It is most commonly transmitted from ticks to humans. Humans act as the tick's host for this bacteria. Lyme disease is a ... Each genomic group has varying antigens on its membrane receptor, which are specific to the infection of the host. One such ... While infecting, B. burgdorferi will express proteins that will interact with endothelial cells, platelets, chondrocytes, and ... Ticks can transmit B. burgdorferi to humans, but humans are dead-end hosts, unlikely to continue the life cycle of the ...

... thailandensis antigens to look for the total number of antibodies in human serum. Using IFAT is labour intensive and is not ... platelets, and monocytes. Once bound, the bacteria enter host cells through endocytosis, ending up inside an endocytic vesicle ... Antigen detect tests allow rapid detection of melioidosis. Examples of antigen detection tests are: latex agglutination test ... B. pseudomallei can remain latent in the human body for up to 29 years until it is reactivated during human immunosuppression ...

Sarfati M, Fournier S, Wu CY, Delespesse G (1992). "Expression, regulation and function of human Fc epsilon RII (CD23) antigen ... human platelets, and mast cells - that contribute to the protective functions of the immune system. Its name is derived from ... The positive B cell signaling is initiated by binding of foreign antigen to surface immunoglobulin. The same antigen-specific ... "FCMR Fc mu receptor [Homo sapiens (Human)] - Gene - NCBI". Kubagawa H, Oka S, Kubagawa Y, Torii I, Takayama E, Kang DW, et al ...

Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors ... "Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing ... TdT is a protein expressed early in the development of pre-T and pre-B cells, whereas CALLA is an antigen found in 80% of ALL ... The process as a whole result in an effector cell, typically a T-cell, that can recognize a tumor cell antigen in a manner that ...

... including human beings. This tick is the most commonly identified species responsible for transmitting R. rickettsii to humans ... Both rOmpA and rOmpB are members of a family of surface cell antigens (Sca) which are autotransporter proteins; they act as ... Abnormal laboratory findings seen in patients with Rocky Mountain spotted fever may include a low platelet count, low blood ... The disease is caused by Rickettsia rickettsii, a type of bacterium that is primarily spread to humans by American dog ticks, ...

Maki RG, Old LJ, Srivastava PK (August 1990). "Human homologue of murine tumor rejection antigen gp96: 5'-regulatory and coding ... Zolnierowicz S, Work C, Hutchison K, Fox IH (April 1990). "Partial separation of platelet and placental adenosine receptors ... Chen B, Piel WH, Gui L, Bruford E, Monteiro A (December 2005). "The HSP90 family of genes in the human genome: insights into ... Hutchison KA, Nevins B, Perini F, Fox IH (May 1990). "Soluble and membrane-associated human low-affinity adenosine binding ...

"Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor". ... "Human basophil degranulation is not triggered by very dilute antiserum against human IgE". Nature. 366 (6455): 525-7. Bibcode: ... Benveniste, J.; P. Jurgens; W. Hsueh; J. Aissa (1997). "Transatlantic Transfer of Digitized Antigen Signal by Telephone Link". ... Platelet-activating factor was discovered by Benveniste in the early 1970s. PAF was the first phospholipid known to have ...

Baldassare JJ, Henderson PA, Tarver A, Fisher GJ (May 1997). "Thrombin activation of human platelets dissociates a complex ... complex can load the selected antigen. After loading the antigen, MHC II molecule moves to the cell surface. Thus, we can ... Cao H, Hegele RA (2000). "Human cathepsin S gene (CTSS) promoter -25G/A polymorphism". Journal of Human Genetics. 45 (2): 94-5 ... Contrary, inhibition of cathepsin S will lead to a delay in degradation of Ii and loading the antigen into MHC II as well as ...

... usually showing a common Human Leukocyte Antigen (HLA) type. The Hairy Cell Leukemia Consortium was founded in 2008 to address ... People with low numbers of red blood cells or platelets may also receive red blood cells and platelets through blood ... or easy bleeding due to a low platelet count. Platelet function may be somewhat impaired in HCL patients, although this does ... Human T-lymphotropic virus 2 (HTLV-2) has been isolated in a small number of patients with the variant form of HCL. In the ...

