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*  Monoclonal antibody therapy
Initial research on malignant neoplasms found mAb therapy of limited and generally short-lived success with blood malignancies ... Antibody-drug conjugates (ADCs) are antibodies linked to one or more drug molecules. Typically when the ADC meets the target ... Four major antibody types that have been developed are murine, chimeric, humanised and human. Antibodies of each type are ... Initial therapeutic antibodies were murine analogues (suffix -omab). These antibodies have: a short half-life in vivo (due to ...
*  Pregnancy test
In the 1970s, the discovery of monoclonal antibodies led to the development of the relatively simple and cheap immunoassays, ... and gestational trophoblastic neoplasms.[medical citation needed] Pregnancy tests may be used to determine the viability of a ... These include choriocarcinoma and other germ cell tumors, IgA deficiencies, heterophile antibodies, enterocystoplasties, ...
*  Proliferating cell nuclear antigen
... or monoclonal antibody termed Ki-67 can be used for grading of different neoplasms, e.g. astrocytoma. They can be of diagnostic ... PCNA type 1 and type 2 Antibody Patterns". Antibody Patterns.com. Retrieved 2008-04-15. Dan Krotz. "Structure of a clamp-loader ... Imaging of the nuclear distribution of PCNA (via antibody labeling) can be used to distinguish between early, mid and late S ... However, an important limitation of antibodies is that cells need to be fixed leading to potential artifacts. On the other hand ...
*  Mycoplasma genitalium
The antibody reactivity was due to a protein never known before, and is chemically responsive to all types of human and ... The protein was identified during investigations on the origin of multiple myeloma, a B-cell hematologic neoplasm. To ... "A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union". Science. 343 (6171): 656-661 ... nonhuman antibodies available. The protein is about 50 kDa in size, and composed of 556 amino acids. Future research must focus ...
*  Topoisomerase
... may lead to secondary neoplasms in the patient.[citation needed] Topoisomerase I is the antigen recognized by Anti Scl-70 ... antibodies in scleroderma. There are three main types of topology: Supercoiling Knotting Catenation Outside of the essential ...
*  Index of HIV/AIDS-related articles
... neoplasm - nephrotoxic - neuralgia - neurological complications of AIDS - neuropathy - neutralization - neutralizing antibody ... antibodies - antibody-dependent cell-mediated cytotoxicity (ADCC) - antibody-mediated immunity - antifungal medication - ... functional antibody - fungus - fusin - fusion inhibitor - fusion mechanism - fusion peptide GAG - gamma globulin - gamma ... binding antibody - bioavailability - biological response modifiers (BRMs) - biopsy - biotechnology - blinded study - blips - ...
*  Paraneoplastic pemphigus
... intraepidermal antibodies as well as along the dermoepidermal junction. Patients with low concentration of antibodies only ... in association with an underlying neoplasm". A study concluded in 2009, summarized in 2010, surrounded the surgical removal of ... Demonstration of certain antibodies in the serum was named as the basis for diagnosis of PNP. This piece labeled PNP as a " ... Specifically, antibodies against envoplakin and periplakin were being investigated. Further use of ELISA testing on these ...
*  List of MeSH codes (D12.776)
... antibodies, neoplasm MeSH D12.776.377.715.548.114.248 - antibodies, phospho-specific MeSH D12.776.377.715.548.114.252 - ... antibodies MeSH D12.776.377.715.548.114.071 - antibodies, anti-idiotypic MeSH D12.776.377.715.548.114.107 - antibodies, ... antibodies, bispecific MeSH D12.776.377.715.548.114.143 - antibodies, blocking MeSH D12.776.377.715.548.114.167 - antibodies, ... antibodies, helminth MeSH D12.776.377.715.548.114.191 - antibodies, heterophile MeSH D12.776.377.715.548.114.224 - antibodies, ...
*  List of MeSH codes (D12.776.124)
... antibodies, neoplasm MeSH D12.776.124.486.485.114.248 -- antibodies, phospho-specific MeSH D12.776.124.486.485.114.252 -- ... antibodies, neoplasm MeSH D12.776.124.790.651.114.248 -- antibodies, phospho-specific MeSH D12.776.124.790.651.114.252 -- ... antibodies MeSH D12.776.124.486.485.114.071 -- antibodies, anti-idiotypic MeSH D12.776.124.486.485.114.089 -- antibodies, ... antibodies, blocking MeSH D12.776.124.486.485.114.167 -- antibodies, catalytic MeSH D12.776.124.486.485.114.179 -- antibodies, ...
