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*  Microwave thermotherapy
... to damage and kill cancer cells or to make cancer cells more sensitive to the effects of radiation and certain anticancer drugs ...
*  Ting-Chao Chou
The method has been applied in the combination of anti-cancer drugs, anti-HIV agents, drug-radiation, and traditional Chinese ... The DRI is a measure of how many folds the dose of each drug in a synergistic combination may be reduced, at a given effect ... Combosyn.com, free download). Entering a series of "dose (D) and effect (fa)" into computer for each drug alone and their ... The CI equations for three or more drug combinations have also been derived[3] and can be subjected to computer simulation.[4] ...
*  Hypodontia
... radiation, anticancer chemotherapeutic agents, allergy and toxic epidermal necrolysis after drug. Infectious causes of ... December 2009). "Impact of radiation and chemotherapy on risk of dental abnormalities: a report from the Childhood Cancer ... "Severe and Unrecognized Dental Abnormalities After Drug-Induced Epidermal Necrolysis". Arch Dermatol. 145 (11): 1332-1333. doi: ...
*  Paget's disease of the breast
Adjuvant therapy may also consist of anticancer drugs or hormone therapies. Hormonal therapy reduces the production of hormones ... They usually undergo radiation therapy after the actual procedure to prevent recurrence. A breast-conserving surgery consists ... In Paget's disease, the most common type of adjuvant therapy is radiation following breast-conservative surgery. ... and it is commonly used in cases of invasive cancer by means of drugs such as tamoxifen and anastrozole. The presence of three ...
*  University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
Research in new drug development and new anti-cancer drugs. Virtually every important drug in use in oncology today has been ... UM Radiation oncology physicists developed direct aperture optimization (DAO), an IMRT planning technique that dramatically ... The center actively participates in new drug development and conducts pilot studies and Phase I, II and III clinical trials. In ... UM Professor of pharmacology Angela H. Brodie, Ph.D., pioneered the development of a new class of breast cancer drugs, ...
*  Mitotic catastrophe
It can also be triggered by agents influencing the stability of microtubule spindles, various anticancer drugs and mitotic ... Mitotic catastrophe is the primary mechanism underlying reproductive cell death in cancer cells treated with ionizing radiation ... It has been observed following delayed DNA damage induced by ionizing radiation. ... "Delayed induction of DNA strand breaks following mitotic catastrophe occurring as a result of radiation G2 checkpoint ...
*  William A. Haseltine
Haseltine began to focus on improving chemotherapy by deepening the understanding of how drugs and radiation used to treat ... Many of the anti-cancer treatments kill the rapidly growing cancer cells by damaging DNA. The Haseltine lab was among the first ... A drug that inhibits the rev protein has been approved by the USA Food and Drug administration for treatment of HIV infection. ... Photoproducts Induced in a DNA by Ultraviolet Radiation". Journal of Radiation Biology. 50 (4): 641-648. doi:10.1080/ ...
*  Developmental toxicity
... drugs (e.g. anticancer drugs, tetracyclines, many hormones, thalidomide), and environmental chemicals (e.g. mercury, lead, ... There are a number of chemicals, biological agents (such as bacteria and viruses), and physical agents (such as radiation) used ... DES (diethylstilbestrol) is a drug that mimics estrogen, a female hormone. From 1938 until 1971 doctors prescribed this drug to ... Typical factors causing developmental toxicity are radiation, infections (e.g. rubella), maternal metabolic imbalances (e.g. ...
*  NAD(P)H dehydrogenase (quinone 1)
Vitamin K is used as radiation sensitizer or in mixtures with other chemotherapeutic drugs to treat several types of cancer. ... ROS generated in redox cycling contributes to anticancer activity of vitamin K. NQO1 competes with enzymes that redox cycle ... Dong GZ, Oh ET, Lee H, Park MT, Song CW, Park HJ (May 2010). "Beta-lapachone suppresses radiation-induced activation of nuclear ... Individuals with decreased NQO1 expression/activity have reduced p53 stability, which may lead to resistance to drugs such as ...
