Cell Death and Differentiation. 12 (6): 637-48. doi:10.1038/sj.cdd.4401647. PMID 15846369. Chiu A, Xu W, He B, Dillon SR, Gross ... B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a ... ALLO-715 is a CAR-T therapy by Allogene Therapeutics that targets B-cell maturation antigen (BCMA). As of June 2021[update], it ... January 2020). "Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies". The Journal of ...

The gp100 protein contains differentiation antigens.[2], and has been widely studied to be used as a target for melanoma ... The gp100 protein is a melanoma antigen i.e. a tumor-associated antigen. Short fragments of it have been used to develop the ... According to a case study, modifications of GP100, such as GP100-209 and GP100-208, have shown a greater number of antigen- ... In the mouse model, an HR-gp100-based vaccine triggered antigen-specific T cell responses, as shown by proliferation assays, ...

White Cell Differentiation Antigens: 654-55. Loken MR, Shah VO, Civin CI (1987). "Characterization of myeloid antigens on human ... White Cell Differentiation Antigens. pp. 630-35. "Stemcells Redirection". stemcells.nih.gov. Bhatia M, Bonnet D, Murdoch B, Gan ... hematopoietic cell surface antigen defined by a monoclonal antibody raised against KG-1a cells". Journal of Immunology. 133 (1 ... Many markers belong to the cluster of differentiation series, like: CD34, CD38, CD90, CD133, CD105, CD45, and also c-kit - the ...

... (Cluster of Differentiation 300A) is a human gene. The CMRF35 antigen (CMRF35A; MIM 606786), which was identified by ... Tissue Antigens. 55 (2): 101-9. doi:10.1034/j.1399-0039.2000.550201.x. PMID 10746781. Cantoni C, Bottino C, Augugliaro R, et al ... Cluster of differentiation GRCh38: Ensembl release 89: ENSG00000167851 - Ensembl, May 2017 "Human PubMed Reference:". National ...

May 1998). "Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign ... Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein ... Prostate-specific antigen has been shown to interact with protein C inhibitor. Prostate-specific antigen interacts with and ... The term prostate-specific antigen is a misnomer: it is an antigen but is not specific to the prostate. Although present in ...

... derives its name from the cluster of differentiation protocol that identifies cell surface antigens. CD34 was first ... Antigens,+CD34 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... White Cell Differentiation Antigens.Oxford University Press 630-635. Sidney LE, Branch MJ, Dunphy SE, Dua HS, Hopkinson A (June ... White Cell Differentiation Antigens. Oxford University Press, 654-655. Loken M. Shah V. Civin CI.. (1987). "Characterization of ...

The most common dyes act by binding to antigens presented on cells. Common antigens targeted are clusters of differentiation ( ... antigens). This technology is based on the attachment of small, inert, supra-magnetic particles to mAbs specific for antigens ... When a CD73+ antigen expressed itself with RCVRN+ cells (calcium-binding proteins in the eye), it showed researchers that this ... they have the foundation for further research based on the success of pairing non-damaged photoreceptors with a CD73 antigen ...

... these genes exhibit more inter-breed differentiation than intra-breed differentiation. Dogs have been selectively bred for ... Tissue Antigens, 68(6), 502-508. Kennedy, L. J., Davison, L. J., Barnes, A., Short, A. D., Fretwell, N., Jones, C. A., et al. ( ... Tissue Antigens, 68(6), 467-476. Pedersen N, FAU - Liu, H., Liu H, FAU - Millon, L., Millon L, FAU - Greer, K., et al. Dog ... Tissue Antigens, 68(5), 418-426. Safra N, FAU - Pedersen, N. C., Pedersen NC, FAU - Wolf, Z., Wolf Z, FAU - Johnson, E. G., et ...

Perivascular microglia also react strongly to macrophage differentiation antigens. These microglia have been shown to be ... In some cases, microglia can also be activated by IFN-γ to present antigens, but do not function as effectively as if they had ... As mentioned above, resident non-activated microglia act as poor antigen presenting cells due to their lack of MHC class I/II ... In their downregulated form, microglia lack the MHC class I/MHC class II proteins, IFN-γ cytokines, CD45 antigens, and many ...

