Proliferating cell nuclear antigen (PCNA) is a protein involved in DNA synthesis. Under normal physiological conditions PCNA is ... Magadán JG, Pérez-Victoria FJ, Sougrat R, Ye Y, Strebel K, Bonifacino JS (April 2010). "Multilayered mechanism of CD4 ... Ishikura S, Weissman AM, Bonifacino JS (July 2010). "Serine residues in the cytosolic tail of the T-cell antigen receptor alpha ... The ubiquitination system functions in a wide variety of cellular processes, including: Antigen processing Apoptosis Biogenesis ...

Tsuge I, Utsumi KR, Ueda R, Takamoto S, Takahashi T (1985). "Assignment of gene coding human T-cell differentiation antigen, ... augmentation by the CD4 and CD2 coreceptors". J. Exp. Med. 177 (1): 219-23. doi:10.1084/jem.177.1.219. PMC 2190871. PMID ... Overview of all the structural information available in the PDB for UniProt: P30203 (Human T-cell differentiation antigen CD6) ... "Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens". J. ...

DNA vaccines increase immunogenicity of idiotypic tumor antigen by targeting novel fusion proteins to antigen-presenting cells ... demonstrated that CD4 T-cells, in collaboration with macrophages, can kill cancer cells such as multiple myeloma cells in an ... Weiss S, Bogen B. (1991) MHC class II-restricted presentation of intracellular antigen. Cell. Feb 22;64(4):767-76. PMID 1847667 ... Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells. Proc Natl ...

LTCI increases the immune response to foreign antigens and dampens the immune-mediated response to self-antigens by increasing ... To attack tumor cells and viruses, CD-4 cells coordinate the overall immune response and help activate CD8 T-lymphocytes. Often ... Lymphocyte T-cell immunomodulator (LTCI) is an immune regulating polypeptide, which is a potent regulator of CD-4 lymphocyte ...

de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P (September 1997). "CD84 leukocyte antigen is a new member of the Ig ... Successful rearrangement of a reactive TCR supports survival and restriction of expression to CD4 or CD8 alone on single- ... "Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83". ... "Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83". ...

Prout, M. S.; Kyle, R.L.; Ronchese, F.; Le Gros, G. (2018). "IL-4 is a key requirement for IL-4 and IL-4/IL-13 expressing CD4 ... Hilligan, K. L.; Ronchese, F. (2020). "Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell ... where she became interested in antigen presentation by dendritic cells in vivo. In 1994, Ronchese moved to New Zealand to ...

... but IgG+ B cells that are specific for Trypanosoma antigen and not self antigens. Her work was awarded the Prize from the ... They found that TGF-β signaling was specifically restricting the activity and differentiation of anti-viral CD4 T cells. TGF-β ... In 2016, Zúñiga's lab explored the unknown mechanisms by which CD4 T cell activity is suppressed in chronic viral infections. ... TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections. J Clin Invest. 2016 Oct 3;126(10):3799- ...

... antigen, b-cell MeSH D12.776.124.486.485.950.500 - antigens, cd79 MeSH D12.776.124.790.106.050 - alpha 1-antichymotrypsin MeSH ... cd4 immunoadhesins MeSH D12.776.124.486.485.680.660.500 - immunoglobulin constant regions MeSH D12.776.124.486.485.680.745 - ... antigens, cd46 MeSH D12.776.124.486.274.920.250 - complement c1 inactivator proteins MeSH D12.776.124.486.274.920.250.500 - ... antigen-antibody complex MeSH D12.776.124.486.485.114.301 - antitoxins MeSH D12.776.124.486.485.114.301.138 - antivenins MeSH ...

The antigen recognition by T cells is a remarkable process dependent on the T cell receptor (TCR). The TCR is randomly ... High CD8 expression precedes the dual expression of CD4 and CD8 but following clonal selection and expansion, avian T cells ... Using monoclonal antibodies that are specific for chicken T cell surface antigens, the development of T cells in birds is ... Viertlboeck B, Göbel TWF (2008). "Avian T cells: antigen recognition and lineages." Avian Immunol. 6:91-105. Kaiser P, Rothwell ...

