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*  Monoclonal antibody therapy
Humanised antibodies bind antigen much more weakly than the parent murine monoclonal antibody, with reported decreases in ... "Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques". ... Monoclonal antibody therapy is a form of immunotherapy that uses monoclonal antibodies (mAb) to bind monospecifically to ... To reduce murine antibody immunogenicity (attacks by the immune system against the antibody), murine molecules were engineered ...
*  Band of Parents
... mouse-derived) monoclonal antibody called 3F8. Given intravenously, 3F8 binds specifically to neuroblastoma cells and triggers ... However, its use is limited by the body's eventual development of human anti-murine antibody, which neutralizes the effects. ... "Humanized 3F8 Monoclonal Antibody (Hu3F8) in Patients With High-Risk Neuroblastoma and GD2-Positive Tumors - Full Text View - ... 3 million to fund the genetic engineering of the murine cell line that produces 3F8 so that it would produce a new antibody, ...
*  Monoclonal antibody
As of November 2016, thirteen of the nineteen "fully" human monoclonal antibody therapeutics on the market were derived from ... the differences between them were sufficient to invoke an immune response when murine monoclonal antibodies were injected into ... mechanism List of monoclonal antibodies Monoclonal antibody therapy Nomenclature of monoclonal antibodies Polyclonal antibodies ... "Proprietary antibody platform". "Naturally optimized human antibodies". "Proprietary antibody platform". "Proprietary antibody ...
*  Lamina propria
"Evaluation of lymphatic invasion in primary gastric cancer by a new monoclonal antibody, D2-40". Human Pathology. 37 (9): 1193- ... Induced by the IL-6/Soluble-IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated ... Premalignant Cancer in a Murine Model". The Journal of Immunology. 184 (3): 1543-51. doi:10.4049/jimmunol.0801217. PMID ...
*  CD47
Blockade of CD47 with a monoclonal antibody results in macrophage engulfment of bladder cancer cells in vitro. CD47 is also ... CD47 also functions as a marker of self on murine red blood cells which allows RBC to avoid phagocytosis. Red blood cells that ... prostate cancer and ovarian cancer-derived cells. In a mouse model of multiple myeloma, tumor metastasis to bone was decreased ... Jurkat cells and peripheral blood mononuclear cells (PBMC) incubated with the monoclonal antibody Ad22 results in apoptosis ...
*  Immune checkpoint
Anti-OX40 monoclonal antibodies have been shown to have clinical utility in advanced cancer. The pharma company AstraZeneca has ... IDO is known to suppress T and NK cells, generate and activate Tregs and myeloid-derived suppressor cells, and promote tumour ... "LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems". J Clin Invest. 117 ... "CDX-1127 - Monoclonal Antibody Targeting CD27". Celldex Therapeutics. He LZ, Prostak N, Thomas LJ, Vitale L, Weidlick J, ...
*  Cancer immunotherapy
... only the complementarity determining regions of the variable regions are derived from murine sources. Human antibodies have ... Naked monoclonal antibodies are antibodies without added elements. Most antibody therapies use this antibody type. Conjugated ... Antibodies are also referred to as murine, chimeric, humanized and human. Murine antibodies are from a different species and ... Chimeric antibodies attempt to reduce murine antibodies' immunogenicity by replacing part of the antibody with the ...
*  Interleukin 13
Dupilumab is a monoclonal antibody IL-13 and IL-4 modulator that targets the shared receptor of IL-4 and IL-13, IL4Rα. Since IL ... murine studies demonstrated that IL-13 was both necessary and sufficient to generate asthma-like Th2 responses in the mouse ... IL-13Rα2 (which is labelled as a decoy receptor) is derived from Th2 cells and is a pleotropic immune regulatory cytokine. IL- ... a T-cell-derived cytokine that regulates human monocyte and B-cell function". Proceedings of the National Academy of Sciences ...
