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*  Discovery and development of HIV-protease inhibitors
HIV infects T cells that carry the CD4 antigen on their surface. When HIV infects its target cell it requires fusion of the ... CD4 receptor) on the target cell. Then the virus binds to the chemokine coreceptors CXCR4 or CCR5, resulting in conformational ...
*  IL17A
Antigen specific CD4 T cells also limit nasopharyngeal colonization of S. pneumoniae in mouse models. Furthermore, immunization ... Antigen specific Th17 cells were also shown to recognize conserved protein antigens among different K. pneumoniae strains and ... "Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes ... Hayes CE, Hubler SL, Moore JR, Barta LE, Praska CE, Nashold FE (18 March 2015). "Vitamin D Actions on CD4(+) T Cells in ...
*  CD1
"Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes". Nature. 341 (6241): 447-50. doi ... CD1 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... CD1 antigens are expressed on cortical thymocytes, but not on mature T cells. This often remains true in neoplastic cells from ... They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. However their ...
*  Index of biochemistry articles
CD4 antigen - CD45 antigen - CD95 antigen - CDC28 protein kinase - cell - cell adhesion molecule - Cell biology - cell cycle ... T-cell antigen receptors - tachykinin - tachykinin receptor - talin protein - tandem repeat sequence - taste bud - TATA box - ... carcinoembryonic antigen - carrier - carrier protein - CAS registry number - casein - catabolism - catalyst - catalytic domain ... alpha-beta T-cell antigen receptor - alpha-fetoprotein - alpha-globulin - alpha-macroglobulin - alpha-MSH - Ames test - amide ...
*  List of MeSH codes (D23)
... antigen, t-cell MeSH D23.050.301.264.035.104 --- antigens, cd4 MeSH D23.050.301.264.035.105 --- antigens, cd5 MeSH D23.050. ... antigen, t-cell MeSH D23.050.301.264.894.100 --- antigens, cd4 MeSH D23.050.301.264.894.101 --- antigens, cd5 MeSH D23.050. ... antigens, cd3 MeSH D23.101.100.110.103.800 --- receptor-cd3 complex, antigen, t-cell MeSH D23.101.100.110.104 --- antigens, cd4 ... antigens, cd3 MeSH D23.101.100.894.095.800 --- receptor-cd3 complex, antigen, t-cell MeSH D23.101.100.894.100 --- antigens, cd4 ...
*  List of MeSH codes (D12.776.543)
... antigens, cd4 MeSH D12.776.543.750.925.700.605 -- receptors, ccr5 MeSH D12.776.543.750.925.700.650 -- receptors, cxcr4 MeSH ... antigen, b-cell MeSH D12.776.543.750.705.816.821.500 -- antigens, cd79 MeSH D12.776.543.750.705.816.824 -- receptors, antigen, ... antigens, cd22 MeSH D12.776.543.550.200.124 -- antigens, cd24 MeSH D12.776.543.550.200.131 -- antigens, cd31 MeSH D12.776. ... antigens, cd27 MeSH D12.776.543.750.705.852.760.072 -- antigens, cd30 MeSH D12.776.543.750.705.852.760.097 -- antigens, cd40 ...
*  Angus Dalgleish
"The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus". Nature. 312 (5996): 763-767. doi: ... where he helped identify CD4 as the major cellular receptor for HIV. In 1986, he was appointed to a consulting position at ...
*  HLA-DQ1
1992). "Human leukocyte antigen serologic and DNA typing of Behçet's disease and its primary association with B51". Invest. ... CD4 decline and AIDS in hemophilic siblings. Multicenter Hemophilia Cohort and Hemophilia Growth and Development Studies". AIDS ... 1994). "Human leukocyte antigen class II polymorphisms and genetic susceptibility of IDDM in Egyptian children". Diabetes Care ... 1992). "Association of HLA-B51 and lack of association of class II alleles with Behçet's disease". Tissue Antigens. 40 (1): 22- ...
*  Neuroinflammation
ED1 macrophage antigen, CD4, and leukocyte common antigen. These activated microglia decrease the ability for neurons to ... Additionally, T cells may enter through the blood-brain barrier, be activated by local antigen presenting cells, and attack the ...
*  Envelope glycoprotein GP120
Dalgleish AG, Beverley PC, Clapham PR, Crawford DH, Greaves MF, Weiss RA (1984). "The CD4 (T4) antigen is an essential ... Binding to CD4 induces the start of a cascade of conformational changes in gp120 and gp41 that lead to the fusion of the viral ... Since CD4 receptor binding is the most obvious step in HIV infection, gp120 was among the first targets of HIV vaccine research ... Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds[citation needed]. Gp120 ...
