*TOLLIP

"CD26 Mediates Dissociation of Tollip and IRAK-1 from Caveolin-1 and Induces Upregulation of CD86 on Antigen-Presenting Cells". ...

*CD28

When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 ... Mouse CD Antigen Chart Human CD Antigen Chart Human CD28 genome location and CD28 gene details page in the UCSC Genome Browser. ... Association of the TCR of a naive T cell with MHC:antigen complex without CD28:B7 interaction results in a T cell that is ... Schneider H, Cai YC, Prasad KV, Shoelson SE, Rudd CE (Apr 1995). "T cell antigen CD28 binds to the GRB-2/SOS complex, ...

*Macrophage polarization

Antigen presentation is upregulated (MHC II, CD86). M2c macrophages are important for secretion of IL-10, TGF-β. They also ... Typical are pro - inflammatory molecules (e.g. IFN-γ, IL-12, IL-23, TNF, IL-6, IL-1, specific chemokines and antigen ... Ability of TAMs to present tumour-associated antigens is decreased as well as stimulation of the anti-tumour functions of T and ...

*CTLA-4

It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. The CTLA-4 protein is encoded ... on antigen-presenting cells. CTLA-4 binds CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to ... CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and ... In 1987, cytotoxic T-lymphocyte antigen 4, or CTLA-4, was identified by Pierre Golstein and colleagues . In November 1995, the ...

*Acute myeloid dendritic cell leukemia

The markers include CD11c, CD80, CD83, CD86, and major histocompatibility complex class II antigens. The neoplastic dendritic ... Dendritic cells function as antigen-presenting cells. They process antigen material and present it on the surface to other ... February 2002). "Expression of CD86 in acute myelogenous leukemia is a marker of dendritic/monocytic lineage". Exp. Hematol. 30 ...

*Neuroinflammation

CD86, ED1 macrophage antigen, CD4, and leukocyte common antigen. These activated microglia decrease the ability for neurons to ... Additionally, T cells may enter through the blood-brain barrier, be activated by local antigen presenting cells, and attack the ...

*Immune tolerance

Interaction with B7 on T cells Downregulation of CD80/CD86 costimultory molecules on antigen presenting cells upon interaction ... tumor antigens, alloantigens, and self-antigens in inflamed tissue. Immune recognition of non-self-antigens typically ... Self-antigens are present due to endogenous expression, importation of antigen from peripheral sites via circulating blood, and ... Upon exposure to a foreign antigen, either the antigen is eliminated by the standard immune response (resistance), or the ...

*T helper cell

... these T cells must rely on the activation of CD28 for confirmation that they recognise a foreign antigen (as CD80/CD86 is only ... For example, when an antigen-presenting cell expresses an antigen on MHC class II, a CD4+ cell will aid those cells through a ... that a host antigen is foreign. As a result, the CD8+ T cells treat the host cell presenting that antigen as infected, and go ... but unprocessed antigens do not interact with T cells and are not involved in their activation. The antigens that bind to MHC ...

*CD86

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides ... "Entrez Gene: CD86 CD86 molecule". Human CD86 genome location and CD86 gene details page in the UCSC Genome Browser. Davila S, ... CD86 works in tandem with CD80 to prime T cells. The CD86 gene encodes a type I membrane protein that is a member of the ... Pan XM, Gao LB, Liang WB, Liu Y, Zhu Y, Tang M, Li YB, Zhang L (July 2010). "CD86 +1057 G/A polymorphism and the risk of ...

*Abatacept

In order for T cells to be activated and attack an antigen, that antigen must be presented to the T cell by an antigen- ... and the other signal is the CD80 or CD86 molecule (also known as B7-1 and B7-2). Abatacept binds to the CD80 and CD86 molecule ... Abatacept prevents antigen-presenting cells (APCs) from delivering the co-stimulatory signal. This prevents the T cells from ... One of those signals is the major histocompatibility complex (MHC), combined with the antigen, ...

*Artificial antigen presenting cells

... or CD86 (B7.2), although other additional co-stimulation molecules have been identified. When Signal 2 is not expressed, but T ... As specific cancer antigens have been discovered, these antigens can be loaded to aAPCs to successfully stimulate and expand ... It is the specific antigen or epitope that is loaded into the MHC determines the antigen-specificity. The peptide-loaded MHC ... Antigen presenting cells are the sentinels of the immune system and patrol the body for pathogens. When they encounter foreign ...

*Fascin

This suggests Treg-mediated suppression of antigen presenting cells is a multi-step process. In addition to CTLA-4 CD80/CD86 ... T regulatory cell adhesion to antigen presenting dendritic cell causes sequestration of Fascin-1, an actin-bundling protein ... essential for immunological synapse formation, and skews Fascin-1-dependent actin polarization in antigen presenting dendritic ...

*Cancer immunotherapy

... the T-cell receptor binding to an antigen-MHC complex and T-cell surface receptor CD28 binding to CD80 or CD86 proteins. CTLA4 ... Dendritic cells are antigen presenting cells (APCs) in the mammalian immune system. In cancer treatment they aid cancer antigen ... Cancer vaccine Antigen 5T4 Chimeric antigen receptor Coley's Toxins Combinatorial ablation and immunotherapy Cryoimmunotherapy ... Antigens can be added to the antibody and can induce the dendritic cells to mature and provide immunity to the tumor. Dendritic ...

