Mouse CD Antigen Chart Human CD Antigen Chart Human CD19 genome location and CD19 gene details page in the UCSC Genome Browser ... "Entrez Gene: CD19 CD19 molecule". Tedder TF, Isaacs CM (July 1989). "Isolation of cDNAs encoding the CD19 antigen of human and ... B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell ... CD19-targeted therapies based on T cells that express CD19-specific chimeric antigen receptors (CARs) have been utilized for ...
B-cell-associated antigens such as CD19, CD20, CD22, and CD79a are usually expressed. In contrast to small lymphocytic lymphoma ...
... a monoclonal antibody that binds both CD3 and CD19; chimeric antigen receptor T cell therapy using CD19-directed CAR-T cells; ...
Turtle, C., Riddell, S. & Maloney, D. (2016). CD19-Targeted chimeric antigen receptor-modified T-cell immunotherapy for B-cell ... Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified ... doi:10.1002/cpt.392 Turtle, C. J., & Maloney, D. G. (2016). Clinical trials of CD19-targeted CAR-modified T cell therapy; a ... Maloney leads an early-phase clinical trial for patients with certain advanced, treatment-resistant CD19-positive B-cell ...
November 2017). "Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor-modified T- ... Cytokine reaction syndrome may also be induced by certain medications, such as the CD20 antibody rituximab and the CD19 CAR T ... 2016). "Interleukin 6 Is Not Made By Chimeric Antigen Receptor T Cells and Does Not Impact Their Function". Blood. 128 (22): ... December 2016). "Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell-Treated Mice". Journal of Immunology. ...
Cao JX, Gao WJ, You J, Wu LH, Liu JL, Wang ZX (July 2019). "The efficacy of anti-CD19 chimeric antigen receptor T cells for B- ... Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, June CH (August 2011). "T cells with chimeric antigen receptors have ... Porter DL, Levine BL, Kalos M, Bagg A, June CH (August 2011). "Chimeric antigen receptor-modified T cells in chronic lymphoid ... People with CLL undergoing immunotherapy with chimeric antigen receptor T cells have been found to have a high response rate. ...
Antigen CD19 appears only on B cells, which go awry in lymphoma and leukemia. Loss of B cells can be countered with ... In 2016, CD19-specific chimeric antigen receptor (CAR)-modified T cells were used to treat patients with relapsed and ... against B cell antigen CD19 was shown to mediate regression of an advanced B cell lymphoma. By 2010, doctors had begun ... "Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy". ...
In this therapy, mice are immunized with the CD19 antigen and produce anti-CD19 antibodies. Hybridomas developed from mouse ... Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors ... CD19 is a molecule found on all B-cells and can be used as a means of distinguishing the potentially malignant B-cell ... TdT is a protein expressed early in the development of pre-T and pre-B cells, whereas CALLA is an antigen found in 80% of ALL ...
DOI: 10.1158/2159-8290.CD-19-0094 Engle, D.D., Tiriac, H., Rivera, K.D., Pommier, A., Whalen, S., Oni, T.E., Alagesan, B., Lee ... During her postdoctoral studies, Engle focused her efforts on probing a specific carbohydrate antigen, CA19-9, released by ... doi:10.1158/2159-8290.CD-19-0094. ISSN 2159-8290. PMC 6727976. PMID 31197017. Engle, Dannielle D.; Tiriac, Hervé; Rivera, Keith ... Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts ...
... is required in addition to the antigen-specific signal from their antigen receptors. T cells require two signals ... CR2 on mature B cells forms a complex with CD19 and CD81. This complex is called the B cell coreceptor complex for such ... B cell binds antigens with its BCR (a membrane-bound antibody), which transfers intracellular signals to the B cell as well as ... Co-stimulation is a secondary signal which immune cells rely on to activate an immune response in the presence of an antigen- ...
The hairy cells are larger than normal and positive for CD19, CD20, CD22, CD11c, CD25, CD103, and FMC7 antigens. (CD103, CD22, ... usually showing a common Human Leukocyte Antigen (HLA) type. The Hairy Cell Leukemia Consortium was founded in 2008 to address ...
... a phenomenon known as antigen escape. Preclinical studies developing CAR T cells with dual targeting of CD19 plus CD22 or CD19 ... CD19 continues to be the most popular antigen target, followed by BCMA (commonly expressed in multiple myeloma). In 2016, ... These VL and VH regions are selected in advance for their binding ability to the target antigen (such as CD19). The linker ... The first approved treatments use CARs that target the antigen CD19, present in B-cell-derived cancers such as acute ...
Anti-CD19/CD16 diabodies have been shown to enhance the natural killer cell response to B-cell lymphomas. Furthermore, ... CD16+Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short description, Short ... CD antigens". Immunobiology (5 ed.). New York: Garland. ISBN 978-0-8153-3642-6. Georg, Philipp; et al. (2021). "Complement ... Bispecific antibody fragments, such as anti-CD19/CD16, allow the targeting of immunotherapeutic drugs to the cancer cell. ...
The trials will assess combinations of MEDI4736 and one of Juno's CD19 directed chimeric antigen receptor T cell candidates. In ... Lisocabtagene maraleucel (liso-cel), the company's autologous anti-CD19 chimeric antigen receptor (CAR) T-cell immunotherapy ... In December 2014 the company signed an agreement with Opus Bio, Inc for a chimeric antigen receptor (CAR-T) cell product ... fully human binding domain targeting B-cell maturation antigen. In January 2018, Celgene announced it would acquire Juno for $9 ...
