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*  Neutralizing antibody
The difference between neutralizing antibodies and binding antibodies is that neutralizing antibodies neutralize the biological ... A neutralizing antibody (NAb) is an antibody that defends a cell from an antigen or infectious body by neutralizing any effect ... are commonly targeted by neutralizing antibodies. A few examples are Rebif, Betaseron and Avonex. Blocking antibody Mike Recher ... Neutralizing antibodies have shown potential in the treatment of retroviral infections. Medical professionals and researchers ...
*  Broadly neutralizing HIV-1 antibodies
... (bNAbs) are neutralizing antibodies which neutralize multiple HIV-1 viral strains. bNAbs ... Database of Broadly Neutralizing HIV-1 Antibodies (bNAbs) LANL Antibody Database. ... database of broadly neutralizing HIV antibodies. Nucleic Acids Research Database issue Volume 42 Issue D1 1 January 2014 PubMed ... Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature, 458, 636. ...
*  Scripps Research Institute
"IAVIs Neutralizing Antibody Center". scripps.edu. 6 March 2015. "Pearson Center for Alcoholism and Addiction Research". ... Center for Regenerative Medicine Dorris Neuroscience Center Molecular Screening Center IAVI's Neutralizing Antibody Center at ...
*  Barton Haynes
... the isolation of rare broad neutralizing HIV antibodies and their ancestor antibodies; and 8) the development of a new strategy ... He led the group that deciphered the maturation pathways of several types of broadly neutralizing antibodies that point the way ... Host controls of HIV neutralizing antibodies". Science. 344 (6184): 588-589. doi:10.1126/science.1254990. PMC 4162091 . PMID ... the discovery of host tolerance mechanisms that limit the induction of broad neutralizing antibodies in HIV-1 infection; 3) the ...
*  Gp41
"HIV broadly neutralizing antibody targets". Current Opinion in HIV and AIDS. 10 (3): 135-143. doi:10.1097/coh.0000000000000153 ... The fusion peptide on the N-terminus of the gp41 is also a potential target because it contains neutralizing antibody epitopes ... "Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody". Science. 352 (6287): 828-833. doi:10.1126/science ... The structure is cage-like with a hollow center that inhibits antibody access. While gp120 sits on the surface of the viral ...
*  Ricin
"Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned". University of Texas ... Because ricin is a protein, it can be linked to a monoclonal antibody to target cancerous cells recognized by the antibody. The ... Another antidote developed by the U.S. military has been shown to be safe and effective in lab mice injected with antibody-rich ... probably due to his body's production of antibodies. When a ricin-laced pellet was removed from the small of his back it was ...
*  Henipavirus
Both vaccines have been shown[who?] to induce strong neutralizing antibodies in different laboratory animals. Trials began in ... we identified virus replication and generation of neutralizing antibodies, but no clinical disease was observed. As such, this ... Antibodies to Cedar virus were shown to cross react with, but not cross neutralize Hendra or Nipah virus. Despite this close ... On 26 July 2011 a dog living on the Mt Alford property was reported to have HeV antibodies, the first time an animal other than ...
*  2015-16 Zika virus epidemic
The PRINT test looks for viral-specific neutralizing antibodies. However, this test can still produce false positive results, ... A test for IgM antibodies has seen to be effective over longer periods of time, as these antibodies can be present starting 4 ... The methods currently available to test for Zika antibodies cross-react with dengue antibodies. An IgM-positive result in a ... However, it is suggested that a PRINT test be performed following a test for IgM antibodies to help eliminate false positives ...
*  Canakinumab
... a human monoclonal antibody neutralizing IL-1β". MAbs. 7 (6): 1151-60. doi:10.1080/19420862.2015.1081323. PMC 4966334 . PMID ... Canakinumab (INN, trade name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta. It has ...
*  Psoriasis
Individuals with psoriasis may develop neutralizing antibodies against monoclonal antibodies. Neutralization occurs when an ... The lack of neutralizing antibodies against etanercept is probably secondary to the innate presence of the TNF-α receptor, and ... Neutralizing antibodies have not been reported against etanercept, a biologic drug that is a fusion protein composed of two TNF ... Several monoclonal antibodies target cytokines, the molecules that cells use to send inflammatory signals to each other. TNF-α ...
*  Mannose
These mannose residues are the target for broadly neutralizing antibodies. Recombinant proteins produced in yeast may be ... "Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies". Nature ... Crispin, Max; Doores, Katie J (2015-04-01). "Targeting host-derived glycans on enveloped viruses for antibody-based vaccine ... "Mannose addition by yeast Pichia Pastoris on recombinant HER-2 protein inhibits recognition by the monoclonal antibody ...
*  Enterovirus E
Smyth, M. S.; Trudgett, A.; Hoey, E. M.; Martin, S. J.; Brown, F. (1992). "Characterization of neutralizing antibodies to ... "Chemically synthesized peptides elicit neutralizing antibody to bovine enterovirus". The Journal of General Virology. 71 (1): ... Electron microscopy, PCR, complement fixation, antibody fluorescence, neutralization test, and haemagglutination can be used to ...