*  Cancer and nausea
Bowel obstruction and the resulting nausea may also occur as a result of anti-cancer therapy such as radiation, or adhesion ... This pathway has been postulated to be the mechanism by which some anti-cancer drugs such as cisplatin induce emesis. Toxic ... Anti emetic drugs are chosen according to previous effectiveness and side effects. Drugs that are used in the prophylaxis and ... radiation of the upper abdomen, half body irradiation and upper body irradiation Low risk: radiation of the cranium, spine, ...
*  Veliparib
... (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein ... Veliparib may make whole brain radiation treatment work more effectively against brain metastases from NSCLC. It has been shown ... It was derived from a prior lead compound (A 620223). The FDA awarded orphan drug status in November 2016 for NSCLC. As of 2017 ... Drug:+ABT-888 "A Study Evaluating Efficacy of ABT-888 in Combination With Temozolomide in Metastatic Melanoma" "ABT-888 and ...
*  Spindle checkpoint
Gautschi, O.; Heighway, J.; Mack, P. C.; Purnell, P. R.; Lara, P. N.; Gandara, D. R. (2008). "Aurora Kinases as Anticancer Drug ... Radiation Research. 41 (3): 516-37. doi:10.2307/3572841. JSTOR 3572841. PMID 5438206. Rieder, CL; Palazzo, RE (1992). "Colcemid ... Using drugs such as nocodazole and colchicine, the mitotic spindle disassembles and the cell cycle is blocked at the metaphase- ... Using these drugs (see the review from Rieder and Palazzo in 1992), the putative control mechanism was named Spindle Assembly ...
*  Cancer research
Radiation therapy took hold in the 1900s. Chemotherapeutics were developed and refined throughout the 20th century. The U.S. ... Emerging topics of cancer treatment research include: Anti-cancer vaccines Oncophage Sipuleucel-T (Provenge) is a prostate ... cancer vaccine Newer forms of chemotherapy Gene therapy Photodynamic therapy Radiation therapy Reoviridae (Reolysin drug ... These applications include surgery, radiation therapy, chemotherapy, hormone therapy, immunotherapy and combined treatment ...
*  Ibritumomab tiuxetan
"Antibody-targeted radiation cancer therapy". Nat Rev Drug Discov. 3 (6): 488-499. doi:10.1038/nrd1413. ISSN 1474-1776. PMID ... Expert Review of Anticancer Therapy. 2 (5): 485-493. doi:10.1586/14737140.2.5.485. ISSN 1473-7140. Schaefer, N. G.; Huang, P.; ... ibritumomab tiuxetan was the first radioimmunotherapy drug approved by the Food and Drug Administration (FDA) in 2002 to treat ... The drug uses the monoclonal mouse IgG1 antibody ibritumomab (pronounced as ) in conjunction with the chelator tiuxetan, to ...
*  Wendy Mesley
... anti-cancer drug Herceptin. That same month her documentary "Chasing the Cancer Answer" was aired, and generally well received ... After undergoing treatment, including two lumpectomies, chemotherapy and radiation, Mesley returned to the CBC full-time in ...
*  DNA repair protein XRCC4
"The role of XRCC4 in carcinogenesis and anticancer drug discovery". Recent Pat Anticancer Drug Discov. 3 (3): 209-19. doi: ... One of these include ionizing radiation, such as γ radiation and X-rays, which ionize the deoxyribose groups in the DNA ... "DNA repair enzymes are correctives for DNA damage induced by carcinogens and anticancer drugs", it should not be surprising ... "they may serve as candidate targets for personalized anticancer drugs". The possibility of detecting endometriosis on this ...
*  Kanagawa Cancer Center
Project Hypoxia Biology Research Project Epigenetics Research Progect Drug Molucular Design Research Project Anticancer Drug ... In 2015, I-ROCK (Ion-beam Radiation Oncology Center in Kanagawa) in the Cancer Center will be open as a new Heavy-ion treatment ... Head and Neck Oncology Neurosurgery Plastic and Reconstructive Surgery Dermatology Diagnostic Radiology Pathology Radiation ...
*  Hydroxycarbamide
Similar to other antimetabolite anti-cancer drugs, it acts by disrupting the DNA replication process of dividing cancer cells ... This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering ... "Hydroxycarbamide". International Drug Price Indicator Guide. Retrieved 8 December 2016. Hamilton, Richart (2015). Tarascon ... may take 7-21 days to recover after the drug has been discontinued), alopecia (hair loss), skin changes, abnormal liver enzymes ...
