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*  PTGS1
... such as linoleic acid and eicosapentaenoic acid. Metabolism of arachidonic acid forms a labile intermediate peroxide, PGG2, ... While metabolizing arachidonic acid primarily to PGG2, COX-1 also converts this fatty acid to small amounts of a racemic ... The cyclooxygenase activity incorporates two oxygen molecules into arachidonic acid or alternate polyunsaturated fatty acid ... It converts free arachidonic acid, released from membrane phospholipids at the sn-2 ester binding site by the enzymatic ...
*  Epoxydocosapentaenoic acid
... arachidonic acid, to epoxyeicosatrienoic acids (EETs); another CYP epoxygenase pathway metabolizes the 20-carbon omega-3 fatty ... see 20-Hydroxyeicosatetraenoic acid), i.e. 19-hydroxyeicosatetraenoic acid and/or 20-hydroxyeicosatetranoic acid, take on ... These tissues are known to metabolize arachidonic acid to EETs; it has been shown or is presumed that they also metabolize DHA ... Spector, A. A. (2009). "Arachidonic acid cytochrome P450 epoxygenase pathway". The Journal of Lipid Research. 50 Suppl: S52-6. ...
*  Lipoxygenase
... arachidonic acid, linoleic acid, dihomo-γ-linolenic acid, and adrenic acid; the omega-3 fatty acids, eicosapentaenoic acid, ... ALOX15 actually prefers linoleic acid over arachidonic acid, metabolizing linoleic acid to 12-hydroperoxyoctadecaenoic acid (13 ... Alox12b does not metabolize arachidonic acid as free acd but dose metabolize arachidonic acid methyl ester to its 12R- ... docosahexaenoic acid, and alpha-linolenic acid; and the omega-9 fatty acid, mead acid. Certain types of the lipoxygenases, e.g ...
*  15-Hydroxyeicosatetraenoic acid
... a metabolite of arachidonic acid. Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15( ... 13E-eicosatetraenoic acid (15(R)-HpETE). Human cells release arachidonic acid (i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid) from ... Maas, R. L.; Turk, J; Oates, J. A.; Brash, A. R. (1982). "Formation of a novel dihydroxy acid from arachidonic acid by ... However this enzyme has a preference for metabolizing linoleic acid rather than arachidonic acid. It therefore forms linoleic ...
*  Prostaglandin
They are synthesized in the cell from the essential fatty acids (EFAs). An intermediate arachidonic acid is created from ... Prostaglandins are produced following the sequential oxygenation of arachidonic acid, DGLA or EPA by cyclooxygenases (COX-1 and ... They are a subclass of eicosanoids and of the prostanoid class of fatty acid derivatives. The structural differences between ... They are derived enzymatically from fatty acids. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring. ...
*  Arachidonic acid
... β-hydroxy β-methylbutyric acid, and phosphatidic acid. Arachidonic acid is one of the most abundant fatty acids in the brain, ... Arachidonic Acid at acnp.org Arachidonic Acid at the US National Library of Medicine Medical Subject Headings (MeSH). ... Arachidonic acid is also used in the biosynthesis of anandamide. Some arachidonic acid is converted into ... Like DHA, neurological health is reliant upon sufficient levels of arachidonic acid. Among other things, arachidonic acid helps ...
*  Arachidonic acid 5-hydroperoxide
... (5-hydroperoxyeicosatetraenoic acid, 5-HPETE) is an intermediate in the metabolism of ... 5-Hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid; or c) the specialized pro-resolving mediators of inflammation, ... arachidonic acid by the ALOX5 enzyme in humans or Alox5 enzyme in other mammals. The intermediate is then further metabolized ...
*  Neurochemical
Eicosanoids act as neuromodulators via the Arachidonic acid cascade. Orexins (-A and -B) are involved in a number of cognitive ... "Arachidonic Acid". Neuropsychopharmacology: The Fifth Generation of Progress. Retrieved 2006-03-03. "Neurotrophic factors". ...
*  Leukotriene-A4 hydrolase
This enzyme participates in arachidonic acid metabolism. As of late 2007, 4 structures have been solved for this class of ... Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase". J. Biol. ... "Molecular cloning and amino acid sequence of leukotriene A4 hydrolase". Proc. Natl. Acad. Sci. U.S.A. 84 (19): 6677-81. doi: ...
*  15-hydroxyprostaglandin-D dehydrogenase (NADP+)
This enzyme participates in arachidonic acid metabolism. Watanabe K, Shimizu T, Iguchi S, Wakatsuka H, Hayashi M, Hayaishi O ( ...
*  Zanvil A. Cohn
Regulation of arachidonic acid metabolites in macrophages. J. Exp. Med. 152:324-335. 1982 With W. A. Scott, N. A. Pawlowski, H ... Regulation of arachidonic acid metabolism by macrophage activation. J. Exp. Med. 155:1148-1160. With W. C. Van Voorhis, G. ... Bacterial lipopolysaccharides prime macrophages for enhanced release of arachidonic acid metabolites. J. Exp. Med. 164:165-179 ...
*  Leukotriene-B4 20-monooxygenase
This enzyme participates in arachidonic acid metabolism. It employs one cofactor, heme. Romano MC, Eckardt RD, Bender PE, ...