... differentiation and antigen-presenting functions. In: Nature Reviews Immunology. doi:10.1038/nri.2017.28 Nichols, ... The intermediate subpopulation is important for antigen presentation and T lymphocyte stimulation. Briefly, antigen ... These are phagocytosis, antigen presentation, and cytokine production. Phagocytosis is the process of uptake of microbes and ... Aside from their differentiation capacity, monocytes can also directly regulate immune responses. As explained before, they are ...

Immunologically they are characterized as members of the CD66 cluster of differentiation. The proteins include CD66a, CD66b, ... Carcinoembryonic+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) CEA at Lab Tests Online CEA: ... Carcinoembryonic antigen (CEA) describes a set of highly-related glycoproteins involved in cell adhesion. CEA is normally ... Asad-Ur-Rahman F, Saif MW (June 2016). "Elevated Level of Serum Carcinoembryonic Antigen (CEA) and Search for a Malignancy: A ...

Fukuda M, Carlsson SR (1987). "Leukosialin, a major sialoglycoprotein on human leukocytes as differentiation antigens". Med. ... CD43+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human SPN genome location and SPN gene ... Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in ... it is generally less effective at demonstrating this condition than is CD3 antigen. However, it may be useful as part of a ...

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene. The Fos gene family consists of 4 ... differentiation, and transformation. AP-1 (transcription factor) GRCh38: Ensembl release 89: ENSG00000075426 - Ensembl, May ... "Entrez Gene: FOSL2 FOS-like antigen 2". Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (March 1990). "Isolation of human ... Molven A, Houge G, Berger R (November 1996). "Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2 ...

TI-1 antigens have an intrinsic B cell activating activity, that can directly cause proliferation and differentiation of B ... It results in proliferation and differentiation of B lymphocytes and production of antibodies. TI-2 antigens can activate only ... TI-1 antigen, which has an activity that can directly activate B cells and TI-2 antigen, which has highly repetitive structure ... An example of TI-1 antigen is lipopolysaccharide (LPS) or bacterial DNA. Second group of TI antigens consists mainly of highly ...

The Kell protein has also recently been designated CD238 (cluster of differentiation 238). Kell antigens are important in ... The Kell antigen system (also known as the Kell-Cellano system) is a human blood group system, that is, a group of antigens on ... The Kell antigens are K, k, Kpa, Kpb, Jsa and Jsb. The Kell antigens are peptides found within the Kell protein, a 93- ... Individuals without K antigens(K0) who have formed an antibody to a K antigen, must be transfused with blood from donors who ...

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene. The Fos gene family consists of 4 ... differentiation, and transformation. FOSL1 has been shown to interact with USF1 (human gene) and C-jun. AP-1 (transcription ... "Entrez Gene: FOSL1 FOS-like antigen 1". Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). " ... "Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13". Genomics. 18 (1): ...

Differentiation. 4 (10): 821-30. PMID 8274451. Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO ... Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (November 1999). "Antigens recognized by autologous antibody in patients with renal- ...

Langerhans cells are antigen-presenting cells but have undergone further differentiation. Skin Langerhans cells express CD1a, ... phagocytosis and antigen presentation. Phagocytosis is the main process of macrophages and antigen presentation the main ... Their main activity is antigen presentation; they express Factor XIIIa, CD1c, and Class II Human leukocyte antigens. A subset ... They express LCAs (leucocyte common antigens) CD45, CD14, CD33, and CD4 (also expressed by T helper cells). These histiocytes ...

Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDA gene. The myeloid cell nuclear ... "Entrez Gene: MNDA myeloid cell nuclear differentiation antigen". Burrus GR, Briggs JA, Briggs RC (February 1992). " ... nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen ... "The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located ...

