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*  Monoclonal antibody therapy
Tumor cells, however are highly abnormal, and many display unusual antigens. Some such tumor antigens are inappropriate for the ... Hooks MA, Wade CS, Millikan WJ (1991). "Muromonab CD-3: a review of its pharmacology, pharmacokinetics, and clinical use in ... Humanised antibodies bind antigen much more weakly than the parent murine monoclonal antibody, with reported decreases in ... Increases in antibody-antigen binding strength have been achieved by introducing mutations into the complementarity determining ...
*  Catumaxomab
It binds to antigens CD3 and EpCAM. It is in clinical trials in the United States currently and is used in Europe. It was ... By binding to such a cell via one arm, to a T lymphocyte via the other arm and to an antigen-presenting cell like a macrophage ... of an anti-EpCAM antibody and one half of an anti-CD3 antibody, so that each molecule of catumaxomab can bind both EpCAM and ... CD3. In addition, the Fc-region can bind to an Fc receptor on accessory cells like other antibodies, which has led to calling ...
*  CD3G
1991). "The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 ... T cell antigen receptor (TCR) is associated on the T cell surface with a complex of protein called CD3. CD3G (gamma chain) is ... 1989). "Dephosphorylation of the human T lymphocyte CD3 antigen". Eur. J. Biochem. 181 (1): 55-65. doi:10.1111/j.1432-1033.1989 ... 1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor ...
*  CD3D
1991). "The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 ... 1989). "Dephosphorylation of the human T lymphocyte CD3 antigen". Eur. J. Biochem. 181 (1): 55-65. doi:10.1111/j.1432-1033.1989 ... 1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor ... 1991). "Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3 ...
*  CD5 (protein)
"Evidence for an association between the T cell receptor/CD3 antigen complex and the CD5 antigen in human T lymphocytes". Eur. J ... CD5 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD5 genome location and CD5 gene ... CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed. In humans, the gene is located on the ... Raab M, Yamamoto M, Rudd CE (1994). "The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase ...
*  CD3 (immunology)
CD3 Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... The TCR, ζ-chain, and CD3 molecules together constitute the TCR complex. The CD3γ, CD3δ, and CD3ε chains are highly related ... In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with a molecule known ... and it is at this latter stage that CD3 antigen begins to migrate to the cell membrane. The antigen is found bound to the ...
*  CD43
... it is generally less effective at demonstrating this condition than is CD3 antigen. However, it may be useful as part of a ... CD43 antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human SPN genome location and SPN gene ... Fukuda M, Carlsson SR (1987). "Leukosialin, a major sialoglycoprotein on human leukocytes as differentiation antigens". Med. ...
*  Nc/Nga mice model
These seven candidate genes are: - thymus cell antigen 1 theta (Thy1) - CD3 antigen delta, epsilon and gamma polypeptide (Cd3d, ...
*  List of MeSH codes (D23)
... antigens, cd2 MeSH D23.101.100.110.103 --- antigens, cd3 MeSH D23.101.100.110.103.800 --- receptor-cd3 complex, antigen, t-cell ... antigens, cd2 MeSH D23.101.100.894.095 --- antigens, cd3 MeSH D23.101.100.894.095.800 --- receptor-cd3 complex, antigen, t-cell ... antigens, cd2 MeSH D23.050.301.264.035.103 --- antigens, cd3 MeSH D23.050.301.264.035.103.800 --- receptor-cd3 complex, antigen ... antigens, cd2 MeSH D23.050.301.264.894.095 --- antigens, cd3 MeSH D23.050.301.264.894.095.800 --- receptor-cd3 complex, antigen ...
*  Acute biphenotypic leukaemia
The presence of specific T-lymphoid antigens, cytoplasmic CD3 (cCD3), MPO and CD 19 became the most important standard for ...
*  PLCD3
"Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor ...
*  PLCG2
"Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor ... associates with the B cell antigen receptor complex and regulates lymphocyte signaling". Immunity. 5 (4): 353-63. doi:10.1016/ ...
*  T-cell surface glycoprotein CD3 epsilon chain
Müller B, Cooper L, Terhorst C (January 1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor ... The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T- ... T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B, CD3EAP and NCK2. CD3 (immunology) Cluster ... DeNofrio D, Radcliff G, Weinhold KJ, Denning SM (August 1995). "CD3 delta and epsilon gene expression in CD3-CD16+ natural ...
*  Trifunctional antibody
A trifunctional antibody is a monoclonal antibody with binding sites for two different antigens, typically CD3 and a tumor ... CD3), ertumaxomab (HER2/neu / CD3), FBTA05 (CD20 / CD3, proposed trade name Lymphomun)and TRBS07 (GD2 / CD3, proposed trade ... The net effect is that this type of drug links T cells (via CD3) and monocytes/macrophages, natural killer cells, dendritic ... 2008). "Immunotherapy of recurrent B-cell malignancies after allo SCT with Bi20 (FBTA05), a trifunctional anti-CD3 x anti-CD20 ...
*  ZAP70
"Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells". The Journal ... The most important member of the CD3 family is CD3-zeta, to which ZAP-70 binds (hence the abbreviation). The tandem SH2-domains ... Lindholm CK, Henriksson ML, Hallberg B, Welsh M (July 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells ... Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB (August 1995). "Ligation of the T-cell antigen receptor (TCR) induces ...