*  15-hydroxyicosatetraenoate dehydrogenase
This enzyme participates in arachidonic acid metabolism. Sok DE, Kang JB, Shin HD (1988). "15-Hydroxyeicosatetraenoic acid ... H+ The 3 substrates of this enzyme are 15-Hydroxyicosatetraenoic acid (i.e. 15(S)-15-hydroxy-5,8,11-cis-13-trans- ...
*  Arachidonate 8-lipoxygenase
Bundy GL, Nidy EG, Epps DE, Mizsak SA, Wnuk RJ (1986). "Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian ... This enzyme participates in arachidonic acid metabolism. As of late 2007, only one structure has been solved for this class of ...
*  Epoxide hydrolase 2
These enzymes epoxidize the double bonds in arachidonic acid to form four regioisomers. Arachidonic acid is also the precursor ... There are epoxides of other lipids besides arachidonic acid such as the omega three docosahexaenoic acid (DHA) and ... Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD (August 1996). "Novel metabolic pathways for linoleic and arachidonic acid ... Spector AA (April 2009). "Arachidonic acid cytochrome P450 epoxygenase pathway". J. Lipid Res. 50 Suppl (Suppl): S52-6. doi: ...
*  Fever
When these cytokine factors bind, the arachidonic acid pathway is then activated. One model for the mechanism of fever caused ... PGE2 release comes from the arachidonic acid pathway. This pathway (as it relates to fever), is mediated by the enzymes ... In other words, exogenous factors cause release of endogenous factors, which, in turn, activate the arachidonic acid pathway. ...
*  Prostaglandin-F synthase
This enzyme participates in arachidonic acid metabolism. As of late 2007[update], 7 structures have been solved for this class ...
*  Prostaglandin-E2 9-reductase
This enzyme participates in arachidonic acid metabolism. As of late 2007, 3 structures have been solved for this class of ...
*  Leukotriene-E4 20-monooxygenase
This enzyme participates in arachidonic acid metabolism. Orning L (1987). "Omega-oxidation of cysteine-containing leukotrienes ...
*  Leukotriene-C4 synthase
This enzyme participates in arachidonic acid metabolism. As of late 2007, 3 structures have been solved for this class of ...
*  Omega-3 fatty acid
arachidonic acid) than those of omega−3. This necessitates that omega−6 and omega−3 be consumed in a balanced proportion; ... Omega−3 fatty acids-also called ω−3 fatty acids or n−3 fatty acids-are polyunsaturated fatty acids (PUFAs) with a double bond ( ... "Omega−3 fatty acids, fish oil, alpha-linolenic acid: Related terms". Omega−3 fatty acids, fish oil, alpha-linolenic acid. Mayo ... Three omega−3 fatty acids are important in human physiology, α-linolenic acid (18:3, n-3; ALA), eicosapentaenoic acid (20:5, n- ...
*  Prostaglandin-D synthase
This enzyme participates in arachidonic acid metabolism. In March 2012 American scientists reported a discovery that shows this ...
*  Leukotriene B4 receptor 2
... see 12-Hydroxyeicosatetraenoic acid, by a member of the 15-lipoxygenase pathway of arachidonic acid metabolism, 15(S)-HETE (see ... Eicosanoid receptor 12-Hydroxyheptadecatrienoic acid 12-Hydroxyeicosatetraenoic acid 15-Hydroxyicosatetraenoic acid GRCh38: ... Cabral M, Martín-Venegas R, Moreno JJ (Aug 2013). "Role of arachidonic acid metabolites on the control of non-differentiated ... These messenger ligands are any one of a range of structurally different arachidonic acid metabolites made and released by ...
*  Prostacyclin
PGI2 is derived from the ω-6 arachidonic acid. PGI3 is derived from the ω-3 EPA. Prostacyclin can be synthesized from the ... These convert arachidonic acid to prostaglandin H2 (PGH2), the immediate precursor of prostacyclin. Since thromboxane (an ... The research team synthesized nearly 1,000 analogues.[citation needed] Essential fatty acid "epoprostenol" at Dorland's Medical ... I3 are formed in man after dietary eicosapentaenoic acid: identification and quantification by capillary gas chromatography- ...
*  PLA2G2D
Leslie CC (2004). "Regulation of arachidonic acid availability for eicosanoid production". Biochem. Cell Biol. 82 (1): 1-17. ... 2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501 . ...
*  Prostaglandin-endoperoxide synthase 2
Arachidonic acid can bind to E-cat and E-allo, but the affinity of AA for E-allo is 25 times that for Ecat. Palmitic acid, an ... While metabolizing arachidonic acid primarily to PGG2, COX-2 also converts this fatty acid to small amounts of a racemic ... The conversion of arachidonic acid to PGG2 can be shown as a series of radical reactions analogous to polyunsaturated fatty ... First, hydrogen is abstracted from carbon 13 of arachidonic acid, and then two molecules of oxygen are added by the PTGS2 (COX- ...
*  Myosin-light-chain phosphatase
However, it is unclear how arachidonic acid functions as an inhibitor. Two competing theories are that either arachidonic acid ... One other proposed regulatory strategy involves arachidonic acid. When arachidonic acid is added to tensed muscle tissue, the ... such as arachidonic acid and cAMP, also regulate the enzyme. Smooth muscle tissue is mostly made of actin and myosin, two ... Myosin's regulatory subunit MLC20 binds to both the hydrophobic and acid grooves of PP1 and MYPT1, the regulatory site on ...