... +Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... Regulation by the CD45 tyrosine phosphatase". J. Immunol. 145 (8): 2448-54. PMID 1976695. Luzzati AL, Pugliese O, Giacomini E, ... The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen ... It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor. It ...

Sialyl Lewis X is also one of the most important blood group antigens and is displayed on the terminus of glycolipids that are ... Immunohistochemical panels for the diagnosis of Hodgkins disease typically employ CD15 along with CD30 and CD45; the latter ... Sialyl Lewis x is also an inflammation-associated antigen on liver cells. It becomes over expressed on diseased liver cells and ... Sialyl LewisX (sLeX), also known as cluster of differentiation 15s (CD15s) or stage-specific embryonic antigen 1 (SSEA-1), is a ...

Her PhD supervisor was Eric Bell, the first to describe CD45 expression on memory T cells. After her PhD, she completed ... Marshall's work has investigated how mast cells are involved in the early immune response to infection and antigen. She is best ... One of which Depends on Persisting Antigen". The Journal of Experimental Medicine. 185 (4): 767-776. doi:10.1084/jem.185.4.767 ... roles of mast cells and their ability to mobilize dendritic cells during the early immune response to infection or antigen. Her ...

Greer SF, Justement LB (May 1999). "CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein ... "SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates ...

... +Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CD22 genome location and CD22 gene ... Greer SF, Justement LB (May 1999). "CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein ... This happens when the BCR is cross-linked by the antigen. Phosphorylation is mediated by Lyn, a protein tyrosine kinase (PTK) ... A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux". The Journal of Biological Chemistry. 275 (23 ...

So if TCR exhibit high or inappropriate affinity for the self antigen expressed on mTEC, the thymocyte will be destroyed. mTEC ... TECs originate from non-hematopoietic cells that are characterized by negative expression of CD45 and positive expression of ... Aire mediates negative selection of auto-reactive T-cells and organ-specific antigens' expression on mTECs. The outcome of a ... Alexandropoulos, Konstantina; Danzl, Nichole M. (28 March 2012). "Thymic epithelial cells: antigen presenting cells that ...

Wu L, Fu J, Shen SH (April 2002). "SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription". ... Kosco KA, Cerignoli F, Williams S, Abraham RT, Mustelin T (January 2008). "SKAP55 modulates T cell antigen receptor-induced ... Wu L, Fu J, Shen SH (April 2002). "SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription". ... the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the ...

At the same time it has to ignore any self-antigen and tolerate harmless antigens such as food antigens. The signal ... Tonic TCR signalling is avoided by the presence of phosphatase CD45 that removes phosphorylation from tyrosine residues and ... The antigen sensitivity is higher in antigen-experienced T cells than in naive T cells. Naive T cells pass through the process ... T cells move on quickly from antigens that do not trigger responses, rapidly scanning pMHC on an antigen-presenting cell (APC) ...

Wang J, Liu X, Lu H, Jiang C, Cui X, Yu L, Fu X, Li Q, Wang J (March 2015). "CXCR4(+)CD45(-) BMMNC subpopulation is superior to ... "The promiscuous chemokine binding profile of the Duffy antigen/receptor for chemokines is primarily localized to sequences in ...

Wange RL, Malek SN, Desiderio S, Samelson LE (September 1993). "Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor ... April 1995). "Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase". European ... Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB (August 1995). "Ligation of the T-cell antigen receptor (TCR) induces ... August 1998). "Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor- ...

... an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases". The Journal of Biological ... regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 ... and Vav after B cell antigen receptor activation". The Journal of Biological Chemistry. 272 (43): 27362-27368. doi:10.1074/jbc. ... regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 ...

Polymersomes can mimic antigen presenting cells when loaded with tumor antigens to elicit a stronger immunogenic response, ... Leukocytes maintain the expression of CD47 and CD45 biomarkers which indicate to other cells what they are and that they should ... They serve a key role in presenting antigens to T-cells which produce immune system alerting signals upon coming into contact ... Artificial Antigen Presenting Cells (aAPCs) are polystyrene beads with stimulating receptor ligands. aAPCs loaded with ...