2015-05-04). "A tetravalent bispecific TandAb (CD19/CD3), AFM11, efficiently recruits T cells for the potent lysis of CD19(+) ... The binding of a BsAb to its target antigens can lead to a variety of effects. The most widely used application of this ... Blinatumomab, which targets CD19 and CD3, is used in the treatment of Philadelphia chromosome negative B cell acute ... Factor IXa and Factor X in the coagulation cascade are the cognate antigens which are bound by RG6013. These two factors are ...
The presence of specific T-lymphoid antigens, cytoplasmic CD3 (cCD3), MPO and CD 19 became the most important standard for ...
The trials will assess combinations of MEDI4736 and one of Juno Therapeutics' CD19 directed chimeric antigen receptor T-cell ...
With respect to diagnosing BNS, flow cytometry analyzes CSF contents for B-cells expressing the pan antigens CD19 and CD20, ...
2020-11-05). "Initial Clinical Activity of FT596, a First-in-Class, Multi-Antigen Targeted, Off-the-Shelf, iPSC-Derived CD19 ... Chimeric antigen receptors (CARs) are genetically modified receptors targeting cell surface antigens that provide a valuable ... "Retargeting NK-92 cells by means of CD19- and CD20-specific chimeric antigen receptors compares favorably with antibody- ... which subsequently enables antigen-specific T and B cell responses. Instead of acting via antigen-specific receptors, lysis of ...
"Retargeting NK-92 cells by means of CD19- and CD20-specific chimeric antigen receptors compares favorably with antibody- ... July 2016). "CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell malignancies". Journal of ... Zhang C, Oberoi P, Oelsner S, Waldmann A, Lindner A, Tonn T, Wels WS (2017). "Chimeric Antigen Receptor-Engineered NK-92 Cells ... CD19 (a type of B cell receptor), human epidermal growth factor receptor 2 (HER2/ErbB2) and epidermal growth factor receptor ( ...
Dendritic cells are antigen-presenting cells (APCs) in the mammalian immune system. In cancer treatment they aid cancer antigen ... This treatment removes CD19 positive cells (B-cells) from the body (including the diseased cells, but also normal antibody- ... Unlike CAR-T's cell surface antigens, TCR-T can recognize that larger set of intracellular antigen fragments. However, TCR-T ... Antigens can be added to the antibody and can induce the dendritic cells to mature and provide immunity to the tumor. Dendritic ...
LLPC do not need antigen restimulation to generate antibodies. Human LLPC population can be identified as CD19- CD38hi CD138+ ... Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells. It ... After leaving the bone marrow, the B cell acts as an antigen-presenting cell (APC) and internalizes offending antigens, which ... The absence of antigens and the depletion of B cells does not appear to have an effect on the production of high-affinity ...
Her group was among the first to demonstrate impressive activity of CD19 chimeric antigen receptor (CAR T cells) therapies for ... "T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 ... The trial was conducted at the Stanford Center for Cancer Cell Therapy, which modified the chimeric antigen receptor T cell ( ... Mackall holds a number of patents relating to peptides, antigen receptors and T cell fitness enhancements. She has served on ...
"T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 ... Her clinical trials focus on exploring and optimizing chimeric antigen receptor T cell (CAR-T cell) based strategies and other ... "Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia". Blood. 121 (7): 1165-1174. doi: ... "CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy". Nature ...
Once an antigen binds to the CD19 receptor, immediate downregulation in B-cell receptor (BCR) signal expression occurs and ... When compared to the wild type or normal expression of antigen receptors, the B cells bound to CD19 molecules actually ... BCR-antigen interactions and BCR signaling facilitate antigen specificity and reactivity of B10 cells. B10 cell germline BCRs ... Like the B cell, the B10 cell requires antigen specific binding to the surface of CD5 receptor to illicit a response from the T ...
... induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen ... It is associated with agammaglobulinemia-6. The B lymphocyte antigen receptor is a multimeric complex that includes the antigen ... PDBe-KB provides an overview of all the structure information available in the PDB for Human B-cell antigen receptor complex- ... Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated ...
The DLBCL cells have found to express B-cell antigens such as CD19, CD20, and CD22 as well as the transcription factors PAX5, ... Two promising immunotherapy approaches against diffuse large B-cell lymphoma are chimeric antigen receptor (CAR) T cell therapy ...
A phase I clinical trial is recruiting individuals to study the side effects and efficacy of CD19/CD22 chimeric antigen ... Mackall, Crystal (14 May 2022). "Phase I CD19/CD22 Chimeric Antigen Receptor(CAR) T-Cells in Adults With Recurrent/Refractory B ... Only individuals whose neoplastic B-cells express the CD19 cell surface protein are eligible to enter this study. Rezk SA, Zhao ... Epstein-Barr virus nuclear antigen 2 (EBNA-2) (a protein which stimulates infected cells to make >300 gene products some of ...
... less CD19 chimeric antigen receptor (CAR) T-cell product candidate known as FT819. 1998- Krause, Anja; Guo, Hong-Fen; Latouche ... "Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy" ... Isabelle Rivière at MSK, Sadelain's team was the first to report on molecular complete responses induced by CD19 CAR T cells in ... In 2003, Sadelain's lab identified CD19 as a target for CAR therapy in mice. Following the establishment of clinical CAR T cell ...
In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor ... BCR), CD40, or CD19. The abbreviation Lyn is derived from Lck/Yes novel tyrosine kinase, Lck and Yes also being members of the ... Brown VK, Ogle EW, Burkhardt AL, Rowley RB, Bolen JB, Justement LB (Jun 1994). "Multiple components of the B cell antigen ... Yamamoto T, Yamanashi Y, Toyoshima K (Apr 1993). "Association of Src-family kinase Lyn with B-cell antigen receptor". ...