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*  Paraneoplastic syndrome
January 2007). "Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Ovarian Teratoma". Ann. Neurol. ... limbic encephalitis, brainstem encephalitis, opsoclonus myoclonus ataxia syndrome, anti-NMDA receptor encephalitis, and ... In this paradigm, tumor cells express tissue-restricted antigens (e.g., neuronal proteins), triggering an anti-tumor immune ... 2011). "Investigations of Caspr2, an autoantigen of encephalitis and neuromyotonia". Ann. Neurol. 69: 303-311. van Sonderen, A ...
*  Anti-NMDA receptor encephalitis
"Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents". Annals of Neurology. 66 (1): 11-8. doi: ... Anti-NMDA receptor encephalitis, also known as NMDA receptor antibody encephalitis, is an acute form of brain inflammation that ... "Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma". Annals of Neurology. 61 (1): ... "Anti-NMDA-receptor antibody encephalitis: performance evaluation and laboratory experience with the anti-NMDA-receptor IgG ...
*  Encephalitis
Antibody-mediated anti-N-methyl-D-aspartate-receptor encephalitis and Rasmussen encephalitis are examples of autoimmune ... Rasmussen's encephalitis Bickerstaff's encephalitis La Crosse encephalitis Wernicke's encephalopathy Meningitis Cerebritis ... Herpes simplex encephalitis has an incidence of 2-4 per million population per year. Encephalitis with meningitis is known as ... MedlinePlus Encyclopedia Encephalitis Connolly MP, Goodwin E, Schey C, Zummo J (2017). "Toxoplasmic encephalitis relapse rates ...
*  N-Methyl-D-aspartic acid
NMDA receptor NMDA receptor antagonist Anti-NMDA-receptor encephalitis "N-Methylaspartate - Compound Summary". PubChem Compound ... N-Methyl-D-aspartic acid or N-Methyl-D-aspartate (NMDA) is an amino acid derivative that acts as a specific agonist at the NMDA ... Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors (such as ... The mechanism of stimulating NMDA receptor is a specific agonist-binding to its NR2 subunits, and then a non-specific cation ...
*  Teratoma
... s can cause an autoimmune illness called Anti N-methyl-D-aspartate (NMDA) receptor encephalitis. After surgery, there ... condition where ovarian teratomas cause encephalitis associated with antibodies against the N-methyl-D-aspartate receptor ( ... "Anti-NMDA receptor encephalitis", was identified as a serious complication. Patients develop a multistage illness that ... "Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis". Lancet Neurol. 10 (1): 63-74. doi: ...
*  Inflammatory demyelinating diseases of the central nervous system
... white matter lesion and incomplete MRZ reaction in a male patient with anti-N-methyl-D-aspartate receptor encephalitis ... Some researchers think that there could exist an overlapping between Anti-NMDA receptor encephalitis cases and neuromyelitis ... The autoantibodies are anti-AQP4 and anti-MOG so far and the genetic variant is a mutation in the gene NR1H3. Originally found ... Anti-MOG associated spectrum, often clinically presented as an anti-MOG autoimmune encephalomyelitis, but can also appear as ...
*  Autoimmune encephalitis
"Anti-N-methyl-D-aspartate receptor-mediated encephalitis in infants and toddlers: case report and review of the literature". ... "Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents". Annals of Neurology. 66 (1): 11-18. doi: ... "Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma". Annals of Neurology. 61 (1): ... "Anti-N-methyl-d-aspartate receptor encephalitis: review of clinical presentation, diagnosis and treatment". BJPsych Bulletin. ...
*  Anti-glutamate receptor antibodies
Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007 Jan;61(1):25- ... The second large group of anti-glutamate receptor antibodies is associated with different subunits of N-methyl-D-aspartate ( ... NMDA) receptor. Patients with limbic encephalitis, encephalitis, systemic lupus erythematosus, ataxia and epilepsia partialis ... The first anti-glutamate receptor antibody was shown by McNamara JO and colleagues to be directed against the GluR3 subunit of ...
*  Limbic encephalitis
The main antibodies within this group are those against anti-N-methyl-D-aspartate receptors (NMDAR) and the voltage-gated ... Limbic encephalitis is a form of encephalitis, a disease characterized by inflammation of the brain. Limbic encephalitis is ... Anti-NMDAR encephalitis is strongly associated with benign tumours of the ovary (usually teratomas or dermoid cysts). Anti-VGKC ... Limbic encephalitis is classified according to the auto-antibody that causes the disease.The most common types are: Anti-Hu, ...
*  Meningoencephalitis
Anti-N-methyl-D-aspartate (anti-NMDA) receptor antibodies, which are also associated with seizures and a movement disorder. ... Other amebae cause granulomatous amebic encephalitis (GAE), which is a more subacute and can even a non-symptomatic chronic ... Meningitis Meningism Primary amoebic meningoencephalitis Encephalitis Naegleria fowleri "Meningoencephalitis". Oxford ... and encephalitis, which is an infection or inflammation of the brain. Causative organisms include protozoans, viral and ...
*  Causes of schizophrenia
"Prevalence of anti-N-methyl-d-aspartate (NMDA) receptor antibodies in patients with schizophrenia and related psychoses: a ... Lennox, Belinda R.; Coles, Alasdair J.; Vincent, Angela (2012-02-01). "Antibody-mediated encephalitis: a treatable cause of ... "Immunotherapy for patients with acute psychosis and serum N-Methyl d-Aspartate receptor (NMDAR) antibodies: A description of a ... The result showed that although the mice mostly developed normally, on further brain development, glutamate receptors broke ...
*  Quinolinic acid
However, it was not until 1981 that Stone and Perkins showed that quinolinic acid activates the N-methyl-d-aspartate receptor ( ... via anti-oxidant and possibly calcium influx mechanisms. COX-2 inhibitors, such as licofelone have also demonstrated protective ... increased concentrations of quinolinic acid in the CSF of HAND patients correlates with HIV encephalitis and cerebral atrophy. ... Quinolinic acid may undergo further decarboxylation to nicotinic acid (niacin): Oxidation of aspartate by the enzyme aspartate ...
*  NMDA receptor
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein ... NMDARs are associated with a rare autoimmune disease, anti-NMDA receptor encephalitis, that usually occurs due to cross- ... Since 1989 memantine has been recognized to be an uncompetitive antagonist of the N-methyl-D-aspartate receptor (NMDA receptor ... Activation of NMDA receptors requires binding of glutamate or aspartate (aspartate does not stimulate the receptors as strongly ...
*  Glutamate decarboxylase
"Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor ... Dayalu P, Teener JW (November 2012). "Stiff Person syndrome and other anti-GAD-associated neurologic disorders". Seminars in ... limbic encephalitis, and epilepsy. Erlander MG, Tillakaratne NJ, Feldblum S, Patel N, Tobin AJ (July 1991). "Two genes encode ... Reduced GABA levels increase glutamate levels as a consequence of lower inhibition of subtypes of GABA receptors. Higher ...
*  Hippocampus
The synaptic changes depend on a special type of glutamate receptor, the N-methyl-D-aspartate (NMDA) receptor, a cell surface ... A recent study has also revealed atrophy as a result of depression, but this can be stopped with anti-depressants even if they ... Damage to the hippocampus can also result from oxygen starvation (hypoxia), encephalitis, or medial temporal lobe epilepsy. ... Drugs that interfere with NMDA receptors block LTP and have major effects on some types of memory, especially spatial memory. ...