Loading...
*  APOA2
Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene. This gene encodes apolipoprotein (apo-) A-II, ... Brewer HB, Lux SE, Ronan R, John KM (May 1972). "Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein ... Lackner KJ, Law SW, Brewer HB (Sep 1984). "Human apolipoprotein A-II: complete nucleic acid sequence of preproapo A-II". FEBS ... "Entrez Gene: APOA2 apolipoprotein A-II". Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998 ...
*  Apolipoprotein D
"Entrez Gene: APOD apolipoprotein D". Muffat J, Walker DW (2010). "Apolipoprotein D: an overview of its role in aging and age- ... Apolipoprotein D (Apo-D) is a component of high-density lipoprotein that has no marked similarity to other apolipoprotein ... Apolipoproteins D at the US National Library of Medicine Medical Subject Headings (MeSH) Applied Research on Apolipoproteins ... Apolipoprotein D is a protein that in humans is encoded by the APOD gene. Unlike other lipoproteins, which are mainly produced ...
*  Lipoprotein lipase
Kim SY, Park SM, Lee ST (January 2006). "Apolipoprotein C-II is a novel substrate for matrix metalloproteinases". Biochem. ... Two molecules of ApoC-II can attach to each LPL dimer. It is estimated that up to forty LPL dimers may act simultaneously on a ... In the Golgi apparatus, the oligosaccharides are further altered to result in either two complex chains, or two complex and one ... "Activation of lipoprotein lipase by native and synthetic fragments of human plasma apolipoprotein C-II". Proc. Natl. Acad. Sci ...
*  Hyperlipidemia
"Familial type I hyperlipoproteinemia caused by apolipoprotein C-II deficiency". Atherosclerosis. 34 (1): 53-65. doi:10.1016/ ... Hyperlipoproteinemia type II, by far the most common form, is further classified into types IIa and IIb, depending mainly on ... The lipoprotein density and type of apolipoproteins it contains determines the fate of the particle and its influence on ... For treatment of type II, dietary modification is the initial approach, but many patients require treatment with statins (HMG- ...
*  APOL2
Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene. This gene is a member of the apolipoprotein L gene ... Two transcript variants encoding the same protein have been found for this gene. GRCh38: Ensembl release 89: ENSG00000128335 - ... "Entrez Gene: APOL2 apolipoprotein L, 2". Human APOL2 genome location and APOL2 gene details page in the UCSC Genome Browser. ... McGhee KA, Morris DW, Schwaiger S (2005). "Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a ...
*  Apolipoprotein C2
1989). "A deletion mutation in the ApoC-II gene (ApoC-II Nijmegen) of a patient with a deficiency of apolipoprotein C-II". J. ... Apolipoprotein C2 or apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene. The protein encoded by this ... 1988). "Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II ... 1989). "A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency". J. Clin. ...
*  Low-density lipoprotein receptor-related protein 8
Apolipoprotein E (ApoE) plays an important role in phospholipid and cholesterol homeostasis. After binding ApoER2, ApoE is ... Upon reelin binding, Dab1 is phosphorylated by two tyrosine kinases, Fyn and Src. The phosphorylated Dab1 then causes further ... Riddell DR, Sun XM, Stannard AK, Soutar AK, Owen JS (2001). "Localization of apolipoprotein E receptor 2 to caveolae in the ... Herz J (June 2009). "Apolipoprotein E receptors in the nervous system". Curr. Opin. Lipidol. 20 (3): 190-6. doi:10.1097/MOL. ...
*  Apolipoprotein A2
Apolipoprotein A-II is an apolipoprotein found in high density lipoprotein (HDL) cholesterol in plasma. It has an approximate ... High HDL Cholesterol (Hyperalphalipoproteinemia) at eMedicine Apolipoprotein A-II at the US National Library of Medicine ...
*  Apolipoprotein C1
1988). "Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene". J. Biol. Chem. 263 ( ... 1986). "There are two gene sequences for human apolipoprotein CI (apo CI) on chromosome 19, one of which is 4 kb from the gene ... Curry MD, McConathy WJ, Fesmire JD, Alaupovic P (1981). "Quantitative determination of apolipoproteins C-I and C-II in human ... Servillo L, Brewer HB, Osborne JC (1981). "Evaluation of the mixed interaction between apolipoproteins A-II and C-I equilibrium ...