*  Mir-503 microRNA precursor family
"Effect of YB-1 on the regulation of micro RNA expression in drug-sensitive and drug-resistant gastric carcinoma cells". ... "MicroRNA expression after ionizing radiation in human endothelial cells". Radiation Oncology. 5: 25. doi:10.1186/1748-717X-5-25 ... Anticancer research. 30 (2): 629-633. PMID 20332481. Ahn, H. W.; Morin, R. D.; Zhao, H.; Harris, R. A.; Coarfa, C.; Chen, Z. -J ... Radiation Oncology. 7: 38. doi:10.1186/1748-717X-7-38. PMC 3325872 . PMID 22429276. Lu, Y. -C.; Chen, Y. -J.; Wang, H. -M.; ...
*  Germinal center B-cell like diffuse large B-cell lymphoma
They can be administered alone or be linked (conjugated) to anticancer drugs, radioisotopes, or other biologic response ... Delivers chemotherapy or radiation in a targeted manner which allows higher concentrations to be administered Monoclonal ... Reduced susceptibility to apoptosis increases the resistance of cancer cells to radiation and cytotoxic agents. B-cell lymphoma ... A synthetic retinoid that induces apoptosis of cancer cells and acts synergistically with chemotherapeutic drugs by triggering ...
*  Pemetrexed
Avendano, Carmen; Menendez, J. Carlos (April 2008). Medicinal Chemistry of Anticancer Drugs. Amsterdam: Elsevier. p. 37. ISBN 0 ... "Oral Complications of Chemotherapy and Head/Neck Radiation". Cancer Topics - Coping with Cancer. National Cancer Institute. ... In addition to the brand name Alimta, this drug is also marketed in India by Abbott Healthcare as Pleumet and by Cadila ... Pemetrexed (brand name Alimta) is a chemotherapy drug manufactured and marketed by Eli Lilly and Company. Its indications are ...
*  Christie NHS Foundation Trust
... childhood cancers and anti-cancer drug treatment methods.[citation needed] After Ralston Paterson's retirement in 1963, ... and went on to build a world recognised centre for the treatment of cancer by radiation. Among the team was his wife Edith ...
*  Kadmon Corporation
As of December 2012 Kadmon was developing a drug for gastric cancer As of 2012 Kadmon produces four drugs approved by the Food ... XL844 is an inhibitor of protein kinases Chk1 and Chk2 and may increase the sensitivity of cancer cells to radiation therapy. ... Preclinical studies have shown it to enhance the therapeutic activity of several anticancer agents. In 2014 KD018 was in a ... SLx-2101 (KD027) is a phosphodiesterase 5 (PDE5) inhibitor, a class of drug used in the treatment of erectile dysfunction. In ...
*  Timeline of cancer treatment development
... hormonal therapy drug 1961 - Vincristine, anti-cancer alkoloid, isolated from the Madagascar periwinkle plant 1962 - US FDA ... Ewing, who was a fanatical supporter of radiation therapy for cancer. This rivalry and opposition to Dr. Coley leads to the ... Ravina, Enrique (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: ... Anti-Cancer Drugs. 27 (4): 269-77. doi:10.1097/CAD.0000000000000337. PMC 4777220 . PMID 26813865. Gian F. Baronzio (2006). " ...
*  Leukemia
Compared to most anti-cancer drugs, it has relatively few side effects and can be taken orally at home. With this drug, more ... Standard prophylaxis may include radiation of the head and/or drugs delivered directly into the spine. Maintenance treatments ... Many different anti-cancer drugs are effective for the treatment of AML. Treatments vary somewhat according to the age of the ... High-risk patients receive higher drug doses of these drugs, plus additional drugs. CNS prophylaxis (preventive therapy) to ...
*  Cell cycle
... in cancer therapy as the DNA is relatively exposed during cell division and hence susceptible to damage by drugs or radiation. ... ISBN 0-12-324719-5. Presentation on CDC25 PHOSPHATASES: A Potential Target for Novel Anticancer Agents Pramila T, Wu W, Miles S ... p21 is activated by p53 (which, in turn, is triggered by DNA damage e.g. due to radiation). p27 is activated by Transforming ... Sulfhydryls are natural substances that protect cells from radiation damage and tend to be at their highest levels in S and at ...