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ISBN 978-0-12-526451-8. Bryskier A. "Antibacterial Agents; Structure Activity Relationships" (PDF). p. 143. Archived from the ... The primary means of bacterial resistance to macrolides occurs by post-transcriptional methylation of the 23S bacterial ... Macrolide antibiotics do so by binding reversibly to the P site on the 50S subunit of the bacterial ribosome. This action is ... Classification of agents Pharmamotion. Author: Gary Kaiser. The Community College of Baltimore County. Retrieved on July 31, ...
"Targeting antibacterial agents by using drug-carrying filamentous bacteriophages". Antimicrobial Agents and Chemotherapy. 50 (6 ... Bacteriophages are bacterial viruses, evolved to infect bacterial cells; to do that, phages must use characteristic structures ... Purified recombinant phage enzymes can be used as separate antibacterial agents in their own right. Phage therapy also has the ... Borysowski J, Weber-Dabrowska B, Górski A (April 2006). "Bacteriophage endolysins as a novel class of antibacterial agents". ...
"Narrow-Spectrum Antibacterial Agents". MedChemComm. 9: 12-21. doi:10.1039/C7MD00528H. ISSN 2040-2503. PMC 5839511. PMID ... Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome ( ... Antimicrobial Agents and Chemotherapy. 63 (1). doi:10.1128/AAC.01297-18. ISSN 1098-6596. PMC 6325184. PMID 30397052. ( ... indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the ...
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Hiraki, J. (1995). "Basic and applied studies on ε-polylysine". Journal of Antibacterial Antifungal Agents. 23: 349-354. Mazia ... This eventually leads to the abnormal distribution of the cytoplasm causing damage to the bacterial cell that is produced by ... s as delivery agents for antisense oligonucleotides". Pharmaceutical Research. 24 (8): 1581-1589. doi:10.1007/s11095-006-9231-y ... which offers a new way to deliver therapeutic agents specifically to the sites of injury after vascular damage. In 2010, ...
Agents with anti-pseudomonal activity, including doripenem, imipenem, and meropenem, are not recommended in this population. ... Carbapenems are a class of very effective antibiotic agents most commonly used for the treatment of severe bacterial infections ... Structure Activity Relationships "Antibacterial Agents; Structure Activity Relationships," André Bryskier MD; beginning at ... thus inhibiting bacterial cell wall synthesis. However, these agents individually exhibit a broader spectrum of activity ...
Gardnerella at the US National Library of Medicine Medical Subject Headings (MeSH) Mahajan, GB (2012). "Antibacterial agents ... Actinomycetota is one of the dominant bacterial phyla and contains one of the largest of bacterial genera, Streptomyces. ... Although some of the largest and most complex bacterial cells belong to the Actinomycetota, the group of marine Actinomarinales ... Pandey, B.; Ghimire, P.; Agrawal, V.P. (January 12-15, 2004). Studies on the antibacterial activity of the Actinomycetes ...
host DHFR have found application as antibacterial agents. An extensive review of the chemical space of small-molecules that ... Bacteria also need DHFR to grow and multiply and hence inhibitors selective for bacterial vs. ... Hawser S, Lociuro S, Islam K (March 2006). "Dihydrofolate reductase inhibitors as antibacterial agents". Biochemical ... the experimental antimalarial and anti-toxoplasmosis compound JPC-2056 Oral piritrexim, a treatment for metastatic urothelial ...
"New Family Of Antibacterial Agents Uncovered". Science News. ScienceDaily. 2009-01-17. Retrieved 2009-01-17. Jung S, Dingley AJ ... Functionally, the protein causes bacterial cells to clump together and aggregate, changing the morphology of the bacterial ... This potent antibacterial activity extended to known multi-resistant strains of pathogenic bacteria, such as those of ... This results in a disruption of the structure of the bacterial membrane. Hydramacin-1 was first isolated from epithelial cells ...
Quinolones can be classified into generations based on their antibacterial spectra. The earlier-generation agents are, in ... Bacterial cytotoxicity could arise from incomplete repair of closely spaced 8-oxo-2'-deoxyguanosine in the DNA resulting in ... Risks of antibacterial agents in pregnancy]". Le Infezioni in Medicina. 10 (1): 8-15. PMID 12700435. Bar-Oz B, Moretti ME, ... "Antibacterial Agents; Structure Activity Relationships," André Bryskier MD (CS1: long volume value, CS1 maint: DOI inactive as ...
