Loading...
*  Michellamine
Zhang, Heping; Zembower, David; Chen, Zhidong (October 1997). "Structural analogues of the michellamine anti-HIV agents. ... The main use of Michellamines are in anti-HIV medications. They inhibit viral replication of the Protein kinase C and virus- ... Michellamine is an atropisomeric alkaloid which has been found to be a strong anti-HIV viral replication inhibitor. It was ... They have a broad range of effectiveness across most HIV strains, particularly the HIV-2 strain, which is found primarily in ...
*  Cenicriviroc
Reviriego, C (July 2011). "Chemokine CCR2/CCR5 Receptor Antagonist Anti-HIV Agent". Drugs of the Future. 36 (7): 511-7. doi: ... CROI 2013: CCR5/CCR2 Inhibitor Cenicriviroc Has Both Anti-HIV and Anti-inflammatory Effects. Highleyman, Liz. HIVandHepatitis. ... HIV-infected patients taking cenicriviroc had significant reductions in viral load, with the effect persisting up to two weeks ... Cenicriviroc (INN, code names TAK-652, TBR-652) is an experimental drug candidate for the treatment of HIV infection. It is ...
*  Moronic acid
"Anti-AIDS Agents 69. Moronic Acid and Other Triterpene Derivatives as Novel Potent Anti-HIV Agents". Journal of Medicinal ... A particular moronic acid derivative showed potent anti-HIV activity with EC50 values of 0.0085 μM against NL4-3, 0.021 μM ... is under development as an anti-HIV drug; however, moronic acid has shown better antiviral profiles in vitro than bevirimat. ... "Anti-Herpes Simplex Virus Activity of Moronic Acid Purified from Rhus javanica In Vitro and In Vivo". The Journal of ...
*  Etravirine
Other diarylpyrimidine-analogues are currently being used as anti-HIV agents, notably rilpivirine. In 2009, the prescribing ... making it the 30th anti-HIV drug approved in the United States and the first to be approved in 2008. It was also approved for ... Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Department of Health and Human ... HIV-1) infection in antiretroviral treatment-experienced adult patients, who have evidence of viral replication and HIV-1 ...
*  Betulinic acid
Novel 3,28-Disubstituted Betulinic Acid Derivatives as Potent Anti-HIV Agents Aims/Hypothesis Out-licensing. iptechex ... C-3 esterification of betulinic acid led to the discovery of bevirimat, an HIV-1 maturation inhibitor patented by Rhone-Poulenc ... Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory ... on two clones derived from the same human melanoma metastasis suggests the development of clones resistant to this agent will ...
*  Zinc finger inhibitor
"Anti-HIV Agents That Selectively Target Retroviral Nucleocapsid Protein Zinc Fingers without Affecting Cellular Zinc Finger ... "Biophysical Characterization of Zinc Ejection from HIV Nucleocapsid Protein by Anti-HIV 2,2'-Dithiobis[benzamides] and ... Zinc ejectors were patented in 2008 and some have entered Phase I/II trials as a HIV drug. The HIV-1 nucleocapsid protein 7 ( ... Azodicarbonamide (ADA) was the first zinc ejector to go into clinical trial for treatment of HIV. ADA inhibits HIV by ...
*  CCR5 receptor antagonist
"Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: discovery and initial structure-activity relationships for ... Wood A, Armour D (2005). "The discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV ... March 2008). "Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists". Molecular ... They play an important role as co-receptors that HIV type 1 (HIV-1) uses to attach to cells before viral fusion and entry into ...
*  Ting-Chao Chou
The method has been applied in the combination of anti-cancer drugs, anti-HIV agents, drug-radiation, and traditional Chinese ... mainly for anticancer agents.[5] Born in Chang-Ling Village, Hu-Kao Township, Hsin-Chu County, Taiwan on September 9, 1938 ( ... where Dm equals to the anti-log of the x-intercept. This unique theory holds true for all dose-effect curves that follows the ...
*  Diethyl azodicarboxylate
Potential anti-HIV agents". Monatshefte für Chemie - Chemical Monthly. 124: 37. doi:10.1007/BF00808508. Farquhar, David; Khan, ... DEAD is an aza-dienophile and an efficient dehydrogenating agent, converting alcohols to aldehydes, thiols to disulfides and ... Thus, in general DEAD is an aza-dienophile and dehydrogenating agent, converting alcohols to aldehydes, thiols to disulfides ... a potent antitumor agent; and procarbazine, a chemotherapy drug. DEAD is an orange-red liquid which weakens its color to yellow ...
*  Carbocyclic nucleoside
The two guanine antivral carbocyclic nucleosides, the anti-HIV agent abacavir and the anti-hepatitis B agent entecavir, are ... as well as inefficient central nervous system penetration prevented it from further developing as an anti-HIV agent. These ... 1988: Review of Glaxo's synthesis of fluorocarbocyclic nucleosides 1988: (±)-Carbovir first reported with potent anti-HIV ... a potent new anti-herpetic agent". Journal of the Chemical Society, Chemical Communications (10): 656-658. doi:10.1039/ ...
*  Surfactin
2001) Biophysical J 81(3):1547-54 Jung M, Lee S, Kim H, Kim H. Recent Studies on Natural Products as Anti-HIV Agents. (2000). ... This process has been proven through test on several envelop viruses such as HIV and HSV. Also, the isoforms of the fatty acid ... anti-mycoplasma and hemolytic activities. Surfactin's structure consists of a peptide loop of seven amino acids (L-aspartic ...