Immunisation with an auto-antigen to induce an immune response to model autoimmune diseases such as Experimental autoimmune ... "A rationally designed CD4 analogue inhibits experimental allergic encephalomyelitis". Nature. 368 (6473): 744-746. Bibcode: ... "A model for primitive neuroectodermal tumors in transgenic neural transplants harboring the SV40 large T antigen". Am J Pathol ... "Escape of malaria parasites from host immunity requires CD4+CD25+ regulatory T cells". Nature Medicine. 10 (1): 29-30. doi: ...

In allergic asthma, lung inflammation is caused by a CD4 T cell that attacks otherwise harmless allergens. This attack can ... killer immunoglobulin-like receptors and human leucocyte antigen class I in disease". Clinical & Experimental Immunology. 149 ( ...

Immunoassay: detect bacteria, viruses and cancers based on antigen-antibody reactions. Ion channel screening (patch clamp) ... flow cytometry is the gold standard for obtaining CD4 counts, but flow cytometry is a complicated technique that is not ...

The same review found biological factors such as CD4 and CD8 activation and liver inflammation are predictors of sub-acute ... and another found an association with certan variants of human leukocyte antigen genes. Post-viral fatigue syndrome (PVFS) or ...

... and PD-1 has been shown to be over-expressed on tumor antigen-specific (TA-specific) CD8+ T cells and CD8+ tumor ... "A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC". European Journal of Immunology. 39 ... NCT04308785) T cell receptor Antigen GRCh38: Ensembl release 89: ENSG00000181847 - Ensembl, May 2017 GRCm38: Ensembl release 89 ... "TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients". J Clin Invest. 125 (5): 2046-2058. doi:10.1172 ...

1981) Antigen-reactive T cell clones. I. Transcomplementing hybrid I-A-region gene products function effectively in antigen ... His research centers on a molecular and cellular understanding of CD4 T cell responsiveness in mice and man. President of the ... 2009) Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during ...

1994). "A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera". ... 1996). "Nonrheumatoid IgM in Human Hepatitis C Virus-Associated Type II Cryoglobulinemia Recognize Mimotopes of the CD4-Like ... Immunologic properties of Human Hepatitis B Virus Surface Antigen mimotopes displayed on filamentous phage". The Journal of ...

Skin TRM: TRM cells in the skin express cutaneous lymphocyte antigen (CLA) and CCR8 which are skin homing antigens. They have ... Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection". Journal of Immunology. 187 ... Shortly after antigen-specific response in the non-lymphoid tissue, infected tissue is occupied by CD8+ effector-stage T cells ... May 2012). "Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues". Journal ...

O antigen is exposed on the very outer surface of the bacterial cell, and, as a consequence, is a target for recognition by ... showed that LPS causes an IL-10-dependent inhibition of CD4 T-cell expansion and function by up-regulating PD-1 levels on ... They are composed of an O-antigen, an outer core, and an inner core all joined by covalent bonds, and are found in the outer ... The O antigen is attached to the core oligosaccharide, and comprises the outermost domain of the LPS molecule. The composition ...

... need to enter secondary lymph nodes to encounter their antigen. Central memory T-lymphocytes, which have encountered antigen, ... L-selectin expressed on CD4 T lymphocytes has been implicated in mediating adhesion and entry of HIV. L-selectin binds gp120, ... Here they reside ready to proliferate upon re-encountering antigen. Effector memory T-lymphocytes do not express L-selectin, as ... Bradley LM, Duncan DD, Tonkonogy S, Swain SL (September 1991). "Characterization of antigen-specific CD4+ effector T cells in ...

Dendritic Cells and B Cells Cooperate in the Generation of CD4+CD25+Foxp3+ Allogeneic T Cells. Transplant. Proc. 42; 371-5, ... "Analysis of protease in live antigen-presenting cells show regulation of the phagosomal proteolytic contents during dendritic ... 2010 Elgueta R., Sepulveda F., E. Vilches F., Vargas L., Mora J.R., Bono M.R., Rosemblatt M. Imprinting of CCR9 on CD4 T cells ... a mixture of both antigen-presenting cells improves their capacity to efficiently generate regulatory T cells. He also has ...

