The gene, APOE, is mapped to chromosome 19 in a cluster with apolipoprotein C1 (APOC1) and the apolipoprotein C2 (APOC2). The ... "Genetic studies of human apolipoproteins. X. The effect of the apolipoprotein E polymorphism on quantitative levels of ... Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in the ... Apolipoprotein E enhances proteolytic break-down of this peptide, both within and between cells. The isoform APOE-ε4 is not as ...

Myklebost O, Rogne S (August 1986). "The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein ... "Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene". The Journal of Biological ... Apolipoprotein C-I is a protein component of lipoproteins that in humans is encoded by the APOC1 gene. The protein encoded by ... "Entrez Gene: APOC1 apolipoprotein C-I". Puppione DL, Ryan CM, Bassilian S, Souda P, Xiao X, Ryder OA, Whitelegge JP (March 2010 ...

... (Apo-AI) is a protein that in humans is encoded by the APOA1 gene. As the major component of HDL particles, ... The encoded apolipoprotein AI, is a 28.1 kDa protein composed of 243 amino acids; 21 peptides have been observed through mass ... Apolipoprotein AI has also been isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect ... Apolipoprotein AI is the major protein component of high density lipoprotein (HDL) particles in plasma. Chylomicrons secreted ...

... is the primary apolipoprotein of chylomicrons, VLDL, Lp(a), IDL, and LDL particles (LDL-commonly known as "bad ... Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. It is commonly used to detect risk of ... Su Q, Tsai J, Xu E, Qiu W, Bereczki E, Santha M, Adeli K (2009). "Apolipoprotein B100 acts as a molecular link between lipid- ... MedlinePlus Encyclopedia: Apolipoprotein B100 Cromwell WC, Otvos JD, Keyes MJ, Pencina MJ, Sullivan L, Vasan RS, Wilson PW, ...

Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I". The Journal of Biological ... Apolipoprotein D (ApoD) is a component of HDL that has no marked similarity to other apolipoprotein sequences. It has a high ... "Entrez Gene: APOD apolipoprotein D". Muffat J, Walker DW (January 2010). "Apolipoprotein D: an overview of its role in aging ... Apolipoproteins+D at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Applied Research on Apolipoproteins ...

... is an autosomal dominant disorder resulting from a missense mutation which reduces the affinity of ... apoB-100 for the low-density lipoprotein receptor (LDL Receptor). This causes impairments in LDL catabolism, resulting in ...

Olofsson SO, Borèn J (November 2005). "Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic ... Apolipoprotein B can exist in two forms: B-100 and B-48. Apolipoprotein B-100 is present on several lipoproteins, including ... Apolipoprotein B-100 has been linked to the development of atherosclerosis. ApoB is ancestrally universal to all animals, as ... Huebbe P, Rimbach G (August 2017). "Evolution of human apolipoprotein E (APOE) isoforms: Gene structure, protein function and ...

... D Apolipoprotein E Apolipoprotein F Apolipoprotein H - a misnomer Apolipoprotein L Apolipoprotein M ... HuGENet Review Apolipoprotein AI Mutations and Information Apolipoproteins. Apo A1, B, C2. Apolipoproteins information This ... Apolipoprotein F (apoF) is one of the minor apolipoprotein in blood plasma and it is a lipid transfer inhibit protein to ... Apolipoprotein synthesis in the intestine is regulated principally by the fat content of the diet. Apolipoprotein synthesis in ...

Cholesterol is imported into the neuron by apolipoprotein E (apoE) via LRP1 receptors on the cell surface. It has been ... Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein ... "Apolipoprotein E isoform-specific effects on lipoprotein receptor processing". Neuromolecular Medicine. 16 (4): 686-696. doi: ... "Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein". The ...