"M-07e human leukemic factor-dependent cell line provides a rapid and sensitive bioassay for the human cytokines GM-CSF and IL-3 ... Su, IJ; Balk, SP; Kadin, ME (August 1988). "Molecular basis for the aberrant expression of T cell antigens in postthymic T cell ... that spontaneously matures to megakaryocytes and produces platelet-like particles". Leukemia. 14 (1): 142-52. doi:10.1038/sj. ... NCI-60, 60 human cancer cell lines used by the NCI List of breast cancer cell lines Quentmeier, H; Pommerenke, C; Dirks, WG; ...

When an antiserum is given, the human immune system can mistake the proteins present for harmful antigens. The body produces ... A blood sample may be taken and tested, which will show thrombocytopenia (low platelets), leukopenia (low white blood cells), ... Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5-10 days ...

A low white blood cell count, and low platelet count in the blood may be observed. A low level of neutrophils (a specific type ... Bone marrow tumour cells express the following antigen targets CD20 (98.3%), CD22 (88.3%), CD40 (83.3%), CD52 (77.4%), IgM ( ... American Journal of Human Genetics. 79 (4): 695-701. doi:10.1086/507687. PMC 1592553. PMID 16960805. Treon, S. P.; Xu, L.; Yang ... Platelet aggregation studies are optional. Serum protein electrophoresis results indicate evidence of a monoclonal spike but ...

Krueppel-like factor 1 is a protein that in humans is encoded by the KLF1 gene. The gene for KLF1 is on the human chromosome 19 ... Duffy antigen/chemokine receptor or Fy), Scianna (ERMAP), MN (glycophorin A), Diego(band 3), P1, i, AnWj (CD44) etc. Antigens ... Over-expression of KLF1 results in a reduction of the number of circulating platelets and hastens the onset of the β-globin ... Next-Generation sequencing efforts have revealed a surprisingly high prevalence of mutations in human KLF1. The chance of a ...

... levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with ... 2001). "Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G ... Koszdin KL, Bowen BR (Oct 1992). "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E- ... Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene. The alpha-1,3-fucosyltransferases ...

Human ARR3 genome location and ARR3 gene details page in the UCSC Genome Browser. v t e (Articles with short description, Short ... Ermakova NA, Alekberova ZS, Prokaeva TB (2004). "Autoimmunity to S-Antigen and Retinal Vasculitis in Patients with Behçet's ... 2002). "Agonist-induced internalization of the platelet-activating factor receptor is dependent on arrestins but independent of ... Arrestin-C, also known as retinal cone arrestin-3, is a protein that in humans is encoded by the ARR3 gene. Arrestin GRCh38: ...

Tec kinase is activated in platelets upon platelet stimulation with thrombin or collagen. Tec kinase is involved in the ... TEC resides on chromosome 4, locus 4p12 in humans. TEC is located only 1.5kb away from TXK, another member of the Tec kinase ... Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, ... Tyrosine-protein kinase Tec is a tyrosine kinase that in humans is encoded by the TEC gene. Tec kinase is expressed in ...

In humans, the P antigen (also known as globoside), one of many cellular receptors that contribute to a person's blood type, is ... Low platelets are associated with an increased risk of bleeding, bruising, and petechiae, with lower blood counts that impact ... The human fetal liver cDNA library (chosen because of its high enrichment of CD34+ cells), compared with peripheral blood or ... Because it infects red blood cells as a result of the affinity for the P antigen, parvovirus causes complete cessation of red ...

CAR-T cells, which utilizes genetic modification of human T-cells to contain antigen binding sequences in addition to the ... In addition, the system utilized anti-PDL1 antibody delivery, increasing platelet release of programmed cell death molecules ... Engineered chimeric antigen receptor (CAR)-T cell delivery is the methodology by which clinicians introduce the cancer- ... The classic method of administration of CAR-T cells to cancers within the human body is through intravenous (IV) central line ...

The release of the platelet contents stimulates additional platelet aggregation and initiates clot formation.1 This release ... Han J, Meng H, Xu L, Chou L. "Anti-Inflammatory Effect of Bioactive Glass on Human Periodontal Intrabony Defects." J Dent Res, ... The inflammatory response and other antigens in the wound also attract lymphocytes. These immune cells release cytokines, such ... Within minutes of defect formation, platelets collect at the site of the injury and adhere to the exposed collagen fibers. ...

The ABO blood group system involves two antigens and two antibodies found in human blood. The two antigens are antigen A and ... have their own systems of surface antigens, and sensitization to platelet or WBC antigens can occur as a result of transfusion ... Antigen A with antibody B Antigen B with antibody A Antigen AB with neither antibody A nor B Antigen null (group O) with both ... Regarding the antigen property of the blood all human beings can be classified into four groups, those with antigen A (group A ...

