Aphidicolin
ISBN 978-0-12-465327-6. DeFilippes, FM (Nov 1984). "Effect of aphidicolin on vaccinia virus: isolation of an aphidicolin- ... Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. It is a ... Aphidicolin product page Archived June 26, 2006, at the Wayback Machine from Fermentek v t e (Webarchive template wayback links ... Natural aphidicolin is a secondary metabolite of the fungus Nigrospora oryzae. Dhillon VS, Husain SA, Ray GN (2003). " ...
Wolff rearrangement
Robert Ireland's synthesis of (±)-aphidicolin uses the Wolff rearrangement to do a tandem ring-contraction, and [2 + 2] ... aphidicolin and (.+-.)-.beta.-chamigrene". J. Org. Chem. 49 (6): 1001-1013. doi:10.1021/jo00180a010.{{cite journal}}: CS1 maint ...
Vinylcyclopropane rearrangement
Trost, B. M.; Nishimura, Yoshio; Yamamoto, Kagetoshi (1979). "A Total Synthesis of Aphidicolin". J. Am. Chem. Soc. 101 (5): ... In 1979 Trost reported the synthesis of Aphidicolin using methodology around the vinylcyclopropane rearrangement developed in ...
Nigrospora sphaerica
Aphidicolin is a mycotoxin originally known to be produced by the fungus, Cephalosporium aphidicola. This antiviral compound ... Starratt, A. N.; Loschiavo, S. R. (March 1974). "The production of aphidicolin by Nigrospora sphaerica". Canadian Journal of ...
Oxymercuration reaction
McMurry, J. E.; Andrus A.; Ksander G. M.; Muesser, J. H.; Johnson, M. A. "Stereospecific Total Synthesis of Aphidicolin.". ...
NAALADL2
Murano I, Kuwano A, Kajii T (August 1989). "Fibroblast-specific common fragile sites induced by aphidicolin". Human Genetics. ...
Induced cell cycle arrest
Aphidicolin is an antibiotic isolated from the fungus Cephalosporum aphidicola. It is a reversible inhibitor of eukaryotic ... "Structural basis for inhibition of DNA replication by aphidicolin". Nucleic Acids Research. 42 (22): 14013-21. doi:10.1093/nar/ ...
Cell synchronization
Nagano, H; Ikegami, S (November 1980). "Aphidicolin: a specific inhibitor of eukaryotic DNA polymerase alpha". Seikagaku: The ...
FRA3A
Fragile site, aphidicolin type, common, fra(3)(p24.2) is a protein that in humans is encoded by the FRA3A gene. "Human PubMed ... "Entrez Gene: Fragile site, aphidicolin type, common, fra(3)(p24.2)". Retrieved 2014-08-05. v t e (Articles with short ...
Aspergillus oryzae
... aphidicolin, terretonin, and andrastin A by plasmid insertion; paxilline and aflatrem by co-transformation; and aspyridone, ...
Haloferax larsenii
Sensitivity to novobiocin, bacitracin, anisomycin, aphidicolin, and rifampicin have been observed. However, no sensitivity has ...
Tolypocladium inflatum
"Isolation and Characterization of Aphidicolin and Chlamydosporol Derivatives from Tolypocladium inflatum". Journal of Natural ...
Cell cycle checkpoint
They used aphidicolin (APH) to inhibit DNA polymerase and prevent DNA replication. When treated with Cyclin B in interphase, ...
Cyanidioschyzon
The chemical agent aphidicolin can be added to easily and effectively synchronize chloroplast division. The peroxisome division ... of chloroplast division in the ultramicro-alga Cyanidioschyzon merolae by treatment with both light and aphidicolin". J. Phycol ...
Monocerin
"Effects of monocerin on cell cycle progression in maize root meristems synchronized with aphidicolin". Plant Cell Reports. 15 ( ...
FRAXD
"FRAXD fragile site, aphidicolin type, common, fra(X)(q27.2) D [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. " ... FRAXD or FRAXD gene is a gene symbol for fragile site, aphidicolin type, common, fra(X)(q27.2) D. The locus of the gene is ...
Chromosomal fragile site
The majority of breakages at CFSs are induced by low doses of the antibiotic aphidicolin (APH). Co-treatment with low ... Glover, TW; Berger, C; Coyle, J; Echo, B (1984). "DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at ...
Betaenone B
3-deoxyaphidicolin and aphidicolin-17-monoacetate". Nucleic Acids Research. 11 (4): 1197-209. doi:10.1093/nar/11.4.1197. PMC ...
Betaenone A
3-deoxyaphidicolin and aphidicolin-17-monoacetate". Nucleic Acids Res. 11 (4): 1197-2000. doi:10.1093/nar/11.4.1197. PMC 325786 ...
Betaenone C
3-deoxyaphidicolin and aphidicolin-17-monoacetate". Nucleic Acids Res. 11 (4): 1197-2000. doi:10.1093/nar/11.4.1197. PMC 325786 ...
Aphidicolan-16beta-ol synthase
"Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α ... a key enzyme responsible for formation of an unusual diterpene skeleton in biosynthesis of aphidicolin". Journal of the ...
POLD1
In the presence of DNA damage or replication stress (UV light, methyl methanesulfonate, hydroxyurea or aphidicolin), the POLD4/ ...
Precambrian body plans
Further studies to support the theory of cell-proliferation were done by introducing then removing the drug aphidicolin which ...
Medicinal fungi
Subsequent discoveries included alamethicin, aphidicolin, brefeldin A, cephalosporin, cerulenin, citromycin, eupenifeldin, ...
Fractional kill
... or aphidicolin, each of which had been documented to exert its effects in a particular phase of the cell cycle. Surprisingly, ...
Ralph Raphael
He and his students published syntheses of 2-deoxyribose, aaptamine, aphidicolin, apiose, arachidonic acid, arcyriaflavin B, ...
Chromosome 3
... aphidicolin type, common, fra(3)(p24.2) FRMD4B encoding protein FERM domain containing 4B GHRLOS: non-coding RNA ghrelin ...
Fermentek
Aphidicolin Experimental drugs and drug precursors: Parthenolide, Puromycin, Rapamycin, Anisomycin, Thapsigargin, cyclopamine, ...
List of MeSH codes (D02)
... aphidicolin MeSH D02.455.849.291.162 - atractyloside MeSH D02.455.849.291.206 - diterpenes, abietane MeSH D02.455.849.291.228 ...
Robert A. Holton
Most notable are prostaglandin F2α, narwedine, aphidicolin, taxusin, Taxol and hemibrevetoxin B. Dr. Holton also serves as ...