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Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant ... glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ... mediated transgene delivery induces growth suppression, apoptosis, radiosensitization, and overcomes temozolomide resistance in ... "Footprint-free" human induced Pluripotent Stem Cell-derived astrocytes for in vivo cell-based therapy. Stem Cells and Dev [in ...
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"Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation". ... April 1996). "Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor ... a chemical that induced skin papillomas. CAPE significantly reduced the number of papillomas. Demestre M, Messerli SM, Celli N ... "Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B". Proc ...
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On the molecular level, calcium influx is not the only factor responsible for apoptosis induced by excitoxicity. Recently, it ... October 1997). "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene". Nature. 389 ( ... brain-derived neurotrophic factor), not activating apoptosis. Exogenous excitotoxins refer to neurotoxins that also act at ... "NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice". The Journal of Clinical Investigation. 120 (7 ...
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... can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. In murine γδ T ... Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF (June 1997). "CD27, a member of the tumor necrosis factor ... induces apoptosis and binds to Siva, a proapoptotic protein". Proceedings of the National Academy of Sciences of the United ... CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co- ...
When the mitochondrial membrane potential changes, apoptosis-inducing factors (AIFs) are also released. These trigger apoptosis ... Pardaxin inhibits proliferation and induces apoptosis of human cancer cell lines. Its 33-amino acid structure contains many ... Cyt c activates the caspase chain that leads to apoptosis. ROS also activates the JNK pathway. JNK is phosphorylated, which ... Pardaxin triggers reactive oxygen species (ROS). ROS production disrupts protein folding and induces the unfolded protein ...
Apoptosis involves the mitochondrial release of cytochrome c and apoptosis-inducing factor (AIF), which activate caspase- ... factor VIII deficiency (hemophilia A), and factor V Leiden mutation. Infectious disorders such as central nervous system (CNS) ... Many different risk factors play a role in causing a neonatal stroke. Some maternal disorders that may contribute to neonatal ... Apoptosis mechanisms may have a more prominent role in developing an ischemic brain injury in neonatal humans than in adult ...
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"TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis". The Journal of ... Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (April 2002). "Caspase-2 induces apoptosis by releasing ... Ruzzene M, Penzo D, Pinna LA (May 2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis ... In intrinsic activation, cytochrome c from the mitochondria works in combination with caspase-9, apoptosis-activating factor 1 ...
Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis ... "Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Death-inducing Signaling Complex and its Modulation by c-FLIP ... tumor necrosis factor-related apoptosis-inducing ligand) have been shown to induce DISC-mediated apoptosis. Specifically, TRAIL ... APO-1-mediated apoptosis can be inhibited by a variety of factors, including the viral caspase inhibitors CrmA and p35, as well ...