*  Rudi Pauwels
... and obtained a PhD with a dissertation on Development of New Anti-HIV Agents. He did research on virology at the Rega Institute ... At Tibotec he continued his work on HIV. In 1999, he was elected as board member of the Flemish Institute for Biotechnology ( ... Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives, Nature. 1990 Feb 1;343( ...
*  Micellar solubilization
Jain A, Ran Y, Yalkowsky S, "Effect of pH-Sodium Lauryl Sulfate Combination on Solubilization of PG-300995 (an Anti-HIV Agent ...
*  Cytidine
For example, KP-1461 is an anti-HIV agent that works as a viral mutagen, and zebularine exists in E. coli and is being examined ...
*  Trichosanthin
July 1999). "Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein ... Li MX, Yeung HW, Pan LP, Chan SI (November 1991). "Trichosanthin, a potent HIV-1 inhibitor, can cleave supercoiled DNA in vitro ...
*  Leuckart reaction
... and anti-HIV agents. Researchers were able to synthesize tetrahydro-1,4-benzodiazepin-5-ones with excellent yields and purities ... Water hydrolyzes formamide to give ammonium formate, which acts as a reducing agent and adds on to the N-formyl derivative. ... Researchers performed the reaction via solid-phase synthesis and used formic acid as the reducing agent. Eschweiler-Clarke ... one using ammonium formate and the other using formamide as the reducing agent. It requires high temperatures, usually between ...
*  Zalcitabine
... was first synthesized in the 1960s by Jerome Horwitz and subsequently developed as an anti-HIV agent by Samuel ... CS1 maint: Multiple names: authors list (link) NIH Bio and Oral History of Samuel Broder describing the development of anti-HIV ... For these reasons it is now rarely used to treat human immunodeficiency virus (HIV), and it has even been removed from ... Zalcitabine was the third antiretroviral to be approved by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS ...
*  Gramicidin
... a topical contraceptive and antimicrobial agent with anti-HIV activity, against herpes simplex viruses type 1 and 2 in vitro". ...
*  Bryostatin
They have been studied in clinical trials as anti-cancer agents, as anti-AIDS/HIV agents and in people with Alzheimer's disease ... Bryostatin has also been studied in people with HIV. Bryostatin 1 was first isolated in the 1960s by George Pettit from ... As of 2014 over thirty clinical trials had been conducting, using bryostatin alone and in combination with other agents, in ...
*  DMOZ - Health: Pharmacy: Drugs and Medications: E: Enfuvirtide
Manufacturer Roche explains this class of anti-HIV agent, with details of indications and side-effects. Information in English ...
*  Hydrolysable tannin
1990). "Anti-AIDS agents, 2: Inhibitory effects of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte ... HPLC determination Tannins, including gallo and ellagic acid (epigallitannins), are inhibitors of HIV replication. 1,3,4-Tri-O- ... Two compounds, punicalin and punicacortein C, inhibited purified HIV reverse transcriptase. Hydrolysable tannins have shown ... galloylquinic acid, 3,5-di-O-galloyl-shikimic acid, 3,4,5-tri-O-galloylshikimic acid, punicalin, punicalagin inhibited HIV ...
*  Neotripterifordin
Anti-AIDS agents--XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural ... Neotripterifordin is an anti-viral diterpene lactone isolated from Tripterygium wilfordii. ...
*  Chugai Pharmaceutical Co.
1996 anti-viral chemotherapeutic agent Hivid released (HIV reverse transcriptase inhibitor) 1997 - HIV protease inhibitor ... If Mitemcinal can be shown to be as effective a prokinetic agent, it would represent a significant advance in the GI field as ... Produced an anti-influenza virus Tamiflu (Roche) 2015 - In March the company announced it would co-commercialise Athersys's ... Invirase released 1999 - immunosuppressive agent Cellcept released 2000 - Release of an antiemetic drug Kytril, developed to ...
*  Discovery and development of HIV-protease inhibitors
Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. International Journal of Antimicrobial Agents ... They are highly effective against HIV and have, since the 1990s, been a key component of anti-retroviral therapies for HIV/AIDS ... In common usage HIV usually implies HIV-1. HIV-1 protease is one of the best known aspartic proteases, and an attractive target ... The Stanford HIV RT and Protease Sequence Database (also called the "HIV Drug Resistance Database") was formed in 1998 with HIV ...
*  Pyroptosis
These agents could form a new and exciting 'anti-AIDS' therapy for HIV-infected subjects in which the treatment targets the ... "Dissecting How CD4 T Cells Are Lost During HIV Infection". Cell Host Microbe. 19: 280-91. doi:10.1016/j.chom.2016.02.012. PMC ... Some examples of pyroptosis include salmonella-infected macrophages and abortively HIV-infected T helper cells. The initiation ... such as that elicited by HIV-1, this beneficial response does not eradicate the primary stimulus. In fact, it appears to create ...
*  Prostitution in the United States
The prostitution of children in the United States is a concern, with an FBI agent saying, "What we've learned is if you have ... After several years of pressure from law enforcement and anti-prostitution groups, Craigslist closed this section in September ... 12 percent of prostitutes are possibly HIV-positive. A 2004 TNS poll reported 15 percent of all men have paid for sex and 30 ... an anti-prostitution drive in San Francisco attracted huge crowds to public meetings. At one meeting attended by 7,000 people, ...