"Risks of antibacterial agents in pregnancy". Le Infezioni in Medicina: Rivista Periodica di Eziologia, Epidemiologia, ... Ofloxacin is used in the treatment of bacterial infections such as: Acute bacterial exacerbations of chronic obstructive ... An eye drop may be used for a superficial bacterial infection of the eye and an ear drop may be used for otitis media when a ... Agents Chemother. 22 (4): 548-53. doi:10.1128/aac.22.4.548. PMC 183791. PMID 6960805. Owens RC, Ambrose PG (July 2005). " ...
... need DHFR to grow and multiply and hence inhibitors selective for bacterial DHFR have found application as antibacterial agents ... Regardless, trimethoprim and sulfamethoxazole in combination has been used as an antibacterial agent for decades. Folate is ... Trimethoprim, an antibiotic, inhibits bacterial DHFR while methotrexate, a chemotherapy agent, inhibits mammalian DHFR. However ... Hawser S, Lociuro S, Islam K (March 2006). "Dihydrofolate reductase inhibitors as antibacterial agents". Biochemical ...
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Pongs, O. (1979). "Chapter 3: Chloramphenicol". In Hahn, eFred E. (ed.). Mechanism of Action of Antibacterial Agents. ... and other infectious bacterial diseases. Since its discovery, chloromycetin has been linked to an increased risk of fatal ... Wright, Peter M.; Seiple, Ian B.; Myers, Andrew G. (2014). "The Evolving Role of Chemical Synthesis in Antibacterial Drug ... the remainder of her career and spent the latter part of it researching fertility drugs and the synthesis of blood-lipid agents ...
Pongs, O. (1979). "Chapter 3: Chloramphenicol". In Hahn, eFred E. (ed.). Mechanism of Action of Antibacterial Agents. ... "Chloramphenicol spectrum of bacterial susceptibility and Resistance" (PDF). Archived from the original (PDF) on 11 February ... Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ... During the last decade chloramphenicol has been re-evaluated as an old agent with potential against systemic infections due to ...
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"Long-circulating bacteriophage as antibacterial agents". Proceedings of the National Academy of Sciences. 93 (8): 3188-3192. ... He is best known for his work on bacterial transcription and the biology of bacteriophage lambda. He has made important ... the organization of the bacterial nucleoid, and phage therapy. Adhya was born in Kolkata, India and studied chemistry at the ...
Long-circulating bacteriophage as antibacterial agents. Proc. Natl. Acad. Sci. USA 93:3188-3192. Gupta, K., Y. Lee and J. Yin. ... Phage ecology and bacterial pathogenesis, p. 66-91. In M. K. Waldor, D. I. Friedman, and S. L. Adhya (eds.), Phages: Their Role ... More than one phage can coinfect the same bacterial cell. When this happens, the phage can exchange genes, which is equivalent ... Phage-bacterial coevolution is typically studied within the context of phage community ecology. This article incorporates ...
He then cleaved the double helix of another virus; an antibacterial agent known as bacteriophage lambda. In the third step, he ... Such biological barriers included fastidious bacterial hosts that were unable to survive in natural environments. Other ... In experiments designed to introduce or propagate DNA from non-viral or other low risk agents in animal cells, only low risk ... The moderate risk level of containment was intended for experiments in which there was a probability of generating an agent ...
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Zhang L, He J, Bai L, Ruan S, Yang T, Luo Y (July 2021). "Ribosome-targeting antibacterial agents: Advances, challenges, and ... Buynak JD (September 2007). "Cutting and stitching: the cross-linking of peptidoglycan in the assembly of the bacterial cell ... Dalhoff A (February 2021). "Selective toxicity of antibacterial agents-still a valid concept or do we miss chances and ignore ... Since anti-pathogen inhibitors generally target only one enzyme, such drugs are highly specific and generally produce few side ...
... a Novel Fluorocycline Antibacterial Agent". Drugs. 76 (5): 567-588. doi:10.1007/s40265-016-0545-8. ISSN 1179-1950. PMID ... "Eravacycline is active against bacterial isolates expressing the polymyxin resistance gene mcr-1" (PDF). Antimicrobial Agents ... Sutcliffe, J. A.; O'Brien, W.; Fyfe, C.; Grossman, T. H. (2013-11-01). "Antibacterial activity of eravacycline (TP-434), a ... Antimicrobial Agents and Chemotherapy. 58 (4): 1847-1854. doi:10.1128/AAC.01614-13. ISSN 1098-6596. PMC 4023720. PMID 24342651 ...
"Looking for the new preparations for antibacterial therapy. V. New antimicrobial agents from the oxazolidinones groups in ... Developed during the nineties when several bacterial strains were becoming resistant against such antibiotics as vancomycin. ... "Mechanism of action of the oxazolidinone antibacterial agents". Expert Opinion on Investigational Drugs. 8 (8): 1195-1202. doi: ... The antibacterial effect of oxazolidinones is by working as protein synthesis inhibitors, targeting an early step involving the ...