*  Rheumatic fever
During a streptococcal infection, mature antigen-presenting cells such as B cells present the bacterial antigen to CD4+T cells ... Self-antigen-specific antibodies generated via molecular mimicry between human proteins and streptococcal antigens up-regulate ... Molecular mimicry occurs when epitopes are shared between host antigens and Streptococcus antigens. This causes an autoimmune ... Human leukocyte antigen (HLA) class II allele DR7 (HLA-DR7) is most often associated with RHD, and its combination with certain ...
*  IL2RA
Mouse CD Antigen Chart Human CD Antigen Chart CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth ... Though IL2RA has been used as a marker to identify CD4+FoxP3+ regulatory T cells in mice, it has been found that a large ...
*  CD8A
Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE (1989). "The CD4 and CD8 antigens are coupled to a protein- ... The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen ... "Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells ... The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell ...
*  Lck
Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE (May 1989). "The CD4 and CD8 antigens are coupled to a protein- ... Thome M, Duplay P, Guttinger M, Acuto O (Jun 1995). "Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell ... It associates with the cytoplasmic tails of the CD4 and CD8 co-receptors on T helper cells and cytotoxic T cells, respectively ... Lck has been shown to interact with: ADAM15, CD2, CD44, CD4, COUP-TFII, DLG1, NOTCH1, PIK3CA, PTPN6, PTPRC, UNC119, SYK, UBE3A ...
*  Lutzner cells
... but stimulates the over production of other antigens like CD4. This mutation is a clonal gene rearrangement at the TCR-γ gene. ... It binds to a specific antigen to initiate an immune response. T-cell antibodies bind to antigens such as virus infected cells ... Once this antigen is lost, the T-cell antibodies will never be able to detect the pathogen, allowing the pathogen to increase ... When a cutaneous lymphocyte antigen is expressed in the skin, the CD4+ Lutzner cell travels to the epidermis and dermis layers ...
*  Christopher E. Rudd
1989) The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc. ... 1998) The CD4 receptor is complexed to a T-cell specific tyrosine kinase (pp58) in detergent lysates from human T lymphocytes. ... CD4, CD8 and the TcR/CD3 Complex: a novel class of protein tyrosine kinase receptor (1990) Immunology Today, 11, 400-406 ... In particular he made the seminal discovery that that CD4 and CD8 co-receptor molecules are linked to the p56 lck src family ...
*  Major histocompatibility complex, class II, DQ alpha 1
1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ... Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 ... Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): ... Marsh SG, Bodmer JG (1993). "HLA class II nucleotide sequences, 1992". Tissue Antigens. 40 (5): 229-43. doi:10.1111/j.1399- ...
*  HLA-DPB1
1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ... HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene. HLA-DPB ... 1991). "Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated ... Eiermann TH, Uhl S, Fakler J, Goldmann SF (1992). "A novel HLA-DPB1 sequence, DPB1*2301". Tissue Antigens. 40 (2): 108-10. doi: ...
*  HLA-DOB
1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ... HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene. HLA-DOB ... 1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing". J ...
*  HLA-DMB
1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ... HLA class II histocompatibility antigen, DM beta chain is a protein that in humans is encoded by the HLA-DMB gene. HLA-DMB ... Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 ...
*  HLA-DR
1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ... Identification of these antigens has led to greater success and longevity in organ transplant. Antigens most responsible for ... The complex of HLA-DR (Human Leukocyte Antigen - antigen D Related) and its ligand, a peptide of 9 amino acids in length or ... cell responses that eventually lead to the production of antibodies against the same peptide antigen. Antigen presenting cells ...
*  HLA-DQA2
1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ... Also known as HLA-DXA or DAAP-381D23.2, it is part of the human leucocyte antigen system. The protein encoded by this gene is ... HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. ...
*  HLA-DRB3 (gene)
1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ... Gorski J, Mach B (1986). "Polymorphism of human Ia antigens: gene conversion between two DR beta loci results in a new HLA-D/DR ... HLA class II histocompatibility antigen, DRB3-1 beta chain is a protein that in humans is encoded by the HLA-DRB3 gene. The ... Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 ...
*  HLA-DRB5
1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ... HLA class II histocompatibility antigen, DRB5 beta chain is a protein that in humans is encoded by the HLA-DRB5 gene. The ... Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 ... Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): ...
*  HLA-DRB4
1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ... Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 ... Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): ... Wu S, Saunders TL, Bach FH (1987). "Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two ...
*  GNLY
Granulysin is a member of the saposin-like protein (SAPLIP) family and is released from cytotoxic T cells upon antigen ... 2003). "CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15". ... Krensky AM, Clayberger C (March 2009). "Biology and clinical relevance of granulysin". Tissue Antigens. 73 (3): 193-8. doi: ...