The activity of local renin-angiotensin systems and alternative pathways of angiotensin II formation may make an important ... into the peptide angiotensin I. Angiotensin I is further cleaved by an enzyme that is located primarily but not exclusively in ... This cleavage produces angiotensin II, the most vasoactive peptide. Angiotensin II is a potent constrictor of all blood vessels ... Angiotensin II also causes the adrenal glands to release aldosterone, which stimulates the epithelial cells of the kidneys to ...
... which starts a cascade of reactions that lead to formation of angiotensin II. Angiotensin receptors in cells of the zona ... Angiotensin II and extracellular potassium are the two main regulators of aldosterone production. The amount of sodium present ... Mineralocorticoid secretion is regulated mainly by the renin-angiotensin-aldosterone system (RAAS), the concentration of ... Crowley, SD; Coffman, TM (2012). "Recent advances involving the renin-angiotensin system". Experimental Cell Research. 318 (9 ...
The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk ... Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48- ... between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin (1-7) also ... "Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo". Hypertension ...
Certain enzymes are capable of breaking down bradykinin (Angiotensin Converting Enzyme, Aminopeptidase P). Progesterone can ... Journal of the Renin-Angiotensin-Aldosterone System. 9 (4): 221-5. doi:10.1177/1470320308096405. PMID 19126663. S2CID 206729914 ...
... and with lower affinity as an agonist of angiotensin II receptor type 2, mimicking the action of angiotensin II. Its practical ... De Witt BJ, Garrison EA, Champion HC, Kadowitz PJ (September 2000). "L-163,491 is a partial angiotensin AT(1) receptor agonist ... Alterman M (March 2010). "Development of selective non-peptide angiotensin II type 2 receptor agonists". Journal of the Renin- ... L-163,491 is an experimental drug which acts as a partial agonist of angiotensin II receptor type 1, ...
Brasier AR, Recinos A, Eledrisi MS (August 2002). "Vascular inflammation and the renin-angiotensin system". Arteriosclerosis, ...
subsequently angiotensin II was indicted - Ganong, Mulrow)). Denton and colleagues showed direct action of Angiotensin II on ... appetite involves response to reduction of brain intracellular sodium concentration whereas in others the hormone Angiotensin ...
Drapala A, Sikora M, Ufnal M (September 2014). "Statins, the renin-angiotensin-aldosterone system and hypertension - a tale of ... another beneficial effect of statins". Journal of the Renin-Angiotensin-Aldosterone System. 15 (3): 250-258. doi:10.1177/ ...
Škrbić R, *Igić R. Seven decades of angiotensin (1939-2009). Peptides 2009;30:1945-50. Igić R, Škrbić R. The renin-angiotensin ... The renin-angiotensin system and its blockers. Igić R, Škrbić R. Srp Arh Celok Lek. 2014 Nov-Dec;142(11-12):756-63. doi: ... Angiotensin I converting enzyme activity in the choroid plexus and in the retinal. In: Buckley JP, Ferrario CM, eds. Central ... Metabolism of angiotensin I by guinea pig aqueous humor. Can J Physiol Pharmacol 2001;79:627-30. Igić R, Behnia R. Properties ...
Agapitov AV, Haynes WG (March 2002). "Role of endothelin in cardiovascular disease". Journal of the Renin-Angiotensin- ...
Inhibition of ACE with ACE inhibitors leads to decreased conversion of angiotensin I to angiotensin II (a vasoconstrictor) but ... Angiotensin converting enzyme (ACE), also termed kininase II, inactivates a number of peptide mediators, including bradykinin. ... It is better known for activating angiotensin. Neutral endopeptidase also deactivates kinins and other mediators. ...
... angiotensin converting enzyme 2 (ACE2). However, it was later discovered that neutralization of ACE2 by recombinant antibodies ...
These mechanisms include the activation of the sympathetic nervous system as well as the activation of the renin-angiotensin- ... Three theories have been proposed to explain this:[citation needed] An overactive Renin-angiotensin system leads to ... Segura J, Ruilope LM (October 2007). "Obesity, essential hypertension and renin-angiotensin system". Public Health Nutrition. ... Saitoh S (April 2009). "[Insulin resistance and renin-angiotensin-aldosterone system]". Nihon Rinsho. Japanese Journal of ...
Journal of the Renin-Angiotensin-Aldosterone System. 12 (3): 231-237. doi:10.1177/1470320310388440. PMID 21163863. S2CID ...
Agonists of the receptor include angiotensin-(1-7). Antagonist include A-779 (angiotensin-1-7 with c-terminal proline ... Canals M, Jenkins L, Kellett E, Milligan G (Jun 2006). "Up-regulation of the angiotensin II type 1 receptor by the MAS proto- ... Jackson TR, Blair LA, Marshall J, Goedert M, Hanley MR (Sep 1988). "The mas oncogene encodes an angiotensin receptor". Nature. ... "Entrez Gene: MAS1 MAS1 oncogene". Hanley MR (1992). "Molecular and cell biology of angiotensin receptors". Journal of ...
