid decarboxylase (AADC) enzyme, which converts ... Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 5: Excitatory and Inhibitory Amino Acids". In Sydor A, Brown RY. Molecular ... benzoic acid, hippuric acid, norephedrine, and phenylacetone. Among these metabolites, the active sympathomimetics are 4- ... This reaction is catalyzed by the HXM-A and HXM-B medium-chain acid:CoA ligases and requires energy in the form of ATP. ... The ...
*  Monoamine neurotransmitter
... and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes. Monoaminergic systems, i.e., the networks ... All monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, ... neurotransmitters are neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring ...
*  L-DOPA
... it is converted into dopamine by the enzyme aromatic L-amino acid decarboxylase, also known as DOPA decarboxylase. Pyridoxal ... Dopamine is formed by the decarboxylation of L-DOPA by aromatic L-amino acid decarboxylase (AADC). L-DOPA can be directly ... "Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology" (PDF). Clinical Chemistry. 38 (12): 2405-10. PMID ... L-DOPA is produced from the amino acid L-tyrosine by the enzyme tyrosine hydroxylase. It is also the precursor for the ...
*  Phenethylamine
... from the amino acid L-phenylalanine by enzymatic decarboxylation via the enzyme aromatic L-amino acid decarboxylase. In ... the gene for aromatic amino acid decarboxylase (AADC), the major enzyme involved in the synthesis of the trace amines, is ... phenethylamine is synthesized in catecholamine neurons from L-phenylalanine by aromatic amino acid decarboxylase at ... Acetoacetic acid (AAA) and ß-phenylethylamine (PEA) performed best in this experiment. On beef meat pieces, PEA reduced the ...
*  Catecholamine
... which is metabolized by l-aromatic amino acid decarboxylase (AADC; see Cooper et al., 2002) to the transmitter dopamine. This ... The amino acids phenylalanine and tyrosine are precursors for catecholamines. Both amino acids are found in high concentrations ... Catecholamines are derived from the amino acid tyrosine, which is derived from dietary sources as well as synthesis from ... The enzyme tyrosine hydroxylase (TH) converts the amino acid l-tyrosine into 3,4- dihydroxyphenylalanine (l-DOPA). The ...
*  Carbidopa/levodopa/entacapone
Carbidopa is a peripheral aromatic L-amino acid decarboxylase (AADC) inhibitor. Carbidopa, which also does not cross the blood- ...
*  Tolcapone
... carbidopa and benserazide are aromatic L-amino acid decarboxylase (AADC) inhibitors. Without administration of tolcapone, the ... It melts at 143 to 146 °C (289 to 295 °F), is practically insoluble in water and acids but soluble in 0.1 M aqueous sodium ... hydroxylation by CYP3A4 and CYP2A6 with subsequent oxidation to a carboxylic acid, and possibly a minor path with reduction to ... in 0.1 M hydrochloric acid / ethanol). Its chemical name is 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone. A synthesis of ...
*  Sympathoadrenal system
... aromatic L-amino acid decarboxylase, dopamine-β-hydroxylase, and phenylethanolamine N-methyltransferase. The release of ...
*  Neurobiological effects of physical exercise
... phenethylamine is synthesized in catecholamine neurons from L-phenylalanine by aromatic amino acid decarboxylase at ... Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 5: Excitatory and Inhibitory Amino Acids". In Sydor A, Brown RY. Molecular ... Two reviews noted a study where the mean 24 hour urinary β-phenylacetic acid acid concentration following just 30 minutes of ... The 24 hour mean urinary concentration of phenylacetic acid was increased by 77% after exercise. ... As phenylacetic acid ...