The company also advanced other clinical-stage products, including Nimotuzumab, an EGFR-targeting monoclonal antibody, and ... which have been implicated in a number of hematological and immune cell disorders including myeloproliferative neoplasms and ... YM BioSciences' principal medicine of interest was a monoclonal antibody - Nimotuzumab - targeting the epidermal growth factor ...
Monoclonal antibodies e.g. rituximab (anti-CD20) and eculizumab (anti-C5) have been used but the therapeutic benefits are ... as well as hematological malignancies including non-Hodgkin lymphoma and myeloproliferative neoplasms. The exact pathogenesis ... As a weak, biphasic antibody, it absorbs to the P antigen in the cold temperature as in the periphery in the primary phase, and ... Autoimmune hemolytic anemia Warm-antibody type Primary Secondary (lymphoproliferative disorders, autoimmune disorders): 259 ...
All women generated antibodies against hCG, but only 119 (80%) generated antibody titers clearly above 50 ng/mL, which was the ... hCG was discovered to be expressed in certain kinds of malignant neoplasms, including breast cancer, adenocarcinoma of the ... In passive immunity the desired antibody titers are achieved by injecting antibodies directly into an animal. The efficacy of ... anti-sperm antibodies are not likely to have adverse health effects, since anti-sperm antibodies are produced by up to 70% of ...
Autoimmune conditions such as anti-p62 antibodies, which inhibit p62 complexes have links to primary biliary cirrhosis which ... is commonly found in precancerous dysplasias and malignant neoplasms. Nucleoporin protein aladin is a component of the nuclear ... "Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a ...
... (T-ALL) is a type of acute lymphoblastic leukemia with aggressive malignant neoplasm of the ... where the first protects the body against viruses and bacteria through antibody production which can directly destroy target ... T-ALL is a precursor for lymphoid neoplasm. Its clinical presentation most commonly includes infiltration of the central ...
Anti-CD74 antibody-doxorubicin conjugate, IMMU-110, in a human multiple myeloma xenograft and in monkeys. P. Sapra, R. Stein, J ... September 2007). "CD74: a new candidate target for the immunotherapy of B-cell neoplasms". Clinical Cancer Research. 13 (18 Pt ... hLL1-Dox Milatuzumab has been linked to doxorubicin to form an antibody-drug conjugate or ADC (known as hLL1-Dox or IMMU-110) ... The drug is the first anti-CD74 antibody that has entered into human testing and is currently being studied for the treatment ...
... binds to antibodies in certain area of systemic lupus and Sjögren patients that contain anti-Ro/SSA antibodies. ... which makes CALR mutations the second most common in myeloproliferative neoplasms. All mutations (insertions or deletions) ... Hence antibodies that block CD47 might be useful as a cancer treatment. In mice models of myeloid leukemia and non-Hodgkin ... "Congenital heart block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases". The Journal of ...
Myotonic dystrophy N segment N-end rule Narrow heritability Natural selection Negative control Neo-Darwinism Neomorph Neoplasm ... Anagenesis Anaphase Aneuploid Aneuploid cell Aneuploidy Angelman syndrome Angiosperm Animal model Annealing Annotation Antibody ... Molecular farming Molecular genetics Molecular imprinting Molecular medicine Molecule Monocistronic mRNA Monoclonal antibody ...
Articles with short description, Short description is different from Wikidata, Epidermal nevi, neoplasms, and cysts, Conditions ... a monoclonal antibody that neutralizes tumor necrosis factor alpha). Both of these individuals showed slowly developing, modest ... Trichofolliculoma Spiradenoma spiradenocarcinoma List of cutaneous conditions List of cutaneous neoplasms associated with ... "Treatment of multiple familial trichoepitheliomas with a combination of aspirin and a neutralizing antibody to tumor necrosis ...
