*Catalysis

Such catalytic antibodies are sometimes called "abzymes". Nanocatalysts are nanomaterials with catalytic activities. They have ... ISBN 1-57259-153-6. Catalytic Antibodies Simply Explained. Documentroot.com (2010-03-06). Retrieved on 2015-11-11. Wei, Hui; ... a unit which was called katal and defined the SI unit for catalytic activity since 1999. Catalytic activity is not a kind of ... such as chemisorbed hydrogen in catalytic hydrogenation. Kinetically, catalytic reactions are typical chemical reactions; i.e. ...

*Kim Janda

In 1993, his group was the first to describe how a catalytic antibody can reroute a chemically disfavored reaction to give an ... Janda's independent career started working on catalytic antibodies. ... Gao, C.; Mao, S.; Lo, C.-H. L.; Wirsching, P.; Lerner, R. A.; Janda, K. D. (25 May 1999). "Making artificial antibodies: A ... Janda has also worked creating peptide and antibody molecules for the treatment of cancer. By employing a novel approach, he ...

*Abzyme

... from catalytic monoclonal antibody), and most often called catalytic antibody, is a monoclonal antibody with catalytic activity ... So far, all catalytic antibodies produced have displayed only modest, weak catalytic activity. The reasons for low catalytic ... Once infected by HIV, patients produce antibodies to the more changeable parts of the viral coat. The antibodies are ... "Catalytic antibodies to HIV: Physiological role and potential clinical utility". Autoimmunity Reviews. 7 (6): 473-9. doi: ...

*HIV/AIDS research

Planque S; Nishiyama Y; Taguchi H; Salas M; Hanson C; Paul S (June 2008). "Catalytic antibodies to HIV: Physiological role and ... who found a way to attach HIV-fighting antibodies to immune cells, creating a HIV-resistant cell population. A microbicide for ... "The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus". Nat. Rev. Microbiol. 6 (2): 143-55. doi: ...

*Supramolecular catalysis

Many catalytic antibodies were developed and studied using this approach. A problem with transition state analogue selection ... The catalytic cycle is almost the same as that in nature, except the substrate is an aromatic aldehyde rather than pyruvate. ... This cyclodextrin catalytic system mimics ribonuclease A by its use of a neutral imidazole and an imidazolium cation to ... Assuming that catalytic activity largely depends on the catalyst's affinity to the transition state, one could synthesize a ...

*RTI-51

Kuhar, M.; Carroll, F.; Bharat, N.; Landry, D. (2001). "Anticocaine catalytic antibodies have no affinity for RTI compounds: ...

*List of cocaine analogues

Catalytic antibodies against cocaine and methods of using and producing same Google patents US 6566084 B1 Deng, Shixian; Bharat ... Cocaine haptens that create catalytic anti-bodies require transitional states as affected in vivo. The first compound of those ... analysis of the specificity of anticocaine antibodies (Ab1) capable of inducing Ab2beta anti-idiotypic antibodies". Immunology ... "Inhibition of cocaine binding to the human dopamine transporter by a single chain anti-idiotypic antibody: its cloning, ...

*Hajos-Parrish-Eder-Sauer-Wiechert reaction

2000, 122, 2395-2396 doi:10.1021/ja994280y Efficient aldolase catalytic antibodies that use the enamine mechanism of natural ... PMID 8525368 Catalytic Asymmetric Synthesis of anti-1,2-Diols Wolfgang Notz and Benjamin List J. Am. Chem. Soc. 2000; 122(30) ... Thus, they described the first use of proline in a catalytic asymmetric aldol reaction. The Schering group worked under non ... This is the same mechanism proposed by Barbas for aldolase antibodies reported by the group in 1995: This enamine mechanism ...

