Snell, N. J. (1 August 2001). "Ribavirin--current status of a broad spectrum antiviral agent". Expert Opinion on ... In 1972, ICN discovered the ribavirin compound, the earliest recorded broad spectrum antiviral agent. Chemists Joseph T. ... "Broad-Spectrum Antiviral Activity of Virazole: 1-f8- D-Ribofuranosyl- 1,2,4-triazole- 3-carboxamide". Science. 177 (4050): 705- ...
Marriott AC, Dimmock NJ (January 2010). "Defective interfering viruses and their potential as antiviral agents". Reviews in ... Antiviral Research. 96 (3): 376-385. doi:10.1016/j.antiviral.2012.09.017. PMC 3526778. PMID 23041142. Scott PD, Meng B, ... July 2021). "Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro ... Given their unique R0>1 mechanism of action, TIPs exhibit high barriers to the evolution of antiviral resistance and are ...
Currently treatment of ARN consists of antiviral therapy administered orally. Typical antiviral agents used include famciclovir ... Taking antiviral agents after the issue is resolved seems to lessen the chance of it spreading to the other eye. ... While there is no prevention for ARN, exposing a patient to antiviral agents in the earlier phases of the outbreak tend to ... The patients were not so responsive to the antiviral agents given to them through an IV, acyclovir specifically. The cases ...
Marriott AC, Dimmock NJ (January 2010). "Defective interfering viruses and their potential as antiviral agents". Reviews in ... "A New Class of Antiviral Therapy Could Treat COVID-19". www.prnewswire.com. Retrieved 2021-12-28. Dimmock NJ, Easton AJ (May ... the interference in infection of host cells and how DI genomes could potentially work as immunostimulatory antiviral agents. ... December 2021). "Identification of a therapeutic interfering particle-A single-dose SARS-CoV-2 antiviral intervention with a ...
Thus, protease inhibitors are developed as antiviral therapeutic agents. Other natural protease inhibitors are used as defense ...
... a first-in-class broad-spectrum antiviral agent". Antiviral Research. 110: 94-103. doi:10.1016/j.antiviral.2014.07.014. PMC ... Antiviral Research. 77 (1): 56-63. doi:10.1016/j.antiviral.2007.08.005. PMID 17888524. "First Generic Drug Approvals". U.S. ... Nitazoxanide, sold under the brand name Alinia among others, is a broad-spectrum antiparasitic and broad-spectrum antiviral ... Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad- ...
There is no antiviral agent known to be effective in treating EV71 infection. However, Sinovac Biotech Ltd., a pharmaceutical ... Other experimental vaccines and antiviral agents are being researched. For example, "both bovine and human lactoferrins were ... New anti-viral drugs should be developed and vaccination of children under five years old should be considered in areas the ... Lin, Jing-Yi; Kung, Yu-An; Shih, Shin-ru (3 September 2019). "Antivirals and vaccines for Enterovirus A71". Journal of ...
De Clercq E, Neyts J (2009). "Antiviral agents acting as DNA or RNA chain terminators". Antiviral Strategies. Handbook of ... A number of antiviral and antibacterial treatment studies have been conducted with inconsistent results. More research and ... In subsets of patients, various viruses and bacteria have been reported as the causative agents of CFS, although consistent and ... it is an inducer of interferon and is considered to be antiviral and immunomodulatory. One RCT evaluated rintatolimod and found ...
Lewis, J. Kathleen; Bothner, Brian; Smith, Thomas J.; Siuzdak, Gary (1998-06-09). "Antiviral agent blocks breathing of the ...
"Activation of cGAS-dependent antiviral responses by DNA intercalating agents". Nucleic Acids Research. 45 (1): 198-205. doi: ...
"History and progress of antiviral drugs: From acyclovir to direct-acting antiviral agents (DAAs) for Hepatitis C". Medicina ... current antiviral agents include aciclovir, penciclovir, foscarnet, and docosanol. Aciclovir acts as a nucleoside analog which ... As seen by most mainstream antiviral agents, the mechanism of treatment for HSV historically is via the inhibition of viral ... The framework for antiviral HSV treatment began with the experimental use of DNA inhibitors, which interrupt the viral ...
It covers antimicrobial, antiviral, antifungal, and antiparasitic agents and chemotherapy. The editor-in-chief is Cesar A. ... Antimicrobial Agents and Chemotherapy is a peer-reviewed scientific journal published by the American Society for Microbiology ... "New Editors-in-Chief Announced for ASM's Antimicrobial Agents and Chemotherapy and Microbiology and Molecular Biology Reviews ...
"Novel activities of safe-in-human broad-spectrum antiviral agents". Antiviral Research. 154: 174-182. doi:10.1016/j.antiviral. ... Azacitidine also has antiviral effects in animal studies as well as its anti-cancer actions, but has not been tested for ... Navada SC, Steinmann J, Lübbert M, Silverman LR (January 2014). "Clinical development of demethylating agents in hematology". ... were first synthesized in Czechoslovakia as potential chemotherapeutic agents for cancer. The most common adverse reactions in ...
"Enantioselective enzymatic synthesis of the anti-viral agent lamivudine (3TC™)". Tetrahedron Letters. 36 (38): 6961-6964. doi: ...
