Loading...
*  Ronald C. Kennedy
Kennedy, R.; Eichberg, J.; Lanford, R.; Dreesman, G. (1986). "Anti-idiotypic antibody vaccine for type B viral hepatitis in ...
*  Chang Yi Wang
T cell anti-idiotypic antibodies reveal differences between two human leukemias. J Exp Med 1984; 160:499. 47. Posnett DN, Wang ... by human T cell lines and peripheral blood T lymphocytes stimulated by PMA and anti-CD3 antibody Anti-CD3 monoclonal antibody. ... Anti-HCV, anti-GOR, and autoimmunity. Lancet 1992, 339:871. 26. Hosein B, Fang CT, Popvsky MA, Ye J, Zhang M and Wang, CY. ... monoclonal antibody S-HCL1 and S-HCL3 allow the diagnosis of hairy cell leukemia. Blood 1985; 65:974. 42. Bushkin Y, Chorney MJ ...
*  Idiotopes
... "anti-idiotypic antibody". If such is the case, the anti-idiotypic antibodies will be able to bind to the B lymphocyte receptor ... Ladjemi MZ (2012). "Anti-idiotypic antibodies as cancer vaccines: achievements and future improvements". Front Oncol. 2: 158. ... Because of the resemblance of anti-idiotypic antibodies to the original antigen, vaccine studies have been performed. These ... If a separate antibody is produced that has specific binding capabilities to an idiotope of the previously described antibody, ...
*  Antiviral drug
This includes anti-VAP antibodies, receptor anti-idiotypic antibodies, extraneous receptor and synthetic receptor mimics. This ... This may include VAP anti-idiotypic antibodies, natural ligands of the receptor and anti-receptor antibodies.[clarification ... and since the process of generating anti-idiotypic antibodies is partly trial and error, it can be a relatively slow process ... One anti-viral strategy is to interfere with the ability of a virus to infiltrate a target cell. The virus must go through a ...
*  Killer yeast
... yeast killer toxin-like anti-idiotypic antibodies". The Journal of Immunology. 152 (6): 3175-82. PMID 8144911. Lowes, K. F.; ... Several experiments suggest that antibodies that mimic the biological activity of killer toxins have application as antifungal ... "Therapeutic potential of yeast killer toxin-like antibodies and mimotopes". FEMS Yeast Research. 5 (1): 11-8. doi:10.1016/j. ... "Idiotypic intravaginal vaccination to protect against candidal vaginitis by secretory, ...
*  Anti-idiotypic vaccine
An example of anti-idiotype antibody is Racotumomab. In one example of producing an anti-idiotypic vaccine, antibodies that ... "anti-idiotypic". The resulting murine antibodies are harvested and used to vaccinate other mice. The resulting antibodies in ... Because the antibody produced using the "anti-idiotypic" process closely resembles the original epitope of the antigen, these ... Anti-idiotypic vaccines comprise antibodies that have three-dimensional immunogenic regions, designated idiotopes, that consist ...
*  Gustav Gaudernack
Jorgensen, T.; Gaudernack, G.; Hannestad, K. (1977). "Production of BALB/c Anti-Idiotypic Antibodies Against the BALB/c Myeloma ... He further generated monoclonal antibodies specific for the hematopoietic stem cell marker, CD34. A joint collaboration with ... and generated monocyte-specific monoclonal antibodies (ID5) in hybridomas. Inspired by his research and without being ... Hospital and Baxter resulted in development of an instrument to isolate hematopoietic stem cells in large scale using anti-CD34 ...
*  Epitope
This property is exploited by the immune system in regulation by anti-idiotypic antibodies (originally proposed by Nobel ... If this second antibody is of IgM class, its binding can upregulate the immune response; if the second antibody is of IgG class ... For example, the epitope is the specific piece of the antigen to which an antibody binds. The part of an antibody that binds to ... Following synthesis, the resulting epitope tag allows the antibody to find the protein or other gene product enabling lab ...
*  List of cocaine analogues
... analysis of the specificity of anticocaine antibodies (Ab1) capable of inducing Ab2beta anti-idiotypic antibodies". Immunology ... "Inhibition of cocaine binding to the human dopamine transporter by a single chain anti-idiotypic antibody: its cloning, ... Schabacker, DS; Kirschbaum, KS; Segre, M (2000). "Exploring the feasibility of an anti-idiotypic cocaine vaccine: ... Catalytic antibodies against cocaine and methods of using and producing same Google patents US 6566084 B1 Deng, Shixian; Bharat ...
*  Racotumomab
2011). Anti-NeuGcGM3 antibodies actively elicited by idiotypic vaccination in non-small cell lung cáncer patients induce tumor ... Racotumomab is an anti-idiotypic mouse monoclonal antibody that mimics NGc gangliosides, thus triggering an immune response ... 2002). An anti idiotype vaccine elicits a specific response to N-glycolylsialic acid residues of glycoconjugates in melanoma ... 2012). Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides - preclinical and clinical data. ...
*  Immune network theory
"Selection of human anti-HIV broadly neutralizing antibodies occurs within the context of a frozen 1F7-idiotypic repertoire". ... and B anti-anti-B (antiidiotypic) antibodies. The former stimulate anti-anti-B T cells and the latter stimulate anti-B T cells ... In the model IgG molecules are selected to have both anti-anti-(self MHC class II) and anti-anti-anti-(self MHC class II) ... of lymphocytes defined by co-selection of both anti-C and anti-anti-C lymphocytes and co-selection of anti-B and anti-anti-B ...