It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells; however, it is ... CD4+CD25+Foxp3+ regulatory T cells, and in a certain subset of activated T cells and B cells. IL-10 can be produced by ... and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of ... It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also ...

gag (group-specific antigen) codes for the precursor gag polyprotein which is processed by viral protease during maturation to ... Env is responsible for binding to its primary host receptor, CD4, and its co-receptor (mainly CCR5 or CXCR4), leading to viral ... Vpu is involved in CD4 degradation involving the ubiquitin proteasome pathway as well as in the successful release of virions ... The post-translational processing produces a surface glycoprotein, gp120 or SU, which attaches to the CD4 receptors present on ...

... antigen, b-cell MeSH D12.776.377.715.548.950.500 - antigens, cd79 MeSH D12.776.377.715.647.100 - alpha-macroglobulins See List ... cd4 immunoadhesins MeSH D12.776.377.715.548.680.660.500 - immunoglobulin constant regions MeSH D12.776.377.715.548.680.745 - ... antigen-antibody complex MeSH D12.776.377.715.548.114.301 - antitoxins MeSH D12.776.377.715.548.114.301.138 - antivenins MeSH ... antigens, polyomavirus transforming MeSH D12.776.624.664.520.420 - papillomavirus e7 proteins MeSH D12.776.624.664.520.750 - ...

This is opposed to other super antigens (SAGs) such as DEA and SEE, that bind to class II MHC through the low-affinity site, ... PTSAgs induce the VB-specific expansion of both CD4 and CD8- subsets of T-lymphocytes. TSST-1 forms homodimers in most of its ...

Rescuing imperfect antigens for immune-oncology. Nat Biotech. Epub ahead of print. Aug 2019. "Peter Edward Fecci". "Leadership ... In 2006, he published a paper entitled "Increased Regulatory T-cell Fraction Amidst a Diminished CD4 Compartment Explains ... "Systemic blockade of CTLA-4 ameliorates glioma-induced changes to the CD4 T-cell compartment without affecting regulatory T- ... Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with ...

Coornaert B, Baens M, Heyninck K, Bekaert T, Haegman M, Staal J, Sun L, Chen ZJ, Marynen P, Beyaert R (2008). "T cell antigen ... "Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation". Cell. 153 (5): 1036-49. doi:10.1016/ ... Ruland J, Duncan GS, Wakeham A, Mak TW (2003). "Differential requirement for Malt1 in T and B cell antigen receptor signaling ... Douanne T, Gavard J, Bidère N (May 2016). "The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor ...

Strains of HIV-1 have been isolated that are able to enter host cells that are CD4 negative. This CD4-independence is ... Callis AH, Ritzi EM (September 1980). "Detection and characterization of mouse mammary tumor virus cell surface antigens: ... Since CD4 receptor binding is the most obvious step in HIV infection, gp120 was among the first targets of HIV vaccine research ... Exposed on the surface of the viral envelope, the glycoprotein gp120 binds to the CD4 receptor on any target cell that has such ...

IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, ... Deletion of IL-13 from mice does not markedly affect either Th2 cell development or antigen-specific IgE responses induced by ...

As well as the active antigen derived from A/California/7/2009 (H1N1), the vaccine contains an immunologic adjuvant AS03 which ... "Use of an influenza virus an oil-in-water emulsion adjuvant to induce CD4 T-cell and/or improved B-memory cell response", ... with narcolepsy modulate the expression of the specific T cell receptor recognition involved in reaction to these antigens, ...

Human leukocyte antigen-DRB1*15 haplotype is a potential risk factor of MS. Because of the increased likelihood of the mother's ... Higher expression of miR-155 and miR-326 is often associated with CD4+T cell differentiation, and with this differentiation, ... The CTLA-4 gene produces an antigen of the same name that is presented on killer T-cells and allows for the suppression of the ... Methylation of this gene represses production of the antigen CTLA-4-a pattern seen in a significant majority of myasthenia ...