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*  Carcinoembryonic antigen
"Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23". FEBS Letters ... Carcinoembryonic Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) CEA at Lab Tests Online CEA: ... Because even monoclonal antibodies to CEA tend to have some degree of cross-reactivity, occasionally giving false positive ... Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion. CEA is normally ...
*  Monoclonal antibody therapy
Humanised antibodies bind antigen much more weakly than the parent murine monoclonal antibody, with reported decreases in ... Major problems associated with murine antibodies included reduced stimulation of cytotoxicity and the formation complexes after ... The advent of monoclonal antibody technology has made it possible to raise antibodies against specific antigens presented on ... Antigen 5T4 Immunotherapy Immunoconjugate Nomenclature of monoclonal antibodies List of monoclonal antibodies, including ...
*  HLA-F
... can associate with TAP (transporter associated with antigen processing) and with the multimeric complex involved in ... "Serum antibodies to human leucocyte antigen (HLA)-E, HLA-F and HLA-G in patients with systemic lupus erythematosus (SLE) during ... it is involved in cross-presentation of exogenous antigen. The complex HLA-F/HLA class-I OC is a ligand for a subset of KIR ( ... the peptide-binding point of contact is a specific HLA class I epitope on the exogenous antigen. The complex HLA-F/HLA class I ...
*  Cap formation
These "patches" are two-dimensional precipitates of antigen-antibody complex and are quite analogous to the three-dimensional ... The antibody is bound to the cell. If the antibody is non-crosslinking (such as a Fab antibody fragment), the bound antibody is ... The crosslinking is most easily achieved using a polyvalent antibody to a surface antigen on the cell. Cap formation can be ... This can be done at 0 °C, room temperature, or 37 °C. If the antibody is crosslinking and bound to the cells at 0 °C, the ...
*  C1 complex
This occurs when C1q binds to antigen-antibody complexes. The antibodies IgM or certain subclasses of IgG complexed with ... The C1 complex (complement component 1, C1) is a protein complex involved in the complement system. It is the first component ... The C1 complex is composed of 1 molecule of C1q, 2 molecules of C1r and 2 molecules of C1s, or C1qr2s2. Activation of the C1 ... The classical pathway C3-convertase (C4bC2b complex) is created, which promotes cleavage of C3. Janeway, CA Jr; Travers P; ...
*  Complement component 1q
Antibodies of the adaptive immune system can bind antigen, forming an antigen-antibody complex. When C1q binds antigen-antibody ... Activation of the C1 complex intitiates the classical complement pathway of the complement system. The antibodies IgM and all ... C1q is a subunit of the C1 enzyme complex that activates the serum complement system. C1q comprises 6 A, 6 B and 6 C chains. ... C1q associates with C1r and C1s in order to yield the C1 complex (C1qr2s2), the first component of the serum complement system ...
*  Opsonin
The antigen-antibody complex can also activate complement through the classical complement pathway. Phagocytic cells do not ... The Fab region of the antibody binds to the antigen, whereas the Fc region of the antibody binds to an Fc receptor on the ... Antibodies can also activate complement via the classical pathway, resulting in deposition of C3b and C4b onto the antigen ... C1q, a member of the C1 complex, is able to interact with the Fc region of antibodies. Pentraxins, collectins, and ficolins are ...
*  Turbidimetry
Immunoturbidimetry uses the classical antigen-antibody reaction. The antigen-antibody complexes are particles which can be ...
*  Complement fixation test
... they will bind to the antigen in step 3 to form antigen-antibody complexes. The complement proteins will react with these ... The complement system is a system of serum proteins that react with antigen-antibody complexes. If this reaction occurs on a ... While detection of antibodies is the more common test format, it is equally possible to test for the presence of antigen. In ... However, if no antibodies against the antigen of interest are present, the complement will not be depleted and it will react ...
*  Periodontal pathology
The presence of complement and antigen-antibody complexes is evident throughout the connective and epithelial tissue. It is in ... Plaque is composed of a complex community of many different species of bacteria. However, specific bacterial species are ... Genco RJ, Mashimo PA, Krygier G, Ellison SA (May 1974). "Antibody-mediated effects on the periodontium". J. Periodontol. 45 (5 ...
*  C4A
The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha ... Carroll MC, Campbell RD, Bentley DR, Porter RR (1984). "A molecular map of the human major histocompatibility complex class III ... This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this ... a highly conserved gene in the class III region of the major histocompatibility complex". Dna. 8 (10): 745-51. doi:10.1089/dna. ...
*  Complement component 4B
The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha ... Yang Z, Mendoza AR, Welch TR, Zipf WB, Yu CY (Apr 1999). "Modular variations of the human major histocompatibility complex ... This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this ... Laich A, Sim RB (Jan 2001). "Complement C4bC2 complex formation: an investigation by surface plasmon resonance". Biochimica et ...
*  Antibody-dependent enhancement
These viruses are phagocytosed as antigen-antibody complexes, and degraded by macrophages. Upon ingestion the antibodies no ... or antibody-dependent cellular cytotoxicity-mediating antibodies (ADCC) in the serum contains infection enhancing antibodies( ... The viruses bind to the antigen binding site at the other end of the antibody. ADE is common in cells cultured in the ... The complement cascade system instead binds C1Q complex attached to the virus surface protein via the antibodies, which in turn ...
