"Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain". Blood. 78 (4): 1047-55. PMID ... Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene. This gene is a member of the Antp homeobox ... "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". ... "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663-74. ...
... Homeodomain Protein at the US National Library of Medicine Medical Subject Headings (MeSH) Drosophila Antennapedia ... Antennapedia is a HOM-C gene first discovered in Drosophila which controls the formation of legs during development. Loss-of- ... Antennapedia also refers to a gene complex in Drosophila which is responsible for formation and differentiation of the thoracic ... It is suggested that Antennapedia arose from Evx, a non-Hox family of genes. This duplication event of Evx into the Antp-class ...
... the resulting protein will recognize Antennapedia-binding enhancer sites. However, all homeodomain-containing transcription ... The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. The homeodomain ... homeodomains of individual Hox proteins usually exhibit greater similarity to homeodomains in other species than to proteins ... Hox proteins are a subset of the homeodomain-containing transcription factors, which are proteins that are capable of binding ...
The homeodomain binds DNA in a sequence-specific manner. However, the specificity of a single homeodomain protein is usually ... "Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex". Journal of ... These genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure ... Such complexes have a much higher target specificity than a single homeodomain protein. Homeodomains are encoded both by genes ...
"Cell Internalization of the Third Helix of the Antennapedia Homeodomain is Receptor-independent". Journal of Biological ... CPP mediated delivery of proteins[edit]. The development of therapeutic proteins that has presented a valuable method to treat ... Several groups have successfully delivered CPP fused proteins in vitro. TAT was able to deliver different proteins, such as ... The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly ...
A homeobox gene is a transcription factor in which a region known as a homeodomain binds to a target gene promoter and controls ... Proboscipedia, also known as the pb gene, is a protein coding gene in Drosophila melanogaster, or fruit fly. This hox gene ... Proboscipedia belongs to the Antennapedia (Antp) homeobox family and the Proboscipedia subfamily. ...
Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 ... This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded ... Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene. ... "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274-8. doi:10.1016/ ...
All homeotic genes share a segment of protein with a similar sequence and structure called the homeodomain (the DNA sequence is ... The Antennapedia complex and the bithorax complex on the third chromosome contain the major homeotic genes required for ... These proteins are known to be ligands for the Notch protein. GLP-1, a Notch protein, is also required for specification of the ... mom-2 is a member of the Wnt family of proteins (i.e. the signal) and mom-5 is a member of the frizzled family of proteins (i.e ...
Thus, the 60 amino acid DNA binding protein domain was named the homeodomain, while the 180 bp nucleotide sequence encoding it ... Another well-known example is Antennapedia: a gain-of-function allele causes legs to develop in the place of antennae. In ... The homeotic-function of certain proteins was first postulated to be that of a "selector" as proposed by Antonio Garcia-Bellido ... By definition selectors were imagined to be (transcription factor) proteins that stably determined one of two possible cell ...
... belongs to the family of proteins that contains homeodomain. Homeodomain is a stretch of 32 specific amino acids in ... Fraenkel E, Pabo CO (August 1998). "Comparison of X-ray and NMR structures for the Antennapedia homeodomain-DNA complex". ... Homeobox protein NOBOX, also known as newborn ovary homeobox protein, is a protein that in humans is encoded by the NOBOX gene. ... Protein structure[edit]. The human NOBOX is a 14 kb protein and encoded by 8 exons.[6] It has a proline rich C terminus and ...
Homeodomain proteins are transcription factors that share a DNA-binding domain called the homeodomain. Changes in the ... For example, the lab gene is found in the 3' position in the Antennapedia complex, and is expressed in the most anterior head ... They encode homeodomain proteins which interact with Hox and other homeotic genes to initiate segment-specific gene regulation ... The proteins do not bind directly to the DNA, rather, they interact with other regulatory proteins which are already bound to ...
Cell internalization of the third helix of the Antennapedia homeodomain is receptor independent. J. Biol. Chem. 271: 18188- ... The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly ... Several groups have successfully delivered CPP fused proteins in vitro. TAT was able to deliver different proteins, such as ... and denaturation of proteins before delivery. In one study, a short amphipathic peptide carrier, Pep-1, and protein complexes ...
The Nanos protein is a translational repressor protein. Bicoid has a DNA-binding homeodomain that binds both DNA and the nanos ... The Antennapedia group of homeotic selector genes includes labial, antennapedia, sex combs reduced, deformed, and proboscipedia ... Nanos protein forms a gradient at the posterior end. The Bicoid protein blocks translation of caudal mRNA so Caudal protein is ... and Caudal proteins is in the transcriptional regulation of other zygotically expressed proteins. Many of these are the protein ...
Derossi D, Joliot AH, Chassaing G, Prochiantz A (April 1994). "The third helix of the Antennapedia homeodomain translocates ... These proteins bind to the extracellular domains of transmembrane receptor proteins, which use an elaborate process of signal ... The type I receptors activate Smad proteins that in turn act as transcription factors that regulate gene transcription. Sonic ... However, most morphogens are secreted proteins that signal between cells. A morphogen spreads from a localized source and forms ...
... consists of the region from T735 to E745 of the IKK-β subunit fused with a sequence derived from the Antennapedia homeodomain ... IKBKG protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) GeneReviews/NIH/NCBI/UW entry on ... Xiao G, Sun SC (October 2000). "Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein". Oncogene. 19 ... Prajapati S, Verma U, Yamamoto Y, Kwak YT, Gaynor RB (January 2004). "Protein phosphatase 2Cbeta association with the IkappaB ...
"25 Years of Homeodomain / Homeobox discovery", Evo devo, HOX, May 10, 2008. "Fly Guy". Science Matters. UC Berkeley. 1 (7). ... So McGinnis carved up the Antennapedia gene and, using those pieces as probes, the trio identified eight genes, which turned ... "Synergistic activation and repression of transcription by Drosophila homeobox proteins". Cell. 56 (4): 573-83. doi:10.1016/0092 ... showed a localized pattern of expression similar to that of Antennapedia, they decided to revisit the classic papers of Ed ...