... and particular forms of human leukocyte antigen from gene variations of HLA-B. A common genetic abnormality, especially in ... Packed red blood cells or whole blood are recommended, while platelets and fresh frozen plasma are usually not. There is not ... PCR and viral antigen detection are more accurate in the first seven days. In 2012 a PCR test was introduced that can run on ... Humans are the primary host of the virus, but it also circulates in nonhuman primates. An infection can be acquired via a ...

... in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". The ... "Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets". The ... Tyrosine-protein kinase Lyn is a protein that in humans is encoded by the LYN gene. Lyn is a member of the Src family of ... Guo B, Kato RM, Garcia-Lloret M, Wahl MI, Rawlings DJ (Aug 2000). "Engagement of the human pre-B cell receptor generates a ...

Protein kinase C theta (PKC-θ) is an enzyme that in humans is encoded by the PRKCQ gene. PKC-θ, a member of serine/threonine ... A junction between an APC (an antigen presenting cell) and a T cell through their TCR and MHC receptors forms an immunological ... and platelets". J. Biol. Chem. 268 (19): 14208-14. doi:10.1016/S0021-9258(19)85228-6. PMID 7686153. Erdel M, Baier-Bitterlich G ... Conant K, Ma M, Nath A, Major EO (1996). "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an ...

1996), "Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RIα2C2) with the antigen ... "Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human ... PKA type I colocalizes with the T-cell and B-cell antigen receptors and causes inhibition of T- and B-cell activation. PKA has ... In lymphocytes, the intracellular levels of cAMP increase upon antigen-receptor stimulation and even more so in response to ...

Niiro H, Clark EA (November 2003). "Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and ... v t e (Articles with short description, Short description is different from Wikidata, Genes on human chromosome 10, All stub ... "Protein kinase C mediates translocation of type II phosphatidylinositol 5-phosphate 4-kinase required for platelet alpha- ... Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha is an enzyme that in humans is encoded by the PIP4K2A gene. ...

This suggests that the activation of endothelial cells and platelets play an important role in the pathogenesis of PDP. VEGF ... 2008). "Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland ... 1992). "Von Willebrand factor antigen in hypertrophic osteoarthropathy". J Rheumatol. 19 (5): 765-767. PMID 1613707. Silveria ... 1992). "Circulating plasma levels of platelet-derived growth factor in patients with hypertrophic osteoarthropathy". Clin Exp ...

Group H streptococci rarely cause human illness unless a human has direct contact with the mouth of a canine. One of the most ... They possess no Lancefield antigens.[citation needed] The viridans streptococci are a large group of commensal bacteria that ... and platelets), and usually results in beta-hemolysis under the surface of blood agar. Streptolysin S is an oxygen-stable ... It is a particularly common GGS in humans, although it is typically found on animals. S. phocae is a GGS subspecies that has ...

McGreal EP, Ikewaki N, Akatsu H, Morgan BP, Gasque P (May 2002). "Human C1qRp is identical with CD93 and the mNI-11 antigen but ... is detected specifically in human cells of myeloid lineage, endothelial cells, and platelets". Journal of Immunology. 160 (4): ... CD93+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CD93 genome location and ... Norsworthy PJ, Taylor PR, Walport MJ, Botto M (August 1999). "Cloning of the mouse homolog of the 126-kDa human C1q/MBL/SP-A ...

This allows the counts of RBCs, WBCs, and platelets to be obtained. The platelet count is easily separated from the WBC count ... The automation of laboratory testing does not remove the need for human expertise (results must still be evaluated by medical ... are used by some analysers to detect many substances by immunoassay and other reactions that employ the use of antibody-antigen ... with minimal human assistance. These measured properties of blood and other fluids may be useful in the diagnosis of disease. ...

Activation of platelets via collagen receptor GPVI stimulates the release of microvesicles from platelet cytoplasmic membranes ... Biró, E; Sturk-Maquelin, KN; Vogel, GM; Meuleman, DG; Smit, MJ; Hack, CE; Sturk, A; Nieuwland, R (December 2003). "Human cell- ... CD154 knockout mice are incapable of producing IgG, IgE, or IgA as a response to antigens. Microvesicles can also transfer ... Sources of microvesicles include megakaryocytes, blood platelets, monocytes, neutrophils, tumor cells and placenta. Platelets ...