An antigen-presenting cell (APC) or accessory cell is a cell that displays antigen bound by major histocompatibility complex ( ... Professional antigen-presenting cells, including macrophages, B cells and dendritic cells, present foreign antigens to helper T ... B cells can internalize antigen that binds to their B cell receptor and present it to helper T cells. Unlike T cells, B cells ... The main types of professional antigen-presenting cells are dendritic cells, macrophages and B cells. Dendritic cells have the ...
... (aAPCs) are engineered platforms for T-cell activation. aAPCs are used as a new technology ... January 2014). "Nanoscale artificial antigen presenting cells for T cell immunotherapy". Nanomedicine. 10 (1): 119-129. doi: ... January 2014). "Nanoscale artificial antigen presenting cells for T cell immunotherapy". Nanomedicine. 10 (1): 119-129. doi: ... the antigen presenting cells activate the T cells-"the soldiers of the immune system"- by delivering stimulatory signals that ...
An antigen-presenting cell vaccine, or an APC vaccine, is a vaccine made of antigens and antigen-presenting cells (APCs). As of ... ISBN 978-0-8261-7215-0.{{cite book}}: CS1 maint: multiple names: authors list (link) Antigen-presenting cell vaccine entry in ... a commonly over-expressed prostate cancer antigen. O'Neill, David W. (November 2010). "Dendritic cells and T cells in ...
Shi HZ (September 2004). "Eosinophils function as antigen-presenting cells". Journal of Leukocyte Biology. 76 (3): 520-7. doi: ... can inhibit proliferation of T cells, suppress antibody production by B cells, induce degranulation by mast cells, and ... They have also been implicated in antigen presentation to T cells. Eosinophils are responsible for tissue damage and ... They form about 2 to 3% of white blood cells in the body. These cells are eosinophilic or "acid-loving" due to their large ...
v t e (All stub articles, Biochemistry stubs, Antigen presenting cells). ... Pan-T antigens are antigens found on all T cells. They include CD2, CD3, CD5 and CD7. Mario Roederer (October 2004). Cytometry ...
McGreal E, Miller J, Gordon S (2005). "Ligand recognition by antigen-presenting cell C-type lectin receptors". Curr Opin ... "Recognition of tumor glycans by antigen-presenting cells". Curr. Opin. Immunol. 18 (1): 105-11. doi:10.1016/j.coi.2005.11.001. ... a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells". Cell. 100 (5): 587-97. doi:10.1016/ ... van den Berg LM, Geijtenbeek TB (2012). "Antiviral Immune Responses by Human Langerhans Cells and Dendritic Cells in HIV-1 ...
McIntire RH, Hunt JS (April 2005). "Antigen presenting cells and HLA-G--a review". Placenta. 26 (Suppl A): S104-S109. doi: ... In dendritic cells, binding to both receptors can prevent dendritic cells from maturing and prevent the activation of T cells. ... It binds to ILT2 on T cells to downregulate T cell chemokine expression. The cytokine expression of T cells mimics that of TH2 ... "Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility ...
... is the transmission of self-antigens between thymic antigen-presenting cells which contributes ... Breed, Elise R.; Lee, S. Thera; Hogquist, Kristin A. (2018). "Directing T cell fate: How thymic antigen presenting cells ... "Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus". Immunity ... "Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction". Immunity. 42 (6): 1048-61. doi: ...
LCs are antigen-presenting cells derived from dendritic cells. In humans, eosinophilic granulomas are considered as a benign ... Tran, Gary; Huynh, Thy N.; Paller, Amy S. (March 2018). "Langerhans cell histiocytosis: A neoplastic disorder driven by Ras-ERK ... Eosinophilic granuloma lesions in dogs primarily consists of eosinophils with addition of various cell subtypes such ... Kumar, Neeta; Sayed, Shahin; Vinayak, Sudhir (2011-01-20). "Diagnosis of Langerhans cell histiocytosis on fine needle ...
An antigen-presenting cell (APC) takes up these proteins; digests them into small peptides; places the peptides in a groove on ... CD8+ T cells) or T helper cells (i.e. CD4+ T cells) to initiate autoimmune reactions that attack self tissues. SCARs are type ... dendritic cells, macrophages, and T cells. It does so by binding to, but not stimulating, these cytokines' receptors, IL1RL2 ... and presents the MHC-associated peptides to the T-cell receptor on CD8+ T or CD4+ T cells. Those peptides expressing a drug- ...