April 2016). "Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent". Drugs. 76 (5): 567-88. doi:10.1007/s40265-016 ... They also bind to some extent the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular ... and structural bases for antibacterial activity of tigecycline". Antimicrobial Agents and Chemotherapy. 50 (6): 2156-66. doi: ... Also, because the molecules are soluble in water it can worsen kidney failure (this is not true of the lipid-soluble agents ...
Takahashi H, Hayakawa I, Akimoto T (2003). "[The history of the development and changes of quinolone antibacterial agents]". ... It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial ... Sissi C, Palumbo M (November 2003). "The quinolone family: from antibacterial to anticancer agents". Current Medicinal ... Gootz TD, Barrett JF, Sutcliffe JA (January 1990). "Inhibitory effects of quinolone antibacterial agents on eucaryotic ...
Salt is added, which acts as an anti-bacterial agent and preservative. Next, a genus of the Aspergillus fungus is added to the ...
Gönenç, I. Ethem; Koutitonsky, Vladimir G.; Rashleigh, Brenda (2007). Assessment of the Fate and Effects of Toxic Agents on ... Environment portal Ecology portal Earth sciences portal Biology portal Anti-predator adaptation - Defensive feature of prey for ... "Bacterial biomineralization: new insights from Myxococcus-induced mineral precipitation". Geological Society, London, Special ...
There is a higher risk of blood clots forming in the legs or pelvis - anti-clot stockings or medication may be ordered to avoid ... The WHO does not recommend the use of antispasmodic agents for prevention of delay in labour. For years an episiotomy was ... Postpartum infections, also historically known as childbed fever and medically as puerperal fever, are any bacterial infections ... Tsatsaris, Vassilis; Cabrol, Dominique; Carbonne, Bruno (2004). "Pharmacokinetics of tocolytic agents". Clinical ...
"Anti-Monkeypox measures introduced at Thai airports". Thai PBS. Archived from the original on 31 May 2022. Retrieved 31 May ... The variola virus, the causative agent of smallpox, is also in this genus. Of the two types in humans, clade II (formerly West ... mostly for pain and bacterial infections that can occur as a result of monkeypox lesions". Studies published a month later, in ...
Stringfellow D, Glasgow L (1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrob Agents Chemother. 2 ( ... The H5N1 influenza virus, also known as bird flu, has resistance to interferon and other anti-viral cytokines that is ... Binding of molecules uniquely found in microbes-viral glycoproteins, viral RNA, bacterial endotoxin (lipopolysaccharide), ... In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral ...
... dihydro-deoxy elephantopin and 8-hydroxyl naringenin are the most important bioactive compounds responsible for anti-bacterial ... Different parts of the plant are used in traditional medicine of India as an astringent agent, cardiac tonic, and diuretic, and ...
... while strontium chloride and potassium nitrate are added as anti-sensitive agents for individuals who have teeth sensitivity. ... Hydrogen fluoride subsequently acidifies the bacterial cytoplasm, inactivating the essential enzymes for bacterial metabolism, ... Topical fluoride also serves as an antimicrobial agent to reduce demineralization by inhibiting the growth of tooth-erupting ... These polysaccharides are necessary for adherence to enamel, while these acids are essential for the synthesis of bacterial ...
The D period refers to the stage between the end of DNA replication and the splitting of the bacterial cell into two daughter ... ISBN 978-0-12-324719-3. "Presentation on CDC25 PHOSPHATASES: A Potential Target for Novel Anticancer Agents". Archived from the ... have tried to invent the synthetic Cdk4/6 inhibitor as Cdk4/6 has been characterized to be a therapeutic target for anti-tumor ... cell growth and the bacterial cell cycle". Nature Reviews. Microbiology. 7 (11): 822-7. doi:10.1038/nrmicro2202. PMC 2887316. ...
They discovered several novel classes of cytostatic agents with nanomolar antitumor activities based on substituted or fused ... and Anti-HCV Activity of 6-Substituted 7-(Het)aryl-7-deazapurine Ribonucleosides". J. Med. Chem. 57 (3): 1097-1110. doi:10.1021 ... "Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases". Nucleic Acids Res. 44 ( ...
Lupane, oleanane and ursane show particular promise as anti-cancer agents. Steroids feature a cucurbitane core, although in ... Squalene serves as precursor for the formation of many triterpenoids, including bacterial hopanoids and eukaryotic sterols. By ...