*Peter G. Schultz

Although their catalytic activities are only rarely strong enough to be of practical use, catalytic antibodies have provided ... Schultz showed that the natural molecular diversity of the immune system could be directed to generate catalytic antibodies. ... His interests are extremely wide-ranging, with applications in such diverse areas as catalytic mechanisms, cell-specialization ... and catalytic properties; also, proteins and small molecules which control important biological processes such as aging, cancer ...

*List of MeSH codes (D12.776.124)

... antibodies, blocking MeSH D12.776.124.486.485.114.167 -- antibodies, catalytic MeSH D12.776.124.486.485.114.179 -- antibodies, ... antibodies, blocking MeSH D12.776.124.790.651.114.167 -- antibodies, catalytic MeSH D12.776.124.790.651.114.179 -- antibodies, ... antibodies MeSH D12.776.124.486.485.114.071 -- antibodies, anti-idiotypic MeSH D12.776.124.486.485.114.089 -- antibodies, ... hiv antibodies MeSH D12.776.124.486.485.114.254.150.500 -- htlv-i antibodies MeSH D12.776.124.486.485.114.254.150.510 -- htlv- ...

*Richard Lerner

Best known for his work on catalytic antibodies, Lerner served as President of The Scripps Research Institute (TSRI) until ... In addition to his research into catalytic antibodies, providing a method of catalyzing chemical reactions thought impossible ... In 1967 Lerner discovered the role of anti-GBM antibodies in the pathogenesis of Goodpasture's disease. As of 2007, Lerner's ... with Sir Gregory Winter for Professor Pieczenik's conception and their development of combinatorial antibody libraries. Under ...

*Ian Wilson (biologist)

... and catalytic antibodies, with a variety of antigens, including steroids, peptides, carbohydrates and viral proteins, such as ...

*Biocatalysis & Biotransformation

... natural and modified enzymes and catalytic antibodies for the synthesis, interconversion or degradation of chemical species. It ...

*Raymond C. Stevens

The interplay between binding energy and catalysis in the evolution of a catalytic antibody Nature 389: 271-5 G. J. Wedemayer, ... Blue-fluorescent antibodies Science 290: 307-13 www.jcsg.org jcimpt.scripps.edu cmpd.scripps.edu ihuman.shanghaitech.edu.cn ... P. A. Patten, L. H. Wang, P. G. Schultz and R. C. Stevens (1997) Structural insights into the evolution of an antibody ... Immunological origins of binding and catalysis in a Diels-Alderase antibody Science 279: 1929-33 A. Simeonov, M. Matsushita, E ...

*Scott K. Dessain

"Neutralization of botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain." PLOS One 3 (8): ... "Neutralization of botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain." PLoS One 3 (8): ... from homeobox genes to DNA tumor viruses and human antibody therapeutics. His technique for cloning native human antibodies has ... Using this cloning method, he and his team have been able to develop antibodies that fight against various toxins and ...

*Dihydrolipoyl transacetylase

"Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis". World ... These are called anti-mitochondrial antibodies (AMA) and anti-nuclear antibodies (ANA), respectively. These antibodies are ... The catalytic domains are assembled into trimers with the active site located at the subunit interface. The topology of this ... that peptides within the catalytic site may present the immunodominant epitopes recognized by the anti-PDC-E2 antibodies in PBC ...

*PCSK9

A number of monoclonal antibodies that bind to and inhibit PCSK9 near the catalytic domain were in clinical trials as of 2014[ ... A possible side effect of the monoclonal antibody might be irritation at the injection site. Before the infusions, participants ... Schmidt AF, Pearce LS, Wilkins JT, Overington JP, Hingorani AD, Casas JP (April 2017). "PCSK9 monoclonal antibodies for the ... A meta-analysis of 24 clinical trials has shown that monoclonal antibodies against PCSK9 can reduce cholesterol, cardiac events ...

