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*  Factor X
The most commonly used anticoagulants in clinical practice, warfarin and the heparin series of anticoagulants and fondaparinux ... Inhibition of the synthesis or activity of Factor X is the mechanism of action for many anticoagulants in use today. Warfarin, ... Direct Xa inhibitors are popular anticoagulants. Factor X is part of fresh frozen plasma and the prothrombinase complex. There ... The efficacy of heparin-based anticoagulants increases as selectivity for Factor Xa increases. LMWH shows increased ...
*  Discovery and development of direct Xa inhibitors
Factor Xa was identified as a promising target for the development of new anticoagulants in the early 1980s. In 1987 the first ... It wasn't until 1954 that it was approved for medicinal use in humans making warfarin the first oral anticoagulant drug. ... Direct Xa inhibitors are a class of relatively new oral anticoagulant drugs that inhibit factor Xa in splitting prothrombin ... Because of these disadvantages there has been an urgent need for better anticoagulant drugs. For a modern society, convenient ...
*  Protein C
... 's anticoagulant role in the human body was first noted by Seegers et al. in 1960, who gave protein C its original ... Because of the crucial role that protein C plays as an anticoagulant, those with deficiencies in protein C, or some kind of ... In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, ... Kisiel W, Canfield WM, Ericsson LH, Davie EW (December 1977). "Anticoagulant properties of bovine plasma protein C following ...
*  Left ventricular thrombus
Anticoagulants are also shown to reduce the risk of embolisms when a thrombus is already formed. Heparin, an injectable, fast- ... Aspirin plus an oral anticoagulant such as warfarin are suggested for individuals at risk for thromboembolic events. ... acting anticoagulant, is effective in high doses for preventing LVT formation after AMI. There are also surgical procedures for ...
*  Lupus anticoagulant
... is a misnomer, as it is actually a prothrombotic agent. Lupus anticoagulant antibodies in living systems ... Both words in the term "lupus anticoagulant" can be misleading: Most patients with a lupus anticoagulant do not actually have ... confirming the diagnosis of a lupus anticoagulant. Treatment for a lupus anticoagulant is usually undertaken in the context of ... lupus anticoagulant and a history of thrombosis should be considered candidates for indefinite treatment with anticoagulants. ...
*  Thrombin time
... or under-filled in order to ensure the correct anticoagulant-to-blood ratio: one part anticoagulant per nine parts blood. The ... is a blood test that measures the time it takes for a clot to form in the plasma of a blood sample containing anticoagulant, ...
*  CD93
... a well characterized anticoagulant. All of them contain a C-type lectin domain, a series of epidermal growth factor like ...
*  Warfarin necrosis
Protein C is an innate anticoagulant, and as warfarin further decreases protein C levels, it can lead to massive thrombosis ... Warfarin-induced skin necrosis (or, more generally, Anticoagulant-induced skin necrosis) is a condition in which skin and ... Verhagen H (1954). "Local haemorrhage and necrosis of the skin and underlying tissues, during anti-coagulant therapy with ... indicating good anticoagulant effect) but still be in a hypercoagulable state. In one third of cases, warfarin necrosis occurs ...
*  Diphenadione
Some of the newer anticoagulant compounds, termed 'second-generation anticoagulants,' may cause human toxicity at a much lower ... The first-generation anticoagulants, for example, are reasonably effective against pest rodents and are less toxic than second- ... Diphenadione is a vitamin K antagonist that has anticoagulant effects and is used as a rodenticide against rats, mice, voles, ... The anticoagulants, indandiones and red squill, are less hazardous to humans and domestic animals. ...
*  Mixing study
The most common inhibitor is a nonspecific inhibitor such as a lupus anticoagulant. Perform a test to demonstrate a ... Nonspecific inhibitors like the lupus anticoagulant usually are not time dependent; the immediate mixture will show ... Devreese KM (2007). "Interpretation of normal plasma mixing studies in the laboratory diagnosis of lupus anticoagulants". ... such as lupus anticoagulant, or specific factor inhibitors, such as antibodies directed against factor VIII. Mixing studies ...
*  Anticoagulant
Oral anticoagulants (OACs) are taken by many people in pill or tablet form, and various intravenous anticoagulant dosage forms ... Common anticoagulants include warfarin and heparin. The use of anticoagulants is a decision based upon the risks and benefits ... Anticoagulants are often used to treat acute deep vein thrombosis. People using anticoagulants to treat this condition should ... The newer anticoagulants (NOACs/DOACs), are more expensive than the traditional ones and should be used with care in patients ...