*  ANGPTL4
Monoclonal antibodies targeting the nANGPTL4 and cANGPTL4 have been developed to distinguish their functions. ANGPTL4 plays an ... Murine influenza infection of the lungs stimulated the expression of ANGPTL4 via a STAT3-mediated mechanism. ANGPTL4 enhanced ... ANGPTL4 in nonexercising muscle presumably leads to reduced local uptake of plasma triglyceride-derived fatty acids and their ... The treatment of infected mice with neutralizing anti-ANGPTL4 antibodies significantly accelerated pulmonary recovery and ...
*  Human Endogenous Retrovirus-W
Using monoclonal fluorescently labeled antibodies the Frendo Lab was able to visualize the Env-W expression at the apical ... The HERV-W derived element of chromosome 12p11.21 and 7q21.2 had 42 hits from the env gene in pancreatic islet tissues and 224 ... One study found 10 out of 35 individuals with recent onset schizophrenia had retroviral pol gene HERV-W transcripts and murine ... A humanized monoclonal antibody called GNbAc1 of the IgG4 class binds with high specificity and affinity to the extracellular ...
*  NS0 cell
... s are a model cell line derived from the nonsecreting murine myeloma used in biomedical research and commercially in ... Galfrè, G; Milstein, C (1981). "Preparation of monoclonal antibodies: strategies and procedures". Methods in Enzymology. 73 (Pt ... Development of murine neoplasms started with work with the BALB/c mice to isolate the IgG1 secreting MOPC21 tumor. From this ... Several therapeutic antibody products are produced using the NS0 cell line including daclizumab and eculizumab. Barnes, LM; ...
*  Sphingosine-1-phosphate
Sonepcizumab is an experimental anti-S1P monoclonal antibody that has had a phase II clinical trial for renal cell carcinoma. ... In fact, S1P even activates fibroblast-derived extracellular matrix protein production. Administration of S1P has been shown to ... "Molecular requirements for doxorubicin-mediated death in murine oocytes". Cell Death and Differentiation. 13 (9): 1466-74. doi: ... Lpath Inc has produced and optimized a monoclonal anti-S1P antibody (Sphingomab). Sphingomab can absorb S1P from the ...
*  Tenascin C
... pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies". Nucleic Acids Res. 19 (3 ... Akhurst RJ, Lehnert SA, Faissner A, Duffie E (1990). "TGF beta in murine morphogenetic processes: the early embryo and ... Rettig WJ, Triche TJ, Garin-Chesa P (1989). "Stimulation of human neuronectin secretion by brain-derived growth factors". Brain ... Also, tenascin-C antibodies have been used to diagnose and create therapies for many different types of cancers. Tenascin ...
*  DNA vaccination
"The production and characterization of murine monoclonal antibodies to a DNA receptor on human leukocytes". The Journal of ... These peptides are derived from endogenous cytosolic proteins that are degraded and delivered to the nascent MHC class I ... Antibody responses generated by DNA are useful as a preparative tool. For example, polyclonal and monoclonal antibodies can be ... Antibody-secreting cells migrate to the bone marrow and spleen for long-term antibody production, and generally localise there ...
*  Cajal-Retzius cell
"Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody". The Journal of Neuroscience. 17 (1): 23-31. ... Soriano E, Del Río JA, Martínez A, Supèr H (April 1994). "Organization of the embryonic and early postnatal murine hippocampus ... Borrell V, Marín O (October 2006). "Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 ... García-Moreno F, López-Mascaraque L, De Carlos JA (January 2007). "Origins and migratory routes of murine Cajal-Retzius cells ...
*  CD34
1985). "A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B, non-T lymphoblasts in acute leukaemia and CGL ... Ogawa M, Tajima F, Ito T, Sato T, Laver JH, Deguchi T (Jun 2001). "CD34 expression by murine hematopoietic stem cells. ... Bellini A, Mattoli S (Sep 2007). "The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and ... A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells". Journal of ...
*  TsIV
November 2005). "Molecular characterization of a neutralizing murine monoclonal antibody against Tityus serrulatus scorpion ... These antivenoms are obtained by the immunisation of horses with a mix of venoms derived from T.Serrulatus and T.Bahiensis. ...