*  Acanthocyte
In liver dysfunction, apolipoprotein A-II deficient lipoprotein accumulates in plasma causing increased cholesterol in RBCs. ... Acanthocytes arise from either of two mechanisms. Alterations in membrane lipids are seen in abetalipoproteinemia and liver ... This particular cause of acanthocytosis (also known as abetalipoproteinemia, apolipoprotein B deficiency, and Bassen-Kornzweig ...
*  DAB1
... and apolipoprotein E receptor-2 (ApoER2; 602600), are also required. Both receptors bound Dab1 on their cytoplasmic tails and ... "Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E ... 19 (2): 239-49. doi:10.1016/S0896-6273(00)80936-8. PMID 9292716. Long H, Bock HH, Lei T, Chai X, Yuan J, Herz J, Frotscher M, ... 47 (2): 165-74. doi:10.1002/gcc.20519. PMID 18008369. Deguchi K, Inoue K, Avila WE, et al. (2003). "Reelin and disabled-1 ...
*  Lipoprotein
HDL particles donate apolipoprotein C-II and apolipoprotein E to the nascent VLDL particle. Once loaded with apolipoproteins C- ... nascent chylomicron particles interact with HDL particles resulting in HDL donation of apolipoprotein C-II and apolipoprotein E ... Apolipoprotein C-II activates LPL, causing hydrolysis of the VLDL particle and the release of glycerol and fatty acids. These ... Via apolipoprotein C-II, mature chylomicrons activate lipoprotein lipase (LPL), an enzyme on endothelial cells lining the blood ...
*  Reelin
Two transcription initiation sites and two polyadenylation sites are identified in the gene structure. The reelin protein ... All members of this family are receptors for Apolipoprotein E (ApoE). Therefore, they are often synonymously referred to as ' ... Moreover, the two main receptors of reelin are able to form clusters that most probably play a major role in the signaling, ... The two main reelin receptors seem to have slightly different roles: VLDLR conducts the stop signal, while ApoER2 is essential ...
*  APOA5
Pennacchio LA, Olivier M, Hubacek JA, Krauss RM, Rubin EM, Cohen JC (November 2002). "Two independent apolipoprotein A5 ... Pennacchio LA, Olivier M, Hubacek JA, Krauss RM, Rubin EM, Cohen JC (November 2002). "Two independent apolipoprotein A5 ... Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene on chromosome 11. It is significantly expressed in ... The creation of two mice models (APOA5 transgenic and APOA5 knock-out) confirmed the important role of this gene in plasma ...
*  Very low-density lipoprotein
As it circulates in blood, it picks up apolipoprotein C-II (apoC-II) and additional apoE donated from high-density lipoprotein ... Nascent VLDL released from the liver contains apolipoprotein B100, apolipoprotein C1 (apoC1), apolipoprotein E (apoE), ... VLDL now meets back up with HDL where apoC-II is transferred back to HDL (but keeps apoE). HDL also transfers cholesteryl ... VLDL is assembled in the liver from triglycerides, cholesterol, and apolipoproteins. VLDL is converted in the bloodstream to ...
*  DNAJB11
... modulates apolipoprotein B mRNA editing". J. Biol. Chem. 276 (49): 46445-52. doi:10.1074/jbc.M109215200. PMID 11584023. Meunier ... 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of ... 2.0.CO;2. ISSN 1466-1268. PMC 312896 . PMID 11147971. "Entrez Gene: DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11". Lau ...
*  Liver
Examples of highly liver-specific proteins include apolipoprotein A II, coagulation factors F2 and F9, complement factor ... From below, the two additional lobes are located between the right and left lobes, one in front of the other. A line can be ... After two to five days, the umbilical vein and ductus venosus are completely obliterated; the former becomes the round ligament ... The liver is grossly divided into two parts when viewed from above - a right and a left lobe, and four parts when viewed from ...
*  APOBEC1
Dance GS, Sowden MP, Cartegni L, Cooper E, Krainer AR, Smith HC (2002). "Two proteins essential for apolipoprotein B mRNA ... Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 also known as C->U-editing enzyme APOBEC-1 is a protein that in ... Like all APOBEC proteins, A1 coordinates a zinc atom with two cysteine and one histidine residues that serve as a Lewis acid. ... Lau PP, Chang BH, Chan L (April 2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec ...