They may contain an anti-bacterial coating and are water resistant. The cap contains a little spring-like spiral, which helps ... It is used as a gastrointestinal agent. Effervescent preparations may enhance absorption and speed up onset of action by ...
"Anti-vaxxers stopped the last Lyme disease vaccine. The FDA has just fast-tracked a new one". Newsweek. 25 July 2017. Archived ... Successful infection of the mammalian host depends on bacterial expression of OspC. Tick bites often go unnoticed because of ... After the identification of B. burgdorferi as the causative agent of Lyme disease, antibiotics were selected for testing, ... Masuzawa T (December 2004). "Terrestrial distribution of the Lyme borreliosis agent Borrelia burgdorferi sensu lato in East ...
... sodium hypochlorite is used to remove all traces of nerve agent or blister agent from Personal Protection Equipment after an ... Sodium hypochlorite in solution exhibits broad spectrum anti-microbial activity and is widely used in healthcare facilities in ... The undissociated (nonionized) hypochlorous acid is believed to react with and inactivate bacterial and viral enzymes. ... 50% sodium hypochlorite is also used to neutralize any accidental releases of the nerve agent in the toxic areas. Lesser ...
Cloning of Bti bacterial genes into the Anabaena cyanobacteria for eradication of tropical diseases: The Bacillus thuringiensis ... Bt) group of bacteria is an important agent used for biological pest control. Bt is a Gram positive, aerobic bacterium which ... which is a potent naturally occurring anti-oxidant. A synthetic version of this pigment is currently used for obtaining pink- ...
Hosts obtain these bacterial symbionts either from the environment, spawning, or the luminous bacterium is evolving with their ... It produces greenish luminescent mucus which may have an anti-predator function. The marine snail Hinea brasiliana uses flashes ... Antimicrobial Agents and Chemotherapy. 49 (1): 380-7. doi:10.1128/AAC.49.1.380-387.2005. PMC 538900. PMID 15616318. Di Rocco, ... Most luminous bacterial inhabit the marine sea, with Photobacterium and Vibrio genera dominating the marine environment. In the ...
The unsaturated derivatives are illustrated by phenylahistin the anti-cancer microtubule binding agent, and the mycotoxin ... 2,5-DKPs have been shown to play a role in interspecies bacterial quorum sensing. For example, the 2,5-DKP cyclo(Phe-Pro) has ... For example, the 2,5-DKP cis-cyclo(Leu-Tyr) has been shown to inhibit bacterial biofilm formation; this property can be ... Derivatives of cyclo(L-His-L-Pro) have been studied extensively to develop therapeutic agents for neurodegeneration. These ...
Formerly, the so-called tributyltin (TBT) compounds were used as biocides (and thus anti-fouling agents). TBTs are toxic to ... In the next 24 hours, this layer allows the process of bacterial adhesion to occur, with both diatoms and bacteria (e.g. Vibrio ... Anti-fouling is the ability of specifically designed materials (such as toxic biocide paints, or non-toxic paints) to remove or ... Anti-fouling paints were tried, and in 1860, the first practical paint to gain widespread use was introduced in Liverpool and ...
"Clinical status of anti-cancer agents derived from marine sources". Anti-Cancer Agents in Medicinal Chemistry. 8 (6): 603-617. ... Brück WM, Sennett SH, Pomponi SA, Willenz P, McCarthy PJ (2008). "Identification of the bacterial symbiont Entotheonella sp. in ...
A pest is any species, strain or biotype of plant, animal, or pathogenic agent injurious to plants or plant products. Worldwide ... "Food body production in Macaranga triloba (Euphorbiaceae): A plant investment in anti-herbivore defense via symbiotic ant ... Rivault, C.; Cloarec, A.; Guyader, A. Le (1993). "Bacterial load of cockroaches in relation to urban environment". Epidemiology ... bacterial or viral infections. Although some insects are polyphagous, many are restricted to one specific crop, or group of ...
In bacterial plasmids, RuvA and RuvB repair DNA damage, and are involved in the recombination process of Holliday junctions. ... Steinmetzer K, Zannis-Hadjopoulos M, Price GB (November 1995). "Anti-cruciform monoclonal antibody and cruciform DNA ... and targeted delivery of anticancer agents to tumorigenic cells by specially constructed cruciform DNA segments has shown ...
Chlorhexidine is another example of a non-specific antimicrobial agent. It acts by disrupting bacterial deposition and plaque ... Chemical compounds such as anti-microbial elements are added to some dental diets to directly target the oral cavity in order ... Zinc salts inhibit bacterial growth by binding to sulfur to control plaque formation, as well as reduce foul oral odours. ... Since small and toy breeds have a much smaller jaw but contain the same number of teeth, crowding allows higher bacterial build ...
