Of 99 human blood samples tested, 6.1% had neutralizing antibodies. As part of a 1954 outbreak investigation of jaundice ... Rathore AP, Saron WA, Lim T, Jahan N, St John AL (February 2019). "Maternal immunity and antibodies to dengue virus promote ... May 2016). "Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody". Cell ... West Africa for the last two decades when blood samples collected between 1992 and 2016 were tested for the ZIKV IgM antibodies ...

... research shows that immunization with adenylate cyclase toxin elicits neutralizing antibodies. Neutralizing antibodies can ... Adenylate cyclase toxin based constructs have been proven to elicit the production of neutralizing antibodies, but lack the ... Antibodies against adenylate cyclase toxin are also present in the serum of humans infected with B. pertussis. ...

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Individuals with psoriasis may develop neutralizing antibodies against monoclonal antibodies. Neutralization occurs when an ... The lack of neutralizing antibodies against etanercept is probably secondary to the innate presence of the TNF-α receptor, and ... Neutralizing antibodies have not been reported against etanercept, a biologic medication that is a fusion protein composed of ... Several monoclonal antibodies target cytokines, the molecules that cells use to send inflammatory signals to each other. TNF-α ...

These mannose residues are the target for broadly neutralizing antibodies. Recombinant proteins produced in yeast may be ... "Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies". Nature ... Crispin, Max; Doores, Katie J (2015-04-01). "Targeting host-derived glycans on enveloped viruses for antibody-based vaccine ... "Mannose addition by yeast Pichia pastoris on recombinant HER-2 protein inhibits recognition by the monoclonal antibody ...

The first neutralizing antibodies were identified in 1993, via experimentation. It was found that the flu neutralizing ... One approach is to use broadly neutralizing antibodies that, unlike the annual seasonal vaccines used over the first decades of ... The highly conserved M2 proton channel was proposed as a potential target for broadly neutralizing antibodies. The challenges ... Cho A, Wrammert J (April 2016). "Implications of broadly neutralizing antibodies in the development of a universal influenza ...

"Engineering antibody therapeutics : approaches to neutralizing bacterial toxins , WorldCat.org". www.worldcat.org. Retrieved ... She moved to the University of Texas at Austin for doctoral research, where she studied antibody therapeutics. She then ... Maynard J; Georgiou G (1 January 2000). "Antibody engineering". Annual Review of Biomedical Engineering. 2: 339-376. doi: ... Maynard created an antibody that can neutralize the anthrax toxin, which was developed by Elusys Therapeutics as Anthim ( ...

Human cytomegalovirus neutralizing antibodies and use thereof (WO2008084410) Neutralizing anti-influenza virus antibodies and ... 2011). "A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins". ... 2022). "Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift". Nature. 602 (7898): 664-670. "Laureate ... 2016). "Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody". Science. 351 (6279): ...

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"Coronavirus (COVID-19) Update: FDA Authorizes First Test that Detects Neutralizing Antibodies from Recent or Prior SARS-CoV-2 ... "Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors". New England Journal of Medicine. 385 (15 ... "The Promise of Antibody Treatments for Covid-19". Wired. May 22, 2020. Archived from the original on May 16, 2023. Wired.com. ... Dawn Furnas (May 26, 2022). "GenScript, fellow NJ biotech partner on COVID-19 antibody test distribution". NJBIZ. Archived from ...

... have been shown to be unable to elicit production of virus neutralizing antibodies. The epitopes which bind neutralizing ... Additionally, a monoclonal antibody with neutralizing functionality has been demonstrated to target antigenic site I. Other ... Upon viral entry into the body and also after vaccination, the body produces virus neutralizing antibodies which bind and ... Apr 2005). "Novel rabies virus-neutralizing epitope recognized by human monoclonal antibody: fine mapping and escape mutant ...

Potential broadly neutralizing antibodies have been cloned in the laboratory (monoclonal antibodies) and are being tested in ... April 1999). "Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo". Immunity. 10 ... December 2021). "A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of ... However, the well-proven route of trying to induce neutralizing antibodies by vaccination has stalled because of the great ...

Kwong, Peter D.; Mascola, John R.; Nabel, Gary J. (September 2013). "Broadly neutralizing antibodies and the search for an HIV- ... His research demonstrated the importance of neutralizing antibodies in protection against HIV and helped explain the reason ... "Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition". The New England Journal of Medicine. 384 (11): ... "Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing". Science. 333 (6049): 1593-1602 ...

23 December 2021). "Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies". Nature. doi:10.1038/d41586- ... The SARS-CoV-2 Omicron variant escaped the majority of existing SARS-CoV-2 neutralizing antibodies, including of sera from ... "Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2". Nature. 602 (7898): 676-681. doi:10.1038/d41586-021 ... rapid antibody or drug development, development platforms, and quick drug repurposing and medication provisioning may also be ...

"Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals". Nature Medicine. 24 ... Oligoclonal antibodies are an emerging immunological treatment relying on the combinatory use of several monoclonal antibodies ... Monoclonal antibody Polyclonal antibodies Immunotherapy Corti, Davide; Kearns, Jeffrey D (23 March 2016). "Promises and ... anti-PD1 antibody) and ipilimumab (anti-CTLA-4 antibody). It is used to treat melanomas, low-risk renal cancer and colorectal ...

However, these antibodies are incapable of neutralizing other serotypes upon reinfection and actually increase viral ... Unfortunately, D7 proteins provoke immune responses, which raise anti-D7 antibody levels. These antibodies inhibit the function ... "Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins". Nature Structural & ... "Direct and indirect interactions in the recognition between a cross-neutralizing antibody and the four serotypes of dengue ...

COVID19 vaccine and neutralizing antibody drugs for SARS-CoV-2 variants and Early cancer diagnosis. 2017: Qiu Shi Outstanding ... "Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients ... "Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies". Nature. Springer Science and Business Media LLC. ... "Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants". ...

... and neutralising antibody activity is retained by some monoclonal antibodies. PCR tests continue to detect the Omicron variant ... Decreased susceptibility to neutralising antibodies, either therapeutic (e.g., convalescent plasma or monoclonal antibodies) or ... B.1.1.7 with E484K assumed to only differ from B.1.1.7 on neutralising antibody activity. 23 November 2020 - 31 January 2021, ... Monoclonal and serum-derived antibodies are reported to be from 10 to 60 times less effective in neutralising virus bearing the ...

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"Quantification of Lyssavirus-Neutralizing Antibodies Using Vesicular Stomatitis Virus Pseudotype Particles". Viruses. 8 (9): ... When the blood drawn from the animal is mixed with the pseudovirus, the protective antibodies bind and neutralize the ...

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Goo L, Chohan V, Nduati R, Overbaugh J. Early development of broad neutralizing antibodies in HIV-1 infected infants. Nat Med. ... Simonich CA, Williams KL, Verkerke HP, Williams JA, Nduati R, Lee KK and Overbaugh J. HIV-1 neutralizing antibodies with ... An antigenic atlas of HIV-1 escape from broadly neutralizing antibodies. Immunity. 50(2): 520-532.e3, 2019. Diab, A. (May 18, ... Comprehensive Mapping of HIV-1 Escape from Broadly Neutralizing Antibody. Cell Host Microbe. 21(6): 777-787, 2017. Dingens AS, ...

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2] [3] A small study of 12 samples published in the nature communications journal showed that the neutralising antibody ... 20 October 2020). "Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants". eLife. 9. doi:10.7554/eLife.61312 ... from a monoclonal antibody with the capability of neutralizing the spike protein variants of SARS-CoV-2. This suggests that ... "associated with escape from neutralising antibodies" which could adversely affect the efficacy of spike protein-dependent COVID ...

GMT of neutralizing antibody in placebo group was 10 (half of lower limit of detection). We found the neutralizing antibody ... Neutralizing antibody, assessed by PRNT50, was expressed as GMT. A number of serum samples from vaccine and placebo groups at ... Accordingly, the neutralizing antibody titer of the Nanocovax injection group was 2 times higher than that of the recovered ... GMT of neutralizing antibody on the Wuhan, Alpha and Delta were 57, 36.2 and 29.6, respectively. Meanwhile, ...

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12 October 2020). "SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies". Nature. doi:10.1038/S41586-020- ... He defined an antibody classification system to determine where on the receptor binding domain that the antibody attaches. ... These antibodies target the N-terminal domain. He is interested in identifying antibodies that can attack all coronaviruses.[ ... "Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies". Cell. ...

HIV-1 envelope glycoprotein contains at least four sites for neutralizing antibodies. Among these sites, the membrane-proximal ... These antibodies are usually picked up in young women with recurrent spontaneous abortions. In anti-cardiolipin-mediated ... Hokama Y, Campora CE, Hara C, Kuribayashi T, Le Huynh D, Yabusaki K. Anticardiolipin antibodies in the sera of patients with ... Anti-cardiolipin antibodies can also be increased in numerous other conditions, including systemic lupus erythematosus, malaria ...

Ø serves as a primary target of neutralizing antibodies in the body. After binding to its target on the host cell surface (its ... This involved monthly administration of RSV-neutralizing antibodies (or immunoglobins) from human donors recovering from the ... Studies of human antibodies in infants and children revealed that the infection was common in early life. The virus was later ... RSV-IVIG has since been replaced with the use of a monoclonal antibody (MAb) that can be delivered through muscular injection. ...