... s (or Antigen-presenting cell activators) are a type of immunotherapy which leverages antigen-presenting cells ( ... Professional antigen-presenting cells - including dendritic cells, macrophages, and B cells - serve an indispensable role in ... Hughes, Catherine E.; Benson, Robert A.; Bedaj, Marija; Maffia, Pasquale (2016). "Antigen-Presenting Cells and Antigen ... "Direct Activation of Antigen-Presenting Cells Is Required for CD8+ T-cell Priming and Tumor Vaccination". Proceedings of the ...
An antigen presenting cell (APC) takes up these alter proteins; digests them into small peptides; places the peptides in a ... CD8+ T cells) and T helper cells (i.e. CD4+ T cells) to initiate autoimmune reactions that attack self tissues. In particular, ... and presents the MHC-associated peptides to T-cell receptors on CD8+ T cells or CD4+ T cells. Those peptides expressing a drug- ... Like other SCARs-inducing drugs, SJS-inducing drugs or their metabolites stimulate CD8+ T cells or CD4+ T cells to initiate ...
Kikutani H, Kumanogoh A (February 2003). "Semaphorins in interactions between T cells and antigen-presenting cells". Nature ... April 2022). "Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma". Blood. 139 ... Kumanogoh A, Kikutani H (September 2003). "Immune semaphorins: a new area of semaphorin research". Journal of Cell Science. 116 ... October 2002). "Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2". Nature. 419 (6907): 629-633. ...
An antigen-presenting cell (APC) takes up these alter proteins; digests them into small peptides; places the peptides in a ... CD8+ T cells) or T helper cells (i.e. CD4+ T cells) to initiate autoimmune reactions that attack self tissues. DRESS syndrome ... induce the DRESS syndrome by interacting with a T-cell receptor is limited to those individuals whose T cells express a T-cell ... stimulate CD8+ T or CD4+ T cells to initiate autoimmune responses by directly binding to the T-cell receptors on these T cells ...
"Corneal immunity is mediated by heterogeneous population of antigenpresenting cells." Journal of Leukocyte Biology 74, no. 2 ( ... he was the first to discover the presence of and characterize resident antigen-presenting cells in the central cornea. Hamrah ... "Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells." ... "Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells". Invest. ...
The conjugated vaccine is exposed to lymphocytes by antigen-presenting cells. There is recognition of the peptide antigen by T- ... Conjugated immunogens are injected to deliver the vaccine, which activates B and T cells in a T cell-dependent manner to create ... cell receptors. With the involvement of cytokines and B cells, a humoral response is elicited, which result in the synthesis of ... Plasmatic cells produce immunoglobulins, the anti-nicotine antibodies that bind to nicotine. The nicotine and nicotine-specific ...
Flannigan, Kyle L.; Geem, Duke; Harusato, Akihito; Denning, Timothy L. (2015-07-01). "Intestinal Antigen-Presenting Cells: Key ... Activity is initiated by the pacemaker cells, (myenteric interstitial cells of Cajal). The gut has intrinsic peristaltic ... Cells of the GI tract release hormones to help regulate the digestive process. These digestive hormones, including gastrin, ... It has been demonstrated that the intake of a high fiber diet could be responsible for the induction of T-regulatory cells ( ...
... phenotyping and functionally characterizing resident bone marrow-derived antigen-presenting cells (APC) of the cornea, (ii) ... "Corneal immunity is mediated by heterogeneous population of antigen-presenting cells". Journal of Leukocyte Biology. 74 (2): ... Fuchsluger, Thomas A.; Jurkunas, Ula; Kazlauskas, Andrius; Dana, Reza (2011). "Corneal endothelial cells are protected from ... tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal ...
... serves as a ssDNA 5' exonuclease in antigen presenting cells. PLD3 is highly expressed in the brain in both humans and ... Both PLD3 and PLD4 are essential for the clearance of nucleic acid product in antigen presenting cells. Deletion of PLD3 and ... PLD3 was identified as a protein in insulin secretory granules derived from pancreatic beta cells. PLD3 is a member of the ... The cytosolic N-terminal of the protein faces towards the cytoplasm of the cell, and lacks consensus sites for N-glycosylation ...
Mesothelial cells are capable of phagocytosis and are antigen-presenting cells. The secretion of glycosaminoglycans and ... The mesothelium is composed of an extensive monolayer of specialized cells (mesothelial cells) that line the body's serous ... Cuboidal mesothelial cells may be found at areas of injury, the milky spots of the omentum, and the peritoneal side of the ... Cancer cells can also metastasize (spread) from their original site to other parts of the body. Most cases of mesothelioma ...