Would confer resistance to therapeutically useful antibiotics or antiviral agents; Would enhance the virulence of a pathogen or ... Stability of the weaponized agent (the ability of the agent to retain its infectivity and virulence after a prolonged period of ... The primary difficulty is not the production of the biological agent, as many biological agents used in weapons can be ... The former US biological warfare program categorized its weaponized anti-personnel bio-agents as either Lethal Agents (Bacillus ...
"Assessment of cytosine arabinoside as an antiviral agent in humans". Antimicrobial Agents and Chemotherapy. 6 (5): 598-602. doi ... Therefore, ara-C is not a useful antiviral agent in humans because of its toxic profile. Cytarabine is also used in the study ... Cytarabine also possesses antiviral activity, and it has been used for the treatment of generalised herpesvirus infection. ... When used as an antiviral, cytarabine-5´-triphosphate functions by inhibiting viral DNA synthesis. Cytarabine is able to ...
It may be useful as antiviral agent in AIDS therapy. The core pentapeptide sequence, TTNYT, consisting of amino acids 4-8 in ... It inhibits kininase II and angiotensin I and has been proposed as an antihypertensive agent. Tuftsin - N(2)-((1-(N(2)-L- ...
An experimental anti-viral agent, pleconaril, is active against picornaviruses. XLA patients, however, are apparently immune to ...
Several nucleoside analogues are used as antiviral or anticancer agents. The viral polymerase incorporates these compounds with ...
"Valinomycin as a potential antiviral agent against coronaviruses: A review". Biomedical Journal. 43 (5): 414-423. doi:10.1016/j ... Valinomycin was recently reported to be the most potent agent against severe acute respiratory-syndrome coronavirus (SARS-CoV) ... Valinomycin acts as a nonmetallic isoforming agent in potassium selective electrodes. This ionophore is used to study membrane ...
This study indicates the possibility of developing an antiviral agent. ZV envelop (E) protein alters properties of human fetal ...
Antiviral agents: Many animal viruses possess an outer envelope composed of viral glycoproteins. These are often required for ... "α-Glucosidase inhibitors as potential broad based anti-viral agents". FEBS Letters. 430 (1-2): 17-22. doi:10.1016/S0014-5793(98 ...
Rahimi H, Mara T, Costella J, Speechley M, Bohay R (May 2012). "Effectiveness of antiviral agents for the prevention of ... It is comparable in effectiveness to prescription topical antiviral agents. Due to docosanol's mechanism of action, there is ... Antivirals creams include acyclovir and penciclovir, which can speed healing by as much as 10%. Oral antivirals include ... A zinc oxide, anesthetic, or antiviral cream appears to decrease the duration of symptoms by a small amount. Antiviral ...
Couchoud-Heyer C (July 2007). "WITHDRAWN: Cytomegalovirus prophylaxis with antiviral agents for solid organ transplantation". ... The selective antiviral response associated with ganciclovir treatment is achieved because of the much weaker inhibition of ... Ganciclovir, sold under the brand name Cytovene among others, is an antiviral medication used to treat cytomegalovirus (CMV) ... Spector SA (1999). "Oral Ganciclovir". Antiviral Chemotherapy 5. Advances in Experimental Medicine and Biology. Vol. 458. pp. ...
seem to be promising candidates for further development as antiviral agents. In the Philippines, Gracilaria have been harvested ... polysaccharides have been shown to be an effective prophylactic agent during in vitro and in vivo experiments against Japanese ...
... antiviral, antifungal and antiparasitic (including antiprotozoal and antihelminthic) agents. Depending on the severity and the ... First, the catalog of infectious agents has grown to the point that virtually all of the significant infectious agents of the ... Second, an infectious agent must grow within the human body to cause disease; essentially it must amplify its own nucleic acids ... Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop ...
The two guanine antiviral carbocyclic nucleosides, the anti-HIV agent abacavir and the anti-hepatitis B agent entecavir, are ... The cyclopentenylcytosine (CPE-C) was developed as a potent antitumor and antiviral agent (phase 1 trials) and exhibited potent ... They both exhibit significant biological activity as antiviral and antitumour agents. A large number of novel carbocyclic ... Marquez, V. E. (April 1996). "CARBQCYCLIC NUCLEOSIDES". In E. De Clercq (ed.). Advances in Antiviral Drug Design. Vol. 2. JAI ...
Polymers of adamantane have been patented as antiviral agents against HIV. Influenza virus strains have developed drug ... The first adamantane derivative used as a drug was amantadine - first (1967) as an antiviral drug against various strains of ... Adamantane readily reacts with various brominating agents, including molecular bromine. The composition and the ratio of the ... Maugh, T. (1979). "Panel urges wide use of antiviral drug". Science. 206 (4422): 1058-60. Bibcode:1979Sci...206.1058M. doi: ...
... a New Antiviral and Antitumour Agent isolated from a Streptomyces". Nature. 211 (5054): 1198-9. Bibcode:1966Natur.211.1198M. ...
Rossmann MG, McKinlay MA, Xiao C (11 November 2010). "Chapter 16:Design of Capsid-binding Antiviral Agents Against Human ...