*  Natural killer cell
To determine the ADCC contribution of monoclonal antibodies, NK-92 cells (a "pure" NK cell line) has been transfected with the ... Most of our current knowledge is derived from investigations of mouse splenic and human peripheral blood NK cells. However, in ... In mice, the majority of research was carried out with murine cytomegalovirus (MCMV) and in models of hapten-hypersensitivity ... This is a major killing mechanism of some monoclonal antibodies like rituximab (Rituxan), ofatumumab (Azzera), and others. The ...
*  Cell encapsulation
The use of monoclonal antibodies for therapy is now widespread for treatment of cancers and inflammatory diseases. Using ... Cellulose sulphate is derived from cotton and, once processed appropriately, can be used as a biocompatible base in which to ... In 1998, a murine model of pancreatic cancer was used to study the effect of implanting genetically modified cytochrome P450 ... "Immunotherapy of a viral disease by in vivo production of therapeutic monoclonal antibodies". Human gene therapy. 11 (10): 1407 ...
*  Thymopoietin
... discrimination from splenin by monoclonal antibodies". Archives of Biochemistry and Biophysics. 228 (1): 292-8. doi:10.1016/ ... TMPO beta is a human homolog of the murine protein LAP2. LAP2 plays a role in the regulation of nuclear architecture by binding ... "Three distinct human thymopoietins are derived from alternatively spliced mRNAs". Proceedings of the National Academy of ...
*  Merkel cell polyomavirus
It belongs to the murine polyomavirus group, one of the three main clades of polyomaviruses. (The group is named for murine ... Antibodies have been developed to stain for T antigen in tumor tissues and appear to be specific for MCV-infected tumor cells. ... This was quickly confirmed by studies of MCC patients from around the world, including evidence for monoclonal integration of ... The cancer may derive from the microscopic Merkel cell nervous organ in the skin and viscera which is responsible for touch and ...
*  CD90
Some of the common monoclonal antibodies used to detect this protein are clones OX7, 5E10, K117 and L127. There have been some ... It is probably the most abundant glycoprotein of murine thymocytes, with about One million copies per cell covering up to 10-20 ... and fetal liver-derived hemopoietic cells. Thy-1 is present on a fraction of brain cells and a fraction of fibroblasts of most ... Single tail vein intravenous injection of antibody (OX7 mouse monoclonal IgG) against Thy1.1 in rats is used as a standard ...
*  IL17A
Other than the monoclonal antibodies, highly specific and potent inhibitors targeting Th17 specific transcription factor RORγt ... in 1993 from a rodent T-cell hybridoma, derived from the fusion of a mouse cytotoxic T cell clone and a rat T cell lymphoma. ... In murine models, treatment with dexamethasone inhibits the release of Th2-related cytokines but does not affect IL-17A ... a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double- ...
*  Polyomaviridae
The viral load as before is also measure by PCR.[citation needed] Tissue staining using a monoclonal antibody against MCV T ... Murine polyomavirus was the first polyomavirus discovered, having been reported by Ludwik Gross in 1953 as an extract of mouse ... The name Papovaviridae derived from three abbreviations: Pa for Papillomavirus, Po for Polyomavirus, and Va for "vacuolating ... Antibody assays are commonly used to detect presence of antibodies against individual viruses. Competition assays are ...
*  Gamma delta T cell
This table refers to variable chain Vγ gene segments and to monoclonal antibodies that detect the corresponding Vγ protein ... IMGT website Heilig, JS; Tonegawa, S (1986). "Diversity of murine gamma genes and expression in fetal and adult T lymphocytes ... the stimuli that trigger Vd1 expansion are not derived from pathogens but instead correspond to endogenous gene products ... This table summarizes the nomenclature of mouse Vγ chains and indicates monoclonal antibodies often used to identify these ...
*  TENM3
also identified Ten-m in Drosophila by screening for tyrosine phosphorylation on cDNA using monoclonal antibodies. However, ... Zhou XH, Brandau O, Feng K, Oohashi T, Ninomiya Y, Rauch U, Fässler R (August 2003). "The murine Ten-m/Odz genes show distinct ... The embryonic Drosophila cDNA library was screened using polymerase chain reaction (PCR) and a primer derived from the EGF-like ...