Other diarylpyrimidine-analogues are currently being used as anti-HIV agents, notably rilpivirine. ... "Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Department of Health and Human ... making it the 30th anti-HIV drug approved in the United States and the first to be approved in 2008.[3] It was also approved ... HIV-1) infection in antiretroviral treatment-experienced adult patients, who have evidence of viral replication and HIV-1 ...
2012). Hepatitis G Virus or GBV-C: A Natural Anti-HIV Interfering Virus. In: Witzany, G. (Ed). Viruses. Essential Agents of ... "Effect of Early and Late GB Virus C Viraemia on Survival of HIV-infected Individuals: A Meta-analysis". HIV Med. 7 (3): 173-180 ... 2004). "Inhibition of HIV-1 replication by GB virus C infection through increases in RANTES, MIP-1alpha, MIP-1beta, and SDF-1 ... 2007). "HIV Entry Inhibition by the Envelope 2 Glycoprotein of GB Virus C". AIDS. 21 (5): 645-7. doi:10.1097/QAD. ...
"Anti-HIV Agents That Selectively Target Retroviral Nucleocapsid Protein Zinc Fingers without Affecting Cellular Zinc Finger ... "Biophysical Characterization of Zinc Ejection from HIV Nucleocapsid Protein by Anti-HIV 2,2'-Dithiobis[benzamides] and ... Zinc ejectors were patented in 2008 and some have entered Phase I/II trials as a HIV drug. The HIV-1 nucleocapsid protein 7 ( ... Azodicarbonamide (ADA) was the first zinc ejector to go into clinical trial for treatment of HIV. ADA inhibits HIV by ...
Two years later the etiology agent for AIDS, the HIV was described. HIV is a retrovirus and has two major serotypes, HIV-1 and ... De Clercq E (April 2009). "Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV". International ... The perfect anti-HIV drug chemical should be effective against drug resistance mutation. Understanding the target RT enzyme and ... Bal TR, Anand B, Yogeeswari P, Sriram D (October 2005). "Synthesis and evaluation of anti-HIV activity of isatin beta- ...
Zhang, Heping; Zembower, David; Chen, Zhidong (October 1997). "Structural analogues of the michellamine anti-HIV agents. ... The main use of Michellamines are in anti-HIV medications. They inhibit viral replication of the Protein kinase C and virus- ... Michellamine is an atropisomeric alkaloid which has been found to be a strong anti-HIV viral replication inhibitor. It was ... They have a broad range of effectiveness across most HIV strains, particularly the HIV-2 strain, which is found primarily in ...
Reviriego, C (July 2011). "Chemokine CCR2/CCR5 Receptor Antagonist Anti-HIV Agent". Drugs of the Future. 36 (7): 511-7. doi: ... CROI 2013: CCR5/CCR2 Inhibitor Cenicriviroc Has Both Anti-HIV and Anti-inflammatory Effects. Highleyman, Liz. HIVandHepatitis. ... HIV-infected patients taking cenicriviroc had significant reductions in viral load, with the effect persisting up to two weeks ... Cenicriviroc (INN, code names TAK-652, TBR-652) is an experimental drug candidate for the treatment of HIV infection. It is ...
1997). "Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination". ... technology and application as anti-parasite and anti-microbial agents". Adv. Parasitol. Advances in Parasitology. 42: 343-410. ... April 15, 1997). "Enhancement of cell-mediated immunity against HIV-1 induced by coinnoculation of plasmid-encoded HIV-1 ... 2003). "Novel engineered HIV-1 East African Clade-A gp160 plasmid construct induces strong humoral and cell-mediated immune ...
... showed no detectable anti-HIV activity in clinical trials. Mifepristone showed initial promise in psychotic major ... Use as a cervical ripening agent has also been described. Mifepristone has been studied as an antiandrogen in the treatment of ... The first sets forth ways to rush experimental drugs, such as aggressive HIV and cancer treatments, to market when speedy ... Flexner C (December 2007). "HIV drug development: the next 25 years". Nat Rev Drug Discov. 6 (12): 959-66. doi:10.1038/nrd2336 ...