Katz AM (1990). "Angiotensin II: Hemodynamic regulator or growth factor?". J Mol Cell Cardiol. 22 (7): 739-747. doi:10.1016/ ...
Journal of the Renin-Angiotensin-Aldosterone System. 12 (3): 231-237. doi:10.1177/1470320310388440. PMID 21163863. S2CID ...
Izawa H, Aoyagi Y (2006). "Inhibition of angiotensin converting enzyme by mushroom". Journal of the Japanese Society for Food ... The mushroom contains nicotianamine, an ACE inhibitor (angiotensin-converting enzyme). Nicotianamine is a metal-chelating ...
Angiotensin-converting-enzyme inhibitors, or ACE inhibitors, are a class of widely-prescribed medications used in hypertension ... Sweitzer, Nancy K. (2003). "What Is an Angiotensin Converting Enzyme Inhibitor?". Circulation. 108 (3): e16-18. doi:10.1161/01. ... as have small peptides that inhibit angiotensin-1-converting enzyme; the venom of the redback, although little-studied, likely ...
The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. ... Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene. This gene encodes ... "Entrez Gene: AGTRAP angiotensin II receptor-associated protein". Human AGTRAP genome location and AGTRAP gene details page in ... 2003). "Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane". ...
UK-414,495 Omapatrilat (dual inhibitor of NEP and angiotensin-converting enzyme) developed by BMS did not receive FDA approval ... Ecadotril Candoxatril Other dual inhibitors of NEP with ACE/angiotensin receptor were (in 2003) being developed by ... "Angiotensin-neprilysin inhibition versus enalapril in heart failure". The New England Journal of Medicine. 371 (11): 993-1004. ...
On the basis of this finding, a non-protein analog of BPF which was effective orally was developed: the first angiotensin ... Bradykinin is also thought to be the cause of the dry cough in some patients on widely prescribed angiotensin-converting enzyme ... A class of drugs called angiotensin-converting-enzyme inhibitors (ACE inhibitors) increase bradykinin levels by inhibiting its ... In humans, bradykinin is broken down by many different kininases: angiotensin-converting enzyme (ACE, kininase II), neprilysin ...
September 2014). "Angiotensin-neprilysin inhibition versus enalapril in heart failure". The New England Journal of Medicine. ... April 2010). "Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor ( ...
Notable examples that have been described in the references include: Peptides of the renin-angiotensin system: angiotensin II ... Kumar R, Singh VP, Baker KM (July 2007). "The intracellular renin-angiotensin system: a new paradigm". Trends in Endocrinology ... PMID 16615083.Singh VP, Baker KM, Kumar R (Apr 2008). "Activation of the intracellular renin-angiotensin system in cardiac ... and angiotensin (1-7) Fibroblast growth factor 2 Parathyroid hormone-related protein Local hormone Autocrine signalling Park, ...
... is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been ... Jenne DE, Tschopp J (1991). "Angiotensin II-forming heart chymase is a mast-cell-specific enzyme". Biochem. J. 276 (2): 567-8. ... "Entrez Gene: CMA1 chymase 1, mast cell". Urata H, Nishimura H, Ganten D (1996). "Chymase-dependent angiotensin II forming ... Caughey GH, Raymond WW, Wolters PJ (2000). "Angiotensin II generation by mast cell alpha- and beta-chymases". Biochim. Biophys ...
These include the angiotensin-converting enzyme inhibitor captopril. Captopril is based on the peptidic bradykinin potentiating ...
ANP has the opposite effect of angiotensin II on the kidney: angiotensin II increases renal sodium retention and ANP increases ... ANP inhibits the effect of Angiotensin II on the mesangial cells, thereby relaxing them. ANP increases the radius and number of ... Other dual inhibitors of NEP with ACE/angiotensin receptor are (in 2003) being developed by pharmaceutical companies. ANP is ... There are three volume regulating systems: two salt saving systems, the renin angiotensin aldosterone system (RAAS) and the ...
"Investigation of angioedema associated with the use of angiotensin-converting enzyme inhibitors and angiotensin receptor ... Brown NJ, Ray WA, Snowden M, Griffin MR (July 1996). "Black Americans have an increased rate of angiotensin converting enzyme ... Sabroe RA, Black AK (February 1997). "Angiotensin-converting enzyme (ACE) inhibitors and angio-oedema". British Journal of ... Israili ZH, Hall WD (August 1, 1992). "Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor ...
Renin-Angiotensin System and Endothelial Dysfunction". Cells. 9 (7): 1652. doi:10.3390/cells9071652. PMC 7407648. PMID 32660065 ...
"A redox switch in angiotensinogen modulates angiotensin release". Nature. 468 (7320): 108-11. Bibcode:2010Natur.468..108Z. doi: ...