... binds to the messenger RNA coding for apolipoprotein B-100 (ApoB-100), a protein that is the main component of low- ... It accumulates in the liver,[citation needed] which is convenient since apolipoprotein B predominantly acts there. Protein ... a second-generation antisense oligonucleotide inhibitor of apolipoprotein B". Clinical Pharmacokinetics. 54 (2): 133-146. doi: ... and ApoB-100 is not translated. After subcutaneous injection, mipomersen reaches highest blood levels after 3 to 4 hours. ...

"Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 ... 100 (7): 4162-7. Bibcode:2003PNAS..100.4162F. doi:10.1073/pnas.0230450100. PMC 153065. PMID 12634421. Cook DG, Leverenz JB, ...

"Covalent attachment of apolipoprotein AI and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the ... Certain apolipoproteins, such as Apo E, ApoA1, and ApoB-100, could potentially functionalize nanoparticles to target the ...

One form is thought to be caused by mutated apolipoprotein B. Another form is associated with microsomal triglyceride transfer ... Hypobetalipoproteinemia is a disorder consisting of low levels of LDL cholesterol or apolipoprotein B, below the 5th percentile ... June 1989). "Familial hypobetalipoproteinemia associated with a mutant species of apolipoprotein B (B-46)". N. Engl. J. Med. ... Notably, in people who do not have the genetic disorder hypobetalipoproteinemia, a very low cholesterol level (less than 100 mg ...

He and his associates were the first to achieve complete synthesis of a plasma apolipoprotein (apo C-I); they also determined ... the complete cDNA and amino acid sequence of apo B-100, one of the largest proteins ever sequenced and a key protein in ...

The receptor also recognizes apolipoprotein E (ApoE) which is found in chylomicron remnants and IDL. In humans, the LDL ... It is a cell-surface receptor that recognizes apolipoprotein B100 (ApoB100), which is embedded in the outer phospholipid layer ... namely lipoprotein lipase and apolipoprotein C-III. Combined, these observations suggest that, as well as LDL cholesterol, ... novel insights from recent kinetic studies of apolipoprotein B-100 metabolism". Atherosclerosis. Supplements. 2 (3): 1-4. doi: ...

Nascent VLDL released from the liver contains apolipoprotein B100, apolipoprotein C1 (apoC1), apolipoprotein E (apoE), ... As it circulates in blood, it picks up apolipoprotein C-II (apoC-II) and additional apoE donated from high-density lipoprotein ... VLDL is assembled in the liver from triglycerides, cholesterol, and apolipoproteins. VLDL is converted in the bloodstream to ... and apolipoprotein E receptor-2". Biochim Biophys Acta. 1529 (1-3): 287-298. doi:10.1016/S1388-1981(00)00155-4. PMID 11111096. ...

HDL particles donate apolipoprotein C-II and apolipoprotein E to the nascent VLDL particle. Once loaded with apolipoproteins C- ... resulting in HDL donation of apolipoprotein C-II and apolipoprotein E to the nascent chylomicron. The chylomicron at this stage ... LDL contains apolipoprotein B (apoB), which allows LDL to bind to different tissues, such as the artery wall if the glycocalyx ... Apolipoprotein C-II activates LPL, causing hydrolysis of the VLDL particle and the release of glycerol and fatty acids. These ...

Kynamro targets the mRNA product of the APOB gene, which codes for the Apolipoprotein B-100 protein, a component of low-density ... lipoprotein (LDL). The binding of mipomersen to the APOB mRNA effectively blocks the translation of ApoB-100, and the gapmer- ...

Advanced the 4955 into drug development, which is a compound that targets Apolipoprotein B and could decrease and manage high ... Received the Red Herring Top 100 Europe Award. 2011: Obtained license from Mass General Hospital for intellectual property ...

... enzymatic activity induces hydrolytic modification of apolipoprotein B-100-containing lipoproteins, including LDL, ...

... the apolipoprotein A1 remnant ratio (Apo A1/ [VLDL₃+IDL]). Lipids Health Dis. 2013 Apr 26;12:55. (Use dmy dates from July 2021 ... The ADA-ACC consensus statement establishes measurement and treatment guidelines for Apolipoprotein B,apoB in addition to LDL ... Also, estimated LDL-C is falsely low when directly measured LDL-C is < 100 mg/dL or when triglycerides are elevated. The VAP ...