... s can also be removed chemically and biologically using antifungal/anti‐mycotoxins agents and antifungal plant ... By means of enzymes (esterase, de-epoxidase), yeast (Trichosporon mycotoxinvorans), or bacterial strains (Eubacterium BBSH 797 ... In the feed and food industry it has become common practice to add mycotoxin binding agents such as montmorillonite or ... Dimorphic fungi, which include Blastomyces dermatitidis and Paracoccidioides brasiliensis, are known causative agents of ...
"Legion campaign backs anti-ACLU bill" (PDF). American Legion. Retrieved March 6, 2013. The American Legion family is involved ... In 1927, the ACLU reported that the Legion "had replaced the [Ku Klux] Klan as the most active agent of intolerance and ... In 1976, an outbreak of bacterial pneumonia occurred in a convention of the Legion at the Bellevue Stratford Hotel in ... It warned members against far-right groups such as the John Birch Society and anti-Semitic groups By the late 1950s the ...
More careful use of antimicrobial agents, such as antibiotics, is also considered vital. As many hospital-acquired infections ... Michels, H.T. (2006), Anti-Microbial Characteristics of Copper, ASTM Standardization News, October, pp. 28-31 Wang, Meng; Wei, ... Pollack, Andrew (2010-02-26). "Doctors Struggle to Treat Gram-Negative Bacterial Infections". The New York Times. ISSN 0362- ... U.S. Department of Defense-funded clinical trials, as presented at the Interscience Conference on Antimicrobial Agents and ...
Kong C, Neoh HM, Nathan S (March 2016). "Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy". ... Mastromarino P, Vitali B, Mosca L (July 2013). "Bacterial vaginosis: a review on clinical trials with probiotics" (PDF). The ... They can be caused by a variety of factors, including: Malnutrition Fatigue Recurrent infections Immunosuppressing agents for ... Mastromarino P, Vitali B, Mosca L (July 2013). "Bacterial vaginosis: a review on clinical trials with probiotics" (PDF). The ...
... famciclovir is effective at treating this infection in cats without the side effects reported with other anti-viral agents. ... These usually resolve within four to seven days, but secondary bacterial infections can cause the persistence of clinical signs ... Conjunctivitis and corneal ulcers are treated with topical antibiotics for secondary bacterial infection. Lysine is commonly ... Antibiotics are commonly used to prevent secondary bacterial infection. There are no specific antiviral drugs in common use at ...
Chelating agents, Enediols, IARC Group 2B carcinogens, Photographic chemicals, Reducing agents). ... Zheng, L. T.; Ryu, G. M.; Kwon, B. M.; Lee, W. H.; Suk, K. (2008). "Anti-inflammatory effects of catechols in ... "Models for the bacterial iron-transport chelate enterochelin". Nature. 262 (5570): 722-724. Bibcode:1976Natur.262..722A. doi: ... urushiols, the active agent in poison ivy (R = (CH2)14CH3, (CH2)7CH=CHCH2CH=CHCH2CH=CH2, and others) catecholamines, drugs ...
A biographer has described Laughlin as "among the most racist and anti-Semitic of early twentieth-century eugenicists." As well ... He was eventually appointed as an expert eugenics agent to the Committee on Immigration and Naturalization (the 1924 law ... bacterial geneticist Herbert Spencer Jennings, condemned Laughlin's statistics as invalid because they compared recent ... and worthless class of anti-social whites of the South". Other scientists from the ERO testified in person. The state won the ...
Kang HJ, Middleditch M, Proft T, Baker EN (December 2009). "Isopeptide bonds in bacterial pili and their characterization by X- ... Maresso AW, Schneewind O (March 2008). "Sortase as a target of anti-infective therapy". Pharmacological Reviews. 60 (1): 128-41 ... Cossart P, Jonquières R (May 2000). "Sortase, a universal target for therapeutic agents against gram-positive bacteria?". ... Another sub-family of sortases (C60B in MEROPS) contains bacterial sortase B proteins that are approximately 200 residues long ...
The top ten best-selling drugs of 2013 totaled $75.6 billion in sales, with the anti-inflammatory drug Humira being the best- ... Agents. 31 (3): 189-92. doi:10.1016/j.ijantimicag.2007.11.010. PMID 18248798. Abraham EP (1987). "Cephalosporins 1945-1986". ... hypothesized that an arsenic-containing dye with similar selective absorption properties could be used to treat bacterial ... Approximately 400 tons of these agents are manufactured each year; this is enough to put approximately 9,000,000 people to ...