*  CD44
Monoclonal antibodies against CD44 variants include bivatuzumab for v6. CD44 is a multistructural and multifunctional cell ... On the contrary, in some neoplasms CD44 upregulation is associated with a favorable outcome. Additionally, in many cases ... Experiments in animals have shown that targeting of CD44 by antibodies, antisense oligonucleotides, and CD44-soluble proteins ... markedly reduces the malignant activities of various neoplasms, stressing the therapeutic potential of anti-CD44 agents. ...
*  Immunoglobulin light chain
Only one type of light chain is present in a typical antibody, thus the two light chains of an individual antibody are ... with a highly divergent ratio indicative of neoplasm. The exact normal ratio of kappa to lambda, according to a novel ... The immunoglobulin light chain is the small polypeptide subunit of an antibody (immunoglobulin). A typical antibody is composed ... Monoclonal antibodies Katzmann JA, Clark RJ, Abraham RS, Bryant S, Lymp JF, Bradwell AR, Kyle RA (2001). "Serum reference ...
*  Monoclonal
The most common usages of this term are: Monoclonal antibodies: A single hybridoma cell, which by chance includes the ... Monoclonal neoplasms (tumors): A single aberrant cell which has undergone an oncogenic event reproduces itself into a large ... In informal laboratory jargon the monoclonal antibodies isolated from cell culture supernatants of these hybridoma clones ( ... appropriate V(D)J recombination to produce the desired antibody, is cloned to produce a large population of identical cells. ...
*  Plasma cell
They secrete high levels of antibodies, ranging from hundreds to thousands of antibodies per second per cell. Unlike their ... Plasmacytoma, multiple myeloma, Waldenström macroglobulinemia and plasma cell leukemia are malignant neoplasms ("cancer") of ... Plasmablasts secrete more antibodies than B cells, but less than plasma cells. They divide rapidly and are still capable of ... Plasma cells can only produce a single kind of antibody in a single class of immunoglobulin. In other words, every B cell is ...
*  Thyroid
The most common neoplasm affecting the thyroid gland is a benign adenoma, usually presenting as a painless mass in the neck. ... These antibodies activate the receptor, leading to development of a goitre and symptoms of hyperthyroidism, such as heat ... Lastly, antibodies against components of the thyroid, particularly anti-TPO and anti-thyroglobulin, can be measured. These may ... Occasionally such antibodies block but do not activate the receptor, leading to symptoms associated with hypothyroidism. In ...
*  Cathepsin K
"Anti-Cathepsin K Antibody (A5871)"". Antibodies.com online catalog. Antibodies.com Ltd. 2018. Retrieved 16 January 2018. Brömme ... 1 February 2013). ""A Broad Survey of Cathepsin K Immunoreactivity in Human Neoplasms"". American Journal of Clinical Pathology ... Cathepsin K antibodies are marketed for research into expression of this enyzme by various cells. Merck had a cathepsin K ... link) ""Cathepsin K Antibodies"". Novus Biologicals online catalog. Novus Biologicals, LLC. 2016. Retrieved 2 October 2016. "" ...
*  Smooth muscle tissue
Intravascular leiomyomatosis is a benign neoplasm that extends through the veins; angioleiomyoma is a benign neoplasm of the ... Anti-smooth muscle antibodies (ASMA) can be a symptom of an auto-immune disorder, such as hepatitis, cirrhosis, or lupus. ... BBC - baby born with smooth muscle condition has 8 organs transplanted Smooth muscle antibody Stomach smooth muscle identified ... using antibody UIUC Histology Subject 265 Histology at KUMC muscular-muscle08 "Smooth Muscle" Histology image: 21701ooa - ...
*  Clone (cell biology)
Another important area where one can talk of "clones" of cells is neoplasms. Many of the tumors derive from one (sufficiently) ... These terms are most commonly used in context of antibodies or immunocytes. This concept of clone assumes importance as all the ... The B cells in the body have two important phenotypes (functional forms) -- the antibody secreting, terminally differentiated ( ... Clone (B-cell biology) Cloning List of animals that have been cloned Polyclonal antibodies Polyclonal response "Clone ...
