... has been shown to interact with: ADD2, BCAR1, C-Raf, CBLC, CD36, CD44, CDH1, CHRNA7, CTNND1, CBL, CSF1R, DLG4, Dystroglycan ... "Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular ... Ilangumaran S, Briol A, Hoessli DC (May 1998). "CD44 selectively associates with active Src family protein tyrosine kinases Lck ...

"Striking similarities between antigen receptor J pieces and sequence in the second chain of the murine CD8 antigen". Nature. ... J., & Johnson, P. (2011). "Differential use of chondroitin sulfate to regulate hyaluronan binding by CD44 in inflammatory and ... "CD44 loss disrupts lung lipid surfactant homeostasis and exacerbates oxidized lipid-induced lung inflammation". Frontiers in ... "TNF-α induction of CD44-mediated leukocyte adhesion by sulfation". Science. 282 (5390): 941-943. Bibcode:1998Sci...282..941M. ...

... +Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... Buess M, Rajski M, Vogel-Durrer BM, Herrmann R, Rochlitz C (October 2009). "Tumor-endothelial interaction links the CD44(+)/ ... Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in ... Gilliam DT, Menon V, Bretz NP, Pruszak J (March 2017). "The CD24 surface antigen in neural development and disease". ...

Role of the adhesion molecule CD44 in lung metastasis. Conditional ablation in MMTV-PyMT breast cancer cells has been done to ... in which MMTV-LTR is used to drive the expression of mammary gland specific polyomavirus middle T-antigen, leading to a rapid ... Lopez, J. I.; Camenisch, T. D.; Stevens, M. V.; Sands, B. J.; McDonald, J; Schroeder, J. A. (2005). "CD44 attenuates metastatic ...

CK19, Cytokeratin 19, K19) Kit L-selectin (CD62L) Lamin A/C Lewis X antigen (Le(X)) LeX Lgr5 Lrp4 MCM2 MCSP Metallothionein (MT ... CD34 CD44 NCAM (CD56) CD73 CD9 CD90 CDCP1 Circulating anticoagulants protein C (PC) CK19 CLV3 cyclic CMP ECMA-7 EDR1 EEC FGF-4 ... May 2006). "Lack of expression of the chondroitin sulphate proteoglycan neuron-glial antigen 2 on candidate stem cell ... Muramatsu T, Muramatsu H (2004). "Carbohydrate antigens expressed on stem cells and early embryonic cells". Glycoconjugate ...

RHAMM is less well studied than the main hyaluronan (HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors ... is a new immunogenic leukemia-associated antigen in acute and chronic myeloid leukemia". Experimental Hematology. 30 (9): 1029- ... While RHAMM has been less studied than CD44 in the process of cancer metastasis, it is likely just as important in this process ... As with CD44, RHAMM can promote focal adhesion turnover by controlling focal adhesion kinase (FAK) phosphorylation and ...

... antigen, also known as prominin-1, is a glycoprotein that in humans is encoded by the PROM1 gene. It is a member of ... CD44, and CD166 in colorectal cancer". Cancer Investigation. 27 (8): 844-50. doi:10.1080/07357900902744502. PMID 19626493. ... Ferrandina G, Martinelli E, Petrillo M, Prisco MG, Zannoni G, Sioletic S, Scambia G (July 2009). "CD133 antigen expression in ... "The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane ...

Here is the parade of killers and how they work: Cytotoxic T cells (also called Tc or antigen-specific cyto -lytic or -toxic T ... HSC also express CD44, low levels of Thy1.1 (CD90), but no IL-7Ra or CD27.[citation needed] This is called the (surface) ... Once in a secondary lymphoid organ the B cell can be introduced to an antigen that it is able to recognize.[citation needed] ... T cells are formed in bone marrow then migrate to the cortex of the thymus to undergo maturation in an antigen-free environment ...

ELPs are Lineage-CD44+CD25-CD117+ and thus closely resemble ETPs, the earliest progenitors in the thymus. Precursors enter the ... The ability of T cells to recognize foreign antigens is mediated by the T cell receptor (TCR), which is a surface protein able ... This allows single positive thymocytes to be exposed to a more complex set of self-antigens than is present in the cortex, and ... Cells which do not have a high affinity for self-antigens survive negative selection. At this stage, some cells are also ...

Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells. It ... stromal cell-derived factor-1α and signalling via CD44 have been shown to play a role in the survival of LLPC. LLPC can also be ... After leaving the bone marrow, the B cell acts as an antigen-presenting cell (APC) and internalizes offending antigens, which ... The absence of antigens and the depletion of B cells does not appear to have an effect on the production of high-affinity ...

... has been shown to interact with: CD44 COL7A1, LPA, IGFBP3, TNC, and TRIB3. Fetal fibronectin Fibronectin type I ... Bruhn HD, Heimburger N (1976). "Factor-VIII-related antigen and cold-insoluble globulin in leukemias and carcinomas". ... Jalkanen S, Jalkanen M (February 1992). "Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin". The ...

Sialyl Lewis X is also one of the most important blood group antigens and is displayed on the terminus of glycolipids that are ... CD43 or CD44. This sialyl-Lewisx mediated binding to selectins allows circulating leukocytes to stick to and roll along ... Sialyl Lewis x is also an inflammation-associated antigen on liver cells. It becomes over expressed on diseased liver cells and ... Sialyl LewisX (sLeX), also known as cluster of differentiation 15s (CD15s) or stage-specific embryonic antigen 1 (SSEA-1), is a ...