Using X-ray crystallography, researchers found the points of attack of the HIV protease inhibitors - agents that block the ... "Research at Argonne helps Abbott Labs develop anti-HIV drug". Archived from the original on 2006-10-22. Retrieved 2006-09-04. ... Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents (May 4, 2006). (Available for download ... Abbott pulls HIV drug in Thai patents protest', Financial Times (14 March 2007) AIDES "People Living with HIV: Let's change the ...
"Anti-AIDS Agents 69. Moronic Acid and Other Triterpene Derivatives as Novel Potent Anti-HIV Agents". Journal of Medicinal ... A particular moronic acid derivative showed potent anti-HIV activity with EC50 values of 0.0085 μM against NL4-3, 0.021 μM ... is under development as an anti-HIV drug; however, moronic acid has shown better antiviral profiles in vitro than bevirimat. ... "Anti-Herpes Simplex Virus Activity of Moronic Acid Purified from Rhus javanica In Vitro and In Vivo". The Journal of ...
Adcock IM (April 2007). "HDAC inhibitors as anti-inflammatory agents". British Journal of Pharmacology. 150 (7): 829-31. doi: ... "Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy". ... and others are being investigated as anti-inflammatory agents. After the successful initial round of in vitro research in ... "Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents". Journal of Hematology & Oncology. 3: 5. doi: ...
Anti-AIDS agents--XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural ... Neotripterifordin is an anti-viral diterpene lactone isolated from Tripterygium wilfordii. ...
... and obtained a PhD with a dissertation on Development of New Anti-HIV Agents. He did research on virology at the Rega Institute ... At Tibotec he continued his work on HIV.[2] In 1999, he was elected as board member of the Flemish Institute for Biotechnology ... Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives, Nature. 1990 Feb 1;343( ...
... a model for in vitro testing of potential anti-HIV drugs". Comp. Immunol. Microbiol. Infect. Dis. 24 (2): 113-22. doi:10.1016/ ... Agents Chemother. 31 (9): 1369-74. doi:10.1128/aac.31.9.1369. PMC 174944 . PMID 2445282. Salvatori D, Vincenzetti S, Maury G, ... "HIV-1-associated central nervous system dysfunction." Krebs FC, Ross H, McAllister J, Wigdahl B. Frank KB, McKernan PA, Smith ... The relationship of visna and HIV as lentiviruses was first published in 1985 by visna researcher Janice E. Clements and ...
They also looked at how the substituent placement on the quinoline derivatives affected the primary anti-HIV inhibitory ... Quinoline and its derivatives are commonly used in antimalarial drugs, fungicides, antibiotics, dyes, and flavoring agents. ... Luo, Z.G; Zeng, C.C.; Wang, F.; HE; Wang, C.X. (2009). "Synthesis and biological activities of quinoline derivatives as HIV-1 ... and anti-inflammatory activities. Additionally, researchers, such as Luo Zai-gang et al., recently looked at the synthesis and ...
"Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin". Antimicrob. Agents Chemother. 47 (8 ... "Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides". J. Biol. Chem. 277 ( ... It is 10,000 times more toxic to HIV than it is to cells." This protein may use the morpheein model of allosteric regulation. ... Zappe H, Snell ME, Bossard MJ (2008). "PEGylation of cyanovirin-N, an entry inhibitor of HIV". Adv. Drug Deliv. Rev. 60 (1): 79 ...
Percudani R, Montanini B, Ottonello S (September 2005). "The anti-HIV cyanovirin-N domain is evolutionarily conserved and ... Agents Chemother. 47 (8): 2518-2525. doi:10.1128/aac.47.8.2518-2525.2003. PMC 166092 . PMID 12878514. Wlodawer A, Botos I, Boyd ... "Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides". J. Biol. Chem. 277 ( ... Mori T, O'keefe BR, Smee DF, Turpin JA, Saucedo CJ, Gustafson KR, Blakeslee D, Buckheit R, Boyd MR (2003). "Potent anti- ...
Novel 3,28-Disubstituted Betulinic Acid Derivatives as Potent Anti-HIV Agents Aims/Hypothesis Out-licensing. iptechex ... C-3 esterification of betulinic acid led to the discovery of bevirimat, an HIV-1 maturation inhibitor patented by Rhone-Poulenc ... Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory ... on two clones derived from the same human melanoma metastasis suggests the development of clones resistant to this agent will ...