*List of MeSH codes (D23)

... antigens, cd79 MeSH D23.050.301.264.035.180 --- antigens, cd80 MeSH D23.050.301.264.035.186 --- antigens, cd86 MeSH D23.050. ... antigens, cd79 MeSH D23.101.100.110.180 --- antigens, cd80 MeSH D23.101.100.110.186 --- antigens, cd86 MeSH D23.101.100.110.194 ... hla-a antigens MeSH D23.050.301.500.450.370.372 --- hla-a1 antigen MeSH D23.050.301.500.450.370.374 --- hla-a2 antigen MeSH ... hla-b antigens MeSH D23.050.301.500.450.380.383 --- hla-b7 antigen MeSH D23.050.301.500.450.380.385 --- hla-b8 antigen MeSH ...

*Gamma delta T cell

The antigens recognized by non-Vδ2 T cells expanded in the above infectious contexts have not been characterized, but the fact ... CD86) and adhesion receptors (CD11a, CD18, CD54). Thus activated Vγ9Vδ2 T cells behave like APCs (γδ T-APC) and present ... It is still not clear whether these non-peptidic antigens bind directly to the Vγ9/Vδ2 TCR or if a presenting element exists. ... However, none of the known antigen-presenting molecules like MHC class I and II or CD1 are required for γδ T cell activation ...

*Regulatory macrophages

Mregs express high levels of co-stimulatory molecules (CD86) and MHC Class II, they have the highest expression of these ... T cells co-culture with Mregs showed intense activation and proliferation, so Mregs act as sufficient antigen-presenting cells ...

*Outline of immunology

Antigen Antigenicity Immunogen Superantigen Allergen Hapten Epitope Linear Conformational Mimotope Tumor antigen Antigen- ... Expressed by APCs CD86 - Expressed by APCs CD28 family receptors CD28 - Expressed by T Cells CD278 (ICOS) - Homodimer, ... T cells Antigen receptor - T cell receptor (TCR) Subunits - [email protected] / [email protected] / [email protected] / [email protected] Co-receptors CD8 (CD8α / CD8β) CD4 ... B cells Antigen receptor - B cell receptor (BCR) Subunits- Immunoglobulin heavy chain / Immunoglobulin light chain Co-receptors ...

*Immunoglobulin V-set domain

... and CD86; in myelin membrane adhesion molecules; in junctional adhesion molecules (JAM); in tyrosine-protein kinase receptors; ... and in the programmed cell death protein 1 (PD1). Immunoglobulin V-set, subgroup InterPro: IPR003596 T-cell surface antigen CD2 ... CD86; CD8A; CD8B; CD8B1; CD96; CEACAM1; CEACAM16; CEACAM19; CEACAM21; CEACAM3; CEACAM4; CEACAM5; CEACAM6; CEACAM7; CEACAM8; ...

*T cell

Antigen-naïve T cells expand and differentiate into memory and effector T cells after they encounter their cognate antigen ... so co-stimulation for these cells comes from the CD80 and CD86 proteins, which together constitute the B7 protein, (B7.1 and ... These self-antigens are expressed by thymic cortical epithelial cells on MHC molecules on the surface of cortical epithelial ... The second signal licenses the T cell to respond to an antigen. Without it, the T cell becomes anergic, and it becomes more ...

*Immune checkpoint

Binding with its two ligands are CD80 and CD86, expressed on dendritic cells, prompts T cell expansion. CD28 was the target of ... CD27 - This molecule supports antigen-specific expansion of naïve T cells and is vital for the generation of T cell memory. ... The ligand for GITR is mainly expressed on antigen presenting cells. Antibodies to GITR have been shown to promote an anti- ... CD40 - This molecule, found on a variety of immune system cells including antigen presenting cells has CD40L, otherwise known ...

*Co-stimulation

... is required in addition to the antigen-specific signal from their antigen receptors. T cells require two signals ... and CD86 (B7.2) on the membrane of APC. Another costimulatory receptor expressed by T cells is ICOS ( Inducible Costimulator), ... B cell binds antigens with its BCR (a membrane-bound antibody), which transfers intracellular signals to the B cell as well as ... This additional binding makes the B cells 100- to 10,000-fold more sensitive to antigen. CR2 on mature B cells forms a complex ...

*Helminth protein

IL-10 is partially responsible for reducing expression of co-stimulatory molecules such as CD86 on macrophages. CD86 is one of ... A helminth protein, or helminthic antigen, is a protein derived from a parasitic worm that causes an immune reaction. When ... Of these, NPA (nematode polyprotein antigen/allergen) FAR, and Sj-FABPc demonstrate different binding affinities for fatty ... and are implicated in reduced reactivity to other antigens. Other helminth proteins promote parasite survival in other ways, ...

*Prostacyclin receptor

The axis inhibits bone marrow-derived dendritic cells (i.e. antigen-presenting cells that process antigen material, present it ... CD86, CD40, and MHC class II molecules) that are critical for developing adaptive immune responses. IL receptor-activated bone ...

*B7 (protein)

There are two major types of B7 proteins: B7-1 or CD80, and B7-2 or CD86. However, it is not known if they differ significantly ... This is also called "Signal 1" and its main purpose is to guarantee antigen specificity of the T cell activation. However, MHC ... B7 is a type of peripheral membrane protein found on activated antigen presenting cells (APC) that, when paired with either a ...

*Dendritic cell

Every helper T-cell is specific to one particular antigen. Only professional antigen-presenting cells (macrophages, B ... Histiocyte Macrophage List of human clusters of differentiation for a list of CD molecules (such as CD80 and CD86) Steinman, R ... Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They ... Here they act as antigen-presenting cells: they activate helper T-cells and killer T-cells as well as B-cells by presenting ...

*Heligmosomoides polygyrus

In addition costimulatory signals via CD80 and CD86 has also be shown important in mounting a Th2 immune response and producing ... Furthermore, a cocktail of H. polygyrus excretory-secretory antigens can be collected, and administered to mice in the presence ...