Some differentiation occurs in response to antigen exposure. Differentiation dramatically changes a cell's size, shape, ... A specialized type of differentiation, known as terminal differentiation, is of importance in some tissues, including ... Differentiation may continue to occur after terminal differentiation if the capacity and functions of the cell undergo further ... Cell differentiation is thus a transition of a cell from one cell type to another and it involves a switch from one pattern of ...

They found that the immune responses to innocuous antigens triggers an increase in the activity of hypothalamic neurons and ... Affect cell growth, proliferation and differentiation. Cause immunosuppression which can lead to an extended amount of time ... Suppress cell adhesion, antigen presentation, chemotaxis and cytotoxicity. Increase apoptosis. Release of corticotropin- ...

Xu W, Banchereau J (January 2014). "The antigen presenting cells instruct plasma cell differentiation". Frontiers in Immunology ... Macrophages are professional antigen presenting cells (APC), meaning they can present peptides from phagocytosed antigens on ... The initial contact between macrophage antigen-bound MHC II and TCR serves as the contact point between the two cells where ... Macrophages can internalize antigens through receptor-mediated phagocytosis. Macrophages have a wide variety of pattern ...

... oncogenic viral antigens, cancer-testis antigens and vascular or stromal specific antigens. Tissue differentiation antigens are ... and some viral antigens are also cancer antigens. Cancer-testis antigens are antigens expressed primarily in the germ cells of ... Other examples include tissue differentiation antigens, mutant protein antigens, ... Certain tumor antigens are thus used as tumor markers. More importantly, tumor antigens can be used in cancer therapy as tumor ...

... of cytotoxic cell differentiation in secondary cultures by subcellular antigens". J. Immunol. 122 (5): 2134. PMID 312858. v t e ...

JL1, a novel differentiation antigen of human cortical thymocyte. J Exp Med. 178:1447-51, 1993 Choi EY, Park WS, Jung KC, Chung ... He also found the novel antigen JL1 on thymocytes, which has been developed as a therapeutic target for leukemia. Today he is ... He also found the novel antigen JL1 expressed in thymocytes (J Exp Med. 178:1447-51, 1993). JL1 is a unique epitope of CD43 ... Another important achievement of his research is the induction of antigen-specific T cell tolerance, which has been a distant ...

LFA-1/ICAM-1 interactions have recently been shown to stimulate signaling pathways that influence T cell differentiation. LFA-1 ... "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte- ... Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key ... The antigen that bound to the monoclonal antibodies was identified as an important molecule in cellular recognition processes. ...

Yu CY, Milstein C (1990). "A physical map linking the five CD1 human thymocyte differentiation antigen genes". EMBO J. 8 (12): ... a family of major histocompatibility complex-related differentiation antigens". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9154-8. ... CD1E+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CD1A genome location and CD1A gene ... The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. ...

Yu CY, Milstein C (1990). "A physical map linking the five CD1 human thymocyte differentiation antigen genes". EMBO J. 8 (12): ... a family of major histocompatibility complex-related differentiation antigens". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9154- ... A differentiation of these two types can be obtained in human by using an antibody against the TCR Vα24 chain, which is ... CD1d+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CD1A genome location and CD1A gene ...

Yu CY, Milstein C (1990). "A physical map linking the five CD1 human thymocyte differentiation antigen genes". EMBO J. 8 (12): ... a family of major histocompatibility complex-related differentiation antigens". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9154-8. ... CD1a (Cluster of Differentiation 1a) is a human protein encoded by the CD1A gene. This gene encodes a member of the CD1 family ... 1988). "Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c". Proc. Natl. Acad. Sci. U.S.A. 84 (24): ...

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a ... "The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol ... In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types ... August 1987). "Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial ...

have characterized OA1 immunologically as a melanoma/melanocyte differentiation antigen. Flow cytometry data suggests that OA1- ... This indicates that OA1 peptide is processed and presented on the surface of melanoma cells to be recognized by antigen- ...

Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) also known as CD66b (Cluster of Differentiation 66b), is a ... 2002). "Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes ... 1990). "Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of ... Cluster of differentiation GRCh38: Ensembl release 89: ENSG00000124469 - Ensembl, May 2017 "Human PubMed Reference:". National ...