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*  PTPRC
... is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common ... A unique secreted adenovirus E3 protein binds to the leukocyte common antigen CD45 and modulates leukocyte functions. Proc Natl ... CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells, but CD45 positioning within ... on a subset of dendritic cells and other antigen-presenting cells. Naive T lymphocytes express large CD45 isoforms and are ...
*  Histiocyte
They express LCAs (leucocyte common antigens) CD45, CD14, CD33, and CD4 (also expressed by T helper cells). These histiocytes ... Their main activity is antigen presentation; they express Factor XIIIa, CD1c, and Class II Human leukocyte antigens. A subset ... Langerhans cells are antigen-presenting cells but have undergone further differentiation. Skin Langerhans cells express CD1a, ... Phagocytosis is the main process of macrophages and antigen presentation the main property of dendritic cells (so called ...
*  Nodular lymphocyte predominant Hodgkin's lymphoma
... and CD79a and also express the common leukocyte antigen CD45, which is uncommon on RSH cells. The LP cells have scant cytoplasm ...
*  Index of biochemistry articles
CD4 antigen - CD45 antigen - CD95 antigen - CDC28 protein kinase - cell - cell adhesion molecule - Cell biology - cell cycle ... T-cell antigen receptors - tachykinin - tachykinin receptor - talin protein - tandem repeat sequence - taste bud - TATA box - ... carcinoembryonic antigen - carrier - carrier protein - CAS registry number - casein - catabolism - catalyst - catalytic domain ... alpha-beta T-cell antigen receptor - alpha-fetoprotein - alpha-globulin - alpha-macroglobulin - alpha-MSH - Ames test - amide ...
*  Microglia
CD45 antigens, and many other surface receptors required to act in the antigen-presenting, phagocytic, and cytotoxic roles that ... In some cases, microglia can also be activated by IFN-γ to present antigens, but do not function as effectively as if they had ... As mentioned above, resident non-activated microglia act as poor antigen presenting cells due to their lack of MHC class I/II ... Once they have been presented with antigens, T-cells go on to fulfill a variety of roles including pro-inflammatory recruitment ...
*  List of MeSH codes (D08)
... antigens, cd45 MeSH D08.811.277.352.650.625.700.200 --- cdc25 phosphatase MeSH D08.811.277.352.650.625.725 --- pyruvate ... antigens, cd38 MeSH D08.811.277.450.770 --- oligo-1,6-glucosidase MeSH D08.811.277.450.770.800 --- sucrase-isomaltase complex ... antigens, cd13 MeSH D08.811.277.656.350.555.200 --- carboxypeptidase b MeSH D08.811.277.656.350.555.250 --- carboxypeptidase h ... antigens, cd13 MeSH D08.811.277.656.675.555.200 --- carboxypeptidase b MeSH D08.811.277.656.675.555.250 --- carboxypeptidase h ...
*  List of MeSH codes (D23)
... antigens, cd40 MeSH D23.050.301.264.035.143 --- antigens, cd43 MeSH D23.050.301.264.035.145 --- antigens, cd45 MeSH D23.050. ... antigens, cd40 MeSH D23.101.100.110.143 --- antigens, cd43 MeSH D23.101.100.110.145 --- antigens, cd45 MeSH D23.101.100.110.146 ... hla-a antigens MeSH D23.050.301.500.450.370.372 --- hla-a1 antigen MeSH D23.050.301.500.450.370.374 --- hla-a2 antigen MeSH ... hla-b antigens MeSH D23.050.301.500.450.380.383 --- hla-b7 antigen MeSH D23.050.301.500.450.380.385 --- hla-b8 antigen MeSH ...
*  Lesional demyelinations of the central nervous system
... small clusters of microglial cells with enhanced major histocompatibility complex class II antigen, CD45 and CD68 antigen ... December 2008). "Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of ... August 2008). "EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN ...
*  BTLA
Pao LI, Bedzyk WD, Persin C, Cambier JC (1997). "Molecular targets of CD45 in B cell antigen receptor signal transduction". J. ... recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells". J. Immunol. 158 (6): 2663-9. ... 1997). "B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation". J. Immunol. ... 2007). "Distinct expression and inhibitory function of B and T lymphocyte attenuator on human T cells". Tissue Antigens. 69 (2 ...
*  Follicular dendritic cell sarcoma
Marker analysis has also led to debate over the origin of the cell type; it coexpresses CD45, a leukocyte common antigen, and ... centers of lymphoid follicles and have an integral role in regulation of the germinal center reaction and present antigens to B ... CD15, a monocyte common antigen. Because of the debate and difficulty of staining, pathologic diagnosis often requires ...
*  LYN
In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor ... Greer SF, Justement LB (May 1999). "CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein ... Brown VK, Ogle EW, Burkhardt AL, Rowley RB, Bolen JB, Justement LB (Jun 1994). "Multiple components of the B cell antigen ... Yamamoto T, Yamanashi Y, Toyoshima K (Apr 1993). "Association of Src-family kinase Lyn with B-cell antigen receptor". ...