Mice deficient in apolipoprotein B are more susceptible to invasive bacterial infection. LDL can be grouped based on its size: ... Each particle contains a single apolipoprotein B-100 molecule (Apo B-100, a protein that has 4536 amino acid residues and a ... The mechanism of antagonism entails binding apolipoprotein B to a S. aureus autoinducer pheromone, preventing signaling through ... organized by a single apolipoprotein B for LDL and the larger particles). A single LDL particle is about 220-275 angstroms in ...

Apolipoprotein E4 allele in a population based study of early onset Alzheimer's disease. Nat Genet. 1994;7:74-9. Hendriks L, et ... Atherosclerosis, apolipoprotein and prevalence of dementia and Alzheimer's disease. The Rotterdam Study. Lancet. 1997;349:151-4 ... 1988;318:1093-100. Hofman A, Hazebroek A, Valkenburg HA. A randomized trial of sodium intake and blood pressure in newborn ...

Familial defective apolipoprotein B-100 Familial dysbetalipoproteinemia (broad beta disease, remnant removal disease) Familial ... 100 (1): 111S-115S. doi:10.1038/jid.1993.33. PMID 8423379. Lynch, Peter J (1994). Dermatology. Williams & Wilkins. ISBN 978-0- ...

Apolipoprotein B, in its ApoB100 form, is the main apolipoprotein, or protein part of the lipoprotein particle. Its gene is ... Class III: LDLR does not properly bind LDL on the cell surface because of a defect in either apolipoprotein B100 (R3500Q) or in ... In January 2013, The US FDA also approved mipomersen, which inhibits the action of the gene apolipoprotein B, for the treatment ... LDL cholesterol normally circulates in the body for 2.5 days, and subsequently the apolipoprotein B portion of LDL cholesterol ...

... although nonglycosylated and immature forms of apolipoprotein[a] are competent to associate with apolipoprotein B-100 in vitro ... The structure of apolipoprotein(a) is similar to plasminogen and tPA (tissue plasminogen activator) and it competes with ... Lipoprotein(a) [Lp(a)] consists of an LDL-like particle and the specific apolipoprotein(a), which is bound covalently to the ... 50 mg/dL (>125 nmol/L) Lp(a) appears with different isoforms (per kringle repeats) of apolipoprotein; 40% of the variation in ...

... sickness Deep vein thrombosis Dabbing Syndrome Defect in synthesis of adenosylcobalamin Defective apolipoprotein B-100 ...

In 1979, researchers discovered that people in Limone possess a mutant form of apolipoprotein (called ApoA-1 Milano) in their ... "Cardiovascular status of carriers of the apolipoprotein A-I(Milano) mutant: the Limone sul Garda study" (PDF). Circulation. 103 ... a dozen of those living here are over the age of 100 (for c. 1,000 total inhabitants).[citation needed] The origin of the ...

These molecules contain apolipoprotein B100 and apolipoprotein E in their shells, and can be degraded by lipoprotein lipase on ... Chylomicrons, the least dense cholesterol transport molecules, contain apolipoprotein B-48, apolipoprotein C, and ... adjusted for apolipoprotein A-I and apolipoprotein B) and increased risk of cardiovascular disease, casting doubt on the ... Upon binding of apolipoprotein B100, many LDL receptors concentrate in clathrin-coated pits. Both LDL and its receptor form ...

apolipoprotein B deficiency, a related condition, is associated with deficiencies of apolipoprotein B.) The MTTP gene provides ... It is caused by a mutation in microsomal triglyceride transfer protein resulting in deficiencies in the apolipoproteins B-48 ... Low levels of plasma chylomicron are also characteristic.[citation needed] There is an absence of apolipoprotein B. On ... The disease is extremely rare with approximately 100 reported cases worldwide since it was first identified by doctors Bassen ...