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*  Monoclonal antibody therapy
Tumor cells, however are highly abnormal, and many display unusual antigens. Some such tumor antigens are inappropriate for the ... Initial research on malignant neoplasms found mAb therapy of limited and generally short-lived success with blood malignancies ... Humanised antibodies bind antigen much more weakly than the parent murine monoclonal antibody, with reported decreases in ... Increases in antibody-antigen binding strength have been achieved by introducing mutations into the complementarity determining ...
*  Radioimmunotherapy
By its nature, RIT requires a tumor cell to express an antigen that is unique to the neoplasm or is not accessible in normal ... In cancer therapy, an antibody with specificity for a tumor-associated antigen is used to deliver a lethal dose of radiation to ... The ability for the antibody to specifically bind to a tumor-associated antigen increases the dose delivered to the tumor cells ... A Phase I trial of 90Y-anti-carcinoembryonic antigen chimeric T84.66 radioimmunotherapy with 5-fluorouracil in patients with ...
*  List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer
The most common malignant neoplasm is a basal cell carcinoma. Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ... List of specialized glands within the human integumentary system List of target antigens in pemphigoid List of target antigens ... in pemphigus The most common benign neoplasm that may develop within a nevus sebaceous is a syringocystadenoma papilliferum, ...
*  CD2
... making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms. Due to its ... CD2 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor. It ... Luzzati AL, Giacomini E, Giordani L, Pugliese O, Viora M, Chersi A (1992). "The antigen-specific induction of normal human ...
*  Proliferating cell nuclear antigen
... or monoclonal antibody termed Ki-67 can be used for grading of different neoplasms, e.g. astrocytoma. They can be of diagnostic ... Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic ... PCNA was originally identified as an antigen that is expressed in the nuclei of cells during the DNA synthesis phase of the ... "Entrez Gene: PCNA proliferating cell nuclear antigen". Leonardi E, Girlando S, Serio G, Mauri FA, Perrone G, Scampini S, Dalla ...
*  Topoisomerase
... may lead to secondary neoplasms in the patient.[citation needed] Topoisomerase I is the antigen recognized by Anti Scl-70 ...
*  List of cutaneous neoplasms associated with systemic syndromes
List of specialized glands within the human integumentary system List of target antigens in pemphigoid List of target antigens ... Many cutaneous neoplasms occur in the setting of systemic syndromes. List of cutaneous conditions List of contact allergens ...
*  Connective tissue
There are many types of connective tissue disorders, such as: Connective tissue neoplasms including sarcomas such as ... providing the ground for starting inflammatory and immune responses upon the detection of antigens. ...
*  TRA (gene)
Manolios N, Kemp O, Li ZG (1994). "The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 ... Dyer MJ (1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms". Blood. 74 (3): 1073-83. PMID 2546634. ... Chilson OP, Kelly-Chilson AE (1989). "Mitogenic lectins bind to the antigen receptor on human lymphocytes". Eur. J. Immunol. 19 ...
*  CD3 (immunology)
ISBN 1-4377-1528-1. CD3 Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart ... and can therefore be used to distinguish them from superficially similar B-cell and myeloid neoplasms. Kuby, Janis; Kindt, ... and it is at this latter stage that CD3 antigen begins to migrate to the cell membrane. The antigen is found bound to the ... The antigen remains present in almost all T-cell lymphomas and leukaemias, ...
*  B-cell receptor
When a B cell is activated by its first encounter with an antigen that binds to its receptor (its "cognate antigen"), the cell ... B-cell receptor signalling is currently a therapeutic target in various lymphoid neoplasms. Seda V, Mraz M (March 2015). "B- ... Corcos D (1990). "Oncogenic potential of the B-cell antigen receptor and its relevance to heavy chain diseases and other B-cell ... B-Cell Antigen Receptors at the US National Library of Medicine Medical Subject Headings (MeSH). ...
*  Thymoma-associated multiorgan autoimmunity
Thymoma is a common neoplasm arising from the thymus, the primary lymphoid organ where T cells become educated to distinguish " ... abnormal thymic education occurs as a result of subtle differences in antigen processing. In TAMA these differences result in ...
*  CD4
CD1 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... CD4 continues to be expressed in most neoplasms derived from T helper cells. It is therefore possible to use CD4 ... The antigen has also been associated with a number of autoimmune diseases such as vitiligo and type I diabetes mellitus. T- ... CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. The ...
*  Neuronal lineage marker
All of these antigens are present in specific neuronal cell types. With these we can define anatomical circuits with a high ... In pathological conditions was also reported that glial neoplasms and reactive glial cells expressed this marker. Calretinin is ... Neuronal Nuclei antigen (NeuN) or Fox-3 is a nuclear protein present in postmitotic stage when start to differentiate into ... Lavezzi, A. M.; Corna, M. F.; Matturri, L. (2013). "Neuronal nuclear antigen (NeuN): a useful marker of neuronal immaturity in ...