... antibodies, neoplasm MeSH D12.776.377.715.548.114.248 - antibodies, phospho-specific MeSH D12.776.377.715.548.114.252 - ... antibodies MeSH D12.776.377.715.548.114.071 - antibodies, anti-idiotypic MeSH D12.776.377.715.548.114.107 - antibodies, ... antibodies, bispecific MeSH D12.776.377.715.548.114.143 - antibodies, blocking MeSH D12.776.377.715.548.114.167 - antibodies, ... antibodies, helminth MeSH D12.776.377.715.548.114.191 - antibodies, heterophile MeSH D12.776.377.715.548.114.224 - antibodies, ...
... the posited mechanism being that anti-CD20 antibodies rendered the T cell antibodies dysfunctional and therefore powerless to ... Because CD20 remains present on the cells of most B-cell neoplasms, and is absent on otherwise similar appearing T-cell ... Antibody FMC7 (Flinders Medical Centre) appears to recognise a conformational variant of CD20 also known as the FMC7 antigen. ... Additional anti-CD20 antibody therapeutics under development (phase II or III clinical trials in 2008) include : Obinutuzumab ...
... neoplasm protein - Nernst equation - nerve - nerve growth factor - nerve growth factor receptor - nerve tissue protein - nerve ... antibody - apoenzyme - apolipoprotein - apoptosis - aquaporin - archaea - arginine - argipressin - aromatic amine - aromatic ... monoclonal antibody - monomer - monosaccharide - monosaccharide transport protein - morphogenesis - morphogenetic field - mos ...
"TMEM229B Gene - GeneCards , T229B Protein T229B Antibody". GeneCards V3 - Human Genes , Gene Database. Retrieved 2011-04-19. " ... B-cell neoplasm, breast carcinoma, Burkitt's lymphoma, colorectal adenocarcinoma, carcinoma, cutaneous T cell lymphoma, ...
Rous, Peyton; Kidd, John G. (1941). "Conditional Neoplasms and Subthreshold Neoplastic States". Journal of Experimental ... "Structural Changes Produced in Brown-Pearce Carcinoma Cells by Means of a Specific Antibody and Complement". Journal of ...
Antibody assays are commonly used to detect presence of antibodies against individual viruses. Competition assays are ... Stewart SE, Eddy BE, Borgese N (June 1958). "Neoplasms in mice inoculated with a tumor agent carried in tissue culture". ... Antibodies to the monkey lymphotropic polyomavirus have been detected in humans suggesting that this virus - or a closely ... The viral load as before is also measure by PCR.[citation needed] Tissue staining using a monoclonal antibody against MCV T ...
Dysfunctions of the levators may occur as a result of autoimmune antibodies attacking and eliminating the neurotransmitter. ... Other causes of ptosis include eyelid neoplasms, neurofibromas or cicatrization after inflammation or surgery. Mild ptosis may ...
The receptor's binding moiety is composed of a membrane-bound antibody that, like all antibodies, has two identical paratopes ... B cell receptor signalling is currently a therapeutic target in various lymphoid neoplasms. It has been shown that BCR ... In structure, the BCR for antigens are almost identical to secreted antibodies. However, there is a distinctive structural ... Merlo, Lauren M. F.; Mandik-Nayak, Laura (2013). Cancer Immunotherapy: Chapter 3-Adaptive Immunity: B Cells and Antibodies. ...
... lymphoid neoplasms, or features of both types of neoplasms. Most commonly, the present with features of myeloid neoplasms with ... Gotlib J (2015). "Tyrosine Kinase Inhibitors and Therapeutic Antibodies in Advanced Eosinophilic Disorders and Systemic ... Like the latter neoplasm, hematologic neoplasms cause by ETV6-JAK2 and BCR-JAK2 are aggressive and progress rapidly. Too few ... A classic example of such a disease is chronic myelogenous leukemia, a neoplasm commonly caused by a mutation that creates the ...
The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 ... cytokeratin 5/6 antibodies that detect two markers of myoepithelial cells, cytokeratin 5 and keratin 6A); 3) the presence of a ... Brogi E, Krystel-Whittemore M (January 2021). "Papillary neoplasms of the breast including upgrade rates and management of ... Tay TK, Tan PH (June 2021). "Papillary neoplasms of the breast-reviewing the spectrum". Modern Pathology. 34 (6): 1044-1061. ...