Drug-resistant viruses are an inevitable consequence of prolonged exposure of HIV-1 to anti-HIV drugs. In the summer of 1981 ... This compound had been prepared in 1964 as a potential anti-cancer agent but was shown to be ineffective. In 1974 zidovudine ... The reverse transcriptase of HIV-1 has been the main foundation for the development of anti-HIV drugs. The first nucleoside ... "HIV and AIDS: 20 years of science", Nature Medicine, 9 (7): 839-843, doi:10.1038/nm0703-839 De-Clercq, E. (2009), "Anti-HIV ...
Li W.-H., Zhang X.-M., Tian R.-R., Zheng Y.-T., Zhao W.-M., Qiu M.-H.,"A new anti-HIV lupane acid from Gleditsia sinensis Lam ... Studies in mice suggest that Gleditsia sinensis ethanolic extract could be an effective therapeutic agent for the treatment of ... A lupane acid extracted from the thorns showed in vitro anti-HIV activity. The fruit extract of Gleditsia sinensis also has ... Chui C.H., Gambari R., Lau F.Y., Teo I.T.N., Ho K.P., Cheng G.Y.M., Ke B., Higa T., Kok H.L., Chan A.S.C., Tang J.C.O."Anti- ...
"Histone deacetylase inhibitors as anti-neoplastic agents". Cancer Letters. 280 (2): 192-200. doi:10.1016/j.canlet.2009.03.013. ... Depletion of Latent HIV in CD4 Cells - Full Text View - ClinicalTrials.gov Batty N, Malouf GG, Issa JP (Aug 2009). " ... In addition, a clinical trial is studying valproic acid effects on the latent pools of HIV in infected persons. HDIs are ... Histone deacetylase inhibitors (HDIs) have a long history of use in psychiatry and neurology as mood stabilizers and anti- ...
1990). "Anti-AIDS agents, 2: Inhibitory effects of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte ... HPLC determination Tannins, including gallo and ellagic acid (epigallitannins), are inhibitors of HIV replication. 1,3,4-Tri-O- ... Two compounds, punicalin and punicacortein C, inhibited purified HIV reverse transcriptase. Hydrolysable tannins have shown ... galloylquinic acid, 3,5-di-O-galloyl-shikimic acid, 3,4,5-tri-O-galloylshikimic acid, punicalin, punicalagin inhibited HIV ...
... that a plausible mechanism for HIV's action has been proposed, and that anti-HIV medication decreases mortality and ... Placebo-controlled studies have found that AZT as a single agent produces modest and short-lived improvements in survival and ... Moreover, in addition to recreational drugs, Duesberg argues that anti-HIV drugs such as zidovudine (AZT) can cause AIDS. ... 1995). "HIV-1 incidence and HIV-1 associated mortality in a cohort of urban factory workers in Tanzania". Genitourin Med. 71 (4 ...
The two guanine antivral carbocyclic nucleosides, the anti-HIV agent abacavir and the anti-hepatitis B agent entecavir, are ... as well as inefficient central nervous system penetration prevented it from further developing as an anti-HIV agent. These ... 1988: Review of Glaxo's synthesis of fluorocarbocyclic nucleosides 1988: (±)-Carbovir first reported with potent anti-HIV ... a potent new anti-herpetic agent". Journal of the Chemical Society, Chemical Communications (10): 656-658. doi:10.1039/ ...
... tablets and oral solution, in combination with other antiretroviral agents, are indicated for the treatment of HIV-1 ... selective anti-human immunodeficiency virus activity". Antimicrobial Agents and Chemotherapy. 41 (5): 1082-1093. PMC 163855 . ... Abacavir should always be used in combination with other antiretroviral agents. Abacavir should not be added as a single agent ... "Nucleoside reverse transcriptase inhibitors (NRTIs or 'nukes') - HIV/AIDS". www.hiv.va.gov. Archived from the original on 2016- ...
They were able to show that indinavir, when used with two other anti-HIV drugs, could significantly reduce the HIV viral load.[ ... 97 patients were randomly assigned to one of the three groups: indinavir monotherapy, AZT and lamivudine, or all three agents. ... Indinavir does not cure HIV/AIDS, but it can extend the length of a person's life for several years by slowing the progression ... It is normally used as one of the three drugs in a triple-combination therapy for the HIV virus.[1] ...