*  Lofepramine
Anticoagulants (blood thinners). Lofepramine may inhibit the metabolism of certain anticoagulants leading to a potentially ...
*  Sticky platelet syndrome
Anticoagulants (e.g. Warfarin, Coumadin) or clopidogrel (Plavix) are often additionally prescribed following formation of a ...
*  Omeprazole
Daly AK, King BP (May 2003). "Pharmacogenetics of oral anticoagulants". Pharmacogenetics. 13 (5): 247-52. doi:10.1097/01.fpc. ...
*  Hepatotoxicity
Arora N, Goldhaber SZ (2006). "Anticoagulants and transaminase elevation". Circulation. 113 (15): e698-702. doi:10.1161/ ...
*  Thrombosis prevention
Anticoagulant medications prevent the formation of blood clots in people who are at high risk for their development. Treating ... Anti-coagulant administration is often given before the start of the operation. There are concerns with the potential of ... Anticoagulants are often prescribed. Pre-operatively some patients receive low-molecular-weight heparin once a day. Additional ... Anticoagulants can be affected by chamomile. Dong quai, garlic, ginger, Ginkgo biloba, bilberry and feverfew can increase ...
*  Betrixaban
... (INN; trade name Bevyxxa; development code PRT-054,021) is an anticoagulant drug which acts as a direct factor Xa ... Sobieraj-Teague, M.; O'donnell, M.; Eikelboom, J. (2009). "New Anticoagulants for Atrial Fibrillation". Seminars in Thrombosis ...
*  Semuloparin sodium
"New parenteral anticoagulants in development". Therapeutic Advances in Cardiovascular Disease. 5 (1): 33-59. doi:10.1177/ ...
*  PER977
... is a small molecule drug that is under investigation as a potential antidote for multiple anticoagulants, including ... November 2012). "Small Molecule Antidote for Anticoagulants". Circulation. 126 (21 Suppl): A11395. ...
*  Diplomatic illness
She's Being Treated with Anticoagulants." The Seattle Times. December 31, 2012. Retrieved August 30, 2016, from HighBeam ...
*  Synovial fluid
ISBN 0-7817-7153-6. "Lupus Anticoagulant". Family Practice Notebook. Archived from the original on 18 January 2013. Retrieved 7 ...
*  Management of atrial fibrillation
Dabigatran is an anticoagulant that works as a direct thrombin inhibitor, and does not require blood tests for INR monitoring, ... "Oral anticoagulants versus antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no ... To compensate for the increased risk of stroke, anticoagulants may be required. However, in the case of warfarin, if someone ... With the likely availability of new oral anticoagulants that avoid the limitations of warfarin (and may even be safer), more ...
*  Discovery and development of direct thrombin inhibitors
Given this broad action of thrombin it stands as a good drug target for anticoagulant drugs such as heparin, warfarin and DTIs ... Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood ... Vitamin K antagonists are the most commonly used oral anticoagulants today and warfarin was the 11th most prescribed drug in ... Since both heparin and warfarin have their downsides the search for alternative anticoagulants has been ongoing and DTIs are ...
*  Direct Xa inhibitor
Specific antidotes to reverse the anticoagulant activity of direct Xa inhibitors and other direct oral anticoagulants (DOACs) ... Direct factor Xa inhibitors ('xabans') are a class of anticoagulant drugs which act directly upon Factor X in the coagulation ... Siegal, D. M.; Cuker, A (2013). "Reversal of novel oral anticoagulants in patients with major bleeding". Journal of Thrombosis ... Soon after this, another naturally occurring inhibitor, tick anticoagulant peptide (TAP) was isolated from the extract of tick ...
*  Edoxaban
A number of anticoagulants inhibit the activity of Factor Xa. Unfractionated heparin (UFH), low molecular weight heparin (LMWH ... Edoxaban (DU-176b, trade names Savaysa, Lixiana) is an oral anticoagulant drug which acts as a direct factor Xa inhibitor. It ... United States of America: McGraw-Hill, 2009 Turpie AG (January 2008). "New oral anticoagulants in atrial fibrillation". ... other anticoagulants), in patients with a history of traumatic or repeated epidural or spinal punctures, a history of spinal ...