*  List of MeSH codes (D12.776)
... antibodies MeSH D12.776.377.715.548.114.071 - antibodies, anti-idiotypic MeSH D12.776.377.715.548.114.107 - antibodies, ... antibodies, bispecific MeSH D12.776.377.715.548.114.143 - antibodies, blocking MeSH D12.776.377.715.548.114.167 - antibodies, ... antibodies, helminth MeSH D12.776.377.715.548.114.191 - antibodies, heterophile MeSH D12.776.377.715.548.114.224 - antibodies, ... hiv antibodies MeSH D12.776.377.715.548.114.254.150.500 - htlv-i antibodies MeSH D12.776.377.715.548.114.254.150.510 - htlv-ii ...
*  List of MeSH codes (D12.776.124)
... antibodies MeSH D12.776.124.486.485.114.071 -- antibodies, anti-idiotypic MeSH D12.776.124.486.485.114.089 -- antibodies, ... antibodies, anti-idiotypic MeSH D12.776.124.790.651.114.107 -- antibodies, archaeal MeSH D12.776.124.790.651.114.125 -- ... antibodies, blocking MeSH D12.776.124.486.485.114.167 -- antibodies, catalytic MeSH D12.776.124.486.485.114.179 -- antibodies, ... antibodies, blocking MeSH D12.776.124.790.651.114.167 -- antibodies, catalytic MeSH D12.776.124.790.651.114.179 -- antibodies, ...
*  K. Christopher Garcia
... hormone recognition by an anti-idiotypic antibody, Science (1992) An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation ... At Stanford University, Garcia has continued to study antigen recognition by both antibodies and TCRs. The Garcia Laboratory ... Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies, Science (2013) Durable antitumor responses ... earliest research as a graduate student at Johns Hopkins University used X-ray crystallography to determine how antibodies ...
*  Creative Diagnostics
Matched antibody pairs Anti-idiotypic Antibodies HBV Core Antigen Antibody Isotyping Kits Protein Antigen Expression Service ... The initial business is antibody-monoclonal and polyclonal antibodies. Later, various kinds of antibody, viral antigens, ... "The Way We Take Care of Antibody Purification". APSence. Retrieved December 16, 2014. "Molecular detection of hepatitis B virus ... Creative Diagnostics is an American biotechnology company that specializes in research and manufacture of antibodies, viral ...
*  Abagovomab
The anti-idiotypic antibody abagovomab in patients with recurrent ovarian cancer. A phase I trial of the AGO-OVAR. Ann Oncol. ... Abagovomab is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen (CA-125) highly ... Immunological consolidation of ovarian carcinoma recurrences with monoclonal anti-idiotype antibody ACA125: immune responses ... "Medical News: ESGO: Anti-CA125 Fails to Slow Ovarian Cancer - in Meeting Coverage, ESGO from". MedPage Today. Retrieved 2011-09 ...
*  Artificial immune system
... network theory proposed by Niels Kaj Jerne that describes the regulation of the immune system by anti-idiotypic antibodies ( ... antibodies that select for other antibodies). This class of algorithms focus on the network graph structures involved where ... antibodies (or antibody producing cells) represent the nodes and the training algorithm involves growing or pruning edges ... Immune Network Algorithms: Algorithms inspired by the idiotypic ... where selection is inspired by the affinity of antigen-antibody ...
*  Betty Diamond
Regulating the isotypic and idiotypic profile of an anti-PC antibody response: lessons from peptide mimics. Mol. Immunol. 39: ... She identified the first idiotype marker on anti-DNA antibodies in patients with lupus, and discovered that anti-DNA antibodies ... single base change in a protective anti-pneumococcal antibody could convert it into a potentially pathogenic anti-DNA antibody ... She also found that a peptide that binds to 50% of anti-DNA antibodies in lupus patients and mice represents an epitope on ...
*  John H. Sampson
Generation of anti-idiotypic reagents in the EGFRvIII tumor-associated antigen system. Cancer Immunology, Immunotherapy. 2002; ... The first is novel mechanisms of delivery of large molecular weight molecules, such as monoclonal antibodies, throughout brain ... Approaches used to target this tumor-specific epitope include unarmed and radiolabeled antibody therapy and cell mediated ... Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection ...
*  Germinal center B-cell like diffuse large B-cell lymphoma
"Therapy of B-cell lymphoma with anti-CD20 antibodies can result in the loss of CD20 antigen expression". Clinical Cancer ... Clonal B-cells spontaneously mutate the idiotypic region of their immunoglobulin. This high mutation rate makes them prone to ... Anti-apoptotic proteins include Bcl-2, Bcl-XL, Bcl-w, Mcl-1. When anti-apoptotic family members are overexpressed, apoptotic ... Monoclonal antibodies are made by injecting human cancer cells into mice so that their immune systems create antibodies against ...
*  Antigen
In most cases, an adapted antibody can only react to and bind one specific antigen; in some instances, however, antibodies may ... autologous and idiotypic or allogenic (homologous) antigens. An autoantigen is usually a normal protein or protein complex (and ... "anti(body)-gen". Epitope - The distinct surface features of an antigen, its antigenic determinant. Antigenic molecules, ... Antigens are "targeted" by antibodies. Each antibody (immune response) is specifically produced by the immune system to match ...