... myeloproliferative neoplasms, multiple myeloma, and lymphoma. The goal of this activity is to improve the knowledge and ... including but not limited to CAR-T therapy and T-cell redirecting bispecific antibodies. Expert faculty will aim to place the ...
Currently antibodies to lipids and peptides in sera, detected by microarrays, can be used as markers of the pathological ... They look like intracranial neoplasms, and sometimes they get biopsied as suspected tumors. Proton MR spectroscopy can help in ... BBB is a tight vascular barrier between the blood and brain that should prevent the passage of antibodies through it, but in MS ... 2015). "Histopathology and clinical course of MOG-antibody-associated encephalomyelitis". Annals of Clinical and Translational ...
During the last several years, myeloproliferative neoplasms (MPNs) have emerged as a leading systemic cause of splanchnic vein ... or antiphospholipid antibody syndrome) is another common cause. Nearly one-third of patients have a myeloproliferative disorder ...
CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed. In humans, the gene is located on the ... About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia and mantle cell ... Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (1 December 2002). "Section 1 - Antibodies (CD 5)". Manual of ... Diagnostic Antibodies for Immunohistology (Second ed.). Greenwich Medical Media. pp. 67-69. ISBN 978-1841101002. OCLC 51439459 ...
... monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide". Cancer Research. 61 (21): 7846-54. ... TGF beta can act as a tumor suppressor in the premalignant stage of the benign neoplasm by inhibiting its growth and inducing ... TRC105 is an experimental antibody targeted at endoglin as an anti-angiogenesis treatment for soft-tissue sarcoma. Cluster of ... "ENG Gene - , EGLN Protein , EGLN Antibody". GeneCards. Fernández-Ruiz E, St-Jacques S, Bellón T, Letarte M, Bernabéu C (1993 ...
One patient with ETV6-FLT3-related myeloid/lymphoid neoplasm obtained a short term remission on sunitinib and following relapse ... Gotlib J (December 2015). "Tyrosine Kinase Inhibitors and Therapeutic Antibodies in Advanced Eosinophilic Disorders and ... Reiter A, Gotlib J (February 2017). "Myeloid neoplasms with eosinophilia". Blood. 129 (6): 704-714. doi:10.1182/blood-2016-10- ... myeloproliferative neoplasm (MPN), and acute myeloid leukemia (AML). The presence of ETV6 gene mutations in myelodysplastic ...
SeV antibodies that cross-reactive with HPIV-1 antibodies are present in most people, however, majority of people do not have ... Its expression is also increased in a wide range of other malignant neoplasms. Factor X (F10) is frequently expressed in normal ... Instead, it can be measured using anti-glycan antibodies, and despite the large collection of such antibodies in a community ... and from antibodies-online.com (No. ABIN6737444) . Monoclonal antibodies (IgG1) to F-protein are available from Kerafast ( ...
... antibody affinity MeSH G04.610.143.140 - antigenic modulation MeSH G04.610.143.232 - binding sites, antibody MeSH G04.610. ... neoplasm regression, spontaneous MeSH G04.335.119.260 - erythrocyte aging MeSH G04.335.122.100 - autocrine communication MeSH ... antibody-dependent cell cytotoxicity MeSH G04.610.270.500 - macrophage activation MeSH G04.610.484.100 - clonal anergy MeSH ... antibody diversity MeSH G04.610.626.073 - antigenic variation MeSH G04.610.626.320 - gene rearrangement, b-lymphocyte MeSH ...
However, the presence of both the CD79a and CD79b ITAM tyrosines were required for normal T cell dependent antibody responses. ... and is also present in virtually all B-cell neoplasms, including B-cell lymphomas, plasmacytomas, and myelomas. It is also ...
Antibodies may be used to determine the expression of protein markers on the surface of cancer cells. Often the expression of ... The remaining 10 percent are either poorly or undifferentiated malignant neoplasms (5%), or squamous cell carcinomas (5%). ...
... electron microscopic and fluorescent antibody studies". The Journal of Investigative Dermatology. 65 (3): 324-30. doi:10.1111/ ... neoplasms, and cysts, Defects in innate immunity). ...