Mesenchymal stem cells can also stimulate the maturation of antigen presenting cells. Antigen presenting cells trigger the ... Mesenchymal stem cells are able to differentiate, or mature from a less specialized cell to a more specialized cell type, to ... In mesenchymal stem cell therapy, most of the cells are extracted from the adult patient's bone marrow Mesenchymal stem cells ... the cells will multiply and differentiate into specialized cells. The number of fully differentiated cells and their phenotype ...
Antigen-presenting cells accumulate near high endothelial venules to process soluble antigens. Antigens are also present on the ... dendritic cells move to the T cell zone or to the B cell follicle along the fibroblast reticular cell network. Dendritic cells ... The sub-populations include: fibroblastic reticular cells (FRCs); folicular dendritic cells (FDCs); lymphatic endothelial cells ... the facilitation of the migration of hematopoietic cells; the presentation of antigens to immune cells at the initiation of the ...
Polymersomes can mimic antigen presenting cells when loaded with tumor antigens to elicit a stronger immunogenic response, ... T-cells have several key functions, including activation of other cells such as B-cells, helper T-cells and CD4+ cells, as well ... Mesenchymal stem cell derived nanoghosts exhibit cancer targeting properties. Artificial Antigen Presenting Cells (aAPCs) are ... These include B-cells, T-cells, and natural killer (NK) cells. B-cells become activated and produce antibodies to bind and tag ...
Antigen-presenting cells (APCs) such as dendritic cells take up antigens from the vaccine, process them into epitopes, and ... Since tumor antigens are antigens found in cancer cells but not normal cells, vaccinations containing tumor antigens should ... A tumor can have many cell types of cells, each with different cell-surface antigens. Those cells are derived from each patient ... to which tumor antigens are added. In this strategy, the antigen-presenting dendritic cells directly stimulate T-cells rather ...
... priming them to kill other cells that present the antigen. Dendritic cells are antigen-presenting cells (APCs) in the mammalian ... These can be either infected cells, or antigen-presenting cells (APCs). They are found in normal tissue and in tumor tissue, ... In normal physiology T-cells are activated by two signals: the T-cell receptor binding to an antigen-MHC complex and T-cell ... Cell types that can be used in this way are natural killer (NK) cells, lymphokine-activated killer cells, cytotoxic T cells and ...
It contains antigen-presenting cells (APCs), such as dendritic cells and macrophages. Some of the white pulp's macrophages are ... Due to them being positioned alongside T cells, it is suggested that these macrophages have a role in antigen presentation or ... In the B cell follicles, the macrophages are important in clearing the apoptotic B cells that occur during the germinal centre ... The T cell zone (periarteriolar sheath) and B cell follicles contain discrete macrophage populations; however, not much is ...
"Tunable heat shock protein-mediated NK cell responses are orchestrated by STAT1 in Antigen Presenting Cells". Scientific ... "Heat shock protein derivatives for delivery of antigens to antigen presenting cells". International Journal of Pharmaceutics. ... They can promote Th17, Th1, Th2 or Treg responses depending on antigen-presenting cells. As a result, the clinical use of heat- ... Tumor cells usually express only a few neo-antigens, which can be targeted by immune system and also not all tumor cells ...
Kupfer A, Singer SJ (November 1989). "The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane ... It also allows cells to measure extracellular rigidity, since cells in which talin is prevented from forming mechanical ... Hynes RO (February 1987). "Integrins: a family of cell surface receptors". Cell. 48 (4): 549-54. doi:10.1016/0092-8674(87)90233 ... at cell-cell contacts. Discovered in 1983 by Keith Burridge and colleagues, talin is a ubiquitous cytosolic protein that is ...
Antigens are delivered to antigen-presenting cells, such as dendritic cells, and B lymphocytes. M cells express the protease ... some antigens are able to infiltrate the M cell barrier and infect the nearby epithelial cells or enter the gut. M cells are ... Unlike their neighbor cells, M cells have the unique ability to take up antigen from the lumen of the small intestine via ... is another example of a cell surface receptor on M cells. M cells lack microvilli but, like other epithelial cells, they are ...
... parenchymal and nonparenchymal liver cells are efficient antigen presenting cells for MAIT. The total murine MAIT cell ... MR1 also serves as the antigen-presenting molecule outside of the thymus that binds to TCR and activates MAIT cells. MAIT cells ... in which a MAIT cell's semi-invariant TCR binds to the MR1 protein presenting antigen. While most T cell subsets have TCRs that ... and promotes the expression of MHC class II on antigen presenting cells. MAIT cells also secrete IL-17, an important pro- ...