*  T-cell prolymphocytic leukemia
... and the neoplastic cells are typically positive for pan-T antigens CD2, CD3, and CD7 and negative for TdT and CD1a. The ...
*  CD79B
Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated ... It is associated with agammaglobulinemia-6. The B lymphocyte antigen receptor is a multimeric complex that includes the antigen ... 1994). "CD5 is associated with the human B cell antigen receptor complex". Eur. J. Immunol. 24 (4): 812-6. doi:10.1002/eji. ... This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding ...
*  CD79
Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated ... Van Noesel C, Brouns G, van Schijndel G, Bende R, Mason D, Borst J, van Lier R (1992). "Comparison of human B cell antigen ... CD79 Antigens at the US National Library of Medicine Medical Subject Headings (MeSH). ... in a similar manner to CD3-generated signal tranduction observed during T cell receptor activation on T cells. Chu P, Arber D ( ...
*  Immunosuppressive drug
Past this period CD3 blocks the TCR-antigen binding and causes conformational change or the removal of the entire TCR3/CD3 ... Muromonab-CD3 is a murine anti-CD3 monoclonal antibody of the IgG2a type that prevents T-cell activation and proliferation by ... Muromonab-CD3 can cause excessive immunosuppression. Although CD3 antibodies act more specifically than polyclonal antibodies, ... CD3 antibodies shift the balance from Th1 to Th2 cells.[citation needed] The patient may develop neutralizing antibodies ...
*  List of MeSH codes (D12.776.543)
... receptor-cd3 complex, antigen, t-cell MeSH D12.776.543.750.705.816.824.825 -- receptors, antigen, t-cell, alpha-beta MeSH ... antigen, b-cell MeSH D12.776.543.750.705.816.821.500 -- antigens, cd79 MeSH D12.776.543.750.705.816.824 -- receptors, antigen, ... antigens, cd22 MeSH D12.776.543.550.200.124 -- antigens, cd24 MeSH D12.776.543.550.200.131 -- antigens, cd31 MeSH D12.776. ... antigens, cd27 MeSH D12.776.543.750.705.852.760.072 -- antigens, cd30 MeSH D12.776.543.750.705.852.760.097 -- antigens, cd40 ...
*  TRA (gene)
Manolios N, Kemp O, Li ZG (1994). "The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 ... San José E, Sahuquillo AG, Bragado R, Alarcón B (1998). "Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/ ... Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 ... Kearse KP, Roberts JL, Singer A (1995). "TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer ...
*  CD3
... or CD-3 may be: CD3 (immunology), an antigen, cluster of differentiation protein (immunology), part of the T cell receptor ... CD3 = CDx3 from Cost of Delay Divided by Duration). Ford CD3 platform MediaMax CD-3, copy protection scheme MiniCD, a 3-inch CD ... TCR) complex on a mature T lymphocyte Cost of delay (CD3 Prioritisation), an approach for scheduling work through a scarce ...
*  Calnexin
van Leeuwen JE, Kearse KP (Apr 1996). "Calnexin associates exclusively with individual CD3 delta and T cell antigen receptor ( ... This association prepares the MHC class I for binding an antigen for presentation on the cell surface. ATP and calcium ions are ... "The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene". Proceedings of ... the job of chaperoning the MHC class I protein while the tapasin links the complex to the Transporter associated with antigen ...
*  Pan-T antigens
... are antigens found on all T cells. They include CD2, CD3, CD5 and CD7. Mario Roederer (October 2004). Cytometry ...
*  CD8
Once the T cell receptor binds its specific antigen Lck phosphorylates the cytoplasmic CD3 and ζ-chains of the TCR complex ... T-cell Group - Cardiff University Mouse CD Antigen Chart Human CD Antigen Chart CD8 alpha - Marker for cytotoxic T lymphocytes ... In addition to aiding with cytotoxic T cell antigen interactions the CD8 co-receptor also plays a role in T cell signaling. The ... This affinity keeps the T cell receptor of the cytotoxic T cell and the target cell bound closely together during antigen- ...
*  Immunosenescence
The cytotoxicity of Natural Killer (NK) cells and the antigen-presenting function of dendritic cells is known to diminish with ... "Age-related impairment of p56lck and ZAP-70 activities in human T lymphocytes activated through the TcR/CD3 complex". Exp ... The age-associated impairment of dendritic Antigen Presenting Cells (APCs) has profound implications as this translates into a ... Hakim, F.T.; R.E. Gress (2007). "Immunosenescence: deficits in adaptive immunity in elderly". Tissue Antigens. 70 (3): 179-189 ...
*  Muromonab-CD3
The T cell receptor-CD3 complex transduces the signal for the T cell to proliferate and attack the antigen. Muromonab-CD3 is a ... It binds to the T cell receptor-CD3-complex (specifically the CD3 epsilon chain) on the surface of circulating T cells, ... the binding of muromonab-CD3 to CD3 can activate T cells to release cytokines like tumor necrosis factor and interferon gamma. ... Muromonab-CD3 (OKT3) was approved by the U.S. Food and Drug Administration (FDA) in 1985, making it the first monoclonal ...