*  Margaret Oakley Dayhoff
... and apolipoproteins A-I, A-II, C-I and C-III. Based on this work, Dayhoff and her coworkers developed a set of substitution ... They had two daughters who became physicians, Ruth and Judith. Judith Dayhoff has a Mathematical Biophysics PhD from University ... Edward S. Dayhoff of Silver Spring; two daughters, Dr. Ruth E. Dayhoff Brannigan of College Park, and Dr. Judith E. Dayhoff of ... 2 (2): 97-98. doi:10.1089/dna.1983.2.97. ISSN 0198-0238. PMID 6347589. (Subscription required (help)). "Margaret Oakley Dayhoff ...
*  Apolipoprotein E
... even if they have two ApoE4 alleles, thus reducing the risk from nine or ten times the odds of getting AD down to just two ... Apolipoprotein E is a fat-binding protein (apolipoprotein) that is part of the chylomicron and Intermediate-density lipoprotein ... The gene, APOE, is mapped to chromosome 19 in a cluster with apolipoprotein C1 (APOC-I) and the apolipoprotein C2. The APOE ... "Genetic studies of human apolipoproteins. X. The effect of the apolipoprotein E polymorphism on quantitative levels of ...
*  Chylomicron
The HDL donates apolipoprotein C-II (APOC2) and apolipoprotein E (APOE) to the nascent chylomicron and, thus, converts it to a ... The main apolipoprotein component is apolipoprotein B-48 (apo B-48). While circulating in blood, chylomicrons exchange ... The triacylglycerol is then combined with phospholipids, cholesterol ester, and apolipoprotein B-48 to form a nascent ... 1-2%). They transport dietary lipids from the intestines to other locations in the body. Chylomicrons are one of the five major ...
*  APOA4
Lohse P, Kindt MR, Rader DJ, Brewer HB (1990). "Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare ... Deeb SS, Nevin DN, Iwasaki L, Brunzell JD (1997). "Two novel apolipoprotein A-IV variants in individuals with familial combined ... Karathanasis SK (1985). "Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes ... "Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene". J ...
*  VLDL receptor
Normal SRE-1 sequences, like those found in LDLR, are characterized by two repeats of the codon CAC separated by two ... This inability to bind LDL is due to VLDLR's incapability to bind apolipoprotein B (apoB), which is present in LDL. Receptor- ... VLDLR-II, on the other hand, lacks exon 16, which encodes for the O-glycosylation domain between sugar regions. VLDLR-III lacks ... The presence of two reelin receptors, VLDLR and ApoER2, has made it difficult to distinguish each protein's specific function. ...
*  Vitellogenin lipid transport domain
Apolipoprotein B can exist in two forms: B-100 and B-48. Apoliporotein B-100 is present on several lipoproteins, including very ... Olofsson SO, Boren J (2005). "Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins ... Apolipoprotein B-100 has been linked to the development of atherosclerosis. APOB ( see native LDL-ApoB structure at 37°C on ... Vitellinogen precursors are multi-domain apolipoproteins that are cleaved into distinct yolk proteins. Different vitellinogen ...
*  Vitellogenin
Apolipoprotein B can exist in two forms: B-100 and B-48. Apolipoprotein B-100 is present on several lipoproteins, including ... Olofsson SO, Borèn J (November 2005). "Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic ... II. Roles of juvenile hormones in adult insects". Advances in Insect Physiology. 26: 1-155. doi:10.1016/S0065-2806(08)60030-2. ... Apolipoprotein B-100 has been linked to the development of atherosclerosis. Honey bees deposit vitellogenin molecules in fat ...
*  MODY 1
Many people with this condition have low levels of triglycerides, lipoprotein(a), apolipoproteins AII and CIII. Mutations in ... the alternative promoter of HNF4A are linked to development of type 2 diabetes.[citation needed] Stokes, A; and Duda K. ...
*  Ovarian cancer
... whereas people with two normal genes would need to acquire two mutations. In the United States, five of 100 women with a first- ... apolipoprotein A1, and transthyretin. OVA1 above 5.0 in premenopausal people and 4.4 in postmenopausal people indicates a high ... Stage II though IV tumors make up the remaining quarter of cases and have a worse prognosis, with 73-88% of patients surviving ... Two methods can be used to determine the ultrasound score and menopausal score, with the resultant scores being referred to as ...