Following this his group generated antibodies that identified rat CD8, a marker of cytotoxic T cells as well as rat CD45. His ... Thomas ML, Barclay AN, Gagnon J, Williams AF (1985). "Purification, chain separation and sequence of the MRC OX-8 antigen, a ... Thomas ML, Barclay AN, Gagnon J, Williams AF (1985). "Evidence from cDNA clones that the rat leukocyte-common antigen (T200) ... differentiation antigens of rat lymphocytes". Cell. 12 (3): 696-703. doi:10.1016/0092-8674(77)90266-5. PMID 303545. S2CID ...

A key step in their investigation occurred in 1992 when monoclonal antibodies to surface CEC antigens were discovered, leading ... and are absent of the hematopoietic marker CD45. The HD-CEC assay identifies these markers based on reaction with specific ...

Ohagi S, Nishi M, Steiner DF (1991). "Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide)". ... a possible substrate for CD45, in human hematopoietic cells". Am. J. Hematol. 54 (1): 1-11. doi:10.1002/(SICI)1096-8652(199701) ...

As detected by immunostaining methods, the malignant cells typically express molecular marker proteins such as CD45 (which is ... or one of the various tests for hepatitis C antigen. Extracavitary PEL is diagnosed based on findings that their mass lesions ... with PEL that is associated with cirrosis due to hepatitis evidence positive serum tests for the hepatitis virus B antigen ( ...

... γc deficiency JAK3 deficiency Interleukin-7 receptor-α deficiency CD45 deficiency CD3δ, CD3ε, or CD3ζ deficiency Coronin-1A ... selective immunoglobulin A deficiency Specific antibody deficiency to specific antigens with normal B cell and normal Ig ...

The antigen-presenting cells (APC) expose on their surface a fraction of the antigen that is recognized either from CD8+T cells ... In general, CD45 acts to promote the active form of LCK by dephosphorylating a tyrosine (Y192) in its inhibitory C-terminal ... There is very little understanding of the role of CD45 isoforms, it is known that they are cell type-specific, and that they ... T cells are able to respond to pathogen and cancer using T-cell receptor, nevertheless, they can also react to self-antigen ...

The Reed-Sternberg cells are identified as large often bi-nucleated cells with prominent nucleoli and an unusual CD45−, CD30+, ... is not routinely used to treat Hodgkin lymphoma due to the lack of CD20 surface antigens in most cases. The use of rituximab in ...

The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like ... in the case of CD45, PTPalpha, and PTPzeta/beta. The binding of different parts of the protein with itself (ex. by folding to ... RPTPmu and CD45". FEBS J. 275 (10): 2597-604. doi:10.1111/j.1742-4658.2008.06407.x. PMID 18422654. S2CID 199555986. Brady- ...

Small CTCs are cytokeratin-positive and CD45-negative, but with sizes and shapes similar to white blood cells. Importantly, ... Biological methods isolate cells based on highly specific antigen binding, most commonly by monoclonal antibodies for positive ... Close validation of the method showed that additional antibodies of cytokeratins or CD45 did not have any advantage. Unlike ... They are also more difficult to isolate because they express neither cytokeratins nor CD45. Otherwise, their morphology, gene ...

White Cell Differentiation Antigens: 654-55. Loken MR, Shah VO, Civin CI (1987). "Characterization of myeloid antigens on human ... Many markers belong to the cluster of differentiation series, like: CD34, CD38, CD90, CD133, CD105, CD45, and also c-kit - the ... hematopoietic cell surface antigen defined by a monoclonal antibody raised against KG-1a cells". Journal of Immunology. 133 (1 ... bone marrow using multicolour immunofluorescence". Leucocyte Typing III: White Cell Differentiation Antigens. pp. 630-35. " ...

This work identified that CD4+OX22hi (OX22 is CD45RC in rats and the equivalent of CD45RB in mice, both isoforms of CD45) T ... Read S, Malmstrom V, Powrie F (2000). "Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of ...

Whereas coronin 1 was required for chemokine-mediated migration, it was dispensable for T cell antigen receptor functions in T ... close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol. 17 (9): 779-87. doi:10.1089/dna.1998.17. ...

For example, expression of CD56, MUC1 (also termed EMA for epithelial membrane antigen), and clusterin and strong uniform ... CD45 (44-74%), and in a far fewer percentage of cases various other marker proteins. These cells do not express ALK and often ...