*  CD79B
1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45". J. ... It is associated with agammaglobulinemia-6. The B lymphocyte antigen receptor is a multimeric complex that includes the antigen ... Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated ... 1994). "CD5 is associated with the human B cell antigen receptor complex". Eur. J. Immunol. 24 (4): 812-6. doi:10.1002/eji. ...
*  T helper cell
With the assistance of a phosphatase present on the intracellular section of CD45 (common leukocyte antigen), these molecules ... For example, when an antigen-presenting cell expresses an antigen on MHC class II, a CD4+ cell will aid those cells through a ... It is unknown what role the relatively bulky extracellular region of CD45 plays during cell interactions, but CD45 has various ... that a host antigen is foreign. As a result, the CD8+ T cells treat the host cell presenting that antigen as infected, and go ...
*  PTPRCAP
2000). "CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction". Eur. J. ... 2004). "PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients". J. Neurol. ... Vogel A, Strassburg CP, Manns MP (2003). "77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: ... 1994). "LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes". J. Biol. Chem. 269 (46): 29102-11. ...
*  CD79A
Reth M (1992). "Antigen receptors on B lymphocytes". Annual Review of Immunology. 10 (1): 97-121. doi:10.1146/annurev.iy. ... CD45". The Journal of Biological Chemistry. 269 (25): 17238-44. PMID 7516335. Pani G, Kozlowski M, Cambier JC, Mills GB, ... Engels N, Wollscheid B, Wienands J (Jul 2001). "Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM ... Brown VK, Ogle EW, Burkhardt AL, Rowley RB, Bolen JB, Justement LB (Jun 1994). "Multiple components of the B cell antigen ...
*  Receptor tyrosine kinase
Cd45, a cell surface glycoprotein, plays a critical role in antigen-stimulated dephosphorylation of specific phosphotyrosines ... Hermiston ML, Zikherman J, Zhu JW (March 2009). "CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase ...
*  CD8A
"Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells ... The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen ... The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell ... Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE (1989). "The CD4 and CD8 antigens are coupled to a protein- ...
*  Immunological synapse
The process of formation begins when the T-cell receptor (TCR) binds to the peptide:MHC complex on the antigen-presenting cell ... d-SMAC (distal-SMAC) enriched in CD43 and CD45 molecules. New investigations, however, have shown that a "bull's eye" is not ... Play media In immunology, an immunological synapse (or immune synapse) is the interface between an antigen-presenting cell or ... p-SMAC (peripheral-SMAC) within which the lymphocyte function-associated antigen-1 (LFA-1) and the cytoskeletal protein talin ...
*  Plasma cell
Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells. It ... the Interleukin-6 receptor and lack of expression of CD45. In humans, CD27 is a good marker for plasma cells, naive B cells are ... After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which ... Pieces of the antigen (which are now known as antigenic peptides) are loaded onto MHC II molecules, and presented on its ...
*  CD15
It is also called Lewis x and SSEA-1 (stage-specific embryonic antigen 1) and represents a marker for murine pluripotent stem ... Immunohistochemical panels for the diagnosis of Hodgkins disease typically employ CD15 along with CD30 and CD45; the latter ... Sialyl Lewis X CD15 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Kerr MA, Stocks SC (November ... CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation antigen - an immunologically significant molecule. CD15 ...
*  Kinetic-segregation model of T cell activation
CD45 phosphatase is not completely excluded from the close-contact zone and thus the signal generated in the case of a ... How Do T Cells Recognize Antigen?". Current Biology. Cambridge, MA: Cell Press. 15 (10): R382-R385. doi:10.1016/j.cub.2005.05. ... CD45 steric exclusion extends the phosphorylation half-lives of TCR/peptide-MHC complexes, which are trapped within the close- ... As the authors propose, this forms small zones of close contact, from which the inhibitory CD45 phosphatase molecules with ...
*  Galectin
This process prevents the circulation of T cells that are self-reactive and recognise self antigen. Both galectin-1 and ... CD43 and CD45 are involved in apoptosis. Galectin-7 is expressed under the p53 promoter and may have a key role in regulating ...
*  CD2
... Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... Regulation by the CD45 tyrosine phosphatase". J. Immunol. 145 (8): 2448-54. PMID 1976695. Luzzati AL, Pugliese O, Giacomini E, ... The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen ... It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor. It ...
*  Multiple myeloma
However, this antigen disappears rapidly ex vivo. Recently, however, it was discovered that the surface antigen CD319 (SLAMF7) ... CD319 positive and CD19 and CD45 negative.[citation needed] Cytogenetics may also be performed in myeloma for prognostic ...
*  CD22
... Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD22 genome location and CD22 gene ... Greer SF, Justement LB (May 1999). "CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein ... A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux". The Journal of Biological Chemistry. 275 (23 ... "SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates ...
*  Hodgkin's lymphoma
The Reed-Sternberg cells are identified as large often bi-nucleated cells with prominent nucleoli and an unusual CD45-, CD30+, ... is not routinely used to treat Hodgkin's lymphoma due to the lack of CD20 surface antigens in most cases. The use of rituximab ...