*  Rabies virus
... have been shown to be unable to elicit production of virus neutralizing antibodies. The epitopes which bind neutralizing ... Additionally, a monoclonal antibody with neutralizing functionality has been demonstrated to target antigenic site I. Other ... Upon viral entry into the body and also after vaccination, the body produces virus neutralizing antibodies which bind and ... Apr 2005). "Novel rabies virus-neutralizing epitope recognized by human monoclonal antibody: fine mapping and escape mutant ...
*  Orungo virus
Tomori O, Fabiyi A (Sep 1976). "Neutralizing antibodies to Orungo virus in man and animals in Nigeria". Tropical and ... Antibodies to the virus have been found in humans, monkeys, sheep, and cattle. "Virus Taxonomy: 2011 Release". International ...
*  Bovine papillomavirus
Protection appears to be mediated via type-specific neutralising antibodies. Vaccination of calves as early as 4-6 weeks might ...
*  2F5 antibody
2F5 is a broadly neutralizing human monoclonal antibody (mAb) that has been shown to bind to and neutralize HIV-1 in vitro, ... 2F5 is not the only HIV-1-neutralizing antibody found; however, it is the broadest and prevents viral infection when ... A major goal recently in HIV-1 vaccinations is eliciting the broadly neutralizing antibodies before the virus is actually ... Stiegler, G. (2003-04-01). "Therapeutic potential of neutralizing antibodies in the treatment of HIV-1 infection". Journal of ...
*  Antonio Lanzavecchia
Neutralizing antibodies were isolated against SARS, cytomegalovirus, avian influenza and dengue virus. Unusually potent ... Human monoclonal antibodies and vaccine design: Taking advantage of his studies on human memory B cells (16), Lanazvecchia ... issues on the role of somatic mutations and the pathways leading to the development of broadly neutralizing antibodies and ... These fully human monoclonal antibodies can be used not only as drugs for prophylaxis and therapy of infectious diseases, but ...
*  Cardiolipin
HIV-1 envelope glycoprotein contains at least four sites for neutralizing antibodies. Among these sites, the membrane-proximal ... These antibodies are usually picked up in young women with recurrent spontaneous abortions. In anti-cardiolipin-mediated ... Hokama Y, Campora CE, Hara C, Kuribayashi T, Le Huynh D, Yabusaki K. Anticardiolipin antibodies in the sera of patients with ... Anti-cardiolipin antibodies can also be increased in numerous other conditions, including systemic lupus erythematosus, malaria ...
*  Carlumab
"Structural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888". Molecular Immunology. 51 (2): 227-233. doi: ... Carlumab (alternate identifier CNTO 888) is a discontinued human recombinant monoclonal antibody (type IgG1 kappa) that targets ... a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors". Cancer Chemotherapy and Pharmacology ... a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer". ...
*  Zika fever
Smithburn, K. C.; Kerr, J. A.; Gatne, P. B. (1 April 1954). "Neutralizing antibodies against certain viruses in the sera of ... Later on, serology for the detection of specific IgM and IgG antibodies to Zika virus can be used. IgM antibodies can be ... Surveys have found antibodies to Zika in healthy people in India which could indicate past exposure, though it could also be ... This means that not only can the virus cross the placental barrier, but also the antibodies produced by the mother can reach ...
*  Multiple sclerosis drug pipeline
Interferon injections can induce neutralising antibodies against them, turning the medication ineffective. IFN-β 1b is more ... Natalizumab can also induce neutralising antibodies 4 to 6 months after treatment initiation. Fetuin-A (alpha-2-HS-glycoprotein ... Human anti-chimeric antibodies (HACA) appear in patients treated with Rituximab. MTX reduces them. A safety analysis of RA ... other anti-CD20 monoclonal antibody, also in phase II for MS, and phase III for others autoimmune diseases Stem cell ...
*  Fresolimumab
"A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions". Proceedings of the National Academy of ... Fresolimumab (GC1008) is a human monoclonal antibody and an immunomodulator. It is intended for the treatment of idiopathic ... Fresolimumab was discovered by Cambridge Antibody Technology (CAT) scientists and was one of a pair of candidate drugs that ...
*  Interferon beta-1a
One of the factors related to non-respondance is the presence of high levels of interferon beta neutralizing antibodies. ... Interferon therapy, and specially interferon beta 1b, induces the production of neutralizing antibodies, usually in the second ... Giovannoni G, Munschauer FE, Deisenhammer F (November 2002). "Neutralising antibodies to interferon beta during the treatment ...
*  Anakinra
... production of antibodies with neutralizing activity. Blood and blood forming organs : Frequently, decrease in neutrophil counts ... A meeting of experts on Schnitzler's syndrome concluded that "Interleukin-1-neutralizing agents such as anakinra are clearly ...
*  DKK1
Neutralizing antibody against DKK-1 reversed DHT effects on outer root sheath keratinocytes. DKK-1 expression is attenuated by ...
*  Phage display
"In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden ... Antibody phage display was later used by Carlos F. Barbas at The Scripps Research Institute to create synthetic human antibody ... HUMIRA, an antibody to TNF alpha, was the world's first fully human antibody, which achieved annual sales exceeding $1bn. Below ... The invention of antibody phage display revolutionised antibody drug discovery. Initial work was done by laboratories at the ...