*  BALB/c
... most commonly reticular neoplasms, lung tumours, and renal tumours. Most substrains have a "long reproductive life-span", are ... an important process for the production of monoclonal antibodies. They are also reported as having a "low mammary tumour ...
*  Autoimmune autonomic ganglionopathy
Where an underlying neoplasm is the cause, treatment of this condition is indicated in order to reduce progression of symptoms ... If the AAG is paraneoplastic, they have a form of cancer, and their immune system has produced paraneoplastic antibodies in ... Additionally, a blood test showing high levels of the antibody ganglionic nicotenic acetylcholine receptor (gAChr) occur in ... Paola Sandroni & Phillip A. Low (2009). "Other Autonomic Neuropathies Associated with Ganglionic Antibody". Autonomic ...
*  Milatuzumab
A Phase I study of Milatuzumab, a humanized anti-CD74 antibody, and Veltuzumab, a humanized anti-CD20 antibody, in patients ... CD74: a new candidate target for the immunotherapy of B-cell neoplasms. R. Stein, M.J. Mattes, T.M. Cardillo, H.J. Hansen, C.H ... Anti-CD74 antibody-doxorubicin conjugate, IMMU-110, in a human multiple myeloma xenograft and in monkeys. P. Sapra, R. Stein, J ... hLL1-Dox Milatuzumab has been linked to doxorubicin to form an antibody-drug conjugate or ADC (known as hLL1-Dox or IMMU-110) ...
*  Radioimmunotherapy
By its nature, RIT requires a tumor cell to express an antigen that is unique to the neoplasm or is not accessible in normal ... In cancer therapy, an antibody with specificity for a tumor-associated antigen is used to deliver a lethal dose of radiation to ... The ability for the antibody to specifically bind to a tumor-associated antigen increases the dose delivered to the tumor cells ... Antibody-targeted radiation cancer therapy. Nature Rev Drug Discovery 2004; 3:488-98. FIbritumomab Tiuxetan (Zevalin™) ...
*  Immunoproliferative disorder
... s, also known as immunoproliferative diseases or immunoproliferative neoplasms, are disorders of ... also known as antibodies). These disorders are subdivided into three main classes, which are lymphoproliferative disorders, ...
*  Autoimmune hemolytic anemia
Classification of the antibodies is based on their activity at different temperatures and their etiology. Antibodies with high ... Less common causes of warm-type AIHA include neoplasms other than lymphoid, and infection. Secondary cold type AIHA is also ... AIHA can be caused by a number of different classes of antibody, with IgG and IgM antibodies being the main causative classes. ... Usually, the antibody becomes active when it reaches the limbs, at which point it opsonizes RBCs. When these RBCs return to ...
*  NS0 cell
Development of murine neoplasms started with work with the BALB/c mice to isolate the IgG1 secreting MOPC21 tumor. From this ... Several therapeutic antibody products are produced using the NS0 cell line including daclizumab and eculizumab. Barnes, LM; ... Galfrè, G; Milstein, C (1981). "Preparation of monoclonal antibodies: strategies and procedures". Methods in Enzymology. 73 (Pt ... they are naturally antibody producing suspension cells. Gene amplication is typically performed using GS-transfected NS0 cells ...
*  Lloyd J. Old
Quantitative analysis of antibody localization in human metastatic colon cancer: A phase I study with monoclonal antibody A33. ... Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci USA. 1995;92:11810-11813. ... Of the monoclonal antibodies developed in Dr. Old's laboratory, thirteen have been licensed and seven are in clinical trials. ... the anti-EGFr antibody Hu806, which Abbott Laboratories acquired exclusive world-wide rights to develop in a major licensing ...
*  List of diseases (C)
Colavita-Kozlowski syndrome Cold agglutination syndrome Cold agglutinin disease Cold antibody hemolytic anemia Cold contact ... Carrington syndrome Cartilage-hair hypoplasia Cartilage hair hypoplasia like syndrome Cartilaginous neoplasms Cartwright-Nelson ... hypoxia Cerebral malformations hypertrichosis claw hands Cerebral palsy Cerebral thrombosis Cerebral ventricle neoplasms ... Choriocarcinoma Chorioretinitis Chorioretinopathy dominant form microcephaly Choroid plexus cyst Choroid plexus neoplasms ...