*  Plasma cell
Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells. It ... Plasmacytoma, multiple myeloma, Waldenström macroglobulinemia and plasma cell leukemia are malignant neoplasms ("cancer") of ... After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which ... Pieces of the antigen (which are now known as antigenic peptides) are loaded onto MHC II molecules, and presented on its ...
*  Chronic lymphocytic leukemia
Hairy cell leukemia is also a neoplasm of B lymphocytes, but the neoplastic cells have a distinct morphology under the ... Porter DL, Levine BL, Kalos M, Bagg A, June CH (2011). "Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia ... ISBN 0-7817-5007-5. Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and ... "T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced ...
*  List of histologic stains that aid in diagnosis of cutaneous conditions
List of specialized glands within the human integumentary system List of target antigens in pemphigoid List of target antigens ... associated with internal malignancy List of cutaneous conditions caused by mutations in keratins List of cutaneous neoplasms ... of genes mutated in cutaneous conditions List of genes mutated in pigmented cutaneous lesions List of human leukocyte antigen ...
*  Epithelial cell adhesion molecule
Balzar, M; Winter MJ; de Boer CJ; Litvinov SV (October 1999). "The biology of the 17-1A antigen (Ep-CAM)". J. Mol. Med. 77 (10 ... Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for ... First discovered in 1979, EpCAM was initially described as a dominant surface antigen on human colon carcinoma. Because of its ... 1994). "Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule". The Journal of Cell Biology. 125 (2): ...
*  Large-cell lung carcinoma with rhabdoid phenotype
Lung cancers are now considered a large and extremely heterogeneous family of neoplasms that feature widely varying genetic, ... Typically, markers expressed in LCLC-RP include those seen in "generic" NSCLC's, such as epithelial membrane antigen (EMA, 61 ... They also more frequently express "non-carcinomatous" markers typically associated with "dedifferentiated" neoplasms. ... rhabdoid neoplasms (i.e. those that do not contain cells containing other histological variants) Although Colby and colleagues ...
*  Calreticulin
... but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen, but this was later ... which makes CALR mutations the second most common in myeloproliferative neoplasms. All mutations (insertions or deletions) ... This association prepares the MHC class I for binding an antigen for presentation on the cell surface. Calreticulin is also ... "A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an ...
*  Endolymphatic sac
Neoplasms of the endolymphatic sac are very rare tumors. This article incorporates text in the public domain from the 20th ... Antigen diffusion from the perilymphatic space of the cochlea. Laryngoscope 1995; 105:623-628 Rask-Andersen H, Danckwardt- ...
*  Pericyte
Hemangiopericytoma is a rare vascular neoplasm, or abnormal growth, that may either be benign or malignant. In its malignant ... During the early proliferative phase (0-12 months) the tumors express proliferating cell nuclear antigen (pericytesna), ...
*  List of spiders associated with cutaneous reactions
... system List of mites associated with cutaneous reactions List of target antigens in pemphigoid List of target antigens in ... associated with internal malignancy List of cutaneous conditions caused by mutations in keratins List of cutaneous neoplasms ... cutaneous lesions List of histologic stains that aid in diagnosis of cutaneous conditions List of human leukocyte antigen ...
*  Clonal hypereosinophilia
... lymphoid neoplasms, or features of both types of neoplasms. Most commonly, the present with features of myeloid neoplasms with ... It mediates at least in part the cell proliferating signaling stimulated by PDGF receptors as well as by antigen receptors on T ... Like the latter neoplasm, hematologic neoplasms cause by ETV6-JAK2 and BCR-JAK2 are aggressive and progress rapidly. Too few ... PDGFRA-associated eosinophilic neoplasms are the most common forms of clonal eosinophilia, accounting for some 40% to 50% of ...
*  List of cutaneous conditions
... system List of spiders associated with cutaneous reactions List of target antigens in pemphigoid List of target antigens in ... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... Melanocytic nevi and neoplasms are caused by either a proliferation of (1) melanocytes, or (2) nevus cells, a form of ... an overview with emphasis on the myeloid neoplasms". Chem. Biol. Interact. 184 (1-2): 16-20. doi:10.1016/j.cbi.2009.10.009. ...
*  Papillary tumors of the pineal region
Papillary tumor of the pineal region (PTPR) is a recently described neoplasm that has been formally recognized in the 2007 ... epithelial membrane antigen) → - GFAP (glial fibrillary acidic protein) → + Synaptophysin → - Chromogranin → - NSE (neuron- ... The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary ...