CD94+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Genes on human chromosome 12, ... T cells in response to CD3-mediated stimulation". Journal of Leukocyte Biology. 70 (2): 219-24. doi:10.1189/jlb.70.2.219. PMID ... KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has ... Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type ...

... antigen presentation by mouse fibroblast and hamster B-cell lines », Cell, 36, 1984, p. 319-327 Gabert, J. et al., « ... The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules », Cell, 68, 1992, p. 83-95 Aguado ... which are responsible for capturing and presenting T cell antigens particularly effectively - present in tissues such as skin ...

"Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2". Immunity. 6 (2): 155- ... phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4". Biochem. Biophys. Res. Commun. 252 ( ...

A dose of i.n. administered antigen can be much smaller than of oral administered antigen, because antigens are not exposed to ... It requires Id2 gene, which induce genesis of CD3−CD4+CD45+ cells. These cells accumulates on the site of NALT after birth and ... M cells are typical for antigen intake from mucosa. In some areas of NALT, there are lymphatic vessels and HEVs (high ... B cells go through isotype switching and produce antigen-specific IgM, IgG and mainly IgA. Activated B cells can migrate ...

Lindholm CK, Henriksson ML, Hallberg B, Welsh M (July 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells ... an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases". The Journal of Biological ... "Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2". Immunity. 6 (2): 155- ... "Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2". Immunity. 6 (2): 155- ...

If the KIR receptors of NK cell find their cognate antigen on the surface of target cell, formation of the lytic synapse is ... The accumulation and polarization of actin is triggered by TCR/CD3 interactions with integrins and small GTPases (such as Rac1 ... The process of formation begins when the T-cell receptor (TCR) binds to the peptide:MHC complex on the antigen-presenting cell ... In immunology, an immunological synapse (or immune synapse) is the interface between an antigen-presenting cell or target cell ...

da Silva AJ, Janssen O, Rudd CE (December 1993). "T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 ... an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases". The Journal of Biological ... SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events". Frontiers in Immunology. 12: 703534. doi:10.3389/fimmu.2021.703534. ...

CD3 has been used to detect lymphocytes in tumor samples. Tumor immune infiltration can also be determined using gene ... Autologous TIL therapy for metastatic melanoma has broad T cell recognition of both defined and undefined tumor antigens ... TILs can not only recognize over-expressed self/melanocyte differentiation antigens, such as Melan-A/MART-1 (melanoma-specific ... which uses anti-CD3 activation for a typical period of two weeks. The final post-REP TIL is infused back into the patient. The ...

Shan X, Wange RL (October 1999). "Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and ... Sommers CL, Samelson LE, Love PE (January 2004). "LAT: a T lymphocyte adapter protein that couples the antigen receptor to ... Lindholm CK, Henriksson ML, Hallberg B, Welsh M (July 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells ... Shan X, Wange RL (October 1999). "Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and ...

It was originally named theta (θ) antigen, then Thy-1 (THYmocyte differentiation antigen 1) due to its prior identification in ... This locus is very close to CD3 & CD56/NCAM genes. Some believe that there may be a functional significance of both this gene ... The antigen Thy-1 was the first T cell marker to be identified. Thy-1 was discovered by Reif and Allen in 1964 during a search ... Reif AE, Allen JM (1964). "The AKR thymic antigen and its distribution in leukemias and nervous tissue". J. Exp. Med. 120 (3): ...

They have complete block in anti-CD3-induced T cell activation and decrease in regulatory T cells progenitors. After infection ... GITR interacts with its ligand (GITRL) that is expressed on antigen-presenting cells (APC) and endothelial cells. Human ... and rescue T cells from anti-CD3-induced apoptosis. GITR can be used as Treg marker and its signaling abrogates the suppressive ...

... s target cancerous or virally infected cells through binding human leukocyte antigen (HLA) presented peptide antigens and ... However, the danger of activating a wide variety of nonspecific cytotoxic T cell clones via anti-CD3 scFv exists, leading to ... This picomolar affinity binding results in the diseased cells becoming coated in CD3 co-receptor specific scFv antibody ... TCRs, like antibodies, constitute an important antigen recognition system within the immune system; but, whereas antibodies are ...

... antigen, b-cell MeSH D12.776.377.715.548.950.500 - antigens, cd79 MeSH D12.776.377.715.647.100 - alpha-macroglobulins See List ... muromonab-cd3 MeSH D12.776.377.715.548.114.619.393.700 - rho(d) immune globulin MeSH D12.776.377.715.548.114.619.574 - ... antigen-antibody complex MeSH D12.776.377.715.548.114.301 - antitoxins MeSH D12.776.377.715.548.114.301.138 - antivenins MeSH ... muromonab-cd3 MeSH D12.776.377.715.548.114.240 - antibodies, neoplasm MeSH D12.776.377.715.548.114.248 - antibodies, phospho- ...

... antigen, b-cell MeSH D12.776.124.486.485.950.500 - antigens, cd79 MeSH D12.776.124.790.106.050 - alpha 1-antichymotrypsin MeSH ... muromonab-cd3 MeSH D12.776.124.486.485.114.619.393.700 - rho(d) immune globulin MeSH D12.776.124.486.485.114.619.574 - ... muromonab-cd3 MeSH D12.776.124.790.651.114.619.393.700 - rho(d) immune globulin MeSH D12.776.124.790.651.114.619.574 - ... antigens, cd46 MeSH D12.776.124.486.274.920.250 - complement c1 inactivator proteins MeSH D12.776.124.486.274.920.250.500 - ...

Hirohashi N, Nakao M, Kubo K, Yamada A, Shichijo S, Hara A, Sagawa K, Itoh K (Dec 1993). "A novel antigen (H47 Ag) on human ... "Engagement of ILT2/CD85j in Sézary syndrome cells inhibits their CD3/TCR signaling". Blood. 100 (3): 1019-25. doi:10.1182/blood ... The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a ... on cytokine production by antigen-stimulated human T cells". Journal of Immunology. 168 (1): 207-15. doi:10.4049/jimmunol.168.1 ...

Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors ... and the intracellular domain of CD3-zeta containing ITAM repeats. Other sequences frequently included are: 4-1bb and OX40. The ... TdT is a protein expressed early in the development of pre-T and pre-B cells, whereas CALLA is an antigen found in 80% of ALL ... The process as a whole result in an effector cell, typically a T-cell, that can recognize a tumor cell antigen in a manner that ...

During this time she unraveled the structure of the CD3/T cell complex. After graduation she worked with Immunologists Dr Jan E ... that recognizes a common epitope on the human T cell receptor for antigen". Journal of Immunology. 135 (3): 1922-1928. doi: ... Haks, Mariëlle C.; Krimpenfort, Paul; Borst, Jannie; Kruisbeek, Ada M. (1998-04-01). "The CD3γ chain is essential for ... Jacobs, Heinz; Vandeputte, Dmitri; Tolkamp, Louis; De Vries, Evert; Borst, Jannie; Berns, Anton (April 1994). "CD3 components ...

Bezouska K, Nepovím A, Horváth O, Pospísil M, Hamann J, Feizi T (March 1995). "CD 69 antigen of human lymphocytes is a calcium- ... CD4 expression and CD3 signaling". The EMBO Journal. 16 (4): 673-84. doi:10.1093/emboj/16.4.673. PMC 1169669. PMID 9049297. ... Hamann J, Fiebig H, Strauss M (June 1993). "Expression cloning of the early activation antigen CD69, a type II integral ... Ziegler SF, Ramsdell F, Alderson MR (September 1994). "The activation antigen CD69". Stem Cells. 12 (5): 456-65. doi:10.1002/ ...

Tsuge I, Utsumi KR, Ueda R, Takamoto S, Takahashi T (1985). "Assignment of gene coding human T-cell differentiation antigen, ... "Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors". J. Exp. Med. 177 (1): 219- ... Overview of all the structural information available in the PDB for UniProt: P30203 (Human T-cell differentiation antigen CD6) ... "Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens". J. ...

... is able to bind the LCK with phosphorylated Y394, the phosphorylated ZAP70 and the phosphorylated ζ chain of CD3 complex ... The expression of PTPN22 is upregulated after an activation of T cells and an antigen-experienced T cell have higher expression ... In the absence of PTPN22, T cell cannot discriminate between strong and weak antigens sufficiently and those T cells become ... PTPN22-deficient T cells have a prolonged interval of contact with an antigen presenting cell, which present a low affinity ...

If the TCR is specific for that antigen, it binds to the complex of the class I MHC molecule and the antigen, and the T cell ... CD8 T cells can also show Activation Induced Cell Death or AICD which is mediated by CD3 receptor complex. Recently, a platelet ... The antigen could be any exogenous antigen, such as viral proteins, or an endogenous protein. Recently, a number of possible ... Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigen. An antigen is a molecule capable ...

... is required in addition to the antigen-specific signal from their antigen receptors. T cells require two signals ... TIM1, TIM4, ICOS, CD3 or DR3 and several molecules from the SLAM family were shown to induce polarization towards TH2. In ... B cell binds antigens with its BCR (a membrane-bound antibody), which transfers intracellular signals to the B cell as well as ... This additional binding makes the B cells 100- to 10,000-fold more sensitive to antigen. CR2 on mature B cells forms a complex ...

The other proteins in the complex are the CD3 proteins: CD3εγ and CD3εδ heterodimers and, most important, a CD3ζ homodimer, ... Antigen-naive T cells expand and differentiate into memory and effector T cells after they encounter their cognate antigen ... T cell exhaustion can be triggered by several factors like persistent antigen exposure and lack of CD4 T cell help. Antigen ... These self-antigens are expressed by thymic cortical epithelial cells on MHC molecules, which reside on the surface of cortical ...

In all reported cases, these T cells express the CD3 cluster of differentiation protein complex but vary in their expression of ... Unlike celiac disease, ITCLD-GT: a) is unresponsive to gluten-free diets: b) is negative for antigens detected in standard ... or CD4+/CD8+ T-cells that stain for CD3 but not CD56 or Epstein-Barr virus products. Notably, the affected T cells have an ... has infiltrating clonal T cells which do not express HLA-DQ2 or HLA-DQ8 human leukocyte antigens; and d) have lesions populated ...

The chimeric antigen receptor (CAR) T cell immunotherapies based on GC33, hYP7 and HN3 are being developed at various stages ... October 2017). "An anti-glypican 3/CD3 bispecific T cell-redirecting antibody for treatment of solid tumors". Science ... Phung Y, Gao W, Man YG, Nagata S, Ho M (September 2012). "High-affinity monoclonal antibodies to cell surface tumor antigen ... June 2020). "Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic ...

The ligation leads to disruption of the interaction between NKp30 and CD3ζ and thus decreases the activation of NK cells and ... Tissue Antigens. 58 (4): 255-8. doi:10.1034/j.1399-0039.2001.580406.x. PMID 11782277. "Entrez Gene: NCR3 natural cytotoxicity ... which associates with negatively charged aspartate in TM domain of ITAM adaptor molecules CD3ζ and FCεRIγ. This is a common ... while NKp30c mediates immunosuppressive signaling most likely because of reduced association with CD3ζ adaptor after cross- ...

Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". ... "Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling ...

The positive B cell signaling is initiated by binding of foreign antigen to surface immunoglobulin. The same antigen-specific ... Chauhan and coworkers reported the colocalization of the labeled ICs with the CD3 complex on activated CD4+ T cell surface, ... When an appropriate allergic antigen or parasite is present, the cross-linking of at least two IgE molecules and their Fc ... IgE antibodies bind to antigens of allergens. These allergen-bound IgE molecules interact with Fcε receptors on the surface of ...

B-lymphocyte antigen CD20 or CD20 is expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and ... Tamayose K, Sato N, Ando J, Sugimoto K, Oshimi K (December 2002). "CD3-negative, CD20-positive T-cell prolymphocytic leukemia: ... CD20+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) representations of the shape are found ... Stamenkovic I, Seed B (June 1988). "Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III ...

Su, IJ; Balk, SP; Kadin, ME (August 1988). "Molecular basis for the aberrant expression of T cell antigens in postthymic T cell ... CD56+/CD3-/TCRgammadelta-), derived from a single patient with CD56+ non-Hodgkin's lymphoma". Leukemia. 15 (10): 1641-9. doi: ... "Establishment of the T-cell large granular lymphocyte leukemia cell line MOTN-1 carrying natural killer-cell antigens". ... establishment of the cell line and presence of leukemia-associated antigens". Journal of the National Cancer Institute. 59 (1 ...