*DNA polymerase alpha catalytic subunit

Tanaka S, Hu SZ, Wang TS, Korn D (1982). "Preparation and preliminary characterization of monoclonal antibodies against human ... DNA polymerase alpha catalytic subunit is an enzyme that in humans is encoded by the POLA1 gene. Pol α has limited processivity ... The Pol α complex (pol α-DNA primase complex) consists of four subunits: the catalytic subunit POLA1, the regulatory subunit ... Hsi KL, Copeland WC, Wang TS (1991). "Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a ...

*Catalytic triad

The Ser-His-Asp triad has been inserted into an antibody, as well as a range of other proteins. Similarly, catalytic triad ... Non-catalytic proteins have been used as scaffolds, having catalytic triads inserted into them which were then improved by ... Catalytic triads have also been inserted into otherwise non-catalytic proteins, or protein mimics. Subtilisin (a serine ... "Design of a serine protease-like catalytic triad on an antibody light chain displayed on the yeast cell surface". Applied ...

*List of MeSH codes (D12.776)

... antibodies, blocking MeSH D12.776.377.715.548.114.167 - antibodies, catalytic MeSH D12.776.377.715.548.114.179 - antibodies, ... antibodies MeSH D12.776.377.715.548.114.071 - antibodies, anti-idiotypic MeSH D12.776.377.715.548.114.107 - antibodies, ... hiv antibodies MeSH D12.776.377.715.548.114.254.150.500 - htlv-i antibodies MeSH D12.776.377.715.548.114.254.150.510 - htlv-ii ... hepatitis a antibodies MeSH D12.776.377.715.548.114.254.450.504 - hepatitis b antibodies MeSH D12.776.377.715.548.114.254.450. ...

*Receptor tyrosine kinase

Herceptin, a monoclonal antibody that is capable of binding to the extracellular domain of RTKs, has been used to treat HER2 ... Drugs have been developed to target the extracellular domain or the catalytic domain, thus inhibiting ligand binding, receptor ... The intracellular C terminal region displays the highest level of conservation and comprises catalytic domains responsible for ... Protein Tyrosine Phosphatase (PTPs) are a group of enzymes that possess a catalytic domain with phosphotyrosine-specific ...

*Lysozyme

The catalytic relevance was examined with single walled carbon nanotubes (SWCN) field effect transitors (FETs), where a ... Grivel JC, Smith-Gill SJ (1996). Lysozyme: Antigenic structure as defined by antibody and T cell responses. CRC Press. pp. 91- ... For example, blocking the catalytic activity of lysozyme by mutation of critical amino acid in the active site (52-Asp -> 52- ... The Phillips Mechanism proposed that the enzyme's catalytic power came from both steric strain on the bound substrate and ...

*Immunoperoxidase

Example 3. An untagged primary antibody is detected using a general secondary antibody that recognises all antibodies ... Other catalytic enzymes such as alkaline phosphatase can be used instead of peroxidases for both direct and indirect staining ... Monoclonal antibodies that consist of only one type of antibody tend to provide greater antigen specificity, and also tend to ... These stains use antibodies to bind to specific antigens, usually of protein or glycoprotein origin. Since antibodies are ...

*NuA4 histone acetyltransferase complex

The catalytic subunit of the complex has been identified as the product of ESA1, an essential gene required for cell cycle ... Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive ... In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). Post-translational ...

*NCK1

The Nck (non-catalytic region of tyrosine kinase adaptor protein 1) belongs to the adaptor family of proteins. The nck gene was ... "The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its ... initially isolated from a human melanoma cDNA library using a monoclonal antibody produced against the human melanoma- ...

*Index of biochemistry articles

... catalytic domain - CCR5 receptor - CD4 antigen - CD45 antigen - CD95 antigen - CDC28 protein kinase - cell - cell adhesion ... antibody - apoenzyme - apolipoprotein - apoptosis - aquaporin - archaea - arginine - argipressin - aromatic amine - aromatic ... monoclonal antibody - Monomer - Monosaccharide - monosaccharide transport protein - morphogenesis - Morphogenetic field - mos ...