*  Bowel-associated dermatosis-arthritis syndrome
These antigen-antibody complexes are thought to be caused by excessive exposure to bacterial antigens (especially ... Immune complexes are thought to cause blood vessel damage, attracting neutrophils into the skin and synovium in BADAS. ... These antibodies possibly stimulate migration of neutrophils into the affected joints and skin. The effect of antibacterial ... Immune complex-mediated vessel damage and increased neutrophil migration". Arch. Intern. Med. 144 (4): 738-40. doi:10.1001/ ...
*  Ekkehard Kallee
with Uta Eistert and Richard Wahl: Inhibitory and Disruptive Effects of Some Antirheumatics on Antigen-Antibody Complexes. (PDF ... with F. Lohss: Spurennachweis von Albumin durch Analyse von Antigen-Antikörperpraezipitaten., Clinica chimica acta; ... Trichloressigsäure-Aceton-Extraktion von Albuminen aus Seren und Antigen-Antikorper-Präzipitaten. In: Zeitschrift für ...
*  Classical complement pathway
The classical complement pathway is initiated by antigen-antibody complexes with the antibody isotypes IgG and IgM. Following ... The classical complement pathway can be initiated by the binding of antigen-antibody complexes to the C1q protein. The globular ... and C9 form the membrane attack complex or the C5b-9 complex which forms pores on the target cell membranes to lysing. Because ... leading to the assembly of the membrane attack complex (MAC). The membrane attack complex creates a pore on the target cell's ...
*  Coprecipitation
... "antigen along with an antigen-antibody complex". Coprecipitation is an important issue in chemical analysis, where it is often ...
*  Anti-dsDNA antibodies
Ammonium sulphate is used to precipitate antigen-antibody complexes that form if the sera contains antibodies to dsDNA. The ... Anti-dsDNA antibodies are a group of anti-nuclear antibodies (ANA) the target antigen of which is double stranded DNA. Blood ... However, unlike the Farr Assay it does not dissociate the low avidity antibody complexes, allowing for the detection of both ... Anti-dsDNA antibodies might also be created secondary to the production of antibodies to other proteins within the nucleosome. ...
*  Complement system
Ability of C3b to bind to antigen-associated Ig would work effectively against antigen-antibody complexes to make them soluble ... The classical complement pathway typically requires antigen-antibody complexes for activation (specific immune response), ... which has formed a complex with antigens. C4b and C3b are also able to bind to antigen-associated IgG or IgM, to its Fc portion ... This occurs when C1q binds to IgM or IgG complexed with antigens. A single pentameric IgM can initiate the pathway, while ...
*  Complement receptor
With these receptors, RBCs bring antigen-antibody complexes bound to complement fragments in the blood to the liver and spleen ... Complement activity is not antigen sensitive, but can be triggered by specific antigens. Many white blood cells express ... Complement receptors bind proteins of the complement system, and can thus detect pathogens without mediation by antibodies. ...
*  Radial immunodiffusion
Antigen-antibody complexes are small and soluble when in antigen excess. Therefore, precipitation near the center of the circle ... The quantity and concentration of insoluble antigen-antibody complexes at the outer edge of the circle increase with time. The ... Expansion of the circle reaches an end point and stops when free antigen is depleted and when antigen and antibody reach ... reacts with the antibody, and forms insoluble precipitin complexes. The antigen is quantitated by measuring the diameter of the ...
*  Immune complex
An immune complex, sometimes called an antigen-antibody complex, is a molecule formed from the integral binding of an antibody ... effectively an antigen of its own with a specific epitope. After an antigen-antibody reaction, the immune complexes can be ... The bound antigen and antibody act as a unitary object, ... Immune complexes may themselves cause illness when they are ... Such hypersensitivity progressing to disease states produces the immune complex diseases. Immune complex deposition is a ...
*  Immunoassay
Radioactivity emitted by bound antibody-antigen complexes can be easily detected using conventional methods. RIAs were some of ... the analyte may be an antibody rather than an antigen. In addition to the binding of an antibody to its antigen, the other key ... In immunology the particular macromolecule bound by an antibody is referred to as an antigen and the area on an antigen to ... In some cases, an immunoassay may use an antigen to detect for the presence of antibodies, which recognize that antigen, in a ...
*  Franklin D. Roosevelt's paralytic illness
... probably secondary to the formation of antigen-antibody complexes. Concerning GBS, virtually all of the effective measures that ...
*  Centrifugal micro-fluidic biochip
... enzymes are used to produce a detectable signal from an antibody-antigen complex. At the first step, any antigen present will ... Then, detecting antibodies added to bind to the antigen. The enzyme-linked secondary antibody follows the detecting antibodies ... These tests rely on the specific detection of either the antibody or antigen, and are commonly performed by labeling the ... antibody/antigen of interest through various means such as fluorescent or enzymatic labels. However, washing, mixing, and ...
*  Catenin
"Characterization of antigens recognized by monoclonal and polyclonal antibodies directed against uvomorulin". Proc. Natl. Acad ... see Cadherin-catenin complex in learning and memory). Cell-cell adhesion complexes are required for simple epithelia in higher ... These complexes, which help regulate cell growth in addition to creating and maintaining epithelial layers, are known as ... On the other hand, when Wnt is present, GSK-3B is displaced from the previously mentioned complex, causing β-catenin to not be ...
*  Immunoprecipitation
Continue the incubation to allow antibody-antigen complexes to form. Precipitate the complex of interest, removing it from bulk ... irrelevant antibody of the same antibody subclass as the IP antibody is used instead of the IP antibody itself. This approach ... By using an antibody that is specific to a putative DNA binding protein, one can immunoprecipitate the protein-DNA complex out ... Analyze complexes or antigens of interest. This can be done in a variety of ways: SDS-PAGE (sodium dodecyl sulfate- ...