Bacterial antigens stimulate white blood cells to release MIF into the blood stream. The circulating MIF binds to CD74 on other ... October 2006). "CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex". Immunity ... MIF binds to CD74, inducing its phosphorylation and the recruitment of CD44 which then activates non-receptor tyrosine kinases ... an angiogenic phenotype in human ectopic endometrial cells and triggers the production of major angiogenic factors via CD44, ...

April 2002). "Resolution of lung inflammation by CD44". Science. 296 (5565): 155-8. Bibcode:2002Sci...296..155T. doi:10.1126/ ... C3b and antibodies that exude into the inflamed tissue during the vascular phase bind to and coat the microbial antigens. As ... Leukocytes reaching the tissue interstitium bind to extracellular matrix proteins via expressed integrins and CD44 to prevent ...

Moreover, in the presence of dying cells, PTX3 restricts the cross presentation of antigens derived from dying cells. These ... closely related to the adhesion receptor CD44". The Journal of Cell Biology. 116 (2): 545-57. doi:10.1083/jcb.116.2.545. PMC ... and tumor antigens". Blood. 107 (1): 151-8. doi:10.1182/blood-2005-03-1112. PMID 16166594. Mantovani A, Garlanda C, Bottazzi B ... "The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells". Blood. ...

The antigen-presenting cells (APC) expose on their surface a fraction of the antigen that is recognized either from CD8+T cells ... Lck has been shown to interact with: ADAM15, CD2, CD44, CD4, COUP-TFII, DLG1, NOTCH1, PIK3CA, PTPN6, PTPRC, UNC119, SYK, UBE3A ... T cells are able to respond to pathogen and cancer using T-cell receptor, nevertheless, they can also react to self-antigen ... Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE (May 1989). "The CD4 and CD8 antigens are coupled to a protein- ...

Several regulators of the myofibroblast differentiation pathway have been described, including hyaluronan and CD44 co-receptor ... but also act as stem-niche cells in the intestinal crypts and as parts of atypical antigen-presenting cells. They have both ... and CD44 co-localization in lipid rafts". The Journal of Biological Chemistry. 288 (21): 14824-38. doi:10.1074/jbc.M113.451336 ...

"Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". ... CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression". Molecular Cancer Research. 5 (6): 553-67. doi: ...

Recently, Heneberg proposed that basophils may be defined as the cellular population positive for CD13, CD44, CD54, CD63, CD69 ... pollen proteins or helminth antigens). Recent studies in mice suggest that basophils may also regulate the behavior of T cells ...

... in CD44 correlating with cell migration potential. CD44 is a cell surface protein whose expression has been linked to cancer, ... Using the mammary tumor virus-polyoma middle T-antigen (MMTV-PyMT) mouse model of mammary tumorigenesis, it was shown that ... For example, the Sam68-dependent CD44 alternative splicing of exon v5 is regulated by ERK phosphorylation of Sam68 and Bcl-x ... Cheng C, Sharp PA (Jan 2006). "Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion ...

The oral mucosa is colonized with commensals and is exposed to dietary antigens and pathogens. The ILCs in the oral mucosa help ... In mice, ILC2s express CD44, but not CD161. ILC2s require IL-7 for their development, activating the fundamental transcription ... Although they can present antigens, via MHC class II receptors, ILCs lack co-stimulatory molecules, and therefore play a role ... "High and interrelated rates of PD-L1+ CD14+ antigen-presenting cells and regulatory T cells mark the microenvironment of ...

Singleton PA, Bourguignon LY (2004). "CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan- ... 2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other ...

... dependent antigens". Proc. Natl. Acad. Sci. U.S.A. 90 (5): 1887-91. Bibcode:1993PNAS...90.1887N. doi:10.1073/pnas.90.5.1887. ... "Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44". Immunity. 49 (4): 709- ...

In cancer cells, CD44, death receptor-3 (DR3), LAMP1, and LAMP2 were identified as E-selectin ligands present on colon cancer ... E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or ... Shirure VS, Liu T, Delgadillo LF, Cuckler CM, Tees DF, Benencia F, Goetz DJ, Burdick MM (January 2015). "CD44 variant isoforms ...

... (OPN) expression is modulated by Schistosoma mansoni egg antigen. Schistosoma mansoni egg antigens directly ... Although the exact mechanisms of osteopontin signaling in PDAC are unknown, it binds to CD44 and integrins to trigger processes ... Zhu B, Suzuki K, Goldberg HA, Rittling SR, Denhardt DT, McCulloch CA, Sodek J (January 2004). "Osteopontin modulates CD44- ... "Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration". Journal of Cellular ...

It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte ... proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2". ... "Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton ...

In the nucleus of prostate cancer cells, MTDH has been shown to affect alternative splicing of genes such as CD44, which may ... 2021-11-29). "Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti- ...

Ren J, Li Y, Kufe D (May 2002). "Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin ... promote the adhesion of tumor cells with low expression of MUC1 to HUVECs through upregulation of N-cadherin and CD44". ... 2002). Yamamoto M, Bharti A, Li Y, Kufe D (May 1997). "Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta ... September 2001). "The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src ...

CD44 can also be used as a cancer stem cell marker in a subset of glioblastoma tumour cells. Glioblastoma cancer stem cells ... September 2009). "Detection of human herpesvirus-6 variants in pediatric brain tumors: association of viral antigen in low ...

... an indicator of antigen-induced signal transduction in antigen-binding cells". Journal of Immunology. 122 (4): 1278-84. doi: ... Components of the extracellular matrix such as fibronectin and hyaluronan can also bind to such receptors (integrins and CD44, ... The Journal of Immunology 121 (1), 345-353 Sobotka, A.K. Dembo, M, Goldstein, B and Lichtenstein, L M, (1979) Antigen-specific ... whose antigen-binding site is identical to that of antibodies